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21 results on '"Ferreira, Camila L."'

15. Decreased BDNF levels in amygdala and hippocampus after intracerebroventricular administration of ouabain

Author

Jornada, Luciano K., Valvassori, Samira S., Resende, Wilson R., Moretti, Morgana, Ferreira, Camila L., Fries, Gabriel R., Kapczinski, Flavio, and Quevedo, João

Subjects
BDNF, mania, nervous system, Na/K ATPase, ouabain, ouabaína
Abstract

OBJECTIVE: The present study aims to investigate the effects of ouabain intracerebroventricular injection on BDNF levels in the amygdala and hippocampus of Wistar rats. METHODS: Animals received a single intracerebroventricular injection of ouabain (10-3 and 10-2 M) or artificial cerebrospinal fluid and immediately, 1h, 24h, or seven days after injection, BDNF levels were measured in the rat's amygdala and hippocampus by sandwich-ELISA (n = 8 animals per group). RESULTS: When evaluated immediately, 3h, or 24h after injection, ouabain in doses of 10-2 and 10-3 M does not alter BDNF levels in the amygdala and hippocampus. However, when evaluated seven days after injection, ouabain in 10-2 and 10-3 M, showed a significant reduction in BDNF levels in both brain regions evaluated. DISCUSSION: In conclusion, we propose that the ouabain decreased BDNF levels in the hippocampus and amygdala when assessed seven days after administration, supporting the Na/K ATPase hypothesis for bipolar illness. OBJETIVO: O presente estudo tem como objetivo investigar os efeitos da injeção intracerebroventricular de ouabaína sobre os níveis de BDNF na amígdala e no hipocampo de ratos Wistar. MÉTODOS: Os animais receberam uma única injeção intracerebroventricular de ouabaína (10-3 and 10-2 M) ou fluido cerebroespinhal artificial e, imediatamente, 3h, 24h ou sete dias após a injeção, os níveis de BDNF foram mensurados na amígdala e hipocampo dos ratos por ELISA sandwich (n = 8 animais por grupo). RESULTADOS: Quando avaliados imediatamente após a injeção, 3h ou 24h, ouabaína nas doses 10-2 e 10-3 M não alterou os níveis de BDNF em ambas as estruturas avaliadas. Entretanto, quando avaliados sete dias após a injeção, ouabaína nas doses 10-2 e 10-3 M mostrou uma significante redução nos níveis de BDNF em amígdala e hipocampo. CONCLUSÃO: Em conclusão, propõe-se que a administração de ouabaína diminuiu os níveis de BDNF em amígdala e hipocampo quando avaliados sete dias após a injeção, suportando a hipótese da participação da Na/K ATPase no transtorno bipolar.

Published
2012

16. Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania

Author

Stertz, Laura, primary, Fries, Gabriel Rodrigo, additional, Aguiar, Bianca Wollenhaupt de, additional, Pfaffenseller, Bianca, additional, Valvassori, Samira S., additional, Gubert, Carolina, additional, Ferreira, Camila L., additional, Moretti, Morgana, additional, Ceresér, Keila M., additional, Kauer-Sant'Anna, Márcia, additional, Quevedo, João, additional, and Kapczinski, Flavio, additional

Published
2013
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17. Differences between dextroamphetamine and methamphetamine: behavioral changes and oxidative damage in brain of Wistar rats

Author

da-Rosa, Dayane D., primary, Valvassori, Samira S., additional, Steckert, Amanda V., additional, Arent, Camila O., additional, Ferreira, Camila L., additional, Lopes-Borges, Jéssica, additional, Varela, Roger B., additional, Mariot, Edemilson, additional, Dal-Pizzol, Felipe, additional, Andersen, Monica L., additional, and Quevedo, João, additional

Published
2011
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19. DNA damage after intracerebroventricular injection of ouabain in rats

Author

Jornada, Luciano K., primary, Valvassori, Samira S., additional, Arent, Camila O., additional, Leffa, Daniela, additional, Damiani, Adriani A., additional, Hainzenreder, Giana, additional, Ferreira, Camila L., additional, Moretti, Morgana, additional, Andrade, Vanessa M., additional, and Quevedo, João, additional

Published
2010
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20. Na+,K+-ATPase activity in an animal model of mania.

Author

Zugno, Alexandra I., Valvassori, Samira S., Scherer, Emilene B. S., Mattos, Cristiane, Matté, Cristiane, Ferreira, Camila L., Rezin, Gislaine T., Wyse, Angela T. S., Quevedo, João, and Streck, Emilio L.

Subjects
ANIMAL models of mania, SODIUM/POTASSIUM ATPase, AMPHETAMINES, THERAPEUTIC use of lithium, VALPROIC acid
Abstract

We evaluated Na+,K+-ATPase activity in hippocampus of rats submitted to an animal model of mania which included the use of lithium and valproate. In the acute treatment, amphetamine or saline was administered to rats for 14 days, between day 8 and 14, rats were treated with lithium, valproate or saline. In the maintenance treatment, rats were treated with lithium, valproate or saline, between day 8 and 14, amphetamine or saline were administered. Locomotor activity was assessed by open field test and Na+,K+-ATPase activity was measured. Our results showed that mood stabilizers reversed and prevented amphetamine-induced behavioral effects. Moreover, amphetamine (acute treatment) increased Na+,K+-ATPase activity, and administration of lithium or valproate reversed this effect. In the maintenance treatment, amphetamine increased Na+,K+-ATPase activity in saline-pretreated rats. Amphetamine administration in lithium- or valproate-pretreated animals did not alter Na+,K+-ATPase activity. The findings suggest that amphetamine-induced hyperactivity may be associated with an increase in Na+,K+-ATPase. [ABSTRACT FROM AUTHOR]

Published
2009
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21. Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania.

Author

Stertz, Laura, Fries, Gabriel Rodrigo, de Aguiar, Bianca Wollenhaupt, Pfaffenseller, Bianca, Valvassori, Samira S., Gubert, Carolina, Ferreira, Camila L., Moretti, Morgana, Ceresér, Keila M., Kauer-Sant'Anna, Márcia, Quevedo, João, and Kapczinski, Flavio

Subjects
*AMPHETAMINES, *BIPOLAR disorder, *HISTONE deacetylase, *BRAIN-derived neurotrophic factor, *PREFRONTAL cortex
Abstract

Objective: In the present study, we aimed to examine the effects of repeated D-amphetamine (AMPH) exposure, a well-accepted animal model of acute mania in bipolar disorder (BD), and histone deacetylase (HDAC) inhibitors on locomotor behavior and HDAC activity in the prefrontal cortex (PFC) and peripheral blood mononuclear cells (PBMCs) of rats. Moreover, we aimed to assess brain-derived neurotrophic factor (BDNF) protein and mRNA levels in these samples. Methods: We treated adult male Wistar rats with 2 mg/kg AMPH or saline intraperitoneally for 14 days. Between the 8th and 14th days, rats also received 47.5 mg/kg lithium (Li), 200 mg/kg sodium valproate (VPT), 2 mg/kg sodium butyrate (SB), or saline. We evaluated locomotor activity in the open-field task and assessed HDAC activity in the PFC and PBMCs, and BDNF levels in the PFC and plasma. Results: AMPH significantly increased locomotor activity, which was reversed by all drugs. This hyperactivity was associated with increased HDAC activity in the PFC, which was partially reversed by Li, VPT, and SB. No differences were found in BDNF levels. Conclusion: Repeated AMPH administration increases HDAC activity in the PFC without altering BDNF levels. The partial reversal of HDAC increase by Li, VPT, and SB may account for their ability to reverse AMPH-induced hyperactivity. [ABSTRACT FROM AUTHOR]

Published
2014
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