1. Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero
- Author
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Fajardo-Martinez, Viviana, Ferreira, Fatima, Fuller, Trevon, Cambou, Mary Catherine, Kerin, Tara, Paiola, Sophia, Mok, Thalia, Rao, Rashmi, Mohole, Jyodi, Paravastu, Ramya, Zhang, Dajie, Marschik, Peter, Iyer, Sai, Kesavan, Kalpashri, Borges Lopes, Maria da Conceição, Britto, José Augusto A, Moreira, Maria Elisabeth, Brasil, Patricia, and Nielsen-Saines, Karin
- Subjects
Paediatrics ,Biomedical and Clinical Sciences ,Clinical Research ,Prevention ,Women's Health ,Neurosciences ,Conditions Affecting the Embryonic and Fetal Periods ,Perinatal Period - Conditions Originating in Perinatal Period ,Pregnancy ,Intellectual and Developmental Disabilities (IDD) ,Emerging Infectious Diseases ,Pediatric ,Coronaviruses ,Infectious Diseases ,Brain Disorders ,2.1 Biological and endogenous factors ,Mental health ,Reproductive health and childbirth ,Humans ,Female ,COVID-19 ,Child ,Preschool ,Infant ,Male ,Developmental Disabilities ,SARS-CoV-2 ,Brazil ,Pregnancy Complications ,Infectious ,Prenatal Exposure Delayed Effects ,Adult ,Neurodevelopmental Disorders ,Child Development ,Los Angeles - Abstract
It is unclear if SARS CoV-2 infection during pregnancy is associated with adverse neurodevelopmental repercussions to infants. We assessed pediatric neurodevelopmental outcomes in children born to mothers with laboratory-confirmed SARS CoV-2 infection during pregnancy. Neurodevelopmental outcomes of in-utero exposed children were compared to that of pre-pandemic control children in Los Angeles (LA), CA, USA and Rio de Janeiro, Brazil. Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III), the gold standard tool for evaluating neurodevelopment until 36 months of age and Ages and Stages Questionnaires (ASQ-3), a frequently used screening instrument for evaluating neurodevelopment in this same age group were the assessment tools used. Developmental delay (DD) was defined as having a score
- Published
- 2024