1,190 results on '"Ferrazzi, E."'
Search Results
2. Do differences in diagnostic criteria for late fetal growth restriction matter?
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Arabin, B., Berger, A., Bergman, E., Bhide, A., Bilardo, C.M., Breeze, A.C., Brodszki, J., Calda, P., Cesari, E., Cetin, I., Derks, J., Ebbing, C., Ferrazzi, E., Frusca, T., Ganzevoort, W., Gyselaers, W., Hecher, K., Klaritsch, P., Krofta, L., Lindgren, P., Lobmaier, S.M., Marlow, N, Maruotti, G.M., Mecacci, F., Myklestad, K., Prefumo, F., Raio, L., Richter, J., Sande, R.K., Valensise, H., Visser, G.H.A., Wee, L., Mylrea-Foley, Bronacha, Napolitano, Raffaele, Gordijn, Sanne, Wolf, Hans, Lees, Christoph C., and Stampalija, Tamara
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- 2023
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3. Association of umbilical vein flow with abnormal fetal growth and adverse perinatal outcome in low‐risk population: multicenter prospective study
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Ramirez Zegarra, R., primary, Carbone, I. F., additional, Angeli, L., additional, Gigli, F., additional, Di Ilio, C., additional, Barba, O., additional, Cassardo, O., additional, Valentini, B., additional, Ferrazzi, E., additional, and Ghi, T., additional
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- 2024
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4. Heterotopic cervical and isthmic pregnancy
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Orsi, M., primary, Motta, F., additional, Fedele, F., additional, Ossola, M. W., additional, and Ferrazzi, E., additional
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- 2024
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5. Evaluation of fetal cardiac function in pregnancies with well-controlled gestational diabetes
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D’Ambrosi, F., Rossi, G., Soldavini, C. M., Carbone, I. F., Cetera, G. E., Cesano, N., Di Maso, M., and Ferrazzi, E.
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- 2021
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6. Do differences in diagnostic criteria for late fetal growth restriction matter?
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Mylrea-Foley, Bronacha, primary, Napolitano, Raffaele, additional, Gordijn, Sanne, additional, Wolf, Hans, additional, Lees, Christoph C., additional, Stampalija, Tamara, additional, Arabin, B., additional, Berger, A., additional, Bergman, E., additional, Bhide, A., additional, Bilardo, C.M., additional, Breeze, A.C., additional, Brodszki, J., additional, Calda, P., additional, Cesari, E., additional, Cetin, I., additional, Derks, J., additional, Ebbing, C., additional, Ferrazzi, E., additional, Frusca, T., additional, Ganzevoort, W., additional, Gyselaers, W., additional, Hecher, K., additional, Klaritsch, P., additional, Krofta, L., additional, Lindgren, P., additional, Lobmaier, S.M., additional, Marlow, N, additional, Maruotti, G.M., additional, Mecacci, F., additional, Myklestad, K., additional, Prefumo, F., additional, Raio, L., additional, Richter, J., additional, Sande, R.K., additional, Valensise, H., additional, Visser, G.H.A., additional, and Wee, L., additional
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- 2023
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7. OP05.05: Is the umbilical vein flow associated with birthweight? Multicentre prospective study in a low‐risk population
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Zegarra, R. Ramirez, primary, Angeli, L., additional, Di Ilio, C., additional, Carbone, F., additional, Barba, O., additional, Cassardo, O., additional, Gigli, F., additional, Labadini, C., additional, di Pasquo, E., additional, Dall'Asta, A., additional, Ferrazzi, E., additional, and Ghi, T., additional
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- 2023
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8. OC18.06: Comparing ultrasound evaluation of postpartum pelvic floor dysfunction in supine and standing positions
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Coppola, C., primary, D'Ambrosi, F., additional, Fochesato, C., additional, Cappuccio, G., additional, and Ferrazzi, E., additional
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- 2023
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9. Determinants of emergency Cesarean delivery in pregnancies complicated by placenta previa with or without placenta accreta spectrum disorder: analysis of ADoPAD cohort.
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Lucidi, A., Fratelli, N., Maggi, C., Cavalli, C., Sciarrone, A., Buca, D., Garofalo, A., Viora, E., Vergani, P., Betti, M., Vaglio Tessitore, I., Cavaliere, A. F., Buongiorno, S., Vidiri, A., Fabbri, E., Ferrazzi, E., Maggi, V., Cetin, I., Frusca, T., and Ghi, T.
- Abstract
Objectives: To investigate the rate and outcome of emergency Cesarean delivery (CD) in women with placenta previa with or without placenta accreta spectrum disorders (PAS) and to elucidate the diagnostic accuracy of ultrasound in predicting emergency CD. Methods: This was a secondary analysis of a multicenter prospective study involving 16 referral hospitals in Italy (ADoPAD study). Inclusion criteria were women with placenta previa minor (< 20 mm from the internal cervical os) or placenta previa major (covering the os), aged ≥ 18 years, who underwent transabdominal and transvaginal ultrasound assessment at ≥ 26 + 0 weeks of gestation. The primary outcome was the occurrence of emergency CD, defined as the need for immediate surgical intervention performed for emergency maternal or fetal indication, including active labor, cumulative maternal bleeding > 500 mL, severe and persistent vaginal bleeding such that maternal hemodynamic stability could not be achieved or maintained, or category‐III fetal heart rate tracing unresponsive to resuscitative measures. The primary outcome was reported separately in the population of women with placenta previa and no PAS confirmed after birth and in those with PAS. The secondary aim was to report on the strength of association and to test the diagnostic accuracy of ultrasound in predicting emergency CD. Univariate, multivariate and diagnostic accuracy analyses were used to analyze the data. Results: A total of 450 women, including 97 women with placenta previa and PAS and 353 with placenta previa only, were analyzed. In women with placenta previa and PAS, emergency CD was required in 20.6% (95% CI, 14–30%), and 60.0% (12/20) delivered before 34 weeks of gestation. The mean gestational age at delivery was 32.3 ± 2.7 weeks in women undergoing emergency CD and 34.9 ± 1.8 weeks in those undergoing elective CD (P < 0.001). Women undergoing emergency CD had a higher median estimated blood loss (2500 (interquartile range (IQR), 1350–4500) vs 1100 (IQR, 625–2500) mL; P = 0.012), mean units of blood transfused (7.3 ± 8.8 vs 2.5 ± 3.4; P = 0.02) and more frequent placement of a mechanical balloon (50.0% vs 16.9%; P = 0.002) compared with those undergoing elective CD. On univariate analysis, the presence of interrupted retroplacental space, interrupted bladder line and placental lacunae was more common in women not experiencing emergency CD. No comprehensive multivariate analysis could be performed in this subgroup of women. Ultrasound signs of PAS, including presence of interrupted retroplacental space, interrupted bladder line and placental lacunae, were not predictive of emergency CD. In women with placenta previa but no PAS, emergency CD was required in 31.2% (95% CI, 26.6–36.2%), and 32.7% (36/110) delivered before 34 weeks of gestation. The mean gestational age at delivery was lower in women undergoing emergency CD compared with those undergoing elective CD (34.2 ± 2.9 vs 36.7 ± 1.6 weeks; P < 0.001). Pregnancies complicated by emergency CD were associated with a lower birth weight (2330 ± 620 vs 2800 ± 480 g; P < 0.001) and had a higher risk of need for blood transfusion (22.7% vs 10.7%; P = 0.003) compared with those who underwent elective CD. On multivariate analysis, only placental thickness (odds ratio (OR), 1.02 (95% CI, 1.00–1.03); P = 0.046) and cervical length < 25 mm (OR, 3.89 (95% CI, 1.33–11.33); P = 0.01) were associated with emergency CD. However, a short cervical length showed low diagnostic accuracy for predicting emergency CD in these women. Conclusion: Emergency CD occurred in about 20% of women with placenta previa and PAS and 30% of those with placenta previa only and was associated with worse maternal outcome compared with elective intervention. Prenatal ultrasound is not predictive of the risk of emergency CD in women with these disorders. © 2023 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Maternal Serum B Cell activating factor in hypertensive and normotensive pregnancies
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Tay, J., Costanzi, A., Basello, K., Piuri, G., Ferrazzi, E., Speciani, A.F., and Lees, C.C.
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- 2018
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11. Diagnosis of HIV Infection in Pregnancy: Data from a National Cohort of Pregnant Women with HIV in Italy
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Floridia, M., Ravizza, M., Tamburrini, E., Anzidei, G., Tibaldi, C., MacCabruni, A., Guaraldi, G., Alberico, S., Vimercati, A., Antoni, A. Degli, and Ferrazzi, E.
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- 2006
12. The impact of a multilevel approach to reduce emergency hysterectomy for postpartum haemorrhage: Insights from a tertiary referral centre in Northern Italy
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Orsi, M., Ossola, M.W., Iurlaro, E., Perugino, G., Somigliana, E., and Ferrazzi, E.
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Cesarean Section ,Postpartum Hemorrhage ,Obstetrics and Gynecology ,Peripartum hysterectomy ,Maternal near miss ,Hysterectomy ,Postpartum haemorrhage ,Quality improvement ,Tertiary Care Centers ,Reproductive Medicine ,Pregnancy ,Humans ,Settore MED/40 - Ginecologia e Ostetricia ,Female ,Retrospective Studies - Abstract
To assess the effectiveness of the implementation of a multilevel institutional program to reduce the rate of emergency peripartum hysterectomy (EPH) secondary to postpartum haemorrhage (PPH) in a Western world referral centre for obstetrics.Women who delivered at a tertiary care regional obstetric hub in Milan between 2012 and 2020 were retrospectively reviewed to identify cases of EPH. During the study period, several measures aimed at preventing EPH were progressively implemented: reduction of primary and repeated caesarean, update of PPH treatment protocol, implementation of massive transfusion protocol, dedicated clinical pathway for high-risk patients, regular educational sessions, daily review of critical cases with senior consultant, and periodical review of near miss cases by quality improvement committee. To investigate the possible benefits, we divided the detected cases into two groups based on the historical period (Period I, 2012-2016 vs. Period II, 2017-2020) with the main aim of comparing the rate of EPH calculated as EPH ratio per 1000 deliveries.During Period I and II there were 30,241 and 21,270 births; a total of 60 and 25 EPH were performed, respectively. EPH incidence decreased from 2.0 to 1.2‰ across the study periods (p = 0.027). Between Period I and II, we observed a reduction of institutional caesarean section rate (44.4% vs. 40.4%, p 0.0001); among cases undergoing EPH, we reported a significant reduction of massive blood transfusion (83.3% vs. 52.2%, p = 0.002), increased use (56.7% vs. 96.0%, p = 0.0004) and appropriate administration (25.0% vs. 88.0%, p 0.0001) of tranexamic acid, increased use of non-invasive Bakri Balloon tamponade (3.3% vs. 32.0%, p = 0.0002) instead of surgical techniques (38.3% vs. 16.0%, p = 0.043).A reduction of EPH incidence as a severe outcome of obstetric haemorrhage is achievable through a multilevel institutional effort. Our study may inspire a larger-scale program to improve the safety of patients experiencing PPH.
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- 2022
13. Effects of Antenatal Betamethasone on Fetal Doppler Indices and Short Term Fetal Heart Rate Variation in Early Growth Restricted Fetuses
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Fratelli, N., Prefumo, F., Wolf, H., Hecher, K., Visser, G.H.A., Giussani, D., Derks, J.B., Shaw, C.J., Frusca, T., Ghi, T., Ferrazzi, E., Lees, C.C., Arabin, B., Bilardo, C.M., Brezinka, C., Diemert, A., Duvekot, J.J., Ganzevoort, W., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, A.T., Schlembach, D., Schneider, K.T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Wassenaer-Leemhuis, A. van, Aktas, A., Borgione, S., Chaoui, R., Cornette, J.M.J., Diehl, T., Eyck, J. van, Haastert, I.C. van, Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Charante, N.M. van, Tollenaer, S.M., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., Post, J.A.M. van der, Preston, L., Raimondi, F., Reiss, I.K.M., Scheepers, L.S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., TRUFFLE Grp, TRUFFLE Grp Authors, TRUFFLE Grp Collaborating Authors, Obstetrics & Gynecology, Pediatrics, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Interne Geneeskunde, Neonatology, Amsterdam Reproduction & Development (AR&D), Fratelli, Nicola, Prefumo, Federico, Wolf, Han, Hecher, Kurt, Visser, Gerard H A, Giussani, Dino, Derks, Jan B, Shaw, Caroline J, Frusca, Tiziana, Ghi, Tullio, Ferrazzi, E, Lees, Christoph C, Truffle, Group, and Raimondi, Francesco
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medicine.medical_specialty ,Cardiotocography ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,betamethasone ,fetal growth restriction ,obstetrics ,Female ,Fetal Heart ,Fetus ,Humans ,Pregnancy ,Pregnancy Outcome ,Prospective Studies ,Betamethasone ,Fetal Growth Retardation ,Glucocorticoids ,Heart Rate, Fetal ,Ultrasonography, Prenatal ,Antenatal steroid ,Fetal ,03 medical and health sciences ,0302 clinical medicine ,All institutes and research themes of the Radboud University Medical Center ,Heart Rate ,Internal medicine ,Heart rate ,medicine ,TRUFFLE Group ,Prenatal ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Prospective cohort study ,Ultrasonography ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Nuclear Medicine & Medical Imaging ,TRUFFLE Group collaborating authors ,TRUFFLE Group authors ,Cardiology ,business ,Lower limbs venous ultrasonography ,Ductus venosus ,medicine.drug - Abstract
To investigate the effects of the antenatal administration of betamethasone on fetal Doppler and short term fetal heart rate variation (CTG-STV) in early growth restricted (FGR) fetuses. Post hoc analysis of data derived from the TRUFFLE study, a prospective, multicenter, randomized management trial of severe early onset FGR. Repeat Doppler and CTG-STV measurements between the last recording within 48 hours before the first dose of betamethasone (baseline value) and for 10 days after were evaluated. Multilevel analysis was performed to analyze the longitudinal course of the umbilico-cerebral ratio (UC ratio), the ductus venosus pulsatility index (DVPIV) and CTG-STV. We included 115 fetuses. A significant increase from baseline in CTG-STV was found on day + 1 (p = 0.019) but no difference thereafter. The DVPIV was not significantly different from baseline in any of the 10 days following the first dose of betamethasone (p = 0.167). Multilevel analysis revealed that, over 10 days, the time elapsed from antenatal administration of betamethasone was significantly associated with a decrease in CTG-STV (p = 0.045) and an increase in the DVPIV (p = 0.001) and UC ratio (p 0.001). Although steroid administration in early FGR has a minimal effect on increasing CTG-STV one day afterwards, the effects on Doppler parameters were extremely slight with regression coefficients of small magnitude suggesting no clinical significance, and were most likely related to the deterioration with time in FGR. Hence, arterial and venous Doppler assessment of fetal health remains informative following antenatal steroid administration to accelerate fetal lung maturation.ZIEL: Untersuchung des Effekts der antenatalen Gabe von Betamethason auf den fetalen Doppler und die Kurzzeitvariation der fetalen Herzfrequenz (CTG-STV) bei Föten mit früher Wachstumsrestriktion (FGR). Post-hoc-Analyse von Daten der TRUFFLE-Studie, einer prospektiven, multizentrischen, randomisierten Managementstudie bei schwerer, früh einsetzender FGR. Wiederholte Doppler- und CTG-STV-Messungen zwischen der letzten Aufnahme innerhalb von 48 Stunden vor der ersten Betamethason-Dosis (Ausgangswert) und über 10 Tage wurden bewertet. Eine mehrstufige Analyse erfolgte, um den longitudinalen Verlauf der umbilikal-zerebralen Ratio (UC-Ratio), des Pulsatilitätsindex des Ductus venosus (DVPIV) und der CTG-STV zu analysieren. Wir haben 115 Föten eingeschlossen. Ein signifikanter Anstieg der CTG-STV gegenüber dem Ausgangswert wurde am Tag + 1 (p = 0,019) ermittelt, danach gab es keinen Unterschied. Der DVPIV unterschied sich an keinem der 10 Tage nach erster Betamethason-Dosis signifikant vom Ausgangswert (p = 0,167). Eine mehrstufige Analyse ergab, dass die verstrichene Zeit nach der antenatalen Betamethason-Gabe über 10 Tage hinweg signifikant mit der Abnahme der CTG-STV (p = 0,045) und der Zunahme des DVPIV (p = 0,001) und der UC-Ratio (p 0,001) assoziiert war. Obwohl die Steroidverabreichung bei früher FGR eine kleine Auswirkung auf den Anstieg der CTG-STV 1 Tag darauf hatte, waren die Effekte auf die Doppler-Parameter äußerst gering mit Regressionskoeffizienten von geringer Höhe, die nicht auf klinische Signifikanz schließen lassen. Sie stehen höchstwahrscheinlich in Zusammenhang mit der Verschlechterung bei FGR im Laufe der Zeit. Daher bleibt die Beurteilung der arteriellen und venösen Doppler bezüglich des Gesundheitszustandes des Fötus aussagekräftig, nachdem diesem zur Beschleunigung der fetalen Lungenreifung antenatal Steroide verabreicht wurden.
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- 2021
14. Ultrasound for antenatal diagnosis of placenta accreta spectrum in women with placenta previa: results from ADoPAD study
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Fratelli, N., Prefumo, F., Maggi, C., Cavalli, C., Sciarrone, A., Garofalo, A., Viora, E., Vergani, P., Ornaghi, S., Betti, M., Vaglio Tessitore, I., Cavaliere, A. F., Buongiorno, S., Vidiri, A., Fabbri, E., Ferrazzi, E., Maggi, V., Cetin, I., Frusca, T., Ghi, T., Kaihura, C., Di Pasquo, E., Stampalija, T., Belcaro, C., Quadrifoglio, M., Veneziano, M., Mecacci, F., Simeone, S., Locatelli, A., Consonni, S., Chianchiano, N., Labate, F., Cromi, A., Bertucci, E., Facchinetti, F., Fichera, A., Granata, D., Antonio, F. D( extquotesingle)., Foti, F., Avagliano, L., Bulfamante, G. P., Cal(`(i)) and, G., Fratelli, N, Prefumo, F, Maggi, C, Cavalli, C, Sciarrone, A, Garofalo, A, Viora, E, Vergani, P, Ornaghi, S, Betti, M, Tessitore, I Vaglio, Cavaliere, A F, Buongiorno, S, Vidiri, A, Fabbri, E, Ferrazzi, E, Maggi, V, Cetin, I, Frusca, T, Ghi, T, Kaihura, C, Di Pasquo, E, Stampalija, T, Belcaro, C, Quadrifoglio, M, Veneziano, M, Mecacci, F, Simeone, S, Locatelli, A, Consonni, S, Chianchiano, N, Labate, F, Cromi, A, Bertucci, E, Facchinetti, F, Fichera, A, Granata, D, Antonio, F D', Foti, F, Avagliano, L, Bulfamante, G P, and Calì, G
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diagnosi ,placenta accreta spectrum ,cesarean section ,diagnosis ,low-lying placenta ,ultrasound ,placenta previa - Abstract
To evaluate the diagnostic performance of third trimester ultrasound for the diagnosis of clinically significant Placenta accreta spectrum disorder (PAS) in women with a low-lying placenta (less than 20 mm from the internal cervical os) or placenta praevia (covering the os) METHODS: Pregnant women with a low-lying placenta or placenta praevia, age ≥ 18 years and gestational age at ultrasound ≥ 26+0/7 weeks of gestation were prospectively included in the study. Ultrasound suspicion of PAS was raised in the presence of at least one of these signs: (1) obliteration of the hypoechoic space between the uterus and the placenta; (2) interruption of the hyperechoic interface between the uterine serosa and the bladder wall; (3) abnormal placental lacunae. In order to assess the ability of ultrasound to detect clinically significant PAS, a composite outcome comprehensive of both active management at delivery and histopathological confirmation of PAS was considered as the reference standard. PAS was considered of clinical significance if, in addition to histological confirmation, at least one of these procedures was carried out after delivery: use of hemostatic intrauterine balloon, compressive uterine suture, peripartum hysterectomy, uterine/hypogastric artery ligation, uterine artery embolization.
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- 2022
15. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications (IPPIC) Network database: individual participant data meta-analysis
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Allotey, J., Whittle, R., Snell, K. I. E., Smuk, M., Townsend, R., von Dadelszen, P., Heazell, A. E. P., Magee, L., Smith, G. C. S., Sandall, J., Thilaganathan, B., Zamora, J., Riley, R. D., Khalil, A., Thangaratinam, S., Coomarasamy, A., Kwong, A., Savitri, A. I., Salvesen, K. A., Bhattacharya, S., Uiterwaal, C. S. P. M., Staff, A. C., Andersen, L. B., Olive, E. L., Redman, C., Sletner, L., Daskalakis, G., Macleod, M., Abdollahain, M., Ramirez, J. A., Masse, J., Audibert, F., Magnus, P. M., Jenum, A. K., Baschat, A., Ohkuchi, A., Mcauliffe, F. M., West, J., Askie, L. M., Mone, F., Farrar, D., Zimmerman, P. A., Smits, L. J. M., Riddell, C., Kingdom, J. C., van de Post, J., Illanes, S. E., Holzman, C., van Kuijk, S. M. J., Carbillon, L., Villa, P. M., Eskild, A., Chappell, L., Prefumo, F., Velauthar, L., Seed, P., van Oostwaard, M., Verlohren, S., Poston, L., Ferrazzi, E., Vinter, C. A., Nagata, C., Brown, M., Vollebregt, K. C., Takeda, S., Langenveld, J., Widmer, M., Saito, S., Haavaldsen, C., Carroli, G., Olsen, J., Wolf, H., Zavaleta, N., Eisensee, I., Vergani, P., Lumbiganon, P., Makrides, M., Facchinetti, F., Sequeira, E., Gibson, R., Ferrazzani, S., Frusca, T., Norman, J. E., Figueiro, E. A., Lapaire, O., Laivuori, H., Lykke, J. A., Conde-Agudelo, A., Galindo, A., Mbah, A., Betran, A. P., Herraiz, I., Trogstad, L., Smith, G. G. S., Steegers, E. A. P., Salim, R., Huang, T., Adank, A., Zhang, J., Meschino, W. S., Browne, J. L., Allen, R. E., Costa, F. D. S., Klipstein-Grobusch Browne, K., Crowther, C. A., Jorgensen, J. S., Forest, J. -C., Rumbold, A. R., Mol, B. W., Giguere, Y., Kenny, L. C., Ganzevoort, W., Odibo, A. O., Myers, J., Yeo, S. A., Goffinet, F., Mccowan, L., Pajkrt, E., Teede, H. J., Haddad, B. G., Dekker, G., Kleinrouweler, E. C., Lecarpentier, E., Roberts, C. T., Groen, H., Skrastad, R. B., Heinonen, S., Eero, K., Anggraini, D., Souka, A., Cecatti, J. G., Monterio, I., Pillalis, A., Souza, R., Hawkins, L. A., Gabbay-Benziv, R., Crovetto, F., Figuera, F., Jorgensen, L., Dodds, J., Patel, M., Aviram, A., Papageorghiou, A., Khan, K., Clinicum, HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, HUS Children and Adolescents, Lastentautien yksikkö, Children's Hospital, Allotey, J, Whittle, R, Snell, K, Smuk, M, Townsend, R, von Dadelszen, P, Heazell, A, Magee, L, Smith, G, Sandall, J, Thilaganathan, B, Zamora, J, Riley, R, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, A, Salvesen, K, Bhattacharya, S, Uiterwaal, C, Staff, A, Andersen, L, Olive, E, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramirez, J, Masse, J, Audibert, F, Magnus, P, Jenum, A, Baschat, A, Ohkuchi, A, Mcauliffe, F, West, J, Askie, L, Mone, F, Farrar, D, Zimmerman, P, Smits, L, Riddell, C, Kingdom, J, van de Post, J, Illanes, S, Holzman, C, van Kuijk, S, Carbillon, L, Villa, P, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, van Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, C, Nagata, C, Brown, M, Vollebregt, K, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, J, Figueiro, E, Lapaire, O, Laivuori, H, Lykke, J, Conde-Agudelo, A, Galindo, A, Mbah, A, Betran, A, Herraiz, I, Trogstad, L, Steegers, E, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, W, Browne, J, Allen, R, Costa, F, Klipstein-Grobusch Browne, K, Crowther, C, Jorgensen, J, Forest, J, Rumbold, A, Mol, B, Giguere, Y, Kenny, L, Ganzevoort, W, Odibo, A, Myers, J, Yeo, S, Goffinet, F, Mccowan, L, Pajkrt, E, Teede, H, Haddad, B, Dekker, G, Kleinrouweler, E, Lecarpentier, E, Roberts, C, Groen, H, Skrastad, R, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, J, Monterio, I, Pillalis, A, Souza, R, Hawkins, L, Gabbay-Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, Khan, K, Tampere University, Obstetrics and Gynaecology, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), APH - Personalized Medicine, APH - Digital Health, and Obstetrics and gynaecology
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Calibration (statistics) ,Perinatal Death ,Overfitting ,Cohort Studies ,Fetal Development ,0302 clinical medicine ,Discriminative model ,3123 Gynaecology and paediatrics ,Models ,Pregnancy ,GROWTH RESTRICTION ,Statistics ,Medicine ,Prenatal ,030212 general & internal medicine ,Ultrasonography ,RISK ,030219 obstetrics & reproductive medicine ,PRETERM ,Radiological and Ultrasound Technology ,LOW-DOSE ASPIRIN ,DIAGNOSIS TRIPOD ,Obstetrics and Gynecology ,General Medicine ,Statistical ,Stillbirth ,Prognosis ,Pregnancy Complication ,external validation ,individual participant data ,intrauterine death ,prediction model ,stillbirth ,Female ,Humans ,Infant, Newborn ,Models, Statistical ,Pregnancy Complications ,Regression Analysis ,Risk Assessment ,Ultrasonography, Prenatal ,3. Good health ,PREECLAMPSIA ,Meta-analysis ,Human ,Cohort study ,Prognosi ,MEDLINE ,Regression Analysi ,WEEKS GESTATION ,03 medical and health sciences ,VELOCIMETRY ,Radiology, Nuclear Medicine and imaging ,RECURRENCE ,business.industry ,Infant ,Newborn ,R1 ,HYPERTENSIVE DISORDERS ,Reproductive Medicine ,Sample size determination ,Cohort Studie ,RG ,business ,RA ,Predictive modelling - Abstract
Objective Stillbirth is a potentially preventable complication of pregnancy. Identifying women at high risk of stillbirth can guide decisions on the need for closer surveillance and timing of delivery in order to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none has yet been validated externally. In this study, we externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance. Methods MEDLINE, EMBASE, DH-DATA and AMED databases were searched from inception to December 2020 to identify studies reporting stillbirth prediction models. Studies that developed or updated prediction models for stillbirth for use at any time during pregnancy were included. IPD from cohorts within the International Prediction of Pregnancy Complications (IPPIC) Network were used to validate externally the identified prediction models whose individual variables were available in the IPD. The risk of bias of the models and cohorts was assessed using the Prediction study Risk Of Bias ASsessment Tool (PROBAST). The discriminative performance of the models was evaluated using the C-statistic, and calibration was assessed using calibration plots, calibration slope and calibration-in-the-large. Performance measures were estimated separately in each cohort, as well as summarized across cohorts using random-effects meta-analysis. Clinical utility was assessed using net benefit. Results Seventeen studies reporting the development of 40 prognostic models for stillbirth were identified. None of the models had been previously validated externally, and the full model equation was reported for only one-fifth (20%, 8/40) of the models. External validation was possible for three of these models, using IPD from 19 cohorts (491 201 pregnant women) within the IPPIC Network database. Based on evaluation of the model development studies, all three models had an overall high risk of bias, according to PROBAST. In the IPD meta-analysis, the models had summary C-statistics ranging from 0.53 to 0.65 and summary calibration slopes ranging from 0.40 to 0.88, with risk predictions that were generally too extreme compared with the observed risks. The models had little to no clinical utility, as assessed by net benefit. However, there remained uncertainty in the performance of some models due to small available sample sizes. Conclusions The three validated stillbirth prediction models showed generally poor and uncertain predictive performance in new data, with limited evidence to support their clinical application. The findings suggest methodological shortcomings in their development, including overfitting. Further research is needed to further validate these and other models, identify stronger prognostic factors and develop more robust prediction models. (c) 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
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- 2022
16. EP08.39: The association between abnormal umbilical vein flow and undetected small for gestational age: a secondary analysis of a multicentre prospective study.
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Zegarra, R. Ramirez, Valentini, B., Carbone, F., Angeli, L., Gigli, F., Di Ilio, C., Barba, O., Cassardo, O., Ferrazzi, E., and Ghi, T.
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- 2024
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17. OC19.08: Effectiveness of the antihypertensive therapy based on maternal hemodynamic findings in women with HDP: a multicentre prospective study.
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Taverna, M., di Pasquo, E., Giannubilo, S., Valentini, B., Salvi, S., Rullo, R., Fruci, S., Filippi, E., Ornaghi, S., Zullino, S., Farsetti, D., Di Martino, D.D., Vasapollo, B., Locatelli, A., Ciavattini, A., de Santis, M., Rossi, F., Lanzone, A., Mecacci, F., and Ferrazzi, E.
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- 2024
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18. EP39.01: Umbilical vein blood flow reference ranges from an Italian population of uncomplicated singleton pregnancies
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Barbieri, M., primary, Zamagni, G., additional, Fantasia, I., additional, Monasta, L., additional, Bello, L. Lo, additional, Quadrifoglio, M., additional, Di Martino, D., additional, Ferrazzi, E., additional, and Stampalija, T., additional
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- 2022
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19. EP38.02: Accuracy and reproducibility of the umbilical vein blood flow measurements: a systematic review
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Barbieri, M., primary, Zamagni, G., additional, Fantasia, I., additional, Monasta, L., additional, Bello, L. Lo, additional, Quadrifoglio, M., additional, Piccoli, M., additional, Ricci, G., additional, Di Martino, D., additional, Ferrazzi, E., additional, and Stampalija, T., additional
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- 2022
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20. EP41.06: Identification of a partial hydatiform molar pregnancy by non‐invasive cell‐based prenatal testing on single circulating extravillous trophoblasts
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Doffini, A., primary, Mangano, C., additional, Forcato, C., additional, Maranta, C., additional, Giovannone, E., additional, Buson, G., additional, Bolognesi, C., additional, Maiocchi, R., additional, Dori, M., additional, Lattuada, D., additional, Ferrazzi, E., additional, Grati, F., additional, and Ricciardi‐Castagnoli, P., additional
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- 2022
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21. EP15.08: Single circulating extravillous trophoblasts for non‐invasive cell‐based prenatal testing in twin pregnancies
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Doffini, A., primary, Mangano, C., additional, Forcato, C., additional, Maranta, C., additional, Giovannone, E., additional, Buson, G., additional, Bolognesi, C., additional, Maiocchi, R., additional, Dori, M., additional, Lattuada, D., additional, Ferrazzi, E., additional, Grati, F., additional, and Ricciardi‐Castagnoli, P., additional
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- 2022
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22. Functional hemodynamic testing in pregnancy: recommendations of the International Working Group on Maternal Hemodynamics
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Meah, V. L., Backx, K., Davenport, M. H., Bruckmann, A., Cockcroft, J., Cornette, J., Duvekot, J.J., Ferrazzi, E., Foo, F.L., Ghossein‐Doha, C., Gyselaers, W., Khalil, A., McEniery, C.M., Lees, C., Meah, V., Novelli, G.P., Spaanderman, M., Stohr, E., Tay, J., Thilaganathan, B., Valensise, H., and Wilkinson, I.
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- 2018
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23. Anti-SSA/Ro positivity and congenital heart block: obstetric and foetal outcome in a cohort of anti-SSA/Ro positive pregnant patients with and without autoimmune diseases
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Fredi, M, Argolini, Lm, Angeli, F, Trespidi, L, Ramoni, V, Zatti, S, Vojinovic, T, Donzelli, D, Gazzola, Fg, Xoxi, B, Andreoli, L, Lojacono, A, Ferrazzi, E, Montecucco, C, Chighizola, Cb, Meroni, Pl, Franceschini, F, Cimaz, R, Caporali, R, Tincani, A, and Gerosa, M
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Rheumatology ,Immunology ,Immunology and Allergy - Abstract
Neonatal lupus (NL) is an acquired disease caused by the transplacental passage of anti-SSA/Ro antibodies. The rate of congenital heart block (CHB), its most serious manifestation, ranges from 1 to 5%. The aim of this study was to retrospectively assess the prevalence of CHB in anti-SSA/Ro positive pregnant women with or without systemic autoimmune diseases from 2010 to 2020.Patients underwent monthly visit and a shared follow-up programme of weekly (16th-24th week) foetal heart rate assessment by obstetric ultrasound.322 pregnancies in 258 anti-SSA/Ro patients were included; 314 were followed from the beginning of pregnancy because of the known presence of anti-SSA/Ro autoantibodies and 1 case of CHB occurred in an anti-SSA/Ro+ asymptomatic subject (0.3%). In the same period, 8 additional patients were referred to our clinics after in utero CHB diagnosis and subsequent discovery of anti-SSA/Ro without a disease diagnosis. Globally, 9 cases of congenital CHB (2.8%) occurred: 7 complete, 1 II-III degree and 1 rst degree CHB. Anti-SSB/La positivity was associated with a higher risk of CHB (7.8% vs. 1.2%; p=0.0071). No differences in maternal or foetal outcomes were found in comparison with a large cohort of unselected pregnancies except for caesarian section. Hydroxychloroquine (HCQ) was used in 58.3% pregnancies, with a different prevalence according with maternal diagnosis.Our data suggest that anti-SSA/Ro positive patents with a de ned systemic autoimmune disease undergoing a strict follow-up since positive pregnancy test display a low risk of pregnancy complications, including but not limited to NL.
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- 2022
24. Predictors of Women’s Childbirth Experience: A Prospective Longitudinal Study on Italian New Mothers
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Molgora, Sara, Campo, E., Carones, M. B., Ferrazzi, E., Saita, Emanuela, and Facchin, Federica
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longitudinal design ,Settore M-PSI/07 - PSICOLOGIA DINAMICA ,predictors ,Maternity and Midwifery ,Obstetrics and Gynecology ,obstetric factors ,childbirth experience ,psychological variables ,childbirth experience, predictors, obstetric factors, psychological variables, longitudinal design - Abstract
BACKGROUNDWomen’s memories of their childbirth experience tend to remain unchanged over time. This experience can be influenced by obstetric factors as well as by sociodemographic and psychological variables.OBJECTIVETo examine whether women’s perceived childbirth experience changes over time; to identify the predictors (obstetric, sociodemographic, and psychological variables) of this experience immediately after delivery and after 3 months.METHODSThis prospective longitudinal study comprised two hundred and twenty-one Italian women who completed a self-report questionnaire at two assessment points: immediately (1–3 days) after birth (Time 1) and 3 months postpartum (Time 2). At Time 1, the questionnaire included some questions on sociodemographic, psychological, and obstetric information, and the Wijma Delivery Experience Questionnaire (WDEQ(B); at Time 2 women compiled again the WDEQ(B).RESULTSRepeated measures ANOVA revealed that the childbirth experience did not change from Time 1 to Time 2. However, predictors of this experience were different between Time 1 and Time 2: at Time 1, the childbirth experience (WDEQ(B)_t1) was significantly predicted nly by type of cesarean section; at Time 2, the childbirth experience (WDEQ(B)_t2) was significantly predicted by WDEQ(B)_t1, history of psychological disorders, and type of conception.DISCUSSIONSOur findings enhance the understanding of the main predictors of a woman’s childbirth experience. Identifying areas of vulnerability is important for clinical practice, as well as for developing maternal health policies to improve women’s birth experiences, postpartum well-being, and the baby’s development.
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- 2022
25. Clinical Opinion: The diagnosis and management of suspected fetal growth restriction: an evidence-based approach
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Lees C, Romero R, Stampalija T, Dall'asta A, DeVore G, Prefumo F, Frusca T, Visser GHA, Hobbins J, Baschat A, Bilardo CM, Galan H, Campbell S, Maulik D, Figueras-Retuerta F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon L, Poon L, Ferrazzi E, Mari GC, Rizzo G, Kingdom J, Kiserud T, Hecher K, Lees, Christoph C, Romero, Roberto, Stampalija, Tamara, Dall'Asta, Andrea, Devore, Greggory A, Prefumo, Federico, Frusca, Tiziana, Visser, Gerard H A, Hobbins, John C, Baschat, Ahmet A, Bilardo, Caterina M, Galan, Henry L, Campbell, Stuart, Maulik, Dev, Figueras, Francesc, Lee, Wesley, Unterscheider, Julia, Valensise, Herbert, Da Silva Costa, Fabricio, Salomon, Laurent J, Poon, Liona C, Ferrazzi, Enrico, Mari, Giancarlo, Rizzo, Giuseppe, Kingdom, John C, Kiserud, Torvid, and Hecher, Kurt
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Trial of Umbilical and Fetal Flow in Europe ,Prospective Observational Trial to Optimize Pediatric Health ,Placenta ,randomized controlled trial ,fetal biometry ,Disproportionate Intrauterine Growth Intervention Trial at Term ,abdominal circumference ,Umbilical Arteries ,small for gestational age ,systematic review ,Pregnancy ,Prenatal ,Ultrasonography ,Randomized Controlled Trials as Topic ,short-term variation ,fetal death ,Fetal Growth Retardation ,Doppler ,neurodevelopmental outcome ,fetal distress ,umbilical artery pH ,Fetal Weight ,Settore MED/40 ,embryonic structures ,uterine artery ,Female ,cardiotocography ,Human ,cesarean delivery ,Doppler velocimetry ,ductus venosus ,fetal growth ,longitudinal ,middle cerebral artery ,umbilical artery Doppler ,ductus venosu ,Gestational Age ,Article ,Ultrasonography, Prenatal ,Humans ,Obstetrics & Reproductive Medicine ,Infant ,Ultrasonography, Doppler ,fetal distre ,Umbilical Arterie ,1114 Paediatrics and Reproductive Medicine - Abstract
This study reviewed the literature about the diagnosis, antepartum surveillance, and time of delivery of fetuses suspected to be small for gestational age or growth restricted. Several guidelines have been issued by major professional organizations, including the International Society of Ultrasound in Obstetrics and Gynecology and the Society for Maternal-Fetal Medicine. The differences in recommendations, in particular about Doppler velocimetry of the ductus venosus and middle cerebral artery, have created confusion among clinicians, and this review has intended to clarify and highlight the available evidence that is pertinent to clinical management. A fetus who is small for gestational age is frequently defined as one with an estimated fetal weight of
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- 2022
26. Coronavirus and birth in Italy: Results of a national population-based cohort study
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Donati S., Maraschini A., Lega I., D'Aloja P., Sampaolo L., Salvatore M. A., Corsi E., Alberico S., Casucci P., Cetin I., Dardanoni G., Doganiero F., Franchi M. P., Ferrazzi E., Leo L., Liberati M., Locci M., Martini C., Mecacci F., Meloni A., Mignuoli A. D., Mondo L., Patane L., Perrone E., Prefumo F., Ramenghi L., Savasi V., Schettini S., Steinkasserer M., Tateo S., Trojano V., Vergani P., Donati, S, Maraschini, A, Lega, I, D'Aloja, P, Sampaolo, L, Salvatore, M, Corsi, E, Alberico, S, Casucci, P, Cetin, I, Dardanoni, G, Doganiero, F, Franchi, M, Ferrazzi, E, Leo, L, Liberati, M, Locci, M, Martini, C, Mecacci, F, Meloni, A, Mignuoli, A, Mondo, L, Patane, L, Perrone, E, Prefumo, F, Ramenghi, L, Savasi, V, Schettini, S, Steinkasserer, M, Tateo, S, Trojano, V, Vergani, P, Donati S., Maraschini A., Lega I., D'Aloja P., Sampaolo L., Salvatore M.A., Corsi E., Alberico S., Casucci P., Cetin I., Dardanoni G., Doganiero F., Franchi M.P., Ferrazzi E., Leo L., Liberati M., Locci M., Martini C., Mecacci F., Meloni A., Mignuoli A.D., Mondo L., Patane L., Perrone E., Prefumo F., Ramenghi L., Savasi V., Schettini S., Steinkasserer M., Tateo S., Trojano V., and Vergani P.
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Pediatrics ,medicine.medical_treatment ,Infectious Disease Transmission ,medicine.disease_cause ,Adrenal Cortex Hormone ,Population based cohort ,Pregnancy ,Adrenal Cortex Hormones ,Cohort studies ,COVID-19 ,Pregnancy outcome ,SARS-CoV-2 ,Adult ,Cesarean Section ,Coronavirus Infections ,Emigrants and Immigrants ,Female ,Fetal Organ Maturity ,Humans ,Incidence ,Infant, Newborn ,Infectious Disease Transmission, Vertical ,Italy ,Lung ,Pneumonia, Viral ,Pregnancy Complications, Infectious ,Pregnancy Outcome ,Premature Birth ,Procedures and Techniques Utilization ,Prospective Studies ,Stillbirth ,Betacoronavirus ,Pandemics ,Vertical ,Viral ,Prospective cohort study ,pregnancy ,pregnancy outcome ,cohort studies ,Coronavirus ,education.field_of_study ,Infectious ,Human ,medicine.medical_specialty ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Population ,NO ,medicine ,Caesarean section ,National level ,education ,Betacoronaviru ,Pandemic ,business.industry ,Coronavirus Infection ,Infant ,Emigrants and Immigrant ,Pneumonia ,medicine.disease ,Newborn ,COVID-19 Drug Treatment ,Pregnancy Complications ,Prospective Studie ,Pregnancy Complications, Infectiou ,business ,Cohort studie - Abstract
IntroductionThe study was implemented to provide guidance to decision-makers and clinicians by describing hospital care offered to women who gave birth with confirmed COVID-19 infection.Materials and methodsNational population-based prospective cohort study involving all women with confirmed COVID-19 who gave birth between February 25 and April 22, 2020 in any Italian hospital.ResultsThe incidence rate of confirmed SARS-CoV-2 infection in women who gave birth was 2.1 per 1000 maternities at a national level and 6.9/1000 in the Lombardy Region. Overall one third of the women developed a pneumonia and 49.7% assumed at least one drug. Caesarean section rate was 32.9%, no mothers nor newborns died. Six percent of the infants tested positive for SARS – CoV-2 at birth.ConclusionsClinical features and outcomes of COVID-19 in women who gave birth are similar to those described for the general population, most women developing mild to moderate illness.
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- 2020
27. Selective intrauterine growth restriction in monochorionic twins: changing patterns in umbilical artery Doppler flow and outcomes
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Rustico, M. A., Consonni, D., Lanna, M., Faiola, S., Schena, V., Scelsa, B., Introvini, P., Righini, A., Parazzini, C., Lista, G., Barretta, F., and Ferrazzi, E.
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- 2017
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28. Antenatal corticosteroids and perinatal outcome in late fetal growth restriction: analysis of prospective cohort.
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Familiari, A., Napolitano, R., Visser, G. H. A., Lees, C., Wolf, H., Prefumo, F., Arabin, B., Berger, A., Bergman, E., Bhide, A., Bilardo, C. M., Breeze, A. C., Brodszki, J., Calda, P., Cesari, E., Cetin, I., Derks, J. B., Ebbing, C., Ferrazzi, E., and Frusca, T.
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FETAL growth retardation ,PREGNANCY outcomes ,COHORT analysis ,GESTATIONAL age ,BIRTH weight ,FETAL anoxia - Abstract
Objective: The aim of this study is to evaluate the possible role of antenatal administration of corticosteroids for fetal lung maturation on short term perinatal outcomes in late FGR.Methods: This cohort study is a secondary analysis of a multicenter prospective observational study, the TRUFFLE-2 feasibility study, conducted between 2017 and 2018 in 33 European perinatal centers. We included women with singleton pregnancy from 32+0 to 36+6 weeks of gestation with a fetus considered at risk for FGR, defined as estimated fetal weight (EFW) or abdominal circumference (AC) <10th centile, or umbilico-cerebral ratio (UCR) >95th centile, or a fall of more than 40 centile points in AC measurement from the 20 weeks scan. The primary adverse outcome was a composite of abnormal condition at birth or major neonatal morbidity.Results: A total of 86 pregnancies who received antenatal corticosteroids (exposed) were matched with non-exposed pregnancies. Both groups were similar regarding gestational age at inclusion (33 weeks), EFW (1673 g) and UCR (0.68), gestational age at delivery (35.5 weeks) and birth weight (1925 g); the presented values are for both groups combined. No significant differences were observed between exposed and non-exposed for composite adverse outcome (28% vs. 24%; p=0.73) or for any of its elements.Conclusion: The present data do not show a beneficial effect of steroids on short term outcomes in fetuses with late FGR. This article is protected by copyright. All rights reserved. [ABSTRACT FROM AUTHOR]- Published
- 2023
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29. Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction.
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Mylrea-Foley, Bronacha, Wolf, Hans, Stampalija, Tamara, Lees, Christoph, Arabin, B., Berger, A., Bergman, E., Bhide, A., Bilardo, C. M., Breeze, A. C., Brodszki, J., Calda, P., Cetin, I., Cesari, E., Derks, J., Ebbing, C., Ferrazzi, E., Ganzevoort, W., Frusca, T., and Gordijn, S. J.
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- 2023
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30. Fetal cerebral blood-flow redistribution: analysis of Doppler reference charts and association of different thresholds with adverse perinatal outcome
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Wolf, H, Stampalija, T, Lees, CC, Arabin, B, Berger, A, Bergman, E, Bhide, A, Bilardo, CM, Breeze, AC, Brodszki, J, Calda, P, Cesari, E, Cetin, I, Derks, J, Ebbing, C, Ferrazzi, E, Frusca, T, Ganzevoort, W, Gordijn, SJ, Gyselaers, W, Hecher, K, Klaritsch, P, Krofta, L, Lindgren, P, Lobmaier, SM, Marlow, N, Maruotti, GM, Mecacci, F, Myklestad, K, Napolitano, R, Prefumo, F, Raio, L, Richter, J, Sande, RK, Thornton, J, Valensise, H, Visser, GHA, Wee, L, Obstetrics and Gynaecology, APH - Quality of Care, ARD - Amsterdam Reproduction and Development, APH - Digital Health, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Wolf, H, Stampalija, T, C Lees, C, and study group, Truffle
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Doppler ,adverse outcome ,brain sparing ,cerebroplacental ratio ,fetal growth restriction ,middle cerebral artery ,percentile ,reference chart ,umbilicocerebral ratio ,Percentile ,Technology ,IMPACT ,Placenta ,Umbilical Arteries ,Obstetrics and gynaecology ,Pregnancy ,Reference Values ,FOR-GESTATIONAL-AGE ,GROWTH RESTRICTION ,Medicine ,Prospective Studies ,610 Medicine & health ,RISK ,Fetal Growth Retardation ,Radiological and Ultrasound Technology ,Obstetrics ,Radiology, Nuclear Medicine & Medical Imaging ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Obstetrics & Gynecology ,General Medicine ,Original Papers ,TRUFFLE Study Group ,Cerebrovascular Circulation ,Cohort ,Gestation ,Female ,Life Sciences & Biomedicine ,Cohort study ,Adult ,medicine.medical_specialty ,Gestational Age ,DIAGNOSIS ,Risk Assessment ,Ultrasonography, Prenatal ,Fetus ,PULSATILITY INDEX ,MANAGEMENT ,Humans ,Placental Circulation ,Radiology, Nuclear Medicine and imaging ,Obstetrics & Reproductive Medicine ,Original Paper ,Science & Technology ,business.industry ,Infant, Newborn ,Ultrasonography, Doppler ,Odds ratio ,Acoustics ,REFERENCE VALUES ,Reproductive Medicine ,1114 Paediatrics and Reproductive Medicine ,Feasibility Studies ,Observational study ,business - Abstract
OBJECTIVES: First, to compare published Doppler reference charts of the ratios of flow in the fetal middle cerebral and umbilical arteries (i.e. the cerebroplacental ratio (CPR) and umbilicocerebral ratio (UCR)). Second, to assess the association of thresholds of CPR and UCR based on these charts with short-term composite adverse perinatal outcome in a cohort of pregnancies considered to be at risk of late preterm fetal growth restriction. METHODS: Studies presenting reference charts for CPR or UCR were searched for in PubMed. Formulae for plotting the median and the 10th percentile (for CPR) or the 90th percentile (for UCR) against gestational age were extracted from the publication or calculated from the published tables. Data from a prospective European multicenter observational cohort study of singleton pregnancies at risk of fetal growth restriction at 32 + 0 to 36 + 6 weeks' gestation, in which fetal arterial Doppler measurements were collected longitudinally, were used to compare the different charts. Specifically, the association of UCR and CPR thresholds (CPR
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- 2021
31. Uterine artery blood flow volume in pregnant women with an abnormal pulsatility index of the uterine arteries delivering normal or intrauterine growth restricted newborns
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Ferrazzi, E., Rigano, S., Padoan, A., Boito, S., Pennati, G., and Galan, H.L.
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- 2011
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32. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?
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Brezinka, C., Derks, J.B., Diemert, A., Duvekot, J.J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A.T., Schlembach, D., Schneider, K.T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A, Visser, G.H.A., Aktas, A., Borgione, S., Chaoui, R., Cornette, J.M.J., Diehl, T., van Eyck, J, Fratelli, N., van Haastert, I.C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M, Oepkes, D., Ogge, G., van der Post, J.A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I.K.M., Scheepers, L.S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., and Lees, Christoph
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- 2017
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33. Development of customized fetal growth charts in twins
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Arduini, D., Arduino, S., Aiello, E., Boito, S., Celentano, C., Chianchiano, N., Clerici, G., Cosmi, E., D’addario, V., Di Pietro, C., Ettore, G., Ferrazzi, E., Frusca, T., Gabrielli, S., Greco, P., Lauriola, I., Maruotti, G.M., Mazzocco, A., Morano, D., Pappalardo, E., Piastra, A., Rustico, M., Todros, T., Stampalija, T., Visentin, S., Volpe, N., Volpe, P., Zanardini, C., Ghi, Tullio, Prefumo, Federico, Fichera, Anna, Lanna, Mariano, Periti, Enrico, Persico, Nicola, Viora, Elsa, and Rizzo, Giuseppe
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- 2017
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34. OC05.01: Automated isolation of single circulating fetal trophoblasts for prenatal genetic analysis
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Doffini, A., primary, Forcato, C., additional, Mangano, C., additional, Lattuada, D., additional, Aversa, R., additional, Maranta, C., additional, Giovannone, E., additional, Buson, G., additional, Bolognesi, C., additional, Maiocchi, R., additional, Jamal, L., additional, Ahmad, R., additional, Yeo, S., additional, Yeo, T., additional, Saragozza, S., additional, Serafini, M., additional, Biondi, A., additional, Perego, S., additional, Vergani, P., additional, Ferrazzi, E., additional, Grati, F., additional, and Ricciardi‐Castagnoli, P., additional
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- 2021
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35. OC04.06: Fetal biometry: a method for comparing local curve populations with those from major reference standards
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Seidenari, A., primary, Carbone, I., additional, Cavoretto, P.I., additional, Ferrazzi, E., additional, Pilu, G., additional, and Farina, A., additional
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- 2021
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36. External validation of prognostic models to predict stillbirth using International Prediction of Pregnancy Complications ( <scp>IPPIC</scp> ) Network database: individual participant data meta‐analysis
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Allotey, J, Whittle, R, Snell, KIE, Smuk, M, Townsend, R, Dadelszen, P, Heazell, AEP, Magee, L, Smith, GCS, Sandall, J, Thilaganathan, B, Zamora, J, Riley, RD, Khalil, A, Thangaratinam, S, Coomarasamy, A, Kwong, A, Savitri, AI, Salvesen, KÅ, Bhattacharya, S, Uiterwaal, CSPM, Staff, AC, Andersen, LB, Olive, EL, Redman, C, Sletner, L, Daskalakis, G, Macleod, M, Abdollahain, M, Ramírez, JA, Massé, J, Audibert, F, Magnus, PM, Jenum, AK, Baschat, A, Ohkuchi, A, McAuliffe, FM, West, J, Askie, LM, Mone, F, Farrar, D, Zimmerman, PA, Smits, LJM, Riddell, C, Kingdom, JC, Post, J, Illanes, SE, Holzman, C, Kuijk, SMJ, Carbillon, L, Villa, PM, Eskild, A, Chappell, L, Prefumo, F, Velauthar, L, Seed, P, Oostwaard, M, Verlohren, S, Poston, L, Ferrazzi, E, Vinter, CA, Nagata, C, Brown, M, Vollebregt, KC, Takeda, S, Langenveld, J, Widmer, M, Saito, S, Haavaldsen, C, Carroli, G, Olsen, J, Wolf, H, Zavaleta, N, Eisensee, I, Vergani, P, Lumbiganon, P, Makrides, M, Facchinetti, F, Sequeira, E, Gibson, R, Ferrazzani, S, Frusca, T, Norman, JE, Figueiró‐Filho, EA, Lapaire, O, Laivuori, H, Lykke, JA, Conde‐Agudelo, A, Galindo, A, Mbah, A, Betran, AP, Herraiz, I, Trogstad, L, Smith, GGS, Steegers, EAP, Salim, R, Huang, T, Adank, A, Zhang, J, Meschino, WS, Browne, JL, Allen, RE, Costa, F Da Silva, Klipstein‐Grobusch, K, Crowther, CA, Jørgensen, JS, Forest, J‐C, Rumbold, AR, Mol, BW, Giguère, Y, Kenny, LC, Ganzevoort, W, Odibo, AO, Myers, J, Yeo, SA, Goffinet, F, McCowan, L, Pajkrt, E, Teede, HJ, Haddad, BG, Dekker, G, Kleinrouweler, EC, LeCarpentier, É, Roberts, CT, Groen, H, Skråstad, RB, Heinonen, S, Eero, K, Anggraini, D, Souka, A, Cecatti, JG, Monterio, I, Pillalis, A, Souza, R, Hawkins, LA, Gabbay‐Benziv, R, Crovetto, F, Figuera, F, Jorgensen, L, Dodds, J, Patel, M, Aviram, A, Papageorghiou, A, and Khan, K
- Abstract
Objective: Stillbirth is a potentially preventable complication of pregnancy. Identifying women at risk can guide decisions on closer surveillance or timing of birth to prevent fetal death.Prognostic models have been developed to predict the risk of stillbirth, but none have yet been externally validated. We externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis to assess their predictive performance. Methods: We searched Medline, EMBASE, DH-DATA and AMED databases from inception to December 2020 to identify stillbirth prediction models. We included studies that developed or updated prediction models for stillbirth for use at any time during pregnancy. IPD from cohorts within the International Prediction of Pregnancy Complication (IPPIC) Network were used to externally validate the identified prediction models whose individual variables were available in the IPD. We assessed the risk of bias of the models and IPD using PROBAST, and reported discriminative performance using the C-statistic, and calibration performance using calibration plots, calibration slopeand calibration-in-the-large. We estimated performance measures separately in each study, and then summarised across studies using random-effects meta-analysis. Clinical utility was assessed using net benefit. Results: We identified 17 studies reporting the development of 40 prognostic models for stillbirth. None of the models were previously externally validated, and only a fifth (20%, 8/40) reported the full model equation. We were able to validate three of these models using the IPD from 19 cohort studies (491,201 pregnant women) within the IPPIC Network database. Based on evaluating their development studies, all three models had an overall high risk of bias according to PROBAST. In our IPD meta-analysis, the models had summary C-statistics ranging from 0.53 to 0.65; summary calibration slopes of 0.40to 0.88, and generally with observed risks predictions that were too extreme compared to observed risks; and little to no clinical utility as assessed by net benefit. However, there remained uncertainty in performance for some models due to small available sample sizes. Conclusion: The three validated models generally showed poor and uncertain predictive performancein new data, with limited evidence to support their clinical application. Findings suggest methodological shortcomings in their development including overfitting of models. Further research is needed to further validate these and other models, identify stronger prognostic factors, and to develop more robust prediction models
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- 2021
37. Ultrasonography of the Human Yolk Sac
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Ferrazzi, E., Garbo, S., and Nogales, Francisco F., editor
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- 1993
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38. OC14.03: Single scan screening versus longitudinal scan screening of fetal growth restriction in the third trimester: multicentre randomised protocol (RELAIS).
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Familiari, A., Prefumo, F., di Marco, G., Zamagni, G., Bevilacqua, E., Morlando, M., Sarno, L., Di Mascio, D., Mappa, I., Rizzo, G., Tiralongo, G., Valensise, H., Visentin, S., Fichera, A., Scambia, G., Ferrazzi, E., and Stampalija, T.
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- 2024
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39. Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction : prospective cohort study
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Stampalija, T., Thornton, J., Marlow, N., Napolitano, R., Bhide, A., Pickles, T., Bilardo, C. M., Gordijn, S. J., Gyselaers, W., Valensise, H., Hecher, K., Sande, R. K., Lindgren, P., Bergman, E., Arabin, B., Breeze, A. C., Wee, L., Ganzevoort, W., Richter, J., Berger, A., Brodszki, J., Derks, J., Mecacci, F., Maruotti, G. M., Myklestad, K., Lobmaier, S. M., Prefumo, F., Klaritsch, P., Calda, P., Ebbing, C., Frusca, T., Raio, L., Visser, G. H. A., Krofta, L., Cetin, I., Ferrazzi, E., Cesari, E., Wolf, H., Lees, C. C., Brezinka, C., Casagrandi, D., Cerny, A., Dall'Asta, A., Devlieger, R., Duvekot, J., Eggebo, T. M., Fantasia, I., Ferrari, F., Fratelli, N., Ghi, T., Graupner, O., Greimel, P., Hofstaetter, C., Presti, D. Lo, Georg, M., Macsali, F., Marsal, K., Martinelli, P., Mylrea-Foley, B., Mullins, E., Ostermayer, E., Papageorghiou, A., Peasley, R., Ramoni, A., Sarno, L., Seikku, L., Simeone, S., Thilaganathan, B., Tiralongo, G., Valcamonico, A., van Holsbeke, C., Vietheer, A., APH - Quality of Care, ARD - Amsterdam Reproduction and Development, Obstetrics and Gynaecology, APH - Digital Health, Stampalija, T., Thornton, J., Marlow, N., Napolitano, R., Bhide, A., Pickles, T., Bilardo, C. M., Gordijn, S. J., Gyselaers, W., Valensise, H., Hecher, K., Sande, R. K., Lindgren, P., Bergman, E., Arabin, B., Breeze, A. C., Wee, L., Ganzevoort, W., Richter, J., Berger, A., Brodszki, J., Derks, J., Mecacci, F., Maruotti, G. M., Myklestad, K., Lobmaier, S. M., Prefumo, F., Klaritsch, P., Calda, P., Ebbing, C., Frusca, T., Raio, L., Visser, G. H. A., Krofta, L., Cetin, I., Ferrazzi, E., Cesari, E., Wolf, H., Lees, C. C., Brezinka, C., Casagrandi, D., Cerny, A., Dall'Asta, A., Devlieger, R., Duvekot, J., Eggebo, T. M., Fantasia, I., Ferrari, F., Fratelli, N., Ghi, T., Graupner, O., Greimel, P., Hofstaetter, C., Presti, D. L., Georg, M., Macsali, F., Marsal, K., Martinelli, P., Mylrea-Foley, B., Mullins, E., Ostermayer, E., Papageorghiou, A., Peasley, R., Ramoni, A., Sarno, L., Seikku, L., Simeone, S., Thilaganathan, B., Tiralongo, G., Valcamonico, A., Van Holsbeke, C., Vietheer, A., and HUS Gynecology and Obstetrics
- Subjects
Technology ,adverse outcome ,umbilical-cerebral ratio ,Umbilical Arteries ,umbilical artery ,TRUFFLE-2 Group ,Fetal Development ,0302 clinical medicine ,Obstetrics and gynaecology ,Pregnancy ,Reference Values ,3123 Gynaecology and paediatrics ,Interquartile range ,Birth Weight ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Fetal Growth Retardation ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,Obstetrics ,Radiology, Nuclear Medicine & Medical Imaging ,Doppler ,Obstetrics & Gynecology ,Obstetrics and Gynecology ,Gestational age ,General Medicine ,Stillbirth ,3. Good health ,ddc ,Europe ,Fetal Weight ,Pulsatile Flow ,Infant, Small for Gestational Age ,Female ,Waist Circumference ,Rheology ,Life Sciences & Biomedicine ,Live Birth ,middle cerebral artery ,neonatal ,umbilicocerebral ratio ,Radiology, Nuclear Medicine and Medical Imaging ,Adult ,medicine.medical_specialty ,Birth weight ,education ,610 Medicine & health ,Gestational Age ,Reproduktionsmedicin och gynekologi ,DIAGNOSIS ,Ultrasonography, Prenatal ,03 medical and health sciences ,Fetus ,Obstetrics, Gynecology and Reproductive Medicine ,medicine ,MANAGEMENT ,Humans ,Radiology, Nuclear Medicine and imaging ,Risk factor ,Obstetrics & Reproductive Medicine ,Science & Technology ,business.industry ,CEREBROPLACENTAL RATIO ,Infant, Newborn ,Ultrasonography, Doppler ,Acoustics ,Reproductive Medicine ,Relative risk ,1114 Paediatrics and Reproductive Medicine ,Radiologi och bildbehandling ,business - Abstract
OBJECTIVES: To explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities and outcome in late preterm pregnancies at risk of fetal growth restriction. METHODS: This was a prospective cohort study of singleton pregnancies at risk of fetal growth restriction at 32 + 0 to 36 + 6 weeks of gestation, enrolled in 33 European centers between 2017 and 2018, in which umbilical and fetal MCA Doppler velocimetry was performed. Pregnancies were considered at risk of fetal growth restriction if they had estimated fetal weight and/or abdominal circumference (AC)
- Published
- 2020
40. Hepatitis C virus RNA detection in different semen fractions of HCV/HIV-1 co-infected men by nested PCR
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Savasi, V., Parrilla, B., Ratti, M., Oneta, M., Clerici, M., and Ferrazzi, E.
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- 2010
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41. Blood flow volume of uterine arteries in human pregnancies determined using 3D and bi-dimensional imaging, angio-Doppler, and fluid-dynamic modeling
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Rigano, S., Ferrazzi, E., Boito, S., Pennati, G., Padoan, A., and Galan, H.
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- 2010
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42. Re: First-trimester screening for pre-eclampsia: moving from personalized risk prediction to prevention
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Ferrazzi, E.
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- 2015
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43. EUREKA algorithm predicts obstetric risk and response to treatment in women with different subsets of anti-phospholipid antibodies
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Pregnolato F, Gerosa M, Raimondo MG, Comerio C, Bartoli F, Lonati PA, Borghi MO, Acaia B, Ossola MW, Ferrazzi E, Trespidi L, Meroni PL, Chighizola CB.
- Subjects
Algorithm, EUREKA, anti-phospholipid syndrome, hydroxychloroquine, low-dose aspirin, low molecular weight heparin, pregnancy ,immune system diseases ,neoplasms - Abstract
Objectives. aPL, the serum biomarkers of APS, are the most common acquired causes of pregnancy morbidity (PM). This study investigates the impact of aPL positivity fulfilling classification criteria (‘criteria aPL’) and at titres lower than thresholds considered by classification criteria (‘low-titre aPL’) on PM and assesses the effectiveness of low-dose aspirin (LDASA), low molecular weight heparin (LMWH) and HCQ in reducing the probability of PM (PPM). Methods. Longitudinal data on 847 pregnancies in 155 women with persistent aPL at any titre and 226 women with autoimmune diseases and negative aPL were retrospectively collected. A generalized estimating equations model for repeated measures was applied to quantify PPM under different clinical situations. Results. EUREKA is a novel algorithm that accurately predicts the risk of aPL-associated PM by considering aPL titres and profiles. aPL significantly impact PPM when at low titres and when fulfilling classification criteria. PPM was further stratified upon the aPL tests: aCL IgG/IgM and anti-b2-glycoprotein I (b2GPI) IgM, alone or combined, do not affect the basal risks of PPM, an increase occurs in case of positive LA or anti-b2GPI IgG. LDASA significantly affects PPM exclusively in women with low-titre aPL without anti-b2GPI IgG. The LDASAþLMWH combination significantly reduces PPM in all women with low-titre aPL and women with criteria aPL, except those carrying LA and anti-b2GPI IgG. In this group, the addition of HCQ further reduces PPM, although not significantly. Conclusion. EUREKA allows a tailored therapeutic approach, impacting everyday clinical management of aPLpositive pregnant women.
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- 2021
44. Intrapartum prediction of emergency delivery due to non-reassuring fetal status at 40 weeks' gestation in low-risk pregnancies: contribution of Doppler parameters, maternal history, and intrapartum clinical characteristics
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Crovetto F, Cesano N, Rossi F, Acerboni S, Marinis SDE, Basso A, Martinez Portilla RJ, Acaia B, Fedele L, Ferrazzi E, and Persico N
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cerebroplacental ratio ,middle cerebral artery ,Appropriate-gestational-age ,fetal Doppler ,small-gestational-age - Abstract
OBJECTIVE: To assess the added value of Doppler parameters, maternal history, and intrapartum clinical characteristics for the prediction of emergency delivery due to non-reassuring fetal status in low-risk pregnancies. METHODS: This was a prospective cohort of low-risk pregnancies undergoing ultrasound assessment at 40 weeks' gestation within 7 days of delivery. The main outcome was emergency cesarean section due to non-reassuring fetal status. The association between Doppler parameters, intrapartum clinical characteristics, and maternal history was performed by logistic regression. The predictive performance of the constructed models was assessed by receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC). RESULTS: From 403 included pregnancies, 18.6% (n = 75) underwent an emergency delivery due to non-reassuring fetal status. The mean gestational age at birth was 40.5 (SD 5) days. Middle cerebral artery pulsatility index (MCA) and cerebroplacental ratio (CPR) were lower in the emergency cesarean section group (1.16 versus 1.30; p < .001, and 1.61 versus 1.78; p = .001, respectively). There was a higher incidence of small-for-gestational-age neonates (20 versus 10.1%; p = .017), lower Apgar scores at the 5th minute (9.7 versus 9.9; p = .006), and NICU admissions (9 versus 3%; p = .016) in the emergency cesarean section group. The base model comprised nulliparity, and the finding of meconium-stained amniotic fluid during labor, achieving an AUC of 66%, while the addition of the MCA Z-score significantly improved the previous model (AUC: 73%; DeLong: p = .008). CONCLUSIONS: In low-risk pregnant woman at term, the addition of MCA Z-score to a previous model comprising maternal history and intrapartum clinical findings, significantly improves the prediction of emergency delivery due to non-reassuring fetal status.
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- 2021
45. Third-trimester ultrasound for antenatal diagnosis of placenta accreta spectrum in women with placenta previa: results from the ADoPAD study.
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Fratelli, N., Prefumo, F., Maggi, C., Cavalli, C., Sciarrone, A., Garofalo, A., Viora, E., Vergani, P., Ornaghi, S., Betti, M., Vaglio Tessitore, I., Cavaliere, A. F., Buongiorno, S., Vidiri, A., Fabbri, E., Ferrazzi, E., Maggi, V., Cetin, I., Frusca, T., and Ghi, T.
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PLACENTA praevia ,PLACENTA accreta ,PRENATAL diagnosis ,THIRD trimester of pregnancy ,ULTRASONIC imaging ,CESAREAN section ,PLACENTA ,EVALUATION research ,RETROSPECTIVE studies ,FETAL ultrasonic imaging ,LONGITUDINAL method ,RESEARCH ,RESEARCH methodology ,COMPARATIVE studies - Abstract
Objective: To evaluate the performance of third-trimester ultrasound for the diagnosis of clinically significant placenta accreta spectrum disorder (PAS) in women with low-lying placenta or placenta previa.Methods: This was a prospective multicenter study of pregnant women aged ≥ 18 years who were diagnosed with low-lying placenta (< 20 mm from the internal cervical os) or placenta previa (covering the internal cervical os) on ultrasound at ≥ 26 + 0 weeks' gestation, between October 2014 and January 2019. Ultrasound suspicion of PAS was raised in the presence of at least one of these signs on grayscale ultrasound: (1) obliteration of the hypoechogenic space between the uterus and the placenta; (2) interruption of the hyperechogenic interface between the uterine serosa and the bladder wall; (3) abnormal placental lacunae. Histopathological examinations were performed according to a predefined protocol, with pathologists blinded to the ultrasound findings. To assess the ability of ultrasound to detect clinically significant PAS, a composite outcome comprising the need for active management at delivery and histopathological confirmation of PAS was considered the reference standard. PAS was considered to be clinically significant if, in addition to histological confirmation, at least one of these procedures was carried out after delivery: use of hemostatic intrauterine balloon, compressive uterine suture, peripartum hysterectomy, uterine/hypogastric artery ligation or uterine artery embolization. The diagnostic performance of each ultrasound sign for clinically significant PAS was evaluated in all women and in the subgroup who had at least one previous Cesarean section and anterior placenta. Post-test probability was assessed using Fagan nomograms.Results: A total of 568 women underwent transabdominal and transvaginal ultrasound examinations during the study period. Of these, 95 delivered in local hospitals, and placental pathology according to the study protocol was therefore not available. Among the 473 women for whom placental pathology was available, clinically significant PAS was diagnosed in 99 (21%), comprising 36 cases of placenta accreta, 19 of placenta increta and 44 of placenta percreta. The median gestational age at the time of ultrasound assessment was 31.4 (interquartile range, 28.6-34.4) weeks. A normal hypoechogenic space between the uterus and the placenta reduced the post-test probability of clinically significant PAS from 21% to 5% in women with low-lying placenta or placenta previa in the third trimester of pregnancy and from 62% to 9% in the subgroup with previous Cesarean section and anterior placenta. The absence of placental lacunae reduced the post-test probability of clinically significant PAS from 21% to 9% in women with low-lying placenta or placenta previa in the third trimester of pregnancy and from 62% to 36% in the subgroup with previous Cesarean section and anterior placenta. When abnormal placental lacunae were seen on ultrasound, the post-test probability of clinically significant PAS increased from 21% to 59% in the whole cohort and from 62% to 78% in the subgroup with previous Cesarean section and anterior placenta. An interrupted hyperechogenic interface between the uterine serosa and bladder wall increased the post-test probability for clinically significant PAS from 21% to 85% in women with low-lying placenta or placenta previa and from 62% to 88% in the subgroup with previous Cesarean section and anterior placenta. When all three sonographic markers were present, the post-test probability for clinically significant PAS increased from 21% to 89% in the whole cohort and from 62% to 92% in the subgroup with previous Cesarean section and anterior placenta.Conclusions: Grayscale ultrasound has good diagnostic performance to identify pregnancies at low risk of PAS in a high-risk population of women with low-lying placenta or placenta previa. Ultrasound may be safely used to guide management decisions and concentrate resources on patients with higher risk of clinically significant PAS. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]- Published
- 2022
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46. Vaginal Delivery in SARS-CoV-2-infected Pregnant Women in Northern Italy: A Retrospective Analysis
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Ferrazzi, E., primary, Frigerio, L., additional, Savasi, V., additional, Vergani, P., additional, Prefumo, F., additional, Barresi, S., additional, Bianchi, S., additional, Ciriello, E., additional, Facchinetti, F., additional, Gervasi, M.T., additional, Iurlaro, E., additional, Kustermann, A., additional, Mangili, G., additional, Mosca, F., additional, Patane, L., additional, Spazzini, D., additional, Spinillo, A., additional, Trojano, G., additional, Vignali, M., additional, Villa, A., additional, Zuccotti, G.V., additional, Parazzini, F., additional, and Cetine, L., additional
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- 2021
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47. Reproductive Assistance for Infected Couples with Bloodborne Viruses
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Savasi, V., Ferrazzi, E., and Fiore, S.
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- 2008
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48. Critical umbilical artery Doppler abnormalities in early fetal growth restriction and the timing of delivery: an overestimated clinical challenge in daily obstetric practice?
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Lees, C., Marlow, N., Arabin, B., Bilardo, C. M., Brezinka, C., Derks, J. B., Duvekot, J., Frusca, T., Diemert, A., Ferrazzi, E., Ganzevoort, W., Hecher, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T., Thilaganathan, B., Todros, T., van Wassenaer-Leemhuis, A., Valcamonico, A., Visser, G. H., and Wolf, H.
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- 2014
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49. Women Facing HIV. Key Question on Women with HIV Infection: Italian Consensus Workshop
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Carosi, G., Nasta, P., Fiore, S., Matteelli, A., Cauda, R., Ferrazzi, E., Tamburrini, E., Savasi, V., Bini, T., Ravizza, M., Bucceri, A., Vichi, F., Murri, R., Mazzotta, F., and d’Arminio Monforte, A.
- Published
- 2009
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50. Delivery in Pregnant Women Infected With SARS-Co-2: A Fast Review
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Parazzini, F., primary, Bortolus, R., additional, Mauri, P.A., additional, Favilli, A., additional, Gerli, S., additional, and Ferrazzi, E., additional
- Published
- 2021
- Full Text
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