25 results on '"Figueras-Nadal C"'
Search Results
2. ¿Es útil el cribado familiar en el déficit selectivo de inmunoglobulina A?
- Author
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Soler-Palacín, P., Cobos-Carrascosa, E., Martín-Nalda, A., Caracseghi, F., Hernández, M., and Figueras-Nadal, C.
- Published
- 2016
- Full Text
- View/download PDF
3. Imported infectious diseases in tertiary hospitals
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Rius Gordillo, N., Martín Nalda, A., Otero Romero, S., Soler-Palacín, P., Sulleiro Igual, E., Espiau Guarner, M., Fernández-Polo, A., and Figueras Nadal, C.
- Published
- 2014
- Full Text
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4. Patología infecciosa importada en hospitales terciarios
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Rius Gordillo, N., Martín Nalda, A., Otero Romero, S., Soler-Palacín, P., Sulleiro Igual, E., Espiau Guarner, M., Fernández-Polo, A., and Figueras Nadal, C.
- Published
- 2014
- Full Text
- View/download PDF
5. Hepatotoxicidad en el lactante sano expuesto a nevirapina durante el embarazo
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Iveli P, Noguera-Julián A, Soler-Palacín P, Martín-Nalda A, Rovira-Girabal N, Fortuny-Guasch C, and Figueras-Nadal C
- Subjects
Hepatotoxicidad ,Embarazo ,Human immunodeficiency virus ,Pregnancy ,Hepatotoxicity ,Nevirapina ,Nevirapine ,Virus de la inmunodeficiencia humana - Abstract
BACKGROUND: The use of nevirapine in HIV-infected pregnant women is discouraged due to its potential to cause hepatotoxicity. There is limited information available on the toxicity in non-HIV infected newborn exposed to this drug during pregnancy. The aim of the study is to determine the extent of hepatotoxicity in the newborn exposed to nevirapine and HIV during pregnancy. METHODS: A cross-sectional, observational, multicenter study was conducted on a cohort of healthy infants born to HIV-infected mothers, in whom the first determination of alanine aminotransferase (ALT), before 6weeks of age, was collected. Patients were allocated to 2groups according to exposure to nevirapine during pregnancy. Hepatotoxicity was rated according to the AIDS Table for Grading the Severity of Adult and Pediatric Adverse Events (DAIDS). RESULTS: This study included 160newborns from 159pregnancies (88exposed to nevirapine-based regimens and 71 exposed to protease inhibitors-based therapies). No cases of hepatotoxicity were observed according to the DAIDS Table for Grading. Two cases of ALT above normal values (2.8%; 95%CI: 0.3-9.8%) were observed in patients not exposed to nevirapine, and one case (1.1%; 95%CI: 0.0-6.1%) in the group exposed to nevirapine (P=.585). CONCLUSION: The lack of differences between groups suggests that highly active antiretroviral treatment regimens including nevirapine administered during pregnancy do not involve a higher risk of liver disease compared to other treatment combinations.
- Published
- 2016
6. Fiebre y lesiones cutáneas en un paciente con enfermedad granulomatosa crónica
- Author
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Rovira Castellví, P., primary, Martin-Nalda, A., additional, García-Patos, V., additional, Ferrer Fàbrega, B., additional, and Figueras Nadal, C., additional
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- 2014
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7. Evaluación de un programa de valoración de adherencia al tratamiento antirretroviral
- Author
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Valdivia Vadell, C., primary, Soler-Palacín, P., additional, Martín-Nalda, A., additional, Cabañas Poy, M.J., additional, Clemente Bautista, S., additional, Espiau Guarner, M., additional, and Figueras Nadal, C., additional
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- 2011
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8. Espectro de las inmunodeficiencias primarias en un hospital de tercer nivel en un periodo de 10 años
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Martín-Nalda, A., primary, Soler-Palacín, P., additional, Español Borén, T., additional, Caragol Urgelles, I., additional, Díaz de Heredia Rubio, C., additional, and Figueras Nadal, C., additional
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- 2011
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- View/download PDF
9. Fe de errores de “Gammaglobulina subcutánea en inmunodeficiencia común variable. Primera experiencia en España”
- Author
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Maroto Hernando, M., primary, Soler Palacín, P., additional, Martín Nalda, A., additional, Oliveras Arenas, M., additional, Español Boren, T., additional, and Figueras Nadal, C., additional
- Published
- 2010
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- View/download PDF
10. Gammaglobulina subcutánea en inmunodeficiencia común variable. Primera experiencia en España
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Maroto Hernando, M., primary, Soler Palacín, P., additional, Martín Nalda, A., additional, Oliveras Arenas, M., additional, Español Boren, T., additional, and Figueras Nadal, C., additional
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- 2009
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11. Enfermedad neumocócica invasiva y síndrome hemolítico urémico
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Fàbregas Martori, A., primary, Moraga-Llop, F., additional, Nieto Rey, J., additional, Figueras Nadal, C., additional, Soler Palacín, P., additional, and Roqueta Mas, J., additional
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- 2008
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12. La imagen de la semana
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Pinós Desplat, T., primary, Armengol Miró, J.R., additional, and Figueras Nadal, C., additional
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- 2000
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13. Effectiveness and tolerability of ibuprofen-arginine versus paracetamol in children with fever of likely infectious origin.
- Author
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Figueras Nadal, C, García De Miguel, Mª J, Gómez Campderá, A, Pou Fernández, J, Alvarez Calatayud, G, Sánchez Bayle, M, García de Miguel, Ma J, Gómez Campderá, A, Pou Fernández, J, Sánchez Bayle, M, and Paediatric Fever Co-operative Group from the Spanish Paediatric Association
- Subjects
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IBUPROFEN , *ANTIPYRETICS , *ACETAMINOPHEN , *FEVER in children , *DRUG efficacy , *ARGININE , *BIOLOGICAL assay , *COMBINATION drug therapy , *CLINICAL trials , *COMPARATIVE studies , *FEVER , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *EVALUATION research , *RANDOMIZED controlled trials , *BLIND experiment , *NONOPIOID analgesics , *THERAPEUTICS - Abstract
Unlabelled: The aim of this multicentre, double-blind, randomized study was to assess the paediatric antipyretic efficacy of a new ibuprofen formulation containing L-arginine for gastric protection, compared with the efficacy of paracetamol. For this purpose 100 patients were given ibuprofen-arginine (1 drop/kg: 6.67 mg/kg) and 99 paracetamol (4 drops/kg: 10.65 mg/kg). The main efficacy endpoint was the mean change in tympanic temperature 4 h after drug intake. Twelve patients were excluded because of early vomiting or spitting out the medication. The resulting efficacy analysis population included a total of 88 patients treated with ibuprofen-arginine and 87 with paracetamol. Mean change in tympanic temperature (degrees C) showed no difference between groups (p = 0.527) but more patients in the ibuprofen-arginine group attained a temperature reduction greater than 2 degrees C (p = 0.043). A total of 107 patients required antipyretic rescue medication, with a smaller proportion in the ibuprofen-arginine group. Although this was not statistically significant, a trend towards improved activity was observed (p = 0.100). Overall efficacy was judged from the recovery or improvement in 68.8% of patients in the ibuprofen-arginine group compared with 65.5% in the paracetamol group. Nineteen patients reported adverse events, with vomiting being the most common complaint, but no differences were detected between treatments.Conclusion: Based on the present results, ibuprofen-arginine oral drops have shown to be a safe, well-tolerated and potent paediatric antipyretic agent. Hence, ibuprofen-arginine should be considered as an adequate choice for the control of paediatric fever of likely infectious aetiology. [ABSTRACT FROM AUTHOR]- Published
- 2002
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14. Lemierre syndrome in a previously healthy young girl.
- Author
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Figueras Nadal, C, Creus, A, Beatobe, S, Moraga, F, Pujol, M, and Vazquez, E
- Abstract
Unlabelled: Lemierre syndrome is a severe postanginal sepsis complicated by internal jugular thrombophlebitis. We report on a 14 y-old girl affected by high fever, shivering chills, headache, severe lateral neck pain, left ocular proptosis and general malaise. Magnetic resonance imaging of the head and neck showed right internal jugular vein and sigmoid sinus thrombosis. Fusobacterium sp. was identified in the blood culture.Conclusion: Our report is a reminder that Lemierre syndrome still exists and remains potentially life threatening. A high index of suspicion is necessary to prompt diagnosis and treatment. [ABSTRACT FROM AUTHOR]- Published
- 2003
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15. [Hepatotoxicity in healthy infants exposed to nevirapine during pregnancy].
- Author
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Iveli P, Noguera-Julian A, Soler-Palacín P, Martín-Nalda A, Rovira-Girabal N, Fortuny-Guasch C, and Figueras-Nadal C
- Subjects
- Anti-HIV Agents adverse effects, Cross-Sectional Studies, Female, HIV Infections drug therapy, Humans, Infant, Infant, Newborn, Pregnancy, Pregnancy Complications, Infectious virology, Chemical and Drug Induced Liver Injury epidemiology, Maternal Exposure adverse effects, Nevirapine adverse effects
- Abstract
Background: The use of nevirapine in HIV-infected pregnant women is discouraged due to its potential to cause hepatotoxicity. There is limited information available on the toxicity in non-HIV infected newborn exposed to this drug during pregnancy. The aim of the study is to determine the extent of hepatotoxicity in the newborn exposed to nevirapine and HIV during pregnancy., Methods: A cross-sectional, observational, multicenter study was conducted on a cohort of healthy infants born to HIV-infected mothers, in whom the first determination of alanine aminotransferase (ALT), before 6weeks of age, was collected. Patients were allocated to 2groups according to exposure to nevirapine during pregnancy. Hepatotoxicity was rated according to the AIDS Table for Grading the Severity of Adult and Pediatric Adverse Events (DAIDS)., Results: This study included 160newborns from 159pregnancies (88exposed to nevirapine-based regimens and 71 exposed to protease inhibitors-based therapies). No cases of hepatotoxicity were observed according to the DAIDS Table for Grading. Two cases of ALT above normal values (2.8%; 95%CI: 0.3-9.8%) were observed in patients not exposed to nevirapine, and one case (1.1%; 95%CI: 0.0-6.1%) in the group exposed to nevirapine (P=.585)., Conclusion: The lack of differences between groups suggests that highly active antiretroviral treatment regimens including nevirapine administered during pregnancy do not involve a higher risk of liver disease compared to other treatment combinations., (Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
16. Staphylococcus aureus Bacteremia in Children: Changes During Eighteen Years.
- Author
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Cobos-Carrascosa E, Soler-Palacín P, Nieves Larrosa M, Bartolomé R, Martín-Nalda A, Antoinette Frick M, Bernet A, Pumarola T, and Figueras-Nadal C
- Subjects
- Adolescent, Child, Child, Preschool, Drug Resistance, Bacterial, Humans, Infant, Retrospective Studies, Bacteremia epidemiology, Bacteremia microbiology, Staphylococcal Infections epidemiology, Staphylococcal Infections microbiology, Staphylococcus aureus
- Abstract
Background: Staphylococcus aureus is a major cause of bacteremia in children and is associated with high morbidity. Complete data are lacking on the incidence, related risk factors and mortality associated with this infection., Methods: Descriptive study including patients younger than 16 years admitted to a tertiary reference hospital, with blood cultures exclusively positive for S. aureus. Four study periods were established: period 1, 1995-1999; period 2, 2000-2002; period 3, 2006-2008 and period 4, 2010-2012., Results: In total, 269 episodes of S. aureus bacteremia (SAB) occurred in 242 patients. Over the total time studied, the incidence increased from 1.3 to 3.3 cases per 1000 patients hospitalized (relative risk: 2.71; 95% confidence interval: 1.85-3.95) and mortality decreased from 18% to 6% (P = 0.008). There were no differences in the resistance patterns of S. aureus strains. The prevalence of methicillin-resistant S. aureus (MRSA) increased from 3% to 13% between periods 1 and 2 and decreased from 14% to 3% between periods 3 and 4 (P = 0.011). The 30-day cumulative mortality was 3.3%, and the SAB-related mortality was 1.5%. Nosocomial acquisition and age 12-16 years were factors independently related with death on multivariate analysis., Conclusions: The incidence of SAB tripled during the years studied but remained stable in the last period. Antimicrobial resistances did not increase. Although a decrease in mortality was documented, approximately half the 30-day cumulative mortality was caused by SAB.
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- 2015
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17. [Carbapenem antibiotics in hospitalised paediatric patients. Adherence to a therapeutic protocol].
- Author
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Montesinos-Sanchis E, Moraga-Llop FA, Soler-Palacín P, Oliveras-Arenas M, Larrosa Escartín MN, Martínez Gómez X, and Figueras-Nadal C
- Subjects
- Child, Preschool, Clinical Protocols, Community-Acquired Infections drug therapy, Female, Hospitalization, Humans, Infant, Male, Retrospective Studies, Bacterial Infections drug therapy, Carbapenems therapeutic use, Guideline Adherence statistics & numerical data
- Abstract
Objective: To describe the use of carbapenems in children hospitalised outside intensive care and onco-haematology units, and assess adherence to a therapeutic protocol., Patients and Methods: A retrospective observational study was conducted on the use of carbapenems between January 2009 and December 2010. The study included children with a community-acquired infectious disease or a health care-associated infectious disease, and who were admitted to paediatric areas of the Vall d'Hebron University Hospital (Barcelona, Spain), other than intensive care, neonatology and onco-haematology units. Clinical data were collected and antibiotic consumption data were provided by the Pharmacy Department., Results: A total of 51 episodes fulfilled the inclusion criteria. Carbapenem as initial empirical treatment was indicated in 31.4%, and applied as rescue therapy in the remainder. The instructions of the protocol were adhered to in 70.6% of the empirical and 87.5% of the targeted prescriptions (77.6% overall). A better match was found for empirical carbapenem in patients with a previous admission or underlying condition. Factors such as diagnosis, age or antibiotic use prior to admission did not affect the empirical indication of carbapenem., Conclusions: The establishment of a treatment protocol with carbapenem indications in our centre since 2007 has yielded significantly better results on the appropriateness of the prescription than those obtained in other studies., (Copyright © 2012 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
18. [Can we rule out a congenital cytomegalovirus infection when the result of polymerase chain reaction in dried blood spots is negative?].
- Author
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Vives-Oñós I, Soler-Palacín P, Codina-Grau MG, Martín-Nalda A, López-Galera RM, Marín-Soria JL, and Figueras-Nadal C
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- Asymptomatic Diseases, Cross-Sectional Studies, Cytomegalovirus Infections blood, Cytomegalovirus Infections diagnosis, Cytomegalovirus Infections urine, False Negative Reactions, Female, HIV Infections, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Complications, Infectious virology, Retrospective Studies, Urine virology, Viral Load, Viremia blood, Viremia diagnosis, Cytomegalovirus isolation & purification, Cytomegalovirus Infections congenital, DNA, Viral blood, Neonatal Screening methods, Real-Time Polymerase Chain Reaction, Viremia congenital
- Abstract
Introduction: The detection of cytomegalovirus (CMV) DNA by real time polymerase chain reaction (rt-PCR) in dried blood spots collected routinely for metabolic screening has been assessed for the retrospective diagnosis of congenital CMV (cCMV) infection in many studies, but not in Spain. The aim of this study is to analyze the diagnostic accuracy of this technique in our hospital., Methods: A cross-sectional retrospective observational study was conducted including all patients born between January, 2007 and September, 2012 with confirmed cCMV infection. The assessment of CMV DNA was made by using rt-PCR in dried blood spots of these patients., Results: Fourteen patients were included: 4/14 were symptomatic and 4/14 had sequelae. The detection of CMV DNA by rt-PCR was positive in only 7 patients. A statistically significant relationship between low viral load at birth and negative rt-PCR in dried blood spots was demonstrated., Conclusions: Despite the low number of patients included, our data highlight an important amount of false negative results in the DNA CMV detection by rt-PCR in these samples for the retrospective diagnosis of cCMV infection, especially in cases with low viral load at birth., (Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
19. [Fever and skin lesions in a patient with chronic granulomatous disease].
- Author
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Rovira Castellví P, Martin-Nalda A, García-Patos V, Ferrer Fàbrega B, and Figueras Nadal C
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- Adolescent, Fever etiology, Granulomatous Disease, Chronic classification, Granulomatous Disease, Chronic complications, Humans, Male, Skin Diseases etiology, Granulomatous Disease, Chronic diagnosis
- Published
- 2014
- Full Text
- View/download PDF
20. [Evaluation of a program for assessing adherence to antiretroviral treatment].
- Author
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Valdivia Vadell C, Soler-Palacín P, Martín-Nalda A, Cabañas Poy MJ, Clemente Bautista S, Espiau Guarner M, and Figueras Nadal C
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- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Male, Retrospective Studies, Anti-Retroviral Agents therapeutic use, HIV Infections drug therapy, Medication Adherence, Surveys and Questionnaires
- Abstract
Introduction: Poor adherence to antiretroviral treatment (ART) is the commonest cause of treatment failure in children and adults living with HIV, and this is especially important during adolescence. Therefore, any analysis of ART effectiveness in children should include an evaluation of adherence to ART. The aim of this study is to assess the usefulness of an ART adherence monitoring program in an HIV-infected paediatric population., Patients and Methods: An observational and cross-sectional study was performed, within the framework of the "Health Education Program for Optimising Adherence in Paediatric Patients with HIV", which is part of the "I am not alone" project. Adherence was assessed simultaneously by different methods: personal interview, therapeutic drug monitoring, pharmacy dispensing records and evolution of viral load and T CD4+ lymphocyte count., Results: Twenty patients were included (50% female, median age 14.5 years). Percentage of self-reported full adherence was 90% (95% CI: 70-97.2%); however, the median adherence percentage according to pharmacy dispensing records was significantly lower (83.3%, SD=32.88). The average of drugs and dosage forms per day were 3.5 (SD=0.83) and 5.5 (SD=2.72), respectively. There was an inverse relationship between the number of dosage forms per day and adherence scores (F=13.8; P=.002). No single method was statistically related to adherence, although therapeutic drug monitoring showed a trend towards significance., Conclusions: Global adherence to ART was high and was easier with simpler regimens. Self-reported adherence overestimated real adherence to ART in our cohort. The simultaneous use of different methods to assess adherence is recommended in HIV-infected children., (Copyright © 2011 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.)
- Published
- 2011
- Full Text
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21. [Spectrum of primary immunodeficiencies in a tertiary hospital over a period of 10 years].
- Author
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Martín-Nalda A, Soler-Palacín P, Español Borén T, Caragol Urgelles I, Díaz de Heredia Rubio C, and Figueras Nadal C
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- Adolescent, Child, Child, Preschool, Female, Hospitals, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Time Factors, Immunologic Deficiency Syndromes diagnosis, Immunologic Deficiency Syndromes epidemiology, Immunologic Deficiency Syndromes therapy
- Abstract
Introduction: More than 200 primary immunodeficiencies (PID) have been described and about 60% present during childhood. Early diagnosis and treatment have been shown to improve patient outcome., Aim: Analysis of patients with a PID diagnosed in a paediatric tertiary care hospital-referral centre over a period of 10 years., Patients and Methods: Medical records of all paediatric patients followed up in our unit were retrospectively reviewed. Clinical and epidemiological features, laboratory tests, therapy and outcome were analysed., Results: One hundred and eighty nine patients were followed up in this period of time. Antibody disorders were the most common diagnosis. In our series, clinical presentation at diagnosis were: recurrent respiratory infections in selective IgA deficiency and common variable immunodeficiency (CVID) patients, failure to thrive and opportunistic infections (mainly viral infections) in patients with severe combined immunodeficiency (SCID), skin abscesses (Staphylococcus aureus, Serratia spp.) and complicated pneumonia (Aspergillus spp., Rhodococcus equi) in chronic granulomatous disease, congenital heart disease and consistent phenotype in 22q11 deletion syndrome, skin abscesses and ecthyma gangrenosum in severe congenital neutropenia and opportunistic infections and sepsis (Pseudomonas aeruginosa) in children with X-linked agammaglobulinaemia (XLA). Lymphoproliferative disorders were common in CVID. No malignancies were observed during this period. One patient with XLA developed chronic encephalitis. All patients with CVID and XLA were receiving immunoglobulin replacement therapy (8 intravenous and 14 (since 2006) subcutaneous route) and in all but two SCID patients, stem cell transplantation was performed. Outcome was good in most of them except 8 SCID (2 prior and 6 after transplantation), 3 Wiskott-Aldrich syndrome, 1 complete DiGeorge, 1 chronic granulomatous disease and 1 ataxia-telangiectasia patients who died during follow-up., Conclusion: The vast majority of patients included in this series presented with typical clinical features; therefore, basic knowledge of these entities in primary care and collaboration with hospital referral centres should allow a large number of PID in children to be diagnosed at an early stage, leading to proper treatment and monitoring, and therefore improvement of patient prognosis., (Copyright © 2010 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.)
- Published
- 2011
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22. [Common variable immunodeficiency. Prognostic factors for lung damage].
- Author
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Sala Cunill A, Soler-Palacín P, Martín De Vicente C, Labrador Horrillo M, Luengo Sánchez O, and Figueras Nadal C
- Subjects
- Adolescent, Child, Cross-Sectional Studies, Female, Humans, Lung Diseases diagnosis, Male, Prognosis, Common Variable Immunodeficiency complications, Lung Diseases immunology
- Abstract
Background and Objective: Lung damage is considered to be key to Common Variable Immunodeficiency (CVID) prognosis. We describe lung damage in pediatric CVID patients and assess its relationship with memory B cells (MB) phenotype, immunoglobulin G (IgG) levels at the time of diagnosis, and diagnostic delay. We also assessed the prevalence of allergy and autoimmune phenomena., Patients and Method: Cross-sectional study of 17 CVID patients treated at Vall d'Hebron University Hospital. Prevalence ratio and prevalence odds ratio were used to assess the effect of MB cells phenotype, IgG levels and diagnostic delay on lung damage., Results: Five of seventeen patients presented bronchiectasis. Diagnostic delay >5 years was significantly associated with more severe lung damage. MBO phenotype and low IgG levels at the time of diagnosis showed a trend to more severe lung damage without reaching statistical signification. A higher prevalence of allergic or autoimmune phenomena was not observed., Conclusions: Latter diagnosis is associated with greater lung damage in CVID patients. The study of MB cells should be included in the study of these patients., (Copyright (c) 2009 Elsevier España, S.L. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
23. [Subcutaneous gammaglobulin in common variable immunodeficiency. First experience in Spain].
- Author
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Maroto Hernando M, Soler Palacín P, Martin Nalda N, Oliveras Arenas M, Español Boren T, and Figueras Nadal C
- Subjects
- Adolescent, Child, Female, Humans, Infusions, Subcutaneous, Longitudinal Studies, Male, Retrospective Studies, Spain, Common Variable Immunodeficiency drug therapy, Immunologic Factors administration & dosage, gamma-Globulins administration & dosage
- Abstract
Introduction and Aim: Weekly home-based subcutaneous immunoglobulin (SCIg) therapy is an alternative to intravenous immunoglobulin (IVIg) in the treatment of patients with primary antibody deficiencies. The objective of this study was to investigate the efficacy, safety, related quality of life and cost effectiveness of SCIg in our area., Materials and Methods: Observational and descriptive study including paediatric patients with common variable immunodeficiency (CVID) receiving SCIg in our hospital (November 2006 to April 2008). Obtained data were compared with those from the last year with IVIg., Results: Eleven patients with CVID were included. Median age was 15 years. The median trough serum IgG level was 622 mg/dl with IVIg. In patients in whom the SCIg dose was maintained or reduced compared to IVIg, the median trough serum IgG level was 850 mg/dl (p < 0.0005). Annual rate of infection was 2.22 per patient-year, without significant differences to IVIg (p = 0.212). There were 58 treatment-related adverse events (AE) reported with SCIg (45 local AE and 13 systemic AE). The most frequent treatment-related adverse event was infusion-site reaction. Switching to home-based subcutaneous IgG treatment led to significant improvements in quality of life and substantial cost savings., Conclusions: We conclude that subcutaneous administration of 16% SCIg is a safe and cost-effective alternative to IVIg for replacement therapy of primary antibody deficiencies. Median trough serum IgG levels were higher with SCIg. Local AE were common but mild and the incidence decreased over time. Quality of life is significantly improved.
- Published
- 2009
- Full Text
- View/download PDF
24. [Invasive pneumococcal disease and hemolytic uremic syndrome].
- Author
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Fàbregas Martori A, Moraga-Llop F, Nieto Rey J, Figueras Nadal C, Soler Palacín P, and Roqueta Mas J
- Subjects
- Hemolytic-Uremic Syndrome diagnostic imaging, Humans, Infant, Kidney Transplantation, Male, Renal Insufficiency complications, Renal Insufficiency diagnostic imaging, Renal Insufficiency surgery, Severity of Illness Index, Ultrasonography, Hemolytic-Uremic Syndrome microbiology, Pneumococcal Infections complications, Streptococcus pneumoniae isolation & purification
- Abstract
Introduction: Streptococcus pneumoniae is an infrequent casual agent of hemolytic uremic syndrome (HUS) with more severity than classic HUS., Case Report: We present two patients with pneumococcal pneumonia and empyema who developed HUS. One patient the renal function returned to normal and the other needed a renal transplantation., Conclusion: Pneumococcal invasive disease may be a cause of severe HUS, so a high index of suspicion is mandatory to prompt appropriate diagnosis and management.
- Published
- 2008
- Full Text
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25. [D-lactic acidosis in an 11-year-old patient with short bowel syndrome].
- Author
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Soler Palacín P, Garzón Lorenzo P, Castilla Fernández Y, Arranz Amo JA, Scheider S, Tormo Carnicé R, del Toro Riera M, and Figueras Nadal C
- Subjects
- Acidosis, Lactic diagnosis, Child, Humans, Male, Acidosis, Lactic etiology, Short Bowel Syndrome complications
- Abstract
The short bowel syndrome is the result of a congenital or acquired loss of a large part of the small intestine. The most frequent causes of surgical resection of the intestine in infants are arterial or venous thrombosis, intestinal volvulus, necrotizing enterocolitis, and Crohn's disease. Symptoms include nutrient and electrolyte malabsorption, steatorrhea and diarrhea, which can result in failure to thrive. The consequences of extensive small bowel resections consist of nutritional deficiencies, gastric acid hypersecretion, nephrolithiasis, cholelithiasis and lactic acidosis. Of these, D-lactic acidosis is an infrequent but important complication because of the symptoms that it can produce. D-lactic acid in the human organism is generated by intestinal bacteria, D-lactate ingestion, or endogenous production in the methyl glycoxylase pathway. Neurological symptoms such as somnolence, ataxia or altered behavior in a patient with short bowel syndrome should make us think of D-lactic acidosis caused by bacterial overgrowth. We present the case of an 11-year-old boy with short bowel syndrome secondary to multiple resections during the postnatal period who was admitted to hospital for episodes of confusion and altered behavior. The diagnosis was lactic acidosis. Outcome was favorable due to prompt instauration of treatment.
- Published
- 2006
- Full Text
- View/download PDF
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