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2. Sorgo de alto tanino na nutrição e sanidade de juvenis de tambaqui (Colossoma macropomum, Cuvier 1818)

Author

VIANA FILHO, G. B. and GILBERTO BATISTA VIANA FILHO, Orientador: Dr. Jony Koji Dairiki, CPAA.

Subjects
Acantocéfalos, Alimentação, Colossoma Macropomum, Tambaqui
Abstract

O objetivo deste estudo foi avaliar diferentes níveis de inclusão de sorgo com tanino condensável para controle de helmintos, parasitas de tambaqui (acantocéfalos). Made available in DSpace on 2021-12-22T14:05:39Z (GMT). No. of bitstreams: 1 Monografia-Gilberto-Batista-Viana-Filho.pdf: 374908 bytes, checksum: 1470be6bb4f74eb6675122d1c864f2c3 (MD5) Previous issue date: 2021 Monografia (Bacharelado em Zootecnia) - Universidade Federal do Amazonas, Manaus. Orientador: Dr. Jony Koji Dairiki; coorientador: Prof. Dr. Paulo César Machado de Andrade.

Published
2021

3. Estudo do potencial agrícola e não agrícola do Município de Itacuruba, Pernambuco, Brasil

Author

ROCHA FILHO, G. B. da and GILSON BRANDÃO DA ROCHA FILHO, IFPE.

Subjects
Desertificação, Solos, Recursos hídricos, Gestão ambiental
Abstract

A presente pesquisa objetivou avaliar potencialidades agrícolas e não agrícolas, no contexto do semiárido do Nordeste do Brasil, que promovam a geração de renda e contribuam para o desenvolvimento sustentável e inclusão social. A área de estudo escolhida foi o município de Itacuruba – PE, localizado na margem esquerda do Rio São Francisco, no sertão pernambucano, e inserido no núcleo de desertificação de Cabrobó. A pesquisa se desenvolveu a partir de estudos e análises de informações disponíveis sobre o potencial global (agrícola e não agrícola) disponibilizados pela Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA. Embasado nas informações existentes sobre os recursos naturais, foram feitas avaliações do potencial de terras para irrigação e do potencial agroecológico das terras do município. Ainda com base no potencial global e no conhecimento da realidade local, o estudo realizado indicou que os solos apresentam fortes limitações para atividades agrícolas. Porém, a condição de disponibilidade hídrica da região possibilita a viabilidade econômica de outros usos não agrícolas, a exemplo da piscicultura e avicultura já iniciadas, além de potencialidades para geração de energia de matriz solar, eólica e nuclear, assim como o desenvolvimento de um turismo sertanejo sustentável. Dissertação (Mestrado em Gestão Ambiental) - Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco, Recife. Orientador: José Coelho de Araújo Filho, CNPS; Co-orientadora: Renata Maria Caminha Mendes de Oliveira Carvalho, IFPE.

Published
2016

4. Exposição aguda ao cádmio reduz a atividade da enzima conversora de angiotensina I e aumenta a concentração tecidual do metal

Author

BROSEGHINI FILHO, G. B., Franck Maciel Pecanha, MEYRELLES, S. S., and Alessandra Simao Padilha

Abstract

Made available in DSpace on 2018-08-01T22:58:48Z (GMT). No. of bitstreams: 1 tese_8590_Dissertação Gilson Broseguini.pdf: 1127564 bytes, checksum: b0d7b4bf5e3db7bb26c8c827eaa66522 (MD5) Previous issue date: 2015-02-13 A exposição ao cádmio causa diversos problemas cardiovasculares que podem ser resultado de mecanismos como o aumento do estresse oxidativo e alterações da atividade de metaloproteases como a enzima conversora de angiotensina (ECA). De fato, o cádmio exerce efeito inibidor sobre a ECA do soro, mas não se sabe como esse metal afeta a ECA nos tecidos e também não se sabe se após a exposição aguda já ocorre aumento da concentração tecidual do metal. Para elucidar essas questões, uma solução de cádmio foi injetada intravenosamente em ratos Wistar e, após duas horas de exposição, o conteúdo de cádmio e a atividade da ECA foram mensurados em amostras de soro, aorta, pulmão e rim coletadas desses animais. Além disso, para elucidar se o cádmio age diretamente sobre a ECA sérica e tecidual, ensaios de atividade da enzima foram realizados também após a exposição in vitro ao cádmio. Nossos resultados demonstraram que após 120 minutos de exposição ao cádmio o conteúdo de cádmio no sangue e nos tecidos aumentou. A atividade da ECA sérica e pulmonar foram reduzidas após 120 minutos de exposição ao cádmio, entretanto, a atividade da ECA renal e aórtica não foram alteradas. O efeito inibitório induzido sobre a ECA pelo cádmio também foi observado no soro, na aorta e no pulmão, mas não no rim após a exposição in vitro. Além disso, esse efeito inibitório foi parcialmente revertido após a suplementação in vitro de zinco, sugerindo que, possivelmente, ambos os metais interajam ou compitam entre si a nível de sítio ativo da ECA. Sumariando, nossos resultados sugerem que a exposição aguda ao cádmio promove aumento da concentração sanguínea e tecidual do metal. Esse aumento foi acompanhado ação inibitória direta do cádmio sobre a atividade da ECA sérica, pulmonar e aórtica, um efeito que é cádmio-concentração dependente e parcialmente revertido pelo zinco.

Published
2015

5. Global gene expression profiling of oral cavity cancers suggests molecular heterogeneity within anatomic subsites

Author

Severino, Patricia, Alvares, Adriana M., Michaluart, Pedro, Okamoto, Oswaldo K., Nunes, Fabio D., Moreira-Filho, Carlos A., Tajara, Eloiza H., Cury, P. M., Frizzera, A. P.Z., de Carvalho, M. B., Silva, A. M.A., Amar, A., Barbieri, R. B., Bastos, A. U., Carvalho-Neto, P. B., Casemiro, A. F., Chedid, H., Chiappini, P. B.O., Correia, L. A., Costa, A. C.W., Curioni, O. A., Franzi, S. A., Gazito, D., Gutierres, A. P., Lehn, C. N., Martins, A. E., Mercante, A. M.C., Porsani, A. F., Rapoport, A., Rossi, L., Santos, M., Souza, T. B., Takamori, J. T., Dias-Neto, E., Ojopi, E. P.B., Dias, T. H.G., Figueiredo, D. L.A., Mamede, R. C.M., Fukuyama, E. E., Góis-Filho, J. F., Cerione, M., Cicco, R., Settani, F., Valentim, P. J., Yamagushi, F., Cominato, M. L., Mendes, G. S., Paiva, R., Silva, M. J., Leopoldino, A. M., Silva, F. A.M., Moyses, R. A., Arap, S. S., Araújo, N. S.S., Araújo-Filho, V., Brandão, L. G., Cernea, C. R., Durazzo, M., Ferraz, A. R., Gallo, J., Guimarães, P. E.M., Magalhães, R. P., Montenegro, F. L.M., Silva-Filho, G. B., Smith, R. B., Stabenow, E., Tavares, M. R., Turcano, R., Volpi, E. M., Ramos, O., Silva, C., Moreira-Filho, C. A., Nóbrega, F. G. [UNESP], Nóbrega, M. P. [UNESP], Canto, A. L. [UNESP], Macarenco, R. [UNESP], Meneses, C. [UNESP], Correa, P. M.S. [UNESP], Bogossian, A. P. [UNESP], Nunes, F. D., Souza, S. C.O.M., Rodini, C. O., Xavier, F. C.A., Okamoto, O. K., Serafini, L. N., Severino, P., Silva, W. A., Brandão, R. M., Kaneto, C. M., Pinheiro, D. G., Santos, A. R.D., Silva, I. T., Tarlá, M. V.C., Silveira, N. J.F., Tajara, E. H., Rodrigues-Lisoni, F. C., Rodrigues, R. V., Polachini, G. M., Vidotto, A., Cunha, B. R., Carmona-Raphe, J., Wünsch-Filho, V., Costa, A., Figueiredo, R. O., Fortes, C. S., Inamine, R., López, R. V.M., Rodrigues, A. N., Zago, M. A., Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Heliópolis, Universidade de São Paulo (USP), Universidade Federal de São Paulo (UNIFESP), Faculdade de Medicina de São José do Rio Preto, Faculdade de Medicina, Instituto do Câncer Arnaldo Vieira de Carvalho, Universidade Estadual Paulista (UNESP), Instituto de Ensino e Pesquisa Albert Einstein, and UNIVAP

Subjects
Medicine(all), Microarray, Cytoskeleton organization, business.industry, Biochemistry, Genetics and Molecular Biology(all), lcsh:R, Short Report, lcsh:Medicine, General Medicine, Disease, Cell cycle, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Gene expression profiling, stomatognathic diseases, lcsh:Biology (General), Gene expression, Gene chip analysis, Medicine, lcsh:Science (General), business, lcsh:QH301-705.5, Gene, lcsh:Q1-390
Abstract

Made available in DSpace on 2022-04-29T08:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-01 Background: Oral squamous cell carcinoma (OSCC) is a frequent neoplasm, which is usually aggressive and has unpredictable biological behavior and unfavorable prognosis. The comprehension of the molecular basis of this variability should lead to the development of targeted therapies as well as to improvements in specificity and sensitivity of diagnosis. Results: Samples of primary OSCCs and their corresponding surgical margins were obtained from male patients during surgery and their gene expression profiles were screened using whole-genome microarray technology. Hierarchical clustering and Principal Components Analysis were used for data visualization and One-way Analysis of Variance was used to identify differentially expressed genes. Samples clustered mostly according to disease subsite, suggesting molecular heterogeneity within tumor stages. In order to corroborate our results, two publicly available datasets of microarray experiments were assessed. We found significant molecular differences between OSCC anatomic subsites concerning groups of genes presently or potentially important for drug development, including mRNA processing, cytoskeleton organization and biogenesis, metabolic process, cell cycle and apoptosis. Conclusion: Our results corroborate literature data on molecular heterogeneity of OSCCs. Differences between disease subsites and among samples belonging to the same TNM class highlight the importance of gene expression-based classification and challenge the development of targeted therapies. Centro de Pesquisa Experimental Instituto Israelita de Ensino e Pesquisa Albert Einstein Laboratório de Biologia Molecular Hospital Heliópolis Departamento de Cirurgia de Cabeça e Pescoço Hospital das Clínicas Faculdade de Medicina Universidade de São Paulo Departamento de Neurologia e Neurocirurgia Universidade Federal de São Paulo Departamento de Estomatologia Faculdade de Odontologia Universidade de São Paulo Departamento de Pediatria Faculdade de Medicina Universidade de São Paulo Departamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto Departamento de Genética e Biologia Evolutiva Instituto de Biociências Universidade de São Paulo Departamento de Patologia Faculdade de Medicina Hospital Heliópolis Departamento e Instituto de Psiquiatria Faculdade de Medicina USP Serviço de Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Ribeirão Preto USP Serviço de Cirurgia de Cabeça e Pescoço Instituto do Câncer Arnaldo Vieira de Carvalho Departamento de Análises Clínicas Toxicológicas e Bromatológicas Faculdade de Ciências Farmacêuticas de Ribeirão Preto USP Departamento de Cirurgia de Cabeça e Pescoço Faculdade de Medicina USP Departamento de Pediatria Faculdade de Medicina USP Departamento de Biociências e Diagnóstico Bucal Faculdade de Odontologia UNESP Departamento de Estomatologia Faculdade de Odontologia USP Departamento de Neurologia e Neurocirurgia UNIFESP Departamento de Patologia Faculdade de Medicina de Ribeirão Preto USP Instituto de Ensino e Pesquisa Albert Einstein Departamento de Genética Faculdade de Medicina de Ribeirão Preto USP Ciências da Computação UNIVAP Departamento de Biologia Molecular Faculdade de Medicina Departamento de Epidemiologia Faculdade de Saúde Pública USP Departamento de Clínica Médica Faculdade de Medicina de Ribeirão Preto USP Departamento de Biociências e Diagnóstico Bucal Faculdade de Odontologia UNESP

Published
2008

8. Graves' disease radioiodine-therapy: Choosing target absorbed doses for therapy planning.

Author

Willegaignon, J., Sapienza, M. T., Coura Filho, G. B., Watanabe, T., Traino, A. C., and Buchpiguel, C. A.

Subjects
GRAVES' disease, AUTOIMMUNE diseases, RADIATION dosimetry, IODINE isotopes, RADIOIODINATION, THERAPEUTICS
Abstract

Purpose: The precise determination of organ mass ( mth) and total number of disintegrations within the thyroid gland ( [ABSTRACT FROM AUTHOR]

Published
2014
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13. Tropical pyomyositis and human toxocariasis: a clinical and experimental study.

Author

Rayes, Abdunnabi A., Nobre, Vandack, Rayes, A A, Nobre, V, Teixeira, D M, Serufo, J C, Filho, G B, Antunes, C M, and Lambertucci, J R

Subjects
*TOXOCARA, *STAPHYLOCOCCUS aureus infections, *VISCERAL larva migrans, *NEMATODES, *ABSCESSES, *TOXOCARIASIS, *CLIMATOLOGY, *STAPHYLOCOCCUS aureus, *MYOSITIS, *MICE, *ANIMALS
Abstract

Presents clinical and experimental data about the association between Toxocara canis infection and tropical pyomyositis caused by Staphylococcus aureus. Epidemiology and mode of transmission of toxocara infection and tropical pyomyositis; Muscle affected by the diseases; Signs and symptoms of the diseases; Effect of toxocariasis to human immune system.

Published
2000
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14. 10Kin1day: A Bottom-Up Neuroimaging Initiative

Author

Martijn P. van den Heuvel, Lianne H. Scholtens, Hannelore K. van der Burgh, Federica Agosta, Clara Alloza, Celso Arango, Bonnie Auyeung, Simon Baron-Cohen, Silvia Basaia, Manon J. N. L. Benders, Frauke Beyer, Linda Booij, Kees P. J. Braun, Geraldo Busatto Filho, Wiepke Cahn, Dara M. Cannon, Tiffany M. Chaim-Avancini, Sandra S. M. Chan, Eric Y. H. Chen, Benedicto Crespo-Facorro, Eveline A. Crone, Udo Dannlowski, Sonja M. C. de Zwarte, Bruno Dietsche, Gary Donohoe, Stefan Du Plessis, Sarah Durston, Covadonga M. Díaz-Caneja, Ana M. Díaz-Zuluaga, Robin Emsley, Massimo Filippi, Thomas Frodl, Martin Gorges, Beata Graff, Dominik Grotegerd, Dariusz Gąsecki, Julie M. Hall, Laurena Holleran, Rosemary Holt, Helene J. Hopman, Andreas Jansen, Joost Janssen, Krzysztof Jodzio, Lutz Jäncke, Vasiliy G. Kaleda, Jan Kassubek, Shahrzad Kharabian Masouleh, Tilo Kircher, Martijn G. J. C. Koevoets, Vladimir S. Kostic, Axel Krug, Stephen M. Lawrie, Irina S. Lebedeva, Edwin H. M. Lee, Tristram A. Lett, Simon J. G. Lewis, Franziskus Liem, Michael V. Lombardo, Carlos Lopez-Jaramillo, Daniel S. Margulies, Sebastian Markett, Paulo Marques, Ignacio Martínez-Zalacaín, Colm McDonald, Andrew M. McIntosh, Genevieve McPhilemy, Susanne L. Meinert, José M. Menchón, Christian Montag, Pedro S. Moreira, Pedro Morgado, David O. Mothersill, Susan Mérillat, Hans-Peter Müller, Leila Nabulsi, Pablo Najt, Krzysztof Narkiewicz, Patrycja Naumczyk, Bob Oranje, Victor Ortiz-Garcia de la Foz, Jiska S. Peper, Julian A. Pineda, Paul E. Rasser, Ronny Redlich, Jonathan Repple, Martin Reuter, Pedro G. P. Rosa, Amber N. V. Ruigrok, Agnieszka Sabisz, Ulrich Schall, Soraya Seedat, Mauricio H. Serpa, Stavros Skouras, Carles Soriano-Mas, Nuno Sousa, Edyta Szurowska, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Sofie L. Valk, Leonard H. van den Berg, Theo G. M. van Erp, Neeltje E. M. van Haren, Judith M. C. van Leeuwen, Arno Villringer, Christiaan H. Vinkers, Christian Vollmar, Lea Waller, Henrik Walter, Heather C. Whalley, Marta Witkowska, A. Veronica Witte, Marcus V. Zanetti, Rui Zhang, Siemon C. de Lange, University Medical Center [Utrecht], Center for Nanotechnology Innovation, @NEST (CNI), National Enterprise for nanoScience and nanoTechnology (NEST), Scuola Normale Superiore di Pisa (SNS)-Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP)-Istituto Italiano di Tecnologia (IIT)-Consiglio Nazionale delle Ricerche [Pisa] (CNR PISA)-Scuola Normale Superiore di Pisa (SNS)-Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP)-Istituto Italiano di Tecnologia (IIT)-Consiglio Nazionale delle Ricerche [Pisa] (CNR PISA), Psychiatry Department, Adolescent Unit, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of Edinburgh, University of Cambridge [UK] (CAM), Laboratoire Jacques-Louis Lions (LJLL), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Department of Psychiatry, Icahn School of Medicine at Mount Sinai [New York] (MSSM), National University of Ireland [Galway] (NUI Galway), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Trinity College Dublin-St. James's Hospital, University Hospital San Raffaele, Psychiatry and Psychotherapy, Universität Zürich [Zürich] = University of Zurich (UZH), Department of Neurology [Ulm], Universität Ulm - Ulm University [Ulm, Allemagne], Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPI-MiS), Max-Planck-Gesellschaft, Dept. of Psychiatry, University of Marburg, Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences [Leipzig] (IMPNSC), Department of Psychology, Laboratory of Neurogenetics, sans affiliation, Division of Psychiatry, University of Edinburgh-Royal Edinburgh Hospital, Centro de Quimica Estrutural (CQE), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Humboldt-Universität zu Berlin, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), Instituto Superior Técnico, Universidade Técnica de Lisboa, Schizophrenia Research Institute [Sydney], Magnetic Resonance Imaging, Universidade do Minho, Metacohorts Consortium, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Department of Psychiatry and Human Behavior [Irvine], University of California [Irvine] (UCI), University of California-University of California, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin School of Mind and Brain [Berlin], Department of Chemistry, Centre for Molecular Simulation, University of Calgary, Child and Adolescent Psychiatry / Psychology, Utrecht University, Wellcome Trust, Medical Research Council (UK), Canadian Institutes of Health Research, European Research Council, European Commission, German Research Foundation, Science Foundation Ireland, Russian Foundation for Basic Research, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, National Institutes of Health (US), Van Den Heuvel, M. P., Scholtens, L. H., Van Der Burgh, H. K., Agosta, F., Alloza, C., Arango, C., Auyeung, B., Baron-Cohen, S., Basaia, S., Benders, M. J. N. L., Beyer, F., Booij, L., Braun, K. P. J., Filho, G. B., Cahn, W., Cannon, D. M., Chaim-Avancini, T. M., Chan, S. S. M., Chen, E. Y. H., Crespo-Facorro, B., Crone, E. A., Dannlowski, U., De Zwarte, S. M. C., Dietsche, B., Donohoe, G., Plessis, S. D., Durston, S., Diaz-Caneja, C. M., Diaz-Zuluaga, A. M., Emsley, R., Filippi, M., Frodl, T., Gorges, M., Graff, B., Grotegerd, D., Gasecki, D., Hall, J. M., Holleran, L., Holt, R., Hopman, H. J., Jansen, A., Janssen, J., Jodzio, K., Jancke, L., Kaleda, V. G., Kassubek, J., Masouleh, S. K., Kircher, T., Koevoets, M. G. J. C., Kostic, V. S., Krug, A., Lawrie, S. M., Lebedeva, I. S., Lee, E. H. M., Lett, T. A., Lewis, S. J. G., Liem, F., Lombardo, M. V., Lopez-Jaramillo, C., Margulies, D. S., Markett, S., Marques, P., Martinez-Zalacain, I., Mcdonald, C., Mcintosh, A. M., Mcphilemy, G., Meinert, S. L., Menchon, J. M., Montag, C., Moreira, P. S., Morgado, P., Mothersill, D. O., Merillat, S., Muller, H. -P., Nabulsi, L., Najt, P., Narkiewicz, K., Naumczyk, P., Oranje, B., De la Foz, V. O. -G., Peper, J. S., Pineda, J. A., Rasser, P. E., Redlich, R., Repple, J., Reuter, M., Rosa, P. G. P., Ruigrok, A. N. V., Sabisz, A., Schall, U., Seedat, S., Serpa, M. H., Skouras, S., Soriano-Mas, C., Sousa, N., Szurowska, E., Tomyshev, A. S., Tordesillas-Gutierrez, D., Valk, S. L., Van Den Berg, L. H., Van Erp, T. G. M., Van Haren, N. E. M., Van Leeuwen, J. M. C., Villringer, A., Vinkers, C. H., Vollmar, C., Waller, L., Walter, H., Whalley, H. C., Witkowska, M., Witte, A. V., Zanetti, M. V., Zhang, R., De Lange, S. C., Baron-Cohen, Simon [0000-0001-9217-2544], Ruigrok, Amber [0000-0001-7711-8056], and Apollo - University of Cambridge Repository

Subjects
Computer science, diffusion weighted MRI, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Network, Brain mapping, lcsh:RC346-429, HUMAN CONNECTOME, Diffusion, 0302 clinical medicine, Medicine and Health Sciences, yttria mould coating, Cervell, Anàlisi, ComputingMilieux_MISCELLANEOUS, Brain network, 0303 health sciences, Event (computing), Brain, Human Connectome, Top-down and bottom-up design, 3. Good health, Neurology, investment casting, Perspective, Connectome, Difusió, PROJECT, MRI, Connectome analysis, AZ91D-1 wt% CaO, brain, Clinical Neurology, 03 medical and health sciences, SDG 17 - Partnerships for the Goals, Neuroimaging, Journal Article, ddc:610, Diffusion weighted MRI, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, Connectome analysi, Science & Technology, Assaying, [SCCO.NEUR]Cognitive science/Neuroscience, mould–metal interaction, Biology and Life Sciences, Data science, Clinical neurology, network, Neurology (clinical), HUMAN CEREBRAL-CORTEX, 030217 neurology & neurosurgery
Abstract

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain. Ongoing grand-scale projects like the European Human Brain Project (1), the US Brain Initiative (2), the Human Connectome Project (3), the Chinese Brainnetome (4) and exciting world-wide neuroimaging collaborations such as ENIGMA (5) herald the new era of big neuroscience. In conjunction with these major undertakings, there is an emerging trend for bottom-up initiatives, starting with small-scale projects built upon existing collaborations and infrastructures. As described by Mainen et al. (6), these initiatives are centralized around self-organized groups of researchers working on the same challenges and sharing interests and specialized expertise. These projects could scale and open up to a larger audience and other disciplines over time, eventually lining up and merging their findings with other programs to make the bigger picture., The 10Kin1day workshop was generously sponsored by the Neuroscience and Cognition program Utrecht (NCU) of the Utrecht University (https://www.uu.nl/en/research/ neuroscience-and-cognition-utrecht), the ENIGMA consortium (http://enigma.ini.usc.edu), and personal grants: MvdH: NWOVIDI (452-16-015), MQ Fellowship; SB-C: the Wellcome Trust; Medical Research Council UK; NIHR CLAHRC for Cambridgeshire and Peterborough Foundation National Health Services Trust; Autism Research Trust; LB: New Investigator Award, Canadian Institutes of Health Research; Dara Cannon: Health Research Board (HRB), Ireland (grant code HRA-POR2013-324); SC: Research Grant Council (Hong Kong)-GRF 14101714; Eveline Crone: ERC-2010-StG-263234; UD: DFG, grant FOR2107 DA1151/5-1, DA1151/5-2, SFB-TRR58, Project C09, IZKF, grant Dan3/012/17; SD: MRC-RFA-UFSP-012013 (Shared Roots MRC Flagship grant); TF: Marie Curie Programme, International Training Programme, r’Birth; DG: National Science Centre (UMO-2011/02/A/NZ5/00329); BG: National Science Centre (UMO-2011/02/A/NZ5/00329); JH: Western Sydney University Postgraduate Research Award; LH: Science Foundation Ireland, ERC; HH: Research Grant Council (Hong Kong)-GRF 14101714; LJ: Velux Stiftung, grant 369 & UZH University Research Priority Program Dynamics of Healthy Aging; AJ: DFG, grant FOR2107 JA 1890/7-1; KJ: National Science Centre (UMO-2013/09/N/HS6/02634); VK: The Russian Foundation for Basic Research (grant code 15-06-05758A); TK: DFG, grant FOR2107 KI 588/14-1, DFG, grant FOR2107 KI 588/15-1; AK: DFG, grant FOR2107 KO 4291/4-1, DFG, grant FOR2107 KO 4291/3-1; IL: The Russian Foundation for Basic Research (grant code 15-06-05758A); EL: Health and Medical Research Fund - 11121271; SiL: NHMRC-ARC Dementia Fellowship 1110414, NHMRC Dementia Research Team Grant 1095127, NHMRC Project Grant 1062319; CL-J: 537-2011, 2014849; AM: Wellcome Trust Strategic Award (104036/Z/14/Z), MRC Grant MC_PC_17209; CM: Heisenberg-Grant, German Research Foundation, DFG MO 2363/3-2; PM: Foundation for Science and Technology, Portugal - PDE/BDE/113601/2015; KN: National Science Centre (UMO-2011/02/A/NZ5/00329); PN: National Science Centre (UMO-2013/09/N/HS6/02634); JiP: NWO-Veni 451-10-007; PaR: PER and US would like to thank the Schizophrenia Research Institute and the Chief-Investigators of the Australian Schizophrenia Research Bank V. Carr, U. Schall, R. Scott, A. Jablensky, B. Mowry, P. Michie, S. Catts, F. Henskens, and C. Pantelis; AS: National Science Centre (UMO-2011/02/A/NZ5/00329); SS: European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 707730; CS-M: Carlos III Health Institute (PI13/01958), Carlos III Health Institute (PI16/00889), Carlos III Health Institute (CPII16/00048); ES: National Science Centre (UMO-2011/02/A/NZ5/00329); AT: The Russian Foundation for Basic Research (grant code 1506-05758A); DT-G: PI14/00918, PI14/00639; Leonardo Tozzi: Marie Curie Programme, International Training Programme, r’Birth; SV: IMPRS Neurocom stipend; TvE: National Center for Research Resources at the National Institutes of Health (grant numbers: NIH 1 U24 RR021992 (Function Biomedical Informatics Research Network), NIH 1 U24 RR025736-01 (Biomedical Informatics Research Network Coordinating Center; http://www.birncommunity.org) and the NIH Big Data to Knowledge (BD2K) award (U54 EB020403 to Paul Thompson). NvH: NWO-VIDI (452-11-014); MW: National Science Centre (UMO-2011/02/A/NZ5/00329); Veronica O’Keane: Meath Foundation; AV and AW: CRC Obesity Mechanism (SFB 1052) Project A1 funded by DFG. The funding sources had no role in the study design, data collection, analysis, and interpretation of the data.

Published
2019

15. Metalloproteinase-9 immunoexpression and angiogenesis in thyroid follicular neoplasms: relation to clinical and histopathologic features.

Author

FrigugliettI CU, Mello ES, Castro IV, Filho GB, and Alves VA

Subjects
Adenocarcinoma, Follicular blood supply, Adenocarcinoma, Follicular surgery, Adult, Aged, Antigens, CD34 analysis, Biomarkers, Tumor analysis, Chi-Square Distribution, Female, Humans, Immunohistochemistry, Male, Middle Aged, Probability, Prognosis, Retrospective Studies, Sensitivity and Specificity, Thyroid Neoplasms blood supply, Thyroid Neoplasms surgery, Adenocarcinoma, Follicular enzymology, Adenocarcinoma, Follicular pathology, Metalloendopeptidases metabolism, Neovascularization, Pathologic pathology, Thyroid Neoplasms enzymology, Thyroid Neoplasms pathology
Abstract

Background: Thyroid follicular neoplasms (adenoma and carcinoma) may pose considerable difficulties to the differential diagnosis. Because such a distinction is not possible at fine-needle aspiration, surgery is often necessary. Clinical information such as age, sex, and node size is important in case of suspected carcinoma. Follicular carcinoma is characterized by capsular invasion, vascular invasion, and metastatic dissemination mainly by the hematogenic pathway. This invasion depends on collagen degradation in capsule and in subendothelial basement membrane. Collagen degradation has been widely researched in the angiogenesis process and in the hematogenic dissemination mechanism. In this study, we performed clinical and histopathologic assessment of 74 follicular neoplasms, as well as immunohistochemical reactions for CD-34 protein to estimate angiogenesis and for metalloproteinase-9, an enzyme that degrades type IV collagen., Methods: The research was carried out retrospectively in 74 patients who had surgery and were followed up at HC-FMUSP and IBCC. Clinical, histologic, and immunohistochemical variables were compared among the groups of follicular neoplasms and a control group of 36 patients with colloid goiter., Results: No significant statistical difference was found between patients with follicular adenoma and thyroid follicular carcinoma concerning sex (p =.092), age (p =.098), thyroid node size (p =.426), vascularization (p =.388), and immunostaining intensity for metalloproteinase-9 (p =.055). The proportion of immunoreactive cells for metalloproteinase-9 in follicular carcinoma cases was higher than that observed in follicular adenoma cases (p <.001). Patients in more advanced stages of carcinoma were more than 45 years old (p =.006), presented extensive invasion (p <.001), had less vascularization (p =.046), and a had higher proportion of immunoreactive cells for metalloproteinase-9 (p <.001)., Conclusions: The proportion of immunoreactive cells for metalloproteinase-9 in follicular carcinoma was higher than that observed in follicular adenoma, with a significant statistical difference (p <.001). This method must be developed to apply in material obtained by fine-needle aspiration to differentiate follicular adenoma from carcinoma., (Copyright 2000 John Wiley & Sons, Inc.)

Published
2000
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16. Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organs.

Author

Vago AR, Andrade LO, Leite AA, d'Avila Reis D, Macedo AM, Adad SJ, Tostes S Jr, Moreira MC, Filho GB, and Pena SD

Subjects
Adult, Aged, Animals, Chronic Disease, DNA, Protozoan genetics, DNA, Protozoan metabolism, Esophagus parasitology, Female, Genetic Variation, Heart parasitology, Humans, Male, Middle Aged, Tissue Distribution, Chagas Disease parasitology, Trypanosoma cruzi genetics
Abstract

We have previously shown that a low-stringency single-specific primer-polymerase chain reaction (LSSP- PCR) is a highly sensitive and reproducible technique for the genetic profiling of Trypanosoma cruzi parasites directly in tissues from infected animals and humans. By applying LSSP-PCR to the study of the variable region of kinetoplast minicircle from T. cruzi, the intraspecific polymorphism of the kinetoplast-deoxyribonucleic acid (kDNA) sequence can be translated into individual kDNA signatures. In the present article, we report on our success using the LSSP-PCR technique in profiling the T. cruzi parasites present in the hearts of 13 patients with chagasic cardiopathy and in the esophagi of four patients (three of them with chagasic megaesophagus). In two patients, one with the cardiodigestive clinical form of Chagas disease and the other with cardiopathy and an esophageal inflammatory process, we could study both heart and esophagus and we detected distinct kDNA signatures in the two organs. This provides evidence of a differential tissue distribution of genetically diverse T. cruzi populations in chronic Chagas disease, suggesting that the genetic variability of the parasite is one of the determining factors of the clinical form of the disease.

Published
2000
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17. Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis.

Author

Silva Filho GB, Maciel RM, Takahashi MH, Alberti VN, Castro IV, Saldiva PH, Durazzo MD, and Ferraz AR

Subjects
Adolescent, Adult, Aged, Carcinoma, Papillary secondary, Child, Female, Humans, Immunohistochemistry, Lymphatic Metastasis, Male, Middle Aged, Thyroid Neoplasms pathology, Carcinoma, Papillary chemistry, Insulin-Like Growth Factor I analysis, Proliferating Cell Nuclear Antigen analysis, Thyroid Neoplasms chemistry
Abstract

Background: Several tumor factors are associated with papillary thyroid cancer. Most studies do not compare the expressions of these factors in the primary tumors and in their associated cervical metastasis., Methods: Paraffin sections of 20 patients with papillary carcinoma of the thyroid gland with lymph node metastasis were studied. The presence and distribution of insulin-like growth factor I (IGF-I) and proliferating cell nuclear antigen (PCNA) was analyzed, through immunohistochemical technique, in both primaries and lymph node metastasis. The results were correlated with clinical-pathologic data (sex, age, size of primary, multicentricity, thyroid capsule invasion, lymphatic and blood vessels invasion, development of distant metastasis, and associated thyroid diseases)., Results: The qualitative analysis showed the reaction for IGF-I was present in more than 90% of the neoplastic cells in both primaries and lymph node metastasis. No correlation with the clinical-pathological features was observed. Regarding the PCNA, the mean percentage of nuclei stained showed no statistical difference between primaries and metastasis (p = 0.598). Except for age, clinicopathologic data had no influence on the mean percentage of nuclei stained. A correlation was verified between the percentage of cells stained by PCNA in primary tumors and the patients' age (p < 0. 01)., Conclusions: The expressions of these tumor factors are equally intense for both primary and metastatic tissue in papillary thyroid cancer. Despite the small size of the sample, the expressions of IGF-I and PCNA could not be associated to clinical-pathologic features, except for the age. As patients over 40 years old had higher expression of PCNA, this marker may have prognostic significance for patients with papillary thyroid cancer., (Copyright 1999 John Wiley & Sons, Inc. Head Neck 21: 723-727, 1999.)

Published
1999
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18. [Epidemiological characterization of meningococcal disease in a metropolitan area in Southeastern Brazil, 1976-1994].

Author

Gama SG, Marzochi KB, and da Siveira Filho GB

Subjects
Adolescent, Age Factors, Brazil epidemiology, Child, Child, Preschool, Female, Humans, Incidence, Infant, Male, Retrospective Studies, Sex Factors, Socioeconomic Factors, Urban Population, Meningococcal Infections epidemiology
Abstract

Introduction: Meningococcal disease continues to warrant assessment as to its endemic and epidemic multicausality and temporal trends in various locations., Material and Method: Based on a standardization of epidemiological investigation of meningococcal disease in the municipality of Rio de Janeiro county, Southeastern Brazil, as from epidemic of the 1970s a study to characterized the epidemiological characteristics of the disease, was realized. The total of 4,155 cases reported between 1976 and 1994 were analyzed in a retrospective, descriptive, and analytical study, using the epidemiological investigation forms issued by the Municipal Health Secretariat. Statistical analysis was performed using the chi 2, Wilcoxon-Mann-Whitney, and Kruskal-Wallis tests., Results: The study resulted in the definition of three periods, classified as post-epidemic (1976-79), endemic (1980-86), and epidemic (1987-94), differentiated by the incidence rates and the predominant meningococcal serogroup. The mean incidence rates per period in the municipality were 3.51, 1.67, and 6.53 cases/ 100,000 inhabitants, respectively. Serogroups A and C predominated during the post-epidemic period, B and A in the endemic, and B in the epidemic., Conclusion: The mean case fatality rate remained virtually unchanged over time, but it varied by hospital, and during all three periods was lower in the State government reference hospital than in the other hospitals, whether public or private. The highest incidence and case fatality rates were associated with patients under one year of age, and the risk of acquiring the disease was greater among males. The highest incidence coefficients tended to occur in the same areas of the county during the three epidemiological periods, and the shanty-town population was at twice the risk of acquiring the disease.

Published
1997
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19. Pyogenic liver abscesses and acute schistosomiasis mansoni: report on 3 cases and experimental study.

Author

Teixeira R, Ferreira MD, Coelho PM, Filho GB, Azevedo Júnior GM, and Lambertucci JR

Subjects
Acute Disease, Animals, Child, Humans, Liver Abscess diagnostic imaging, Liver Abscess microbiology, Male, Mice, Schistosomiasis mansoni diagnosis, Staphylococcal Infections microbiology, Staphylococcus aureus isolation & purification, Ultrasonography, Liver Abscess complications, Schistosomiasis mansoni complications, Staphylococcal Infections complications
Abstract

Three children with acute schistosomiasis mansoni developed pyogenic liver abscesses. The abscesses were diagnosed by ultrasonography and confirmed during laparotomy. Staphylococcus aureus were the sole bacteria isolated from the abscesses. An experimental study was carried out in mice to establish whether schistosomiasis is a predisposing cause for pyogenic liver abscesses. Seventeen mice (group 1) were infected with 40 Schistosoma mansoni cercariae (LE strain) and 60 d later inoculated intravenously with a strain of Staph. aureus, isolated from a patient with bacteraemia; 17 mice infected with Sch. mansoni (group 2), 19 infected with bacteria alone (group 3), and 18 uninfected mice (group 4), served as controls. Thirteen group 1 mice (77%) developed multiple liver abscesses while none was observed in the controls. These results indicate that acute schistosomiasis mansoni concurrent with Staph. aureus bacteraemia favours the colonization of the liver by bacteria and the development of pyogenic hepatic abscesses.

Published
1996
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