36 results on '"Fidler, Miranda M"'
Search Results
2. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe
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Fidler, Miranda M., Reulen, Raoul C., Winter, David L., Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Byrne, Julianne, Feijen, Elizabeth A. M., Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kuonen, Rahel, Linge, Helena, Maule, Milena, Merletti, Franco, Øfstaas, Hilde, Ronckers, Cecile M., Skinner, Roderick, Teepen, Jop, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuehni, Claudia E., Winther, Jeanette F., de Vathaire, Florent, Kremer, Leontien C., Hjorth, Lars, and Hawkins, Michael M.
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- 2018
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3. Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study
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Reulen, Raoul C., Bright, Chloe J., Winter, David L., Fidler, Miranda M., Wong, Kwok, Guha, Joyeeta, Kelly, Julie S., Frobisher, Clare, Edgar, Angela B., Skinner, Roderick, Wallace, W. Hamish B., and Hawkins, Mike M.
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- 2017
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4. Population-Based Long-Term Cardiac-Specific Mortality Among 34 489 Five-Year Survivors of Childhood Cancer in Great Britain
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Fidler, Miranda M., Reulen, Raoul C., Henson, Katherine, Kelly, Julie, Cutter, David, Levitt, Gill A., Frobisher, Clare, Winter, David L., and Hawkins, Michael M.
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- 2017
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5. Cardiac Mortality Among 200 000 Five-Year Survivors of Cancer Diagnosed at 15 to 39 Years of Age
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Henson, Katherine E., Reulen, Raoul C., Winter, David L., Bright, Chloe J., Fidler, Miranda M., Frobisher, Clare, Guha, Joyeeta, Wong, Kwok F., Kelly, Julie, Edgar, Angela B., McCabe, Martin G., Whelan, Jeremy, Cutter, David J., Darby, Sarah C., and Hawkins, Mike M.
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Adult ,Male ,heart diseases ,Time Factors ,Adolescent ,neoplasms ,mortality ,Young Adult ,Risk Factors ,Original Research Articles ,cardiac deaths ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Humans ,epidemiology ,Female ,Survivors - Abstract
Supplemental Digital Content is available in the text., Background: Survivors of teenage and young adult cancer are acknowledged as understudied. Little is known about their long-term adverse health risks, particularly of cardiac disease that is increased in other cancer populations where cardiotoxic treatments have been used. Methods: The Teenage and Young Adult Cancer Survivor Study cohort comprises 200 945 5-year survivors of cancer diagnosed at 15 to 39 years of age in England and Wales from 1971 to 2006, and followed to 2014. Standardized mortality ratios, absolute excess risks, and cumulative risks were calculated. Results: Two thousand sixteen survivors died of cardiac disease. For all cancers combined, the standardized mortality ratios for all cardiac diseases combined was greatest for individuals diagnosed at 15 to 19 years of age (4.2; 95% confidence interval, 3.4–5.2) decreasing to 1.2 (95% confidence interval, 1.1–1.3) for individuals aged 35 to 39 years (2P for trend
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- 2016
6. Challenges and opportunities in the care of survivors of adolescent and young adult cancers
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Fidler, Miranda M., primary, Frobisher, Clare, additional, Hawkins, Michael M., additional, and Nathan, Paul C., additional
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- 2019
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7. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, primary, Alessi, Daniela, additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Bright, Chloe J., additional, Brown, Morven, additional, Diallo, Ibrahima, additional, Feijen, Elizabeth A.M. (Lieke), additional, Fidler, Miranda M., additional, Frey, Eva, additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Hagberg, Oskar, additional, Harila-Saari, Arja, additional, Hau, Eva M., additional, Haupt, Riccardo, additional, Hawkins, Mike M., additional, Jakab, Zsuzsanna, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kremer, Leontien C.M., additional, Kuehni, Claudia E., additional, Kuonen, Rahel, additional, Ladenstein, Ruth, additional, Lähteenmäki, Päivi Maria, additional, Levitt, Gill, additional, Linge, Helena, additional, LLanas, Damien, additional, Michel, Gisela, additional, Morsellino, Vera, additional, Mulder, Renee L., additional, Reulen, Raoul C., additional, Ronckers, Cécile M., additional, Sacerdote, Carlotta, additional, Skinner, Roderick, additional, Steliarova-Foucher, Eva, additional, van der Pal, Helena J., additional, de Vathaire, Florent, additional, Vũ Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Winter, David L., additional, Winther, Jeanette Falck, additional, Witthoff, Elise, additional, Zadravec Zaletel, Lorna, additional, and Hjorth, Lars, additional
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- 2018
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8. Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study
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Steliarova-Foucher, Eva, primary, Fidler, Miranda M, additional, Colombet, Murielle, additional, Lacour, Brigitte, additional, Kaatsch, Peter, additional, Piñeros, Marion, additional, Soerjomataram, Isabelle, additional, Bray, Freddie, additional, Coebergh, Jan Willem, additional, Peris-Bonet, Rafael, additional, Stiller, Charles A, additional, Hackl, Monika, additional, Zborovskaya, Anna, additional, Dimitrova, Nadya, additional, Valerianova, Zdravka, additional, Dušek, Ladislav, additional, Mägi, Margit, additional, Monnereau, Alain, additional, Clavel, Jacqueline, additional, Velten, Michel, additional, Guizard, Anne-Valérie, additional, Bouvier, Véronique, additional, Troussard, Xavier, additional, Woronoff, Anne-Sophie, additional, Marrer, Emilie, additional, Trétarre, Brigitte, additional, Colonna, Marc, additional, Ganry, Olivier, additional, Grosclaude, Pascale, additional, Holleczek, Berndt, additional, Jakab, Zsuzsanna, additional, Tryggvadóttir, Laufey, additional, Mangone, Lucia, additional, Merletti, Franco, additional, Ferretti, Stefano, additional, Caruso, Bianca, additional, Michiara, Maria, additional, Tumino, Rosario, additional, Falcini, Fabio, additional, Zanetti, Roberto, additional, Tagliabue, Giovanna, additional, Visser, Otto, additional, Ursin, Giske, additional, Mężyk, Ryszard, additional, Kepska, Kamila, additional, Laranja Pontes, José, additional, Primic Žakelj, Maja, additional, Fernández-Delgado, Rafael, additional, Vicente Raneda, Marisa L, additional, Almar Marqués, Enrique, additional, Quirós Garcia, José Ramón, additional, Lopez de Munain, Arantza, additional, Marcos-Gragera, Rafael, additional, Sanchez-Perez, Maria-Jose, additional, Ramos Monserrat, Maria, additional, Ardanaz, Eva, additional, Galceran, Jaume, additional, Khan, Staffan, additional, Kuehni, Claudia E, additional, Bouchardy, Christine, additional, Levi, Fabio, additional, Konzelmann, Isabelle, additional, Rohrmann, Sabine, additional, Vernon, Sally, additional, Brewster, David H, additional, White, Ceri, additional, and Dolya, Anastasia, additional
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- 2018
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9. Global Cancer Inequalities
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Fidler, Miranda M., primary and Bray, Freddie, additional
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- 2018
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10. Reducing Social Inequalities in Cancer: Setting Priorities for Research
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Vaccarella, Salvatore, primary, Lortet-Tieulent, Joannie, additional, Saracci, Rodolfo, additional, Fidler, Miranda M., additional, Conway, David I., additional, Vilahur, Nadia, additional, Sarfati, Diana, additional, Jemal, Ahmedin, additional, Mackenbach, Johan P., additional, Marmot, Michael G., additional, Straif, Kurt, additional, and Wild, Christopher P., additional
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- 2018
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11. Respiratory mortality of childhood, adolescent and young adult cancer survivors
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Fidler, Miranda M, primary, Reulen, Raoul C, additional, Bright, Chloe J, additional, Henson, Katherine E, additional, Kelly, Julie S, additional, Jenney, Meriel, additional, Ng, Antony, additional, Whelan, Jeremy, additional, Winter, David L, additional, Frobisher, Clare, additional, and Hawkins, Michael M, additional
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- 2018
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12. Young adults: a unique group in cancer epidemiological research – Authors' reply
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Fidler, Miranda M, primary, Steliarova-Foucher, Eva, additional, Soerjomataram, Isabelle, additional, Ferlay, Jacques, additional, Gupta, Sumit, additional, and Bray, Freddie, additional
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- 2018
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13. The Future Burden of Colorectal Cancer Among US Blacks and Whites
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Araghi, Marzieh, primary, Fidler, Miranda M, additional, Arnold, Melina, additional, Jemal, Ahmedin, additional, Bray, Freddie, additional, and Soerjomataram, Isabelle, additional
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- 2018
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14. Childhood cancer: the long-term costs of cure
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Fidler, Miranda M, primary and Hawkins, Michael M, additional
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- 2017
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15. Cancer incidence and mortality among young adults aged 20–39 years worldwide in 2012: a population-based study
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Fidler, Miranda M, primary, Gupta, Sumit, additional, Soerjomataram, Isabelle, additional, Ferlay, Jacques, additional, Steliarova-Foucher, Eva, additional, and Bray, Freddie, additional
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- 2017
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16. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe
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Fidler, Miranda M., primary, Reulen, Raoul C., additional, Winter, David L., additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bárdi, Edit, additional, Bautz, Andrea, additional, Bright, Chloe J., additional, Byrne, Julianne, additional, Feijen, Elizabeth A. M., additional, Garwicz, Stanislaw, additional, Grabow, Desiree, additional, Gudmundsdottir, Thorgerdur, additional, Guha, Joyeeta, additional, Haddy, Nadia, additional, Jankovic, Momcilo, additional, Kaatsch, Peter, additional, Kaiser, Melanie, additional, Kuonen, Rahel, additional, Linge, Helena, additional, Maule, Milena, additional, Merletti, Franco, additional, Øfstaas, Hilde, additional, Ronckers, Cecile M., additional, Skinner, Roderick, additional, Teepen, Jop, additional, Terenziani, Monica, additional, Vu-Bezin, Giao, additional, Wesenberg, Finn, additional, Wiebe, Thomas, additional, Jakab, Zsuzsanna, additional, Haupt, Riccardo, additional, Lähteenmäki, Päivi, additional, Zaletel, Lorna Zadravec, additional, Kuehni, Claudia E., additional, Winther, Jeanette F., additional, de Vathaire, Florent, additional, Kremer, Leontien C., additional, Hjorth, Lars, additional, and Hawkins, Michael M., additional
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- 2017
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17. The global cancer burden and human development: A review
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Fidler, Miranda M., primary, Bray, Freddie, additional, and Soerjomataram, Isabelle, additional
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- 2017
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18. Assessing global transitions in human development and colorectal cancer incidence
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Fidler, Miranda M, primary, Bray, Freddie, additional, Vaccarella, Salvatore, additional, and Soerjomataram, Isabelle, additional
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- 2017
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19. Conclusions. Reducing Social Inequalities in Cancer: Setting Priorities for Research.
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Vaccarella, Salvatore, Lortet-Tieulent, Joannie, Saracci, Rodolfo, Fidler, Miranda M., Conway, David I., Vilahur, Nadia, Sarfati, Diana, Jemal, Ahmedin, Mackenbach, Johan P., Marmot, Michael G., Straif, Kurt, and Wild, Christopher
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ONCOLOGY conferences ,ADULT education workshops ,CANCER research ,CANCER & society ,HEALTH equity ,CANCER prevention - Abstract
The article discusses highlights of the workshop held by the International Agency for Research on Cancer (IARC) in April 2018 which focused on identifying research priorities in resolving social inequalities in cancer. Topics explored include the data gathering focused on cancer disparities, the importance of developing cancer prevention initiatives, and the effective delivery of cancer control programs.
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- 2019
20. Chapter 5. Social inequalities in cancer between countries.
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Fidler, Miranda M., Vaccarella, Salvatore, and Bray, Freddie
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CANCER & society ,EQUALITY ,HUMAN Development Index ,SOCIODEMOGRAPHIC factors ,CANCER-related mortality ,COLON cancer ,CANCER statistics - Abstract
The article discusses research which focused on social inequalities in cancer between high and low Human Development Index (HDI) countries. Topics explored include the interaction between sociodemographic factors and disease patterns, the recorded increase in cancer-related cases and deaths worldwide, and the decline in colorectal cancer incidence in countries with very high HDI levels.
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- 2019
21. Long term cause specific mortality among 34 489 five year survivors of childhood cancer in Great Britain: population based cohort study
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Fidler, Miranda M, primary, Reulen, Raoul C, additional, Winter, David L, additional, Kelly, Julie, additional, Jenkinson, Helen C, additional, Skinner, Rod, additional, Frobisher, Clare, additional, and Hawkins, Michael M, additional
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- 2016
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22. A global view on cancer incidence and national levels of the human development index
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Fidler, Miranda M., primary, Soerjomataram, Isabelle, additional, and Bray, Freddie, additional
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- 2016
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23. Risk of Adverse Health and Social Outcomes Up to 50 Years After Wilms Tumor: The British Childhood Cancer Survivor Study
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Wong, Kwok F., primary, Reulen, Raoul C., additional, Winter, David L., additional, Guha, Joyeeta, additional, Fidler, Miranda M., additional, Kelly, Julie, additional, Lancashire, Emma R., additional, Pritchard-Jones, Kathryn, additional, Jenkinson, Helen C., additional, Sugden, Elaine, additional, Levitt, Gill, additional, Frobisher, Clare, additional, and Hawkins, Michael M., additional
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- 2016
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24. Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.
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Bright, Chloe J., Hawkins, Mike M., Winter, David L., Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth A. M., Fidler, Miranda M., Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, and Kuehni, Claudia E.
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CANCER patients ,CENTRAL nervous system ,NERVOUS system ,AFFERENT pathways ,LEIOMYOSARCOMA ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,SARCOMA ,SOFT tissue tumors ,TIME ,EVALUATION research ,DISEASE incidence ,ACQUISITION of data ,SECONDARY primary cancer - Abstract
Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated.Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma.Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers. [ABSTRACT FROM AUTHOR]- Published
- 2018
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25. Aspects of mental health dysfunction among survivors of childhood cancer.
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Fidler, Miranda M, Ziff, Oliver J, Wang, Sarra, Cave, Joshua, Janardhanan, Pradeep, Winter, David L, Kelly, Julie, Mehta, Susan, Jenkinson, Helen, Frobisher, Clare, Reulen, Raoul C, and Hawkins, Michael M
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MENTAL illness risk factors , *TUMORS in children , *CANCER patient psychology , *HEALTH surveys , *RESEARCH funding , *PSYCHOLOGY of the sick , *SURVEYS , *TUMORS , *DISEASE complications , *PSYCHOLOGY - Abstract
Background: Some previous studies have reported that survivors of childhood cancer are at an increased risk of developing long-term mental health morbidity, whilst others have reported that this is not the case. Therefore, we analysed 5-year survivors of childhood cancer using the British Childhood Cancer Survivor Study (BCCSS) to determine the risks of aspects of long-term mental health dysfunction.Procedure: Within the BCCSS, 10 488 survivors completed a questionnaire that ascertained mental health-related information via 10 questions from the Short Form-36 survey. Internal analyses were conducted using multivariable logistic regression to determine risk factors for mental health dysfunction. External analyses were undertaken using direct standardisation to compare mental health dysfunction in survivors with UK norms.Results: This study has shown that overall, childhood cancer survivors had a significantly higher prevalence of mental health dysfunction for 6/10 questions analysed compared to UK norms. Central nervous system (CNS) and bone sarcoma survivors reported the greatest dysfunction, compared to expected, with significant excess dysfunction in 10 and 6 questions, respectively; the excess ranged from 4.4-22.3% in CNS survivors and 6.9-15.9% in bone sarcoma survivors. Compared to expected, excess mental health dysfunction increased with attained age; this increase was greatest for reporting 'limitations in social activities due to health', where the excess rose from 4.5% to 12.8% in those aged 16-24 and 45+, respectively. Within the internal analyses, higher levels of educational attainment and socio-economic classification were protective against mental health dysfunction.Conclusions: Based upon the findings of this large population-based study, childhood cancer survivors report significantly higher levels of mental health dysfunction than those in the general population, where deficits were observed particularly among CNS and bone sarcoma survivors. Limitations were also observed to increase with age, and thus it is important to emphasise the need for mental health evaluation and services across the entire lifespan. There is evidence that low educational attainment and being unemployed or having never worked adversely impacts long-term mental health. These findings provide an evidence base for risk stratification and planning interventions. [ABSTRACT FROM AUTHOR]- Published
- 2015
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26. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A.M. Lieke, Fidler, Miranda M., Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M., Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C. M., Kuehni, Claudia E., Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, Llanas, Damien, Michel, Gisela (Co-Author), Morsellino, Vera, Mulder, Renee L., Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, van der Pal, Helena J., de Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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Late mortality ,Childhood and adolescent cancer ,Second malignancies ,Survivors ,Guidelines ,Cardiac late effects ,3. Good health - Abstract
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment. PanCareSurFup (PCSF) is the first pan-European project to evaluate some of the serious long-term health risks faced by survivors. This article sets out the overall rationale, methods and preliminary results of PCSF. Methods: The PCSF consortium pooled data from 13 cancer registries and hospitals in 12 European countries to evaluate subsequent primary malignancies, cardiac disease and late mortality in survivors diagnosed between ages 0 and 20 years. In addition, PCSF integrated radiation dosimetry to sites of second malignancies and to the heart, developed evidence-based guidelines for long-term care and for transition services, and disseminated results to survivors and the public. Results: We identified 115,596 individuals diagnosed with cancer, of whom 83,333 were 5-year survivors and diagnosed from 1940 to 2011. This single data set forms the basis for cohort analyses of subsequent malignancies, cardiac disease and late mortality and case–control studies of subsequent malignancies and cardiac disease in 5-year survivors. Conclusions: PCSF delivered specific estimates of risk and comprehensive guidelines to help survivors and care-givers. The expected benefit is to provide every European CCS with improved access to care and better long-term health.
27. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J, Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A M Lieke, Fidler, Miranda M, Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M, Haupt, Riccardo, Hawkins, Mike M, Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C M, Kuehni, Claudia E, Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, LLanas, Damien, Michel, Gisela, Morsellino, Vera, Mulder, Renee L, Reulen, Raoul C, Ronckers, Cécile M, Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, Van Der Pal, Helena J, De Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L, Falck Winther, Jeanette, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
BACKGROUND Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment. PanCareSurFup (PCSF) is the first pan-European project to evaluate some of the serious long-term health risks faced by survivors. This article sets out the overall rationale, methods and preliminary results of PCSF. METHODS The PCSF consortium pooled data from 13 cancer registries and hospitals in 12 European countries to evaluate subsequent primary malignancies, cardiac disease and late mortality in survivors diagnosed between ages 0 and 20 years. In addition, PCSF integrated radiation dosimetry to sites of second malignancies and to the heart, developed evidence-based guidelines for long-term care and for transition services, and disseminated results to survivors and the public. RESULTS We identified 115,596 individuals diagnosed with cancer, of whom 83,333 were 5-year survivors and diagnosed from 1940 to 2011. This single data set forms the basis for cohort analyses of subsequent malignancies, cardiac disease and late mortality and case-control studies of subsequent malignancies and cardiac disease in 5-year survivors. CONCLUSIONS PCSF delivered specific estimates of risk and comprehensive guidelines to help survivors and care-givers. The expected benefit is to provide every European CCS with improved access to care and better long-term health.
28. Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe
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Bright, Chloe J, Hawkins, Mike M, Winter, David L, Alessi, Daniela, Allodji, Rodrigue S, Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Byrne, Julianne, Feijen, Elizabeth A M, Fidler, Miranda M, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Guha, Joyeeta, Haddy, Nadia, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kuehni, Claudia E, Linge, Helena, Øfstaas, Hilde, Ronckers, Cecile M, Skinner, Roderick, Teepen, Jop C, Terenziani, Monica, Vu-Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Sacerdote, Carlotta, Jakab, Zsuzsanna, Haupt, Riccardo, Lähteenmäki, Päivi, Zaletel, Lorna Zadravec, Kuonen, Rahel, Winther, Jeanette F, De Vathaire, Florent, Kremer, Leontien C, Hjorth, Lars, and Reulen, Raoul C
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610 Medicine & health ,360 Social problems & social services ,3. Good health - Abstract
Background Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer. Methods We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma. Conclusions For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers.
29. The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
- Author
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Byrne, Julianne, Alessi, Daniela, Allodji, Rodrigue S., Bagnasco, Francesca, Bárdi, Edit, Bautz, Andrea, Bright, Chloe J., Brown, Morven, Diallo, Ibrahima, Feijen, Elizabeth A.M. Lieke, Fidler, Miranda M., Frey, Eva, Garwicz, Stanislaw, Grabow, Desiree, Gudmundsdottir, Thorgerdur, Hagberg, Oskar, Harila-Saari, Arja, Hau, Eva M., Haupt, Riccardo, Hawkins, Mike M., Jakab, Zsuzsanna, Jankovic, Momcilo, Kaatsch, Peter, Kaiser, Melanie, Kremer, Leontien C. M., Kuehni, Claudia E., Kuonen, Rahel, Ladenstein, Ruth, Lähteenmäki, Päivi Maria, Levitt, Gill, Linge, Helena, Llanas, Damien, Michel, Gisela (Co-Author), Morsellino, Vera, Mulder, Renee L., Reulen, Raoul C., Ronckers, Cécile M., Sacerdote, Carlotta, Skinner, Roderick, Steliarova-Foucher, Eva, van der Pal, Helena J., de Vathaire, Florent, Vũ Bezin, Giao, Wesenberg, Finn, Wiebe, Thomas, Winter, David L., Winther, Jeanette Falck, Witthoff, Elise, Zadravec Zaletel, Lorna, and Hjorth, Lars
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Late mortality ,Childhood and adolescent cancer ,Second malignancies ,Survivors ,Guidelines ,Cardiac late effects ,3. Good health - Abstract
Background: Second malignant neoplasms and cardiotoxicity are among the most serious and frequent adverse health outcomes experienced by childhood and adolescent cancer survivors (CCSs) and contribute significantly to their increased risk of premature mortality. Owing to differences in health-care systems, language and culture across the continent, Europe has had limited success in establishing multi-country collaborations needed to assemble the numbers of survivors required to clarify the health issues arising after successful cancer treatment. PanCareSurFup (PCSF) is the first pan-European project to evaluate some of the serious long-term health risks faced by survivors. This article sets out the overall rationale, methods and preliminary results of PCSF. Methods: The PCSF consortium pooled data from 13 cancer registries and hospitals in 12 European countries to evaluate subsequent primary malignancies, cardiac disease and late mortality in survivors diagnosed between ages 0 and 20 years. In addition, PCSF integrated radiation dosimetry to sites of second malignancies and to the heart, developed evidence-based guidelines for long-term care and for transition services, and disseminated results to survivors and the public. Results: We identified 115,596 individuals diagnosed with cancer, of whom 83,333 were 5-year survivors and diagnosed from 1940 to 2011. This single data set forms the basis for cohort analyses of subsequent malignancies, cardiac disease and late mortality and case–control studies of subsequent malignancies and cardiac disease in 5-year survivors. Conclusions: PCSF delivered specific estimates of risk and comprehensive guidelines to help survivors and care-givers. The expected benefit is to provide every European CCS with improved access to care and better long-term health., + ID der Publikation: unilu_35424 + Sprache: Englisch + Letzte Aktualisierung: 2018-12-18 11:58:12
30. Long term cause specific mortality among 34489 five year survivors of childhood cancer in Great Britain : population based cohort study
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British Childhood Cancer Survivor Study Steering Group, Fidler, Miranda M, Reulen, Raoul C, Winter, David L, Kelly, Julie, Jenkinson, Helen C, Skinner, Rod, Frobisher, Clare, and Hawkins, Michael M
31. Social inequalities in cancer between countries
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Fidler MM, Vaccarella S, Bray F, Vaccarella S, Lortet-Tieulent J, Saracci R, Conway DI, Straif K, and Wild CP
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- 2019
32. Reducing Social Inequalities in Cancer: Setting Priorities for Research
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Vaccarella S, Lortet-Tieulent J, Saracci R, Fidler MM, Conway DI, Vilahur N, Sarfati D, Jemal A, Mackenbach JP, Marmot MG, Straif K, Wild CP, Vaccarella S, Lortet-Tieulent J, Saracci R, Conway DI, Straif K, and Wild CP
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- 2019
33. The Future Burden of Colorectal Cancer Among US Blacks and Whites.
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Araghi M, Fidler MM, Arnold M, Jemal A, Bray F, and Soerjomataram I
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- Adult, Aged, Aged, 80 and over, Colorectal Neoplasms ethnology, Female, Forecasting, Humans, Incidence, Male, Middle Aged, SEER Program, United States epidemiology, Black or African American, Black People statistics & numerical data, Colorectal Neoplasms epidemiology, White People statistics & numerical data
- Abstract
Although overall colorectal cancer (CRC) incidence rates in the United States are declining, rates among younger persons (age < 55 years) are increasing, particularly among US whites. We assessed how these trends will impact the future burden (up to 2040) of CRC among US blacks and whites using an age-period-cohort model. Over the last four decades (1973 to 2014), CRC incidence rates for all ages (both sexes) have dropped by 6.6% and 33.9% in US blacks and whites, respectively. Yet we predict an upward turn in CRC cancer incidence rates over the next quarter century, particularly among US whites. The age-standardized rates of CRC were 55.4 and 43.2 per 100 000 among US blacks and whites in 2014, respectively, and are projected to be 49.5 and 43.1 in 2040, respectively. Future interventions are needed to reduce the striking differences in CRC incidence between blacks and whites.
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- 2018
- Full Text
- View/download PDF
34. Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.
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Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, and Reulen RC
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- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Registries, Risk Factors, Time Factors, Young Adult, Cancer Survivors statistics & numerical data, Neoplasms, Second Primary epidemiology, Sarcoma epidemiology, Soft Tissue Neoplasms epidemiology
- Abstract
Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer., Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated., Results: Overall, 301 STS developed compared with 19 expected (SIR = 15.7, 95% confidence interval [CI] = 14.0 to 17.6). The highest standardized incidence ratios were for malignant peripheral nerve sheath tumors (MPNST; SIR = 40.6, 95% CI = 29.6 to 54.3), leiomyosarcomas (SIR = 29.9, 95% CI = 23.7 to 37.2), and fibromatous neoplasms (SIR = 12.3, 95% CI = 9.3 to 16.0). SIRs for MPNST were highest following central nervous system tumors (SIR = 80.5, 95% CI = 48.4 to 125.7), Hodgkin lymphoma (SIR = 81.3, 95% CI = 35.1 to 160.1), and Wilms tumor (SIR = 76.0, 95% CI = 27.9 to 165.4). Standardized incidence ratios for leiomyosarcoma were highest following retinoblastoma (SIR = 342.9, 95% CI = 245.0 to 466.9) and Wilms tumor (SIR = 74.2, 95% CI = 37.1 to 132.8). AERs for all STS subtypes were generally low at all years from diagnosis (AER < 1 per 10 000 person-years), except for leiomyosarcoma following retinoblastoma, for which the AER reached 52.7 (95% CI = 20.0 to 85.5) per 10 000 person-years among patients who had survived at least 45 years from diagnosis of retinoblastoma., Conclusions: For the first time, we provide risk estimates of specific STS subtypes following childhood cancers and give evidence that risks of MPNSTs, leiomyosarcomas, and fibromatous neoplasms are particularly increased. While the multiplicative excess risks relative to the general population are substantial, the absolute excess risk of developing any STS subtype is low, except for leiomyosarcoma after retinoblastoma. These results are likely to be informative for both survivors and health care providers.
- Published
- 2018
- Full Text
- View/download PDF
35. Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe.
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Fidler MM, Reulen RC, Winter DL, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Bright CJ, Byrne J, Feijen EAM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuonen R, Linge H, Maule M, Merletti F, Øfstaas H, Ronckers CM, Skinner R, Teepen J, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuehni CE, Winther JF, de Vathaire F, Kremer LC, Hjorth L, and Hawkins MM
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- Adolescent, Adult, Child, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Humans, Male, Osteosarcoma epidemiology, Retinoblastoma epidemiology, Sarcoma epidemiology, Young Adult, Bone Neoplasms epidemiology, Neoplasms, Second Primary epidemiology, Survivors statistics & numerical data
- Abstract
Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors., Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided., Results: Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk., Conclusions: For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer., (© The Author 2017. Published by Oxford University Press.)
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- 2018
- Full Text
- View/download PDF
36. Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study.
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Reulen RC, Bright CJ, Winter DL, Fidler MM, Wong K, Guha J, Kelly JS, Frobisher C, Edgar AB, Skinner R, Wallace WHB, and Hawkins MM
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- Anemia epidemiology, Anemia etiology, Diabetes Mellitus epidemiology, Diabetes Mellitus etiology, England, Female, Humans, Hypertension epidemiology, Hypertension etiology, Kidney Neoplasms radiotherapy, Pregnancy, Wilms Tumor radiotherapy, Obstetric Labor Complications epidemiology, Obstetric Labor Complications etiology, Pregnancy Complications epidemiology, Pregnancy Complications etiology, Radiotherapy adverse effects, Survivors statistics & numerical data
- Abstract
Background: Female survivors of childhood cancer treated with abdominal radiotherapy who manage to conceive are at risk of delivering premature and low-birthweight offspring, but little is known about whether abdominal radiotherapy may also be associated with additional complications during pregnancy and labor. We investigated the risk of developing pregnancy and labor complications among female survivors of childhood cancer in the British Childhood Cancer Survivor Study (BCCSS)., Methods: Pregnancy and labor complications were identified by linking the BCCSS cohort (n = 17 980) to the Hospital Episode Statistics (HES) for England. Relative risks (RRs) of pregnancy and labor complications were calculated by site of radiotherapy treatment (none/abdominal/cranial/other) and other cancer-related factors using log-binomial regression. All statistical tests were two-sided., Results: A total of 2783 singleton pregnancies among 1712 female survivors of childhood cancer were identified in HES. Wilms tumor survivors treated with abdominal radiotherapy were at threefold risk of hypertension complicating pregnancy (relative risk = 3.29, 95% confidence interval [CI] = 2.29 to 4.71), while all survivors treated with abdominal radiotherapy were at risk of gestational diabetes mellitus (RR = 3.35, 95% CI = 1.41 to 7.93) and anemia complicating pregnancy (RR = 2.10, 95% CI = 1.27 to 3.46) compared with survivors treated without radiotherapy. Survivors treated without radiotherapy had similar risks of pregnancy and labor complications as the general population, except survivors were more likely to opt for an elective cesarean section (RR = 1.39, 95% CI = 1.16 to 1.70)., Conclusions: Treatment with abdominal radiotherapy increases the risk of developing hypertension complicating pregnancy in Wilms tumor survivors, and diabetes mellitus and anemia complicating pregnancy in all survivors. These patients may require extra vigilance during pregnancy., (© The Author 2017. Published by Oxford University Press.)
- Published
- 2017
- Full Text
- View/download PDF
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