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14 results on '"Ferreira-Martins, Joao"'

5. Clonality of Mouse and Human Cardiomyogenesis in Vivo

Author

Hosoda, Toru, D'Amario, Domenico, Cabral-Da-Silva, Mauricio Castro, Zheng, Hanqiao, Padin-Iruegas, M. Elena, Ogorek, Barbara, Ferreira-Martins, João, Yasuzawa-Amano, Saori, Amano, Katsuya, Ide-Iwata, Noriko, Cheng, Wei, Rota, Marcello, Urbanek, Konrad, Kajstura, Jan, Anversa, Piero, Leri, Annarosa, and Prockop, Darwin J.

Published
2009
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7. Abstract 60: Hypoxia Preserves the Quiescent Lineage Negative Phenotype of Cardiac Stem Cells Within the Niche

Author

Sanada, Fumihiro, primary, Mangano, Emily, additional, Kim, Junghyung, additional, Arranto, Christian, additional, Ferreira-Martins, Joao, additional, Signore, Sergio, additional, Fiorini, Claudia, additional, Ide-Iwata, Noriko, additional, Pesapane, Ada, additional, Ricciardi, Mario, additional, Zheng, Hanqiao, additional, Gurusamy, Narasimman, additional, Wybieralska, Ewa, additional, Caballero, Virginia, additional, Cimini, Maria, additional, Goichberg, Polina, additional, Rota, Marcello, additional, Hosoda, Toru, additional, Kajstura, Jan, additional, Anversa, Piero, additional, and Leri, Annarosa, additional

Published
2012
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8. Electrophysiological Properties of the Infarcted Rodent Myocardium

Author

Steadman, Elisabeth, primary, Ferreira-Martins, Joao, additional, Signore, Sergio, additional, Korn, Justin A., additional, Sanada, Fumihiro, additional, Zheng, Hanqiao, additional, Cappetta, Francesco, additional, Hosoda, Toru, additional, Fiorini, Claudia, additional, Leri, Annarosa, additional, Anversa, Piero, additional, Kajstura, Jan, additional, and Rota, Marcello, additional

Published
2011
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9. Ca2+ Oscillations Regulate Growth and Commitment of Stem Cells in the Developing Heart

Author

Ferreira-Martins, Joao, primary, Signore, Sergio, additional, Cappetta, Francesco, additional, Ogorek, Barbara, additional, Steadman, Elisabeth, additional, Korn, Justin A., additional, Ide-Iwata, Noriko, additional, Fiorini, Claudia, additional, Sanada, Fumihiro, additional, Zheng, Hanqiao, additional, Hosoda, Toru, additional, Leri, Annarosa, additional, Anversa, Piero, additional, Kajstura, Jan, additional, and Rota, Marcello, additional

Published
2011
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10. p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo

Author

Kannappan, Ramaswamy, Matsuda, Alex, Ferreira-Martins, João, Zhang, Eric, Palano, Giorgia, Czarna, Anna, Cabral-Da-Silva, Mauricio Castro, Bastos-Carvalho, Adriana, Sanada, Fumihiro, Ide, Noriko, Rota, Marcello, Blasco, Maria A., Serrano, Manuel, Anversa, Piero, and Leri, Annarosa

Subjects
CPC, cardiac progenitor cell, DDR, DNA damage response, WT, wild type, LV, left ventricle, p53-tg, super-p53 transgenic mouse, Aogen, angiotensinogen, Ang II, angiotensin II, AT1R, Ang II type-1 receptor, PDT, population doubling time, ROS, reactive oxygen species, Doxo, doxorubicin, Stem cell engraftment, Diabetes, DNA repair, Stem cell fate
Abstract

p53 is an important modulator of stem cell fate, but its role in cardiac progenitor cells (CPCs) is unknown. Here, we tested the effects of a single extra-copy of p53 on the function of CPCs in the presence of oxidative stress mediated by doxorubicin in vitro and type-1 diabetes in vivo. CPCs were obtained from super-p53 transgenic mice (p53-tg), in which the additional allele is regulated in a manner similar to the endogenous protein. Old CPCs with increased p53 dosage showed a superior ability to sustain oxidative stress, repair DNA damage and restore cell division. With doxorubicin, a larger fraction of CPCs carrying an extra-copy of the p53 allele recruited γH2A.X reestablishing DNA integrity. Enhanced p53 expression resulted in a superior tolerance to oxidative stress in vivo by providing CPCs with defense mechanisms necessary to survive in the milieu of the diabetic heart; they engrafted in regions of tissue injury and in three days acquired the cardiomyocyte phenotype. The biological advantage provided by the increased dosage of p53 in CPCs suggests that this genetic strategy may be translated to humans to increase cellular engraftment and growth, critical determinants of successful cell therapy for the failing heart.

Published
2017
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11. Cardiomyogenesis in the Aging and Failing Human Heart.

Author

Kajstura, Jan, Rota, Marcello, Cappetta, Donato, Ogorek, Barbara, Arranto, Christian, Yingnan Bai, Ferreira-Martins, Joao, Signore, Sergio, Sanada, Fumihiro, Matsuda, Alex, Kostyla, James, Caballero, Maria-Virginia, Fiorini, Claudia, D'Alessandro, David A., Michler, Robert E., del Monte, Federica, Hosoda, Toru, Perrella, Mark A., Leri, Annarosa, and Buchholz, Bruce A.

Published
2012
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12. Calcium Mobilization Via IP3 Receptors Alters Electrical, Calcium Cycling and Contractile Properties of Human and Rodent Cardiomyocytes

Author

Signore, Sergio, Ferreira-Martins, Joao, Steadman, Elisabeth, Korn, Justin A., Goihberg, Polina, Bai, Yingnan A., Sanada, Fumihiro, Zheng, Hanqiao, Fiorini, Claudia, Federica del Monte, Ogorek, Barbara, Cappetta, Francesco, D'Amario, Domenico, Hosoda, Toru, Leri, Annarosa, Anversa, Piero, Kajstura, Jan, and Rota, Marcello

Published
2011
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13. Abstract 60.

Author

Sanada, Fumihiro, Mangano, Emily, Kim, Junghyung, Arranto, Christian, Ferreira-Martins, Joao, Signore, Sergio, Fiorini, Claudia, Ide-Iwata, Noriko, Pesapane, Ada, Ricciardi, Mario, Zheng, Hanqiao, Gurusamy, Narasimman, Wybieralska, Ewa, Caballero, Virginia, Cimini, Maria, Goichberg, Polina, Rota, Marcello, Hosoda, Toru, Kajstura, Jan, and Anversa, Piero

Published
2012

14. Abstract 52.

Author

Kannappan, Ramaswamy, Bai, Yingnan, Signore, Sergio, Cimini, Maria, Ferreira-Martins, Joao, and Goichberg, Polina

Published
2012

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