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307 results on '"Filippi, Antonello"'

2. Lentisk (Pistacia lentiscus) Oil Nanoemulsions Loaded with Levofloxacin: Phytochemical Profiles and Antibiofilm Activity against Staphylococcus spp.

Author

Maurizi, Linda, Lasalvia, Alba, Fabiano, Maria Gioia, D'Intino, Eleonora, Del Cioppo, Francesca, Fraschetti, Caterina, Filippi, Antonello, Ammendolia, Maria Grazia, Conte, Antonietta Lucia, Forte, Jacopo, Corinti, Davide, Crestoni, Maria Elisa, Carafa, Maria, Marianecci, Carlotta, Rinaldi, Federica, and Longhi, Catia

Subjects
ION cyclotron resonance spectrometry, STAPHYLOCOCCUS epidermidis, STAPHYLOCOCCUS aureus, DRUG delivery systems, SKIN infections
Abstract

Most clinical isolates of both Staphylococcus aureus and Staphylococcus epidermidis show the capacity to adhere to abiotic surfaces and to develop biofilms resulting in a contribution to chronic human skin infections. Antibiotic resistance and poor biofilm penetration are the main causes of ineffective therapeutic treatment in killing bacteria within biofilms. A possible strategy could be represented by drug delivery systems, such as nanoemulsions (composed of bioactive oil, surfactant and water phase), which are useful for enhancing the drug permeation of a loaded drug inside the biofilm and its activity. Phytochemical characterization of Pistacia lentiscus oil (LO) by direct infusion Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) allowed the identification of bioactive compounds with antimicrobial properties, including fatty acids and phenolic compounds. Several monoterpenes and sesquiterpenes have been also detected and confirmed by gas chromatography–mass spectrometric (GC-MS) analysis, together providing a complete metabolomic profiling of LO. In the present study, a nanoemulsion composed of LO has been employed for improving Levofloxacin water solubility. A deep physical–chemical characterization of the nanoemulsion including hydrodynamic diameter, ζ-potential, morphology, entrapment efficiency, stability release and permeation studies was performed. Additionally, the antimicrobial/antibiofilm activity of these preparations was evaluated against reference and clinical Staphylococcus spp. strains. In comparison to the free-form antibiotic, the loaded NE nanocarriers exhibited enhanced antimicrobial activity against the sessile forms of Staphylococcus spp. strains. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Anti-Inflammatory and Antioxidant Effects Induced by Allium sativum L. Extracts on an Ex Vivo Experimental Model of Ulcerative Colitis

Author

Recinella, Lucia, primary, Gorica, Era, additional, Chiavaroli, Annalisa, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Cesa, Stefania, additional, Cairone, Francesco, additional, Martelli, Alma, additional, Calderone, Vincenzo, additional, Veschi, Serena, additional, Lanuti, Paola, additional, Cama, Alessandro, additional, Orlando, Giustino, additional, Ferrante, Claudio, additional, Menghini, Luigi, additional, Di Simone, Simonetta Cristina, additional, Acquaviva, Alessandra, additional, Libero, Maria Loreta, additional, Nilofar, Nilofar, additional, Brunetti, Luigi, additional, and Leone, Sheila, additional

Published
2022
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16. Protective Effects Induced by a Hydroalcoholic Allium sativum Extract in Isolated Mouse Heart

Author

Recinella, Lucia, primary, Chiavaroli, Annalisa, additional, Masciulli, Fabrizio, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Cesa, Stefania, additional, Cairone, Francesco, additional, Gorica, Era, additional, De Leo, Marinella, additional, Braca, Alessandra, additional, Martelli, Alma, additional, Calderone, Vincenzo, additional, Orlando, Giustino, additional, Ferrante, Claudio, additional, Menghini, Luigi, additional, Di Simone, Simonetta Cristina, additional, Veschi, Serena, additional, Cama, Alessandro, additional, Brunetti, Luigi, additional, and Leone, Sheila, additional

Published
2021
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19. Chemical and Bioinformatics Analyses of the Anti-Leishmanial and Anti-Oxidant Activities of Hemp Essential Oil

Author

Menghini, Luigi, primary, Ferrante, Claudio, additional, Carradori, Simone, additional, D’Antonio, Marianna, additional, Orlando, Giustino, additional, Cairone, Francesco, additional, Cesa, Stefania, additional, Filippi, Antonello, additional, Fraschetti, Caterina, additional, Zengin, Gokhan, additional, Ak, Gunes, additional, Tacchini, Massimo, additional, and Iqbal, Kashif, additional

Published
2021
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23. Importance of entropy in the diastereoselectivity of 5-substituted 2-methyladamant-2-yl cations

Author

Filippi, Antonello, Trout, Neil A., Brunelle, Patrick, Adcock, William, Sorensen, Ted S., and Speranza, Maurizio

Subjects
Methyl groups -- Research, Methanol -- Research, Biological sciences, Chemistry
Abstract

The diastereofacial selectivity of 2-methyl-5-X-adamant-2-yl cations toward methanol is investigated in the gas phase at 750 Torr and in the 40-120 degreeC temperature range and compared with that of I(sub F) (X = F) and I(sub Si) (X = (CH(sub 3))(sub 3)Si) measured previously under similar conditions. Detailed analysis of the energy surface of the I(sub Me) (X = CH(sub 3)) ion reveals that the activation barrier of its syn addition to methanol is significantly lower than that of the anti attack.

Published
2004

24. Origin of diastereofacial selectivity in tertiary 2-adamantyl cations

Author

Filippi, Antonello, Trout, Neil A., Brunelle, Patrick, Adcock, William, Sorensen, Ted S., and Speranza, Maurizio

Subjects
Cations -- Research, Stereochemistry -- Observations, Chemistry
Abstract

Diastereofacial selectivity in tertiary 2-adamantyl cations was investigated in the gas phase.

Published
2001

25. Hindered inversion of chiral ion-dipole pairs

Author

Filippi, Antonello, Gasparrini, Francesco, and Speranza, Maurizio

Subjects
Chirality -- Research, Ions -- Research, Chemistry
Abstract

Chiral ion-dipole pairs were studied in terms of hindered inversion.

Published
2001

26. Chemico-Biological Characterization of Torpedino Di Fondi® Tomato Fruits: A Comparison with San Marzano Cultivar at Two Ripeness Stages

Author

Ingallina, Cinzia, primary, Maccelli, Alessandro, additional, Spano, Mattia, additional, Di Matteo, Giacomo, additional, Di Sotto, Antonella, additional, Giusti, Anna Maria, additional, Vinci, Giuliana, additional, Di Giacomo, Silvia, additional, Rapa, Mattia, additional, Ciano, Salvatore, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Simonetti, Giovanna, additional, Cordeiro, Carlos, additional, Silva, Marta Sousa, additional, Crestoni, Maria Elisa, additional, Sobolev, Anatoly P., additional, Fornarini, Simonetta, additional, and Mannina, Luisa, additional

Published
2020
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27. Cannabis sativa L. Inflorescences from Monoecious Cultivars Grown in Central Italy: An Untargeted Chemical Characterization from Early Flowering to Ripening

Author

Ingallina, Cinzia, primary, Sobolev, Anatoly P., additional, Circi, Simone, additional, Spano, Mattia, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Di Sotto, Antonella, additional, Di Giacomo, Silvia, additional, Mazzoccanti, Giulia, additional, Gasparrini, Francesco, additional, Quaglio, Deborah, additional, Campiglia, Enio, additional, Carradori, Simone, additional, Locatelli, Marcello, additional, Vinci, Giuliana, additional, Rapa, Mattia, additional, Ciano, Salvatore, additional, Giusti, Anna Maria, additional, Botta, Bruno, additional, Ghirga, Francesca, additional, Capitani, Donatella, additional, and Mannina, Luisa, additional

Published
2020
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28. Phytochemical and biological characterization of Italian “sedano bianco di Sperlonga” Protected Geographical Indication celery ecotype: A multimethodological approach

Author

Ingallina, Cinzia, primary, Capitani, Donatella, additional, Mannina, Luisa, additional, Carradori, Simone, additional, Locatelli, Marcello, additional, Di Sotto, Antonella, additional, Di Giacomo, Silvia, additional, Toniolo, Chiara, additional, Pasqua, Gabriella, additional, Valletta, Alessio, additional, Simonetti, Giovanna, additional, Parroni, Alessia, additional, Beccaccioli, Marzia, additional, Vinci, Giuliana, additional, Rapa, Mattia, additional, Giusti, Anna Maria, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Maccelli, Alessandro, additional, Crestoni, Maria Elisa, additional, Fornarini, Simonetta, additional, and Sobolev, Anatoly P., additional

Published
2020
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29. Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations

Author

Maccelli, Alessandro, primary, Vitanza, Luca, additional, Imbriano, Anna, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Goldoni, Paola, additional, Maurizi, Linda, additional, Ammendolia, Maria Grazia, additional, Crestoni, Maria Elisa, additional, Fornarini, Simonetta, additional, Menghini, Luigi, additional, Carafa, Maria, additional, Marianecci, Carlotta, additional, Longhi, Catia, additional, and Rinaldi, Federica, additional

Published
2019
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30. Theoretical and experimental study of the gas-phase reactions of PFn+ (n=1,2) ions with n-bases. A novel route to phosphorus ions present in interstellar clouds

Author

Filippi, Antonello, Occhiucci, Giorgio, and Speranza, Maurizio

Subjects
Phosphorus compounds -- Research, Phosphorus -- Research, Chemistry
Abstract

Chemical research shows that phosphorus molecules in space are created via the reactions PFn+(n=1,2) + H20, CH3OH, and NH3. Fourier-transform ion cyclotron resonance mass spectrometry and G2 proton loss energy analysis provide a profile of the phosphorus atom's kinetics and thermochemical nature. Oxygen- and nitrogen-containing phosphorus ions including [H, P, O]+ and [H2, P, N]+ ions are created via the above reactions.

Published
1997

31. Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study

Author

Zengin, Gokhan, primary, Menghini, Luigi, additional, Di Sotto, Antonella, additional, Mancinelli, Romina, additional, Sisto, Francesca, additional, Carradori, Simone, additional, Cesa, Stefania, additional, Fraschetti, Caterina, additional, Filippi, Antonello, additional, Angiolella, Letizia, additional, Locatelli, Marcello, additional, Mannina, Luisa, additional, Ingallina, Cinzia, additional, Puca, Valentina, additional, D’Antonio, Marianna, additional, and Grande, Rossella, additional

Published
2018
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33. Binding Motifs in the Naked Complexes of Target Amino Acids with an Excerpt of Antitumor Active Biomolecule: An Ion Vibrational Spectroscopy Assay.

Author

Chiavarino, Barbara, Sinha, Rajeev K., Crestoni, Maria Elisa, Corinti, Davide, Filippi, Antonello, Fraschetti, Caterina, Scuderi, Debora, Maitre, Philippe, and Fornarini, Simonetta

Subjects
AMINO acids, MASS spectrometry, HISTIDINE, SPECTROMETRY, SMALL molecules, IONS
Abstract

The structures of proton‐bound complexes of 5,7‐dimethoxy‐4H‐chromen‐4‐one (1) and basic amino acids (AAs), namely, histidine (His) and lysine (Lys), have been examined by means of mass spectrometry coupled with IR ion spectroscopy and quantum chemical calculations. This selection of systems is based on the fact that 1 represents a portion of glabrescione B, a natural small molecule of promising antitumor activity, while His and Lys are protein residues lining the cavity of the alleged receptor binding site. These species are thus a model of the bioactive adduct, although clearly the isolated state of the present study bears little resemblance to the complex biological environment. A common feature of [1+AA+H]+ complexes is the presence of a protonated AA bound to neutral 1, in spite of the fact that the gas‐phase basicity of 1 is comparable to those of Lys and His. The carbonyl group of 1 acts as a powerful hydrogen‐bond acceptor. Within [1+AA+H]+ the side‐chain substituents (imidazole group for His and terminal amino group for Lys) present comparable basic properties to those of the α‐amino group, taking part to a cooperative hydrogen‐bond network. Structural assignment, relying on the comparative analysis of the infrared multiple photon dissociation (IRMPD) spectrum and calculated IR spectra for the candidate geometries, derives from an examination over two frequency ranges: 900–1800 and 2900–3700 cm−1. Information gained from the latter one proved especially valuable, for example, pointing to the contribution of species characterized by an unperturbed carboxylic OH or imidazole NH stretching mode. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Gas-phase facial diastereoselectivity of equatorial and axial 4-chloro-adamant-2-yl cations

Author

Frachetti, Caterina, Novara, Francesca R., Filippi, Antonello, Speranza, Maurizio, Trout, Neil A., Adcock, William, Marcantoni, Enrico, Renzi, Gabriele, Roselli, Graziella, and Marcolini, Mauro

Subjects
Cations -- Research, Chlorine -- Research, Catalysis -- Research, Biological sciences, Chemistry
Abstract

The acid-catalyzed of C[H.sub.3][super 18]OH to 2-methylene-adamantanes bearing a chlorine atom in the 4-equatorial or 4-axial position is examined in the gas phase. The effects due to differential face salvation phenomena have come from the comparison of the present gas-phase results with those obtained from strictly related studies in solution.

Published
2009

38. Induced-fit in the gas phase: conformational effects on the enantioselectivity of chiral tetra-amide macrocycles

Author

Gasparrini, Francesco, Pierini, Marco, Villani, Claudio, Filippi, Antonello, and Speranza, Maurizio

Subjects
Amino acids -- Chemical properties, Chirality -- Research, Diastereomers -- Chemical properties, Mass spectrometry -- Technology application, Technology application, Chemistry
Abstract

The structure, stability and reactivity of proton-bound diastereomeric [[M.H.A.].sup.+] complexes between some amino acid derivatives and chiral tetra-amide macrocycles are examined in the gas phase by ESI-FT-ICR and ESI-ITMS-CID mass spectrometry. The enantioselectivity has reflected the stability difference between the relevant distereomeric transition structures.

Published
2008

39. Gas-phase diastereoselectivity of secondary 5-substituted (X)-adamant-2-yl (X = F, Si[(C[H.sub.3]).sub.3]) cations

Author

Fraschetti, Caterina, Novara, Francesca R., Filippi, Antonello, Trout, Neil A., Adcock, William, Sorensen, Ted S., and Speranza, Maurizio

Subjects
Silicon compounds -- Electric properties, Diastereomers -- Analysis, Carbon compounds -- Electric properties, Biological sciences, Chemistry
Abstract

The investigation report of secondary 5-X-adamant-2-yl cations [I.sub.x] (X = F, Si[(C[H.sub.3]).sub.3] generated in the gas phase from protonation-induced defluorination of epimeric 2-F-5-X-adamantanes [I.sub.x] and their kinetic diastereoselectivity toward C[H.sub.3.sup.18]OH in the temperature range 40-160 degree Celsius is presented.

Published
2007

40. Crucial role of elusive isomeric eta-complexes in gas-phase electrophilic aromatic alkylations

Author

Marcantoni, Enrico, Roselli, Graziella, Lucarelli, Laura, Renzi, Gabriele, Filippi, Antonello, Trionfetti, Cristiano, and Speranza, Maurizio

Subjects
Isomerization -- Research, Stereochemistry -- Research, Aromatic compounds -- Chemical properties, Biological sciences, Chemistry
Abstract

The kinetics and stereochemistry of the protonation-induced unimolecular isomerization of (R)-1-D1-3-(p-fluorophenyl)butane are investigated in the gas phase at 40-100 degree Celsius and 70-760 Torr. This process leads to the formation of the relevant meta and ortho isomers with partial racemization of the migrating sec-butyl moiety.

Published
2005

41. Polar substituent effects in the bicyclo[1.1.1]pentane ring system: Acidities of 3-substituted bicyclo[1.1.1]pentane-1-carboxy acids

Author

Adcock, William, Baran, Yakup, Filippi, Antonello, Speranza, Maurizio, and Trout, Neil A.

Subjects
Chemical reactions -- Research, Acid-base chemistry -- Research, Biological sciences, Chemistry
Abstract

Experimental gas-phase acidities are reported for a series of 3-substituted (X) bicyclo [1.1.1]pent-1-yl carboxyl acids. Various correlations are presented which clearly point to polar field effects as being the origin of the relative acidities.

Published
2005

43. Role of the solvent on the stability of cycloserine under ESI-MS conditions

Author

Fraschetti, Caterina, Filippi, Antonello, Mannina, Luisa, Sobolev, A. P., and Speranza, Maurizio

Subjects
Spectrometry, Mass, Electrospray Ionization, Acetonitriles, Magnetic Resonance Spectroscopy, dimerization, NMR spectroscopy, Drug Stability, IRMPD spectroscopy, Methanol, Solvents, solvent effects, cycloserine, dimerization, IRMPD spectroscopy, NMR spectroscopy, solvent effects, cycloserine
Abstract

The effects of methanol (M) and acetonitrile (A) on the stability of cycloserine (1) have been studied. InfraRed Multiphoton PhotoDissociation (IRMPD) spectroscopy of the ionic species from electrospray ionization tandem mass spectrometry (ESI-MS) of 1/M and 1/A solutions points to extensive dimerization of 1 to cis-3,6-bis(aminooxymethyl)-2,5-piperidinedione (2), while the same process is not observed in the ESI-MS of 1/M solutions. 1D and 2D nuclear magnetic resonance experiments confirmed these findings by showing that partial dimerization of 1 actually takes place at room temperature in acetonitrile even before ESI-MS analysis. Comparison of nuclear magnetic resonance and IRMPD spectroscopic data from the same 1/A solution suggests that dimerization of cycloserine is enhanced in the ESI source.

Published
2014
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46. Cyclochiral resorcin[4]arenes as effective enantioselectors in the gas phase

Author

Fraschetti, Caterina, Letzel, M. C., Paletta, M., Mattay, J., Speranza, Maurizio, Filippi, Antonello, Aschi, M., and Rozhenko, A. B.

Subjects
Models, Molecular, Spectrometry, Mass, Electrospray Ionization, Macrocyclic Compounds, Fourier Analysis, Phenylalanine, enantiodiscrimination, resorc[4]arene, Stereoisomerism, Kinetics, ligand exchange, cyclochirality, inherent chirality, supramolecularcomplex, supramolecular complex, gas phase, FT-ICR, Gases, Calixarenes
Abstract

The effect of cyclochirality of rccc-2,8,14,20-tetra-n-decyl-4,10,16,22-tetra-O-methylresorcin[4]arene (C) on the enantiodiscrimination of a number of chiral bidentate and tridentate aromatic and aliphatic biomolecules (G) has been investigated by nano-electrospray ionization (nano-ESI)-Fourier transform ion cyclotron resonance mass spectrometry. The experimental approach is based on the formation of diastereomeric proton-bound [C center dot H center dot G](+) complexes by nano-ESI of solutions containing an equimolar amount of quasi-enantiomers (C) together with the chiral guest (G) and the subsequent measurement of the rate of the G substitution by the attack of several achiral and chiral amines. In general, the heterochiral complexes react faster than the homochiral ones, except when G is an aminoalcoholic neurotransmitter whose complexes, beyond that, exhibit the highest enantioselectivity. The kinetic results were further supported by both collision-induced dissociation experiments on some of the relevant [C-2 center dot H center dot G](+) three-body species and Density functional theory (DFT) calculations performed on the most selective systems. Copyright (C) 2012 John Wiley & Sons, Ltd.

Published
2012

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