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8 results on '"Figaredo, Gloria"'

1. Real-life disease monitoring in follicular lymphoma patients using liquid biopsy ultra-deep sequencing and PET/CT

Author

Jiménez-Ubieto, Ana, Poza, María, Martin-Muñoz, Alejandro, Ruiz-Heredia, Yanira, Dorado, Sara, Figaredo, Gloria, Rosa-Rosa, Juan Manuel, Rodriguez, Antonia, Barcena, Carmen, Navamuel, Laura Parrilla, Carrillo, Jaime, Sanchez, Ricardo, Rufian, Laura, Juárez, Alexandra, Rodriguez, Margarita, Wang, Chongwu, de Toledo, Paula, Grande, Carlos, Mollejo, Manuela, Casado, Luis-Felipe, Calbacho, María, Baumann, Tycho, Rapado, Inmaculada, Gallardo, Miguel, Sarandeses, Pilar, Ayala, Rosa, Martínez-López, Joaquín, and Barrio, Santiago

Published
2023
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2. Corrigendum: Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients

Author

Jiménez-Ubieto, Ana, primary, Martín-Muñoz, Alejandro, additional, Poza, María, additional, Dorado, Sara, additional, García-Ortiz, Almudena, additional, Revilla, Enrique, additional, Sarandeses, Pilar, additional, Ruiz-Heredia, Yanira, additional, Baumann, Tycho, additional, Rodríguez, Antonia, additional, Calbacho, María, additional, Sánchez, Pilar Martínez, additional, Pina, José María Sánchez, additional, García-Sancho, Alejandro Martín, additional, Figaredo, Gloria, additional, Gil-Alós, Daniel, additional, Rufián, Laura, additional, Rodríguez, Margarita, additional, Carneros, Laura, additional, Martínez-Laperche, Carolina, additional, Bastos-Oreiro, Mariana, additional, Wang, Chongwu, additional, Cedena, María-Teresa, additional, Rapado, Inmaculada, additional, de Toledo, Paula, additional, Gallardo, Miguel, additional, Valeri, Antonio, additional, Ayala, Rosa, additional, Martínez-López, Joaquín, additional, and Barrio, Santiago, additional

Published
2024
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3. Corrigendum: Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients

Author

Jiménez-Ubieto, Ana, primary, Martín-Muñoz, Alejandro, additional, Poza, María, additional, Dorado, Sara, additional, García-Ortiz, Almudena, additional, Revilla, Enrique, additional, Sarandeses, Pilar, additional, Ruiz-Heredia, Yanira, additional, Baumann, Tycho, additional, Rodríguez, Antonia, additional, Calbacho, María, additional, Sánchez, Pilar Martínez, additional, Pina, José María Sánchez, additional, García-Sancho, Alejandro Martín, additional, Figaredo, Gloria, additional, Rufián, Laura, additional, Rodríguez, Margarita, additional, Carneros, Laura, additional, Martínez-Laperche, Carolina, additional, Bastos-Oreiro, Mariana, additional, Wang, Chongwu, additional, Cedena, María-Teresa, additional, Rapado, Inmaculada, additional, de Toledo, Paula, additional, Gallardo, Miguel, additional, Valeri, Antonio, additional, Ayala, Rosa, additional, Martínez-López, Joaquín, additional, and Barrio, Santiago, additional

Published
2023
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4. Genetic Profiling of Cell-Free DNA in Liquid Biopsies: A Complementary Tool for the Diagnosis of B-Cell Lymphomas and the Surveillance of Measurable Residual Disease

Author

Figaredo, Gloria, primary, Martín-Muñoz, Alejandro, additional, Barrio, Santiago, additional, Parrilla, Laura, additional, Campos-Martín, Yolanda, additional, Poza, María, additional, Rufián, Laura, additional, Algara, Patrocinio, additional, De La Torre, Marina, additional, Jiménez Ubieto, Ana, additional, Martínez-López, Joaquín, additional, Casado, Luis-Felipe, additional, and Mollejo, Manuela, additional

Published
2023
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5. Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients

Author

Jiménez-Ubieto, Ana, Martín-Muñoz, Alejandro, Poza, María, Dorado, Sara, García-Ortiz, Almudena, Revilla, Enrique, Sarandeses, Pilar, Ruiz-Heredia, Yanira, Baumann, Tycho, Rodríguez, Antonia, Calbacho, María, Sánchez, Pilar Martínez, Pina, José María Sánchez, García-Sancho, Alejandro Martín, Figaredo, Gloria, Rufián, Laura, Rodríguez, Margarita, Carneros, Laura, Martínez-Laperche, Carolina, Bastos-Oreiro, Mariana, Wang, Chongwu, Cedena, María-Teresa, Rapado, Inmaculada, de Toledo, Paula, Valeri, Antonio, Ayala, Rosa, Martínez-López, Joaquín, and Barrio, Santiago

Subjects
Immunology, Immunology and Allergy
Published
2023
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6. Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients.

Author

Jiménez-Ubieto, Ana, Martín-Muñoz, Alejandro, Poza, María, Dorado, Sara, García-Ortiz, Almudena, Revilla, Enrique, Sarandeses, Pilar, Ruiz-Heredia, Yanira, Baumann, Tycho, Rodríguez, Antonia, Calbacho, María, Martínez Sánchez, Pilar, Sánchez Pina, José María, García-Sancho, Alejandro Martín, Figaredo, Gloria, Rufián, Laura, Rodríguez, Margarita, Carneros, Laura, Martínez-Laperche, Carolina, and Bastos-Oreiro, Mariana

Subjects
CIRCULATING tumor DNA, CHIMERIC antigen receptors, FOLLICULAR lymphoma, SOMATIC mutation, T cells
Abstract

Background: CART therapy has produced a paradigm shift in the treatment of relapsing FL patients. Strategies to optimize disease surveillance after these therapies are increasingly necessary. This study explores the potential value of ctDNA monitoring with an innovative signature of personalized trackable mutations. Method: Eleven FL patients treated with anti-CD19 CAR T-cell therapy were included. One did not respond and was excluded. Genomic profiling was performed before starting lymphodepleting chemotherapy to identify somatic mutations suitable for LiqBio-MRD monitoring. The dynamics of the baseline mutations (4.5 per patient) were further analyzed on 59 cfDNA follow-up samples. PET/CT examinations were performed on days +90, +180, +365, and every six months until disease progression or death. Results: After a median follow-up of 36 months, all patients achieved a CR as the best response. Two patients progressed. The most frequently mutated genes were CREBBP, KMT2D and EP300. Simultaneous analysis of ctDNA and PET/CT was available for 18 time-points. When PET/CT was positive, two out of four ctDNA samples were LiqBio-MRD negative. These two negative samples corresponded to women with a unique mesenteric mass in two evaluations and never relapsed. Meanwhile, 14 PET/CT negative images were mutation-free based on our LiqBio-MRD analysis (100%). None of the patients had a negative LiqBio-MRD test by day +7. Interestingly, all durably responding patients had undetectable ctDNA at or around three months after infusion. Two patients presented discordant results by PET/CT and ctDNA levels. No progression was confirmed in these cases. All the progressing patients were LiqBio-MRD positive before progression. Conclusion: This is a proof-of-principle for using ctDNA to monitor response to CAR T-cell therapy in FL. Our results confirm that a non-invasive liquid biopsy MRD analysis may correlate with response and could be used to monitor response. Harmonized definitions of ctDNA molecular response and pinpointing the optimal timing for assessing ctDNA responses are necessary for this setting. If using ctDNA analysis, we suggest restricting follow-up PET/CT in CR patients to a clinical suspicion of relapse, to avoid false-positive results. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Dynamic Response Assesment Combining Liquid Biopsy MRD and PET/CT in Follicular Lymphoma Patients Including CAR-T Cell Therapy

Author

Martín-Muñoz, Alejandro, primary, Poza, María, additional, Figaredo, Gloria, additional, Dorado, Sara, additional, Ruiz-Heredia, Yanira, additional, Rodriguez, Margarita, additional, Rufian, Laura, additional, Rodriguez Izquierdo, Antonia, additional, Parrilla-Navamuel, Laura, additional, Wang, Chongwu, additional, Toledo, Paula, additional, Grande Garcia, Carlos, additional, Baumann, Tycho, additional, Calbacho, Maria, additional, Rapado, Inmaculada, additional, Gallardo, Miguel, additional, Canales, Miguel, additional, Sarandeses, Pilar, additional, Mollejo, Manuela, additional, Casado Montero, Luis Felipe, additional, Ayala, Rosa, additional, Martínez-López, Joaquín, additional, Barrio, Santiago, additional, and Jimenez-Ubieto, Ana, additional

Published
2022
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8. Real-Life Disease Monitoring in Follicular Lymphoma Patients Using Liquid Biopsy Ultra-Deep Sequencing and PET/CT

Author

Jiménez-Ubieto, Ana, primary, Poza, Maria, additional, Martin, Alejandro, additional, Ruiz-Heredia, Yanira, additional, Dorado, Sara, additional, Figaredo, Gloria, additional, Rosa-Rosa, Juan Manuel, additional, Rodriguez, Antonia, additional, Barcena, Carmen, additional, Parrilla-Navamuel, Laura, additional, Carrillo, Jaime, additional, Perez, Ricardo Sanchez, additional, Rufian, Laura, additional, Juarez, Alexandra, additional, Rodriguez, Margarita, additional, Wang, Chonwu, additional, de Toledo, Paula, additional, Grande, Carlos, additional, Mollejo, Manuela, additional, Casado, Luis, additional, CALBACHO, Maria, additional, Baumann, Tycho, additional, Rapado, Inmaculada, additional, Gallardo, Miguel, additional, Sarandeses, Pilar, additional, Ayala, Rosa, additional, Martínez-López, Joaquín, additional, and Barrio, Santiago, additional

Published
2022
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