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13 results on '"Findova L"'

1. Bacterial meningitis after sinusitis and otitis media: ear, nose, throat infections are still the commonest risk factors for the community acquired meningitis

Author

Lesnakova, A., Holeckova, K., Kolenova, A., Streharova, A., Kisac, P., Beno, P., Kalavsky, E., Sramka, M., Ondrusova, A., Benca, J., Seckova, S., Sladeckova, V., Bartkovjak, M., Bukovinova, P., Hvizdak, F., Lengyel, P., Sabo, I., Rudinsky, B., Bauer, F., Luzica, R., Bielova, M., Karvaj, M., Huttova, M., Wiczmandyova, D., Svabova, V., Findova, L., Kutna, K., Deadline, J., Diana, E., and Kiwou, M.

Subjects
Community-Acquired Infections, Diabetes Complications, Otitis Media, Risk Factors, Outcome Assessment, Health Care, Humans, Wounds and Injuries, Sinusitis, Alcohol-Related Disorders, Anti-Bacterial Agents, Meningitis, Bacterial
Abstract

We investigated how many cases of bacterial meningitis in our national survey were associated with sinusitis or otitis media. Among 372 cases of bacterial meningitis within our nationwide 17 years survey, 201 cases were community acquired (CBM) and in 40 (20%) otitis media or sinusitis acuta/chronica were reported 1-5 weeks before onset of CBM. Diabetes mellitus (20% vs. 7.5%, p=0.01), alcohol abuse (35% vs. 15.4%, p=0.003) and trauma (30% vs. 14.9%, p=0.02) were significantly associated with CBM after ENT infections. Concerning etiology, CBM after sinusitis/otitis was insignificantly associated with pneumococcal etiology (50% vs. 33.8 %, NS) and significantly associated with other (L. monocytogenes, Str. agalactiae) bacterial agents (9.9 % vs. 25 %, p=0.008) . However those significant differences for new ENT related CBM had no impact on mortality (12.4 % vs. 5%, NS), failure after initial antibiotics (10 % vs. 9.5%, NS) and neurologic sequellae (12.5 % vs. 15.4 %, NS).

Published
2007

2. Bacterial meningitis after craniocerebral trauma in the community

Author

Holeckova, K., Kolenova, A., Lesnakova, A., Steno, J., Streharova, A., Kisac, P., Beno, P., Kalavsky, E., Sramka, M., Ondrusova, A., Benca, J., Seckova, S., Sladeckova, V., Bartkovjak, M., Bukovinova, P., Hvizdak, P., Lengyel, P., Svabova, V., Findova, L., Kutna, K., Deadline, J., Johnson, J., Namulanda, V., Juma, O., Okoth, V., Kovac, M., Rudinsky, B., Bauer, F., Karvaj, M., Sabo, I., Huttova, M., Kenderessy, P., Nosko, P., Paulikova, T., Rusnak, R., Povinsky, J., and Galla, S.

Subjects
Cohort Studies, Community-Acquired Infections, Bacteria, Risk Factors, Outcome Assessment, Health Care, Craniocerebral Trauma, Humans, Brain Damage, Chronic, Alcohol-Related Disorders, Anti-Bacterial Agents, Meningitis, Bacterial
Abstract

Craniocerebral trauma is one of major risk factors for development of meningitis. We reviewed 30 cases of bacterial meningitis occurring in community after craniocerebral trauma. Alcohol abuse was significant risk factor occurring in trauma patients with meningitis present in 50% in our cohort (p=0.0001). The most common pathogen in posttraumatic meningitis was Str. pneumoniae (90% vs. 33.8%, p=0.0001). However mortality was very low, only 5% probably because of early diagnosis and treatment of patients at risk for bacterial meningitis but neurologic sequellea were significantly more common (p=0.00001) in patients after craniocerebral trauma.

Published
2007

3. Haemophillus influenzae community acquired meningitis occurrence in children despite 10 years vaccination

Author

Taziarova, M., Holeckova, K., Lesnakova, A., Sladeckova, V., Bartkovjak, M., Seckova, S., Bukovinova, P., Hvizdak, F., Svabova, V., Findova, L., Kisac, P., Beno, P., Bauer, F., Kovac, M., Karvaj, M., Rudinsky, B., Sabo, I., Bielova, M., Luzica, R., Wiczmandyova, D., Huttova, M., and Ondrusova, A.

Subjects
Community-Acquired Infections, Slovakia, Immunization Programs, Child, Preschool, Outcome Assessment, Health Care, Haemophilus influenzae type b, Humans, Infant, Child, Meningitis, Haemophilus
Abstract

Despite of 10 years vaccination of all children within 1st year in Slovakia against H. influenzae, this severe infection still occurs. Among 201 cases of community acquired bacterial meningitis, 14 (7%) were caused by H. influenzae serotype B. Outcome however, after early institution of treatment was fortunately positive - only 1 patient died (7.1% mortality) and in 2 other neurologic sequellae occurred (14.3%), which were transient and mild.

Published
2007

4. Pneumococcal meningitis in community is frequent after craniocerebral trauma and in alcohol abusers

Author

Benca, J., Lesnakova, A., Holeckova, K., Ondrusova, A., Wiczmandyova, D., Sladecko, V., Hvizdak, F., Bartkovjak, M., Seckova, S., Taziarova, M., Huttova, M., Bielova, M., Luzica, R., Karvaj, M., Kovac, M., Bauer, F., Sabo, I., Svabova, V., Findova, L., Bukovinova, P., and Shahum, A.

Subjects
Community-Acquired Infections, Meningitis, Pneumococcal, Risk Factors, Outcome Assessment, Health Care, Craniocerebral Trauma, Humans, Meningitis, Macrolides, Penicillins, Alcohol-Related Disorders, Anti-Bacterial Agents
Abstract

Aim of this short communication was to assess risk factors and outcome of community acquired pneumococcal meningitis and compare it to all cases of community acquired meningitis. Univariate analysis was used for comparison of 68 pneumococcal to 201 CBM within a Slovak nationwide database of CBM. Significant risk factors for pneumococcal meningitis were previous craniocerebral trauma within 7 days (39.7% vs. 14.9%, p=0.00002), splenectomy (10.3% vs. 3.5%, p=0.03) and alcohol abuse (36.8% vs. 15.4%, p=0.0001). Concerning outcome, mortality was similar (8,8% and 12,4%, NS), proportion of those with neurologic sequellae after CBM due to Str. pneumoniae was insignificantly higher (20.6% vs. 15.4%, NS) in comparison to all CBM. All but 2 strains Str. pneumoniae were susceptible to penicillin and macrolides (3.3% resistance).

Published
2007

5. Predictors of inferior outcome in community acquired bacterial meningitis

Author

Streharova, A., Krcmery, V., Kisac, P., Kalavsky, E., Holeckova, K., Lesnakova, A., Luzinsky, L., Adamkovicova, E., Pavlikova, Z., Spilakova, N., Kacunova, B., Dovalova, V., Wiczmandyova, O., Spanik, S., Liskova, A., Chovancova, D., Kovac, M., Ondrusova, A., Bauer, F., Benca, J., Rudinsky, B., Sramka, M., Kralova, J., Krsakova, A., Krumpolcova, M., Findova, L., Svabova, V., Sladeckova, V., Seckova, S., Saniova, J., Pavlicova, B., Taziarova, M., Bukovinova, P., Kolenova, A., Horvathova, D., Hvizdak, F., Luzica, R., Rolnikova, B., Bocakova, A., Grey, E., Bielova, M., Huttova, E., Sabo, I., and Jalili, N.

Subjects
Community-Acquired Infections, Alcoholism, Slovakia, Chi-Square Distribution, Risk Factors, Brain Injuries, Diabetes Mellitus, Humans, Brain Damage, Chronic, Treatment Failure, Gram-Negative Bacterial Infections, Meningitis, Bacterial
Abstract

The aim of this study was to assess mortality and sequellae within cases from Nationwide survey of community acquired meningitis and identify risk factors for inferior outcome. Risk factors such as underlying disease (diabetes mellitus, cancer, trauma, neonatal age, splenectomy, alcoholism, sepsis, other infections), etiology, clinical symptoms and outcome (death, improvement and cured after modifications of ATB therapy, cured without change of therapy, cured with neurologic sequellae) were recorded and analysed with univariate analysis (chi2 or t test for trends, CDC Atlanta 2004). Analysing risk factors for inferior outcome (death or cured with neurologic sequellae), we compared patients who died or survived with neurologic sequellae to all patients with community acquired bacterial meningitis. Univariate analysis showed that trauma (p0.05), alcohol abuse (p0.05), diabetes, S. aureus (p0.05) and gram-negative etiology (A. baumannii, Ps. aeruginosa or Enterobacteriaceae) (36% vs. 11,9%, p0.05) were predicting inferior outcome. Analysing risk factors for treatment failure (death or failed but cured after change of antibiotic treatment) prior sepsis (34.1% vs. 13.9%, p0.01) and gram-negative etiology (25% vs. 11.9%, p0.02) were statistically significant predictors of treatment failure. Neisseria meningitis had less failures (p0.05). Concerning infection associated mortality again diabetes mellitus (p0.05), alcoholism (p0.05) staphylococcal and gram-negative etiology (p0.05) were significant predictors of death. N. meningitis had surprisingly less treatment failures (appropriate and rapid initial therapy). Neurologic sequellae were more common in patients with alcohol abuse (p0.05), craniocerbral trauma (p0.05) and less common in meningitis with pneumococcal etiology (p0.05).

Published
2007

6. Neuroinfections due to Staphylococcus aureus: an emerging pathogen also in community acquired meningitis

Author

Benca, J., Lesnakova, A., Holeckova, K., Ondrusova, A., Wiczmandyova, D., Sladeckova, V., Hvizdak, F., Bartkovjak, M., Seckova, S., Taziarova, M., Huttova, M., Bielova, M., Luzica, R., Karvaj, M., Kovac, M., Bauer, F., Sabo, I., Svabova, V., Findova, L., Bukovinova, P., and Shahum, A.

Subjects
Community-Acquired Infections, Diabetes Complications, Staphylococcus aureus, Outcome Assessment, Health Care, Diabetes Mellitus, Humans, Staphylococcal Infections, Anti-Bacterial Agents, Meningitis, Bacterial, Oxacillin
Published
2007

9. Fungal neuroinfections and fungaemia: unexpected increase of mortality from invasive fungal infections in 2005-2011 in comparison to 1989-1998: analysis of 210 cases.

Author

Demitrovicova A, Liskova A, Valach M, Izakovic M, Noge A, Baranova J, Kalatova D, Syrovatkova L, Velicova J, Bugykova B, Gulasova I, Seinova D, Mikolasova G, Mutalova M, Pilkova M, Szabo I, Findova L, Madarasz I, Stanzyk M, Mikulickova D, Blazekova M, Jankechova M, Slezakova Z, Kuriplachova G, Visnovsky J, Obrocnikova A, Blumm M, Blumm B, Wolfram S, Zeleny P, Otrubova J, Rudinsky B, Nagyova Z, Vravcova M, Kajaba J, Jexova S, Oravec S, Toth S, Klobucka S, Gerigh J, Schumann F, Ambra R, Bandura P, Bonnack C, Kubisova Z, Palo M, Kalavsky E, Drgona L, Mahesvaari R, and Riedl J

Abstract

Objective: In this short communication we compared the data of fungaemia cases in Slovak hospitals from 1989-1998 published in 1999-2000 with data from 2005-2011., Methods: Risk factors, etiology and outcome of fungaemia between two periods (1989-1998 vs. 2005-2011) were compared and risk factors for death assessed by univariate analysis (CDC 2006 Statistical Package)., Results: In comparison to 1989-1998 when only amphotericin B and fluconazole has been used (55%), in 2005-2011 only 35.2% patients received FLU, but 26.4% received voriconazole, 22% caspofungin and anidulafungin and about 6.6% lipid formulations of Amphotericin B. In etiology, while in 1989-1998 only 37.1% (115/310) represented non-albicans Candida (NAC) and non-Candida yeasts in 2005-2011 already reached 63.7%. The significant increase of breakthrough fungaemia may be a sign of inappropriate empiric therapy.

Published
2013

10. Oral antibiotic use in misdiagnosed infective endocarditis-no impact on mortality.

Author

Krcmery V, Hricak V, Fischer V, Jurco R, Demitrovicova A, Mlkvy P, Karvaj M, Bauer F, Rudinsky B, Kovac M, Kalavsky E, Kisac P, Findova L, and Marks P

Subjects
Administration, Oral, Aged, Endocarditis drug therapy, Endocarditis, Bacterial drug therapy, Gram-Negative Bacteria drug effects, Gram-Negative Bacteria isolation & purification, Gram-Positive Cocci drug effects, Gram-Positive Cocci isolation & purification, Humans, Middle Aged, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Diagnostic Errors, Endocarditis diagnosis, Endocarditis mortality, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial mortality
Published
2007
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11. Comparison of postsurgical and community acquired bacterial meningitis--analysis of 372 cases within a nationwide survey.

Author

Streharova A, Benca J, Holeckova K, Balik J, Sula I, Lesnakova A, Luzinsky L, Pavlikova Z, Adamkovicova E, Spilakova N, Kacunova B, Dovalova V, Kisac P, Beno P, Kalavsky E, Sramka M, Benka J, Ondrusova A, Seckova S, Sladeckova V, Kolenova A, Bartkovjak M, Bukovinova P, Hvizdak F, Lengyel P, Bielova M, Wiczmandyova O, Svabova V, Findova L, Kutna K, Deadline J, Diana E, Krumpolcova M, Kiwou M, Steno J, Stankovic I, Bauer F, Kovac M, Huttova M, Taziarova M, Luzica R, Saniova B, Rudinsky B, Sabo I, Karvaj M, and Johnson MJ

Subjects
Community-Acquired Infections complications, Community-Acquired Infections microbiology, Community-Acquired Infections mortality, Cross Infection complications, Cross Infection microbiology, Humans, Meningitis, Bacterial etiology, Meningitis, Bacterial microbiology, Meningitis, Bacterial therapy, Neurosurgical Procedures adverse effects, Postoperative Complications microbiology, Risk Factors, Slovakia epidemiology, Statistics, Nonparametric, Survival Analysis, Treatment Outcome, Cross Infection mortality, Meningitis, Bacterial mortality, Postoperative Complications mortality
Abstract

The aim of this study was to assess if differences in etiology and risk factors among 372 cases of bacterial meningitis acquired after surgery (PM) or in community (CBM) have impact on outcome of infected patients. Among 372 cases of bacterial meningitis within last 17 years from 10 major Slovak hospitals, 171 were PM and 201 CBM. Etiology, risk factors such as underlying disease, cancer, diabetes alcoholism, surgery, VLBW, ENT infections, trauma, sepsis were recorded and mortality, survival with sequellae, therapy failure were compared in both groups. Significant differences in etiology and risk factors between both groups were reported. Those after neurosurgery had more frequently Coagulase negative staphylococci (p<0.001), Enterobacteriaceae (p=0.01) and Acinetobacter baumannii (p=0.0008) isolated from CSF and vice versa Streptococcus pneumoniae (p<0.001), Neisseria meningitis (p<0.001) and Haemophillus influenza (p=0.0009) were more commonly isolated from CSF in CBM. Neurosurgery (p<0.001), sepsis (p=0.006), VLBW neonates (p=0.00002) and cancer (p=0.0007) were more common in PM and alcohol abuse (p<0.001) as well as otitis/sinusitis (p<0.001) and Roma ethnic group (p=0.001) in CAM. Initial treatment success was significantly more frequently observed among CAM (p<0.001) but cure after modification was more common in PM (p=0.002). Therefore outcome in both groups was similar (14.6% vs. 12.4%, p=NS).

Published
2007

12. Gram-negative bacillary community acquired meningitis is not a rare entity in last two decades.

Author

Taziarova M, Holeckova K, Lesnakova A, Sladeckova V, Bartkovjak M, Seckova S, Bukovinova P, Hvizdak F, Svabova V, Findova L, Kisac P, Beno P, Bauer F, Bauer M, Karvaj M, Rudinsky B, Sabo I, Bielova M, Luzica R, Wiczmandyova O, Huttova M, and Ondrusova A

Subjects
Chi-Square Distribution, Community-Acquired Infections microbiology, Community-Acquired Infections mortality, Gram-Negative Bacteria classification, Gram-Negative Bacterial Infections mortality, Humans, Infant, Newborn, Meningitis, Bacterial microbiology, Meningitis, Bacterial mortality, Outcome Assessment, Health Care, Rare Diseases, Risk Factors, Cross Infection microbiology, Gram-Negative Bacterial Infections complications, Meningitis, Bacterial complications
Abstract

The aim of this short note is to assess gram-negative bacillary community acquired meningitis (CBM) and nosocomial meningitis (NM) within 17 years nationwide survey. All cases of gram-negative bacillary CBM within 1990-2007 were assessed in national database of 372 patients with bacterial meningitis: 69 of gram-negative cases were nosocomial and 24 of gram-negative meningitis cases were CBM. Those 24 cases were compared with all CBM (201 cases) for risk factors and outcome. Among nosocomial gram-negative pathogens, A. baumannii in 23 cases, Ps. aeruginosa in 15 cases and Enterobacteriaceae in 31 cases were isolated. Among CBM, in 13 cases Enterobacteriaceae (Escherichia coli 6, Klebsiella pneumoniae 3, Proteus mirabilis 2, Enterobacter cloacae 2), in 5 cases Ps. aeruginosa and in 6 cases Acinetobacter baumannii were isolated from cerebrospinal fluid (CSF). The only significant risk factor for CBM due to gram-negative bacilli was neonatal age (12.5% vs. 3.5%, p=0.04) as underlying disease. However, mortality among gram-negative bacillary meningitis was significantly higher (12.4% vs. 37.5%, p=0.001) in comparison to other meningitis.

Published
2007

13. Meningococcal meningitis among displaced and refugee camps in southern Sudan.

Author

Benca J, Kralova J, Bukovinova P, Findova L, Bartkovjak M, Seckova S, Ondrusova A, Knieslova D, and Njambi S

Subjects
Anti-Bacterial Agents therapeutic use, Ceftriaxone therapeutic use, Child, Child, Preschool, Chloramphenicol therapeutic use, Disease Notification, Humans, Meningitis, Meningococcal drug therapy, Sudan epidemiology, Treatment Outcome, Meningitis, Meningococcal epidemiology, Population Surveillance, Refugees
Published
2007

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