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This study aims to examine ethics as a moderator of the relationship between competence and independence of auditors with the audit quality of the inspectorate apparatus. The population of this study were employees of the Inspectorate of Maluku Province and Ambon City. Sampling used judgment sampling method with a total sample of 73 respondents. The data collection technique used is a survey technique using a questionnaire. Data analysis used moderated regression analysis (MRA). The results showed that competence had no effect on audit quality, auditor independence had no effect on audit quality. Furthermore, auditor ethics can moderate the relationship between competence and independence of auditors with audit quality, while motivation cannot moderate the relationship between competence and independence of auditors with audit quality.

This was study aimed to examined the effect of the use of information technology, interpersonal communication skills, and leadership styles on employee performance at Islamic Banks in Ambon City. The population of this research are all employees at three Islamic banks in Ambon City.Sampling was conducted using a purposive sampling and number of samples are 65 respondents. Technique of data collection is survey by using questionnaires. Analysis using multiple regression analysis. The results showed that the use of information technology had a positive and significant effect on employee performance. While interpersonal communication skills and leadership style variables do not significantly affect on employee performance. Keywords: Information Technology, Interpersonal Communication Ability, Leadership Style,and Employee Performance, Penelitian ini bertujuan untuk menguji pengaruh penggunaan teknologi informasi, kemampuan berkomunikasi interpersonal, dan gaya kepemimpinan terhadap kinerja karyawan pada Bank Syariah di Kota Ambon. Populasi dalam penelitian ini adalah seluruh karyawan pada tiga Bank Syariah yang terdapat di Kota Ambon. Pengambilan sampel menggunakan purposive sampling yaitu dengan jumlah sampel sebanyak 65 responden. Tenik pengumpulan data yang digunakan adalah teknik survei dengan mengunakan kuisioner. Analisis data menggunakan regresi linear berganda. Hasil penelitian menunjukkan bahwa variabel penggunaan teknologi informasi berpengaruh terhadap kinerja karyawan. Sedangkan variabel kemampuan berkomunikasi interpersonal dan gaya kepemimpinan tidak berpengaruh terhadap kinerja karyawan.Kata Kunci: Teknologi Informasi, Kemampuan Berkomunikasi Interpersonal, Gaya Kepemimpinan, dan Kinerja Karyawan

Objective Currently, there is a missing link in the natural history of COVID-19, from first (usually milder) symptoms to hospitalisation and/or death. To fill in this gap, we characterised COVID-19 patients at the time they were diagnosed in outpatient settings, and estimated 30-day hospital admission and fatality rates. Design Population-based cohort study. Setting Data were obtained from SIDIAP, a primary-care records database covering >6 million people (>80% of the population of Catalonia), linked to COVID-19 RT-PCR tests and hospital emergency, inpatient, and mortality registers. Participants We included all patients in the database who were over 15 years and diagnosed with COVID-19 in outpatient settings between 15 March and 24 April 2020 (10 April for outcome studies). Baseline characteristics included socio-demographics, comorbidity, and previous drug use at the time of diagnosis, and PCR testing and results. Outcome measures Study outcomes included 30-day hospitalisation for COVID-19 and all-cause fatality. Results We identified 118,150 and 95,467 COVID-19 patients for characterisation and outcome studies, respectively. Most were women (58.7%) and young-to-middle-aged (e.g., 21.1% were 45-54 years). Of the 44,575 who were tested with PCR, 32,723 (73.4%) tested positive. In the month after diagnosis, 14.8% [14.6-15.0] were hospitalised, with a greater proportion of men and older people, peaking at age 75-84. Thirty-day fatality was 3.5% [95% CI: 3.4% to 3.6%], higher in men, increasing with age, and highest in those residing in nursing homes (24.5% [23.4% to 25.6%]). Conclusions COVID-19 infections were widespread in the community, including all age-sex strata. However, severe forms of the disease clustered in older men and nursing-home residents. Although initially managed in outpatient settings, 15% of cases required hospitalisation and 4% died within a month of first symptoms. These data are instrumental for designing deconfinement strategies, and will inform healthcare planning and hospital bed allocation in current and future COVID-19 outbreaks.

International audience; Background. - EGFR tyrosine kinase inhibitors and crizotinib are ă nowadays the optimal treatment for metastatic lung cancer with ă activation of EGFR mutations and ALK rearrangement. In addition, several ă targeted agents are in development for lung cancer with other ă oncodrivers. In France, since 2011, six oncodrivers are routinely tested ă in patients with stage IV. The aim of this study was to assess whether ă systematic detection of oncodrivers and matched targeted therapy improve ă overall survival in patients with advanced lung adenocarcinoma. ă Methods. - This study included all consecutive patients treated in our ă department for advanced lung adenocarcinoma from January 2012 to ă December 2013. We studied the impact in survival according to the ă presence of the driver and the targeted therapy. ă Results. - Among the 261 patients included, oncodrivers alterations were ă found in 43.5% of patients: EML4-ALK fusion genes (2.1%), EGFR ă (10.3%), KRAS (27.7%), BRAF (2.5%), HER2 (0.8%), and PI3KCA (0.8%) ă mutations. Twenty-nine percent of patients (n = 32) with oncodrivers ă received matched targeted therapy. Patient treated by targeted agent ă appropriate to an oncogenic driver had a median survival of 21.1 months ă (95% CI: 14.7-27.5). The patients (n=79) who did not receive targeted ă therapy had a median survival of 6.6 months (95% CI: 4.3-8.9). The ă patients (n = 150) without identified driver had a median survival of ă 9.7 months (95% CI: 6.7-11.7); P < 0.001. ă Conclusion. - An actionable oncodriver was routinely detected in nearly ă half of patients with advanced lung adenocarcinoma. This systematic ă detection may influence treatment outcomes, notably with matched ă targeted therapy. (C) 2016 SPLF. Published by Elsevier Masson SAS. All ă rights reserved.