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2. Diagnosis and management of anemia in pediatric inflammatory bowel diseases: Clinical practice guidelines on behalf of the SIGENP IBD Working group

Author

Martinelli, Massimo, Fioretti, Maria Teresa, Aloi, Marina, Alvisi, Patrizia, Arrigo, Serena, Banzato, Claudia, Bramuzzo, Matteo, Campanozzi, Angelo, Civitelli, Fortunata, Knafelz, Daniela, Lionetti, Paolo, Marseglia, Antonio, Musto, Francesca, Norsa, Lorenzo, Palumbo, Giuseppe, Renzo, Sara, Romano, Claudio, Sansotta, Naire, Strisciuglio, Caterina, and Miele, Erasmo

Published
2024
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3. A Retrospective Analysis of the Outcomes of Pregnancies in Women Affected by Overt Diabetes Compared to Women Affected by Pre-Existing Type 2 Diabetes.

Author

Dalfrà, Maria Grazia, Burlina, Silvia, Fioretti, Maria Giulia, and Lapolla, Annunziata

Subjects
TYPE 2 diabetes, PREGNANCY outcomes, GESTATIONAL diabetes, GLYCEMIC control, PREGNANCY complications, RECURRENT miscarriage
Abstract

Background: Pregestational diabetes mellitus, if not well controlled, determines maternal and fetal complications. According to the new diagnostic criteria for gestational diabetes, the diagnosis of diabetes mellitus can also occur in early pregnancy (overt diabetes). Aim: This study aims to determine pregnancy outcomes in women with overt diabetes compared to women with pre-existing type 2 diabetes. Methods: In this retrospective study, we selected women with pre-existing type 2 and overt diabetes who had at least one pregnancy in the 2010–2022 period at the Diabetic Care Unit of Padova. Results: We analyzed 83 pregnancies, and overt diabetes was diagnosed in 18 pregnancies. In total, 95.5% of patients with overt diabetes and 48% of T2DM patients were immigrants (p < 0.143). No patients with overt diabetes planned their pregnancy, while pregnancy was planned in 26.3% of patients with pre-exiting type 2 diabetes (p < 0.05). Periconception and first-trimester glycemic control were the worst in patients with overt diabetes (HbA1c 9.7 ± 3.1% vs. 7.3% ± 2.3%, p < 0.044, at first visit; 8.1 ± 1.9% and 7.0 ± 1.6%, p < 0.037 in the first trimester) with respect to patients with pre-existing type 2 diabetes. As for maternal outcomes, 16.6% of pregnancies ended in miscarriage, and 5.5% of women developed gestational hypertension; as for newborn outcomes, 16.6% of newborns were LGA, and 11.1% were affected by congenital anomalies without any significant difference with respect to women with pre-existing type 2 diabetes. The high rate of congenital malformations in pregnancies of women with overt diabetes is probably a result of the poor, metabolic control observed during the periconception period when the organogenesis of the fetus takes place. Conclusions: It is essential to utilize procedures for diabetes screening in women of childbearing age not only at the beginning of the pregnancy, but also during the preconception phase or the postmenarcheal period when strong risk factors for diabetes onset are present, such as a high BMI, glycemic disorders, and those who fall under high-risk ethnicity categories. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Time to grow up: readiness associated with improved clinical outcomes in pediatric inflammatory bowel disease patients undergoing transition.

Author

Nardone, Olga Maria, Martinelli, Massimo, de Sire, Roberto, Calabrese, Giulio, Caiazzo, Anna, Testa, Anna, Rispo, Antonio, Miele, Erasmo, La Mantia, Alessia, D'Alessandro, Ermelinda, Fioretti, Maria Teresa, Limansky, Lara, Ferrante, Mario, Di Luna, Imma, Staiano, Annamaria, and Castiglione, Fabiana

Subjects
INFLAMMATORY bowel diseases, TRANSITIONAL care, PEDIATRIC gastroenterology, RECEIVER operating characteristic curves, PATIENT compliance, TREATMENT effectiveness, DENTAL emergencies
Abstract

Background: The transition from pediatric to adult healthcare in individuals with inflammatory bowel disease (IBD) poses significant challenges mainly due to the high burden of IBD during adolescence, a critical period of psychosocial development. So far, there are few longitudinal data linking transition readiness to long-term disease outcomes. Objective: We aimed to assess patients' readiness to transition and its impact on clinical outcomes, quality of life, and adherence to therapy. Design: An observational, prospective study was conducted in a tertiary adult and pediatric center, including adolescents aged ⩾17 years with a diagnosis of IBD, who underwent a 'structured transition' program including two joint adult–pediatric visits. Methods: Transition readiness skills were assessed with the Transition Readiness Assessment Questionnaire (TRAQ). All patients completed the TRAQ at the time of recruitment, which occurred during the initial joint adult–pediatric visit, to determine those deemed ready for transition versus those not ready. The Morisky Medication Adherence Scale and the 36-Item Short Form Health Survey Questionnaire (SF-36) were also completed at baseline and after 12 months. Clinical outcomes were collected at the 12-month follow-up. Results: In all, 80 patients were enrolled who had transitioned through a structured transition clinic and completed 12 months of follow-up. In total, 54 patients were ready for the transition, with a mean TRAQ = 3.2 ± 0.5. The number of clinical relapses and hospitalizations at 12 months was lower in ready compared to not-ready patients (p = 0.004 and p = 0.04, respectively). SF-36 did not differ between ready and not-ready patients and pre- and post-transition clinics (p > 0.05). Based on the receiver operating characteristic curve, a TRAQ cutoff ⩾3.16 could predict medication adherence with a sensibility of 77%, a specificity of 82%, and an AUC of 0.81 (0.71–0.91; p < 0.001). Conclusion: Patients ready for transition had better outcomes at 12 months compared to those who were not ready. Therefore, readiness assessment tools should be integrated into transition management to ensure that interventions are targeted, patient-centered, and responsive to individuals' changing needs. Plain language summary: Transition readiness associated with improved clinical outcomes The transition for individuals with inflammatory bowel disease (IBD) is a dynamic and complex process that must be planned and cannot simply be performed once the patient is 18 years old. Since it does not depend solely on the patient's age but also on developmental readiness, it requires preparation and education starting from early adolescence. In the current study, a 'joint-visit' including both pediatric and adult providers yields positive clinical outcomes over 12 months. Patients ready for transition reported fewer relapses, hospitalizations, and improved therapy adherence compared to those not ready. Readiness assessment tools should be integrated into transition clinics to facilitate targeted interventions for IBD patients based on the changing needs of individuals. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Di Comite, Amelia, Borghesi, Alessandro, Tzialla, Chryssoula, Agriesti, Giovanni, Arisio, Riccardo, Franco, Caterina, Guardione, Roberta, Boano, Elena, Catarinella, Alessia, Romano, Cristina, Monetti, Cesare, Sala, Ugo, Carbonara, Caterina, Mastretta, Emmanuele, Del Sordo, Paola, Priolo, Claudio, Galletto, Paolo, Campagnoli, Francesca, Vivalda, Mauro, Bonfante, Giuseppina, Gomirato, Giovanna, Montin, Davide, Camilla, Roberta, Messina, Alessandro, Pieretto, Marta, Cipolla, Domenico, Giuffrè, Mario, Corsello, Giovanni, Natale, Fabio, Vetrano, Gennaro, Tridapalli, Elisabetta, Faldella, Giacomo, Grazia Capretti, Maria, Paolillo, PierMichele, Picone, Simonetta, Lacerenza, Serafina, Gargano, Giancarlo, Magnani, Cristiana, Sergio Saia, Onofrio, Della Casa, Elena, Manzoni, Paolo, García Sánchez, Ruben, Meyer, Michael, Stolfi, Ilaria, Pugni, Lorenza, Messner, Hubert, Cattani, Silvia, Betta, Pasqua Maria, Memo, Luigi, Decembrino, Lidia, Bollani, Lina, Rinaldi, Matteo, Fioretti, Maria, Quercia, Michele, Maule, Milena, Tavella, Elena, Mussa, Alessandro, Laforgia, Nicola, Mosca, Fabio, Magaldi, Rosario, Mostert, Michael, and Farina, Daniele

Published
2018
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7. CLINICAL AND IMAGING FEATURES OF COVID-19 IN NEWBORNS: A RETROSPECTIVE COHORT STUDY IN A REFERRAL COVID HOSPITAL IN ITALY

Author

Rocco, Maria Chiara, primary, Santantonio, Alfredo, additional, Borrelli, Angela, additional, Barra, Giuseppina, additional, Colantuono, Rossella, additional, Rea, Gaetano, additional, Capozzi, Laura, additional, Fioretti, Maria, additional, Rosso, Roberto, additional, Orbinato, Francesco, additional, Vivo, Massimiliano De, additional, Ferrante, Lorenza, additional, Lieto, Roberta, additional, Spena, Giovanna Russo, additional, Magri, Daniela, additional, and Chello, Giovanni, additional

Published
2023
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9. Treatment with Neridronic Acid in a Newborn with Severe and Refractory Hypercalcemia Associated with Subcutaneous Fat Necrosis

Author

Borrelli, Angela Carla, primary, Capozzi, Laura, additional, Vivo, Massimiliano De, additional, Ferrante, Lorenza, additional, Fioretti, Maria, additional, Magri, Daniela, additional, Orbinato, Francesco, additional, Rojo, Silvana, additional, Rosso, Roberto, additional, Spena, Giovanna Russo, additional, Santantonio, Alfredo, additional, and Chello, Giovanni, additional

Published
2023
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10. Induction of Remission With Exclusive Enteral Nutrition in Children With Crohn's Disease: Determinants of Higher Adherence and Response.

Author

Cuomo, Marialaura, Carobbio, Alessandra, Aloi, Marina, Alvisi, Patrizia, Banzato, Claudia, Bosa, Luca, Bramuzzo, Matteo, Campanozzi, Angelo, Catassi, Giulia, D'Antiga, Lorenzo, Paola, Monica Di, Felici, Enrico, Fioretti, Maria Teresa, Gatti, Simona, Graziano, Francesco, Lega, Sara, Lionetti, Paolo, Marseglia, Antonio, Martinelli, Massimo, and Musto, Francesca

Published
2023
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11. Induction of Remission With Exclusive Enteral Nutrition in Children With Crohn’s Disease: Determinants of Higher Adherence and Response

Author

Cuomo, Marialaura, primary, Carobbio, Alessandra, additional, Aloi, Marina, additional, Alvisi, Patrizia, additional, Banzato, Claudia, additional, Bosa, Luca, additional, Bramuzzo, Matteo, additional, Campanozzi, Angelo, additional, Catassi, Giulia, additional, D’Antiga, Lorenzo, additional, Di Paola, Monica, additional, Felici, Enrico, additional, Fioretti, Maria Teresa, additional, Gatti, Simona, additional, Graziano, Francesco, additional, Lega, Sara, additional, Lionetti, Paolo, additional, Marseglia, Antonio, additional, Martinelli, Massimo, additional, Musto, Francesca, additional, Sansotta, Naire, additional, Scarallo, Luca, additional, Zuin, Giovanna, additional, and Norsa, Lorenzo, additional

Published
2022
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12. T Cell Apoptosis by Kynurenines

Author

Fallarino, Francesca, Grohmann, Ursula, Vacca, Carmine, Orabona, Ciriana, Spreca, Antonio, Fioretti, Maria C., Puccetti, Paolo, Allegri, Graziella, editor, Costa, Carlo V. L., editor, Ragazzi, Eugenio, editor, Steinhart, Hans, editor, and Varesio, Luigi, editor

Published
2003
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13. Tryptophan Catabolism in Nonobese Diabetic Mice

Author

Grohmann, Ursula, Fallarino, Francesca, Bianchi, Roberta, Vacca, Carmine, Orabona, Ciriana, Belladonna, Maria Laura, Fioretti, Maria Cristin, Puccetti, Paolo, Allegri, Graziella, editor, Costa, Carlo V. L., editor, Ragazzi, Eugenio, editor, Steinhart, Hans, editor, and Varesio, Luigi, editor

Published
2003
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14. Su1576: EFFECT OF TRANSITION CARE ON CLINICAL OUTCOMES AND TREATMENT ADHERENCE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: AN OBSERVATIONAL PROSPECTIVE STUDY

Author

Nardone, Olga Maria, primary, Martinelli, Massimo, additional, Rispo, Antonio, additional, Testa, Anna, additional, Sire, Roberto de, additional, Caiazzo, Anna, additional, Luna, Imma Di, additional, Fioretti, Maria Teresa, additional, Miele, Erasmo, additional, Staiano, Annamaria, additional, and Castiglione, Fabiana, additional

Published
2022
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19. Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

Author

Fallarino, Francesca, Volpi, Claudia, Fazio, Francesco, Notartomaso, Serena, Vacca, Carmine, Busceti, Carla, Bicciato, Silvio, Battaglia, Giuseppe, Bruno, Valeria, Puccetti, Paolo, Fioretti, Maria C., Nicoletti, Ferdinando, Grohmann, Ursula, and Di Marco, Roberto

Subjects
Neurotransmitter receptors -- Physiological aspects -- Research, T cells -- Physiological aspects -- Research, Multiple sclerosis -- Risk factors -- Care and treatment -- Research
Abstract

High amounts of glutamate are found in the brains of people with multiple sclerosis, an inflammatory disease marked by progressive demyelination. Glutamate might affect neuroinflammation via effects on immune cells. Knockout mice lacking metabotropic glutamate receptor-4 (mGluR4) were markedly vulnerable to experimental autoimmune encephalomyelitis (EAE, a mouse model of multiple sclerosis) and developed responses dominated by interleukin-17-producing T helper ([T.sub.H]17) cells. In dendritic cells (DCs) from those mice, defective mGluR4 signaling--which would normally decrease intracellular cAMP formation--biased [T.sub.H] cell commitment to the [T.sub.H]17 phenotype. In wild-type mice, mGluR4 was constitutively expressed in all peripheral DCs, and this expression increased after cell activation. Treatment of wild-type mice with a selective mGluR4 enhancer increased EAE resistance via regulatory T ([T.sub.reg]) cells. The high amounts of glutamate in neuroinflammation might reflect a counterregulatory mechanism that is protective in nature and might be harnessed therapeutically for restricting immunopathology in multiple sclerosis., Classical neurotransmitters such as monoamines and acetylcholine regulate the magnitude and quality of immune responses (1-4). The recent discovery of interleukin-17 (IL-17)-producing [T.sub.H]17 cells as a distinct subset of effector [...]

Published
2010
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21. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

Author

Romani, Luigina, Fallarino, Francesca, De Luca, Antonella, Montagnoli, Claudia, D'Angelo, Carmen, Zelante, Teresa, Vacca, Carmine, Bistoni, Francesco, Fioretti, Maria C., Grohmann, Ursula, Segal, Brahm H., and Puccetti, Paolo

Subjects
Inflammation -- Risk factors -- Research -- Care and treatment -- Complications and side effects, Chronic granulomatous disease -- Care and treatment -- Research -- Complications and side effects -- Risk factors, Metabolic diseases -- Risk factors -- Research -- Complications and side effects -- Care and treatment, Environmental issues, Science and technology, Zoology and wildlife conservation, Care and treatment, Complications and side effects, Research, Risk factors
Abstract

Author(s): Luigina Romani (corresponding author) [1]; Francesca Fallarino [1]; Antonella De Luca [1]; Claudia Montagnoli [1]; Carmen D'Angelo [1]; Teresa Zelante [1]; Carmine Vacca [1]; Francesco Bistoni [1]; Maria C. [...]

Published
2008
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22. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

Author

Grohmann, Ursula, Volpi, Claudia, Fallarino, Francesca, Bozza, Silvia, Bianchi, Roberta, Vacca, Carmine, Orabona, Ciriana, Belladonna, Maria L, Ayroldi, Emira, Nocentini, Giuseppe, Boon, Louis, Bistoni, Francesco, Fioretti, Maria C, Romani, Luigina, Riccardi, Carlo, and Puccetti, Paolo

Abstract

Glucocorticoid-induced tumor necrosis factor receptor (GITR) on T cells and its natural ligand, GITRL, on accessory cells contribute to the control of immune homeostasis. Here we show that reverse signaling through GITRL after engagement by soluble GITR initiates the immunoregulatory pathway of tryptophan catabolism in mouse plasmacytoid dendritic cells, by means of noncanonical NF-[kappa]B-dependent induction of indoleamine 2,3-dioxygenase (IDO). The synthetic glucocorticoid dexamethasone administered in vivo activated IDO through the symmetric induction of GITR in CD4[sup.+] T cells and GITRL in plasmacytoid dendritic cells. The drug exerted IDO-dependent protection in a model of allergic airway inflammation. Modulation of tryptophan catabolism via the GITR-GITRL coreceptor system might represent an effective therapeutic target in immune regulation. Induction of IDO could be an important mechanism underlying the anti-inflammatory action of corticosteroids., Author(s): Ursula Grohmann [1]; Claudia Volpi [1]; Francesca Fallarino [1]; Silvia Bozza [1]; Roberta Bianchi [1]; Carmine Vacca [1]; Ciriana Orabona [1]; Maria L Belladonna [1]; Emira Ayroldi [2]; Giuseppe [...]

Published
2007
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35. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Manzoni, Paolo, primary, García Sánchez, Ruben, additional, Meyer, Michael, additional, Stolfi, Ilaria, additional, Pugni, Lorenza, additional, Messner, Hubert, additional, Cattani, Silvia, additional, Betta, Pasqua Maria, additional, Memo, Luigi, additional, Decembrino, Lidia, additional, Bollani, Lina, additional, Rinaldi, Matteo, additional, Fioretti, Maria, additional, Quercia, Michele, additional, Maule, Milena, additional, Tavella, Elena, additional, Mussa, Alessandro, additional, Tzialla, Chryssoula, additional, Laforgia, Nicola, additional, Mosca, Fabio, additional, Magaldi, Rosario, additional, Mostert, Michael, additional, Farina, Daniele, additional, Di Comite, Amelia, additional, Borghesi, Alessandro, additional, Agriesti, Giovanni, additional, Arisio, Riccardo, additional, Franco, Caterina, additional, Guardione, Roberta, additional, Boano, Elena, additional, Catarinella, Alessia, additional, Romano, Cristina, additional, Monetti, Cesare, additional, Sala, Ugo, additional, Carbonara, Caterina, additional, Mastretta, Emmanuele, additional, Del Sordo, Paola, additional, Priolo, Claudio, additional, Galletto, Paolo, additional, Campagnoli, Francesca, additional, Vivalda, Mauro, additional, Bonfante, Giuseppina, additional, Gomirato, Giovanna, additional, Montin, Davide, additional, Camilla, Roberta, additional, Messina, Alessandro, additional, Pieretto, Marta, additional, Cipolla, Domenico, additional, Giuffrè, Mario, additional, Corsello, Giovanni, additional, Natale, Fabio, additional, Vetrano, Gennaro, additional, Tridapalli, Elisabetta, additional, Faldella, Giacomo, additional, Grazia Capretti, Maria, additional, Paolillo, PierMichele, additional, Picone, Simonetta, additional, Lacerenza, Serafina, additional, Gargano, Giancarlo, additional, Magnani, Cristiana, additional, Sergio Saia, Onofrio, additional, and Della Casa, Elena, additional

Published
2018
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36. Safflower Production en Argentina

Author

Palomo, Iris Rosana, Fioretti, Maria Nelida, Baioni, Sandra Sonia, Mirassón, Hugo Raúl, Brevedan, Roberto, Gorawala, Prathamesh, and Mandhatri, Srushti

Subjects
PRODUCTION, SAFFLOWER, ARGENTINA, CIENCIAS AGRÍCOLAS, Agricultura, ECOLOGY, Agricultura, Silvicultura y Pesca
Abstract

Safflower is an anternative crop adapted to semiarid regions that would allow to optimize land occupation by crops. Currentlyit is grown in Salta, Santiago del Estero, Chaco provinces and in smaller areas in the semiarid Pampas. It grows slowly especially in emergency and in the rosettestage, so weed problems exists. Fil: Palomo, Iris Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina Fil: Fioretti, Maria Nelida. Universidad Nacional del Sur. Departamento de Agronomía; Argentina Fil: Baioni, Sandra Sonia. Universidad Nacional del Sur. Departamento de Agronomía; Argentina Fil: Mirassón, Hugo Raúl. Universidad Nacional de La Pampa. Facultad de Agronomía; Argentina Fil: Brevedan, Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina. Universidad Nacional del Sur. Departamento de Agronomía; Argentina

Published
2017

37. Is Lactoferrin More Effective in Reducing Late-Onset Sepsis in Preterm Neonates Fed Formula Than in Those Receiving Mother's Own Milk? Secondary Analyses of Two Multicenter Randomized Controlled Trials.

Author

Tavella, Elena, Messina, Alessandro, Pieretto, Marta, Boano, Elena, Carlino, Martina, Manzoni, Paolo, Cattani, Silvia, Betta, Pasqua Maria, Memo, Luigi, Decembrino, Lidia, Bollani, Lina, Tzialla, Chryssoula, Rinaldi, Matteo, Magaldi, Rosario, Fioretti, Maria, Laforgia, Nicola, Quercia, Michele, Mosca, Fabio, Mostert, Michael, and Tarnow-Mordi, William

Subjects
ANTI-infective agents, BREAST milk, CONFIDENCE intervals, GLYCOPROTEINS, INFANT formulas, NEWBORN infants, PREMATURE infant diseases, MEDICAL cooperation, META-analysis, MULTIVARIATE analysis, RESEARCH, SEPSIS, LOGISTIC regression analysis, DATA analysis, SECONDARY analysis, RELATIVE medical risk, DISEASE incidence, DESCRIPTIVE statistics, ODDS ratio, EVALUATION
Abstract

Background  Lactoferrin is the major antimicrobial protein in human milk. In our randomized controlled trial (RCT) of bovine lactoferrin (BLF) supplementation in preterm neonates, BLF reduced late-onset sepsis (LOS). Mother's own milk (MM) contains higher concentrations of lactoferrin than donor milk or formula, but whether BLF is more effective in infants who receive formula or donor milk is uncertain. Aim  To evaluate the incidence of LOS in preterm infants fed MM and in those fed formula and/or donor milk. Study Design  This is a (A) post hoc subgroup analysis, in our RCT of BLF, of its effects in preterm infants fed MM, with or without formula, versus those fed formula and/or donor milk (no-MM) and (B) post hoc meta-analysis, in our RCT of BLF and in the ELFIN (Enteral Lactoferrin in Neonates) RCT, of the effect of BLF in subgroups not exclusively fed MM. Results (A) Of 472 infants in our RCT, 168 were randomized to placebo and 304 were randomized to BLF. Among MM infants, LOS occurred in 22/133 (16.5%) infants randomized to placebo and in 14/250 (5.6%) randomized to BLF (relative risk or risk ratio (RR): 0.34; relative risk reduction (RRR): 0.66; 95% confidence interval (95% CI) for RR: 0.18–0.64; p  < 0.0008). Among no-MM infants, LOS occurred in 7/35 (20.0%) randomized to placebo and in 2/54 (3.7%) randomized to BLF (RR: 0.19; RRR: 0.81; 95% CI for RR: 0.16–0.96; p  = 0.026). In multivariable logistic regression analysis, there was no interaction between BLF treatment effect and type of feeding (p  = 0.628). (B) In 1,891 infants not exclusively fed MM in our RCT of BLF and in the ELFIN RCT, BLF reduced the RR of LOS by 18% (RR: 0.82; 95% CI: 0.71–0.96; p  = 0.01). Conclusion  Adequately powered studies should address the hypothesis that BLF is more effective in infants fed formula or donor milk than those fed MM. Such studies should evaluate whether a specific threshold of total lactoferrin intake can be identified to protect such patients from LOS. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Allogeneic umbilical cord blood red cell concentrates: An innovative blood product for transfusion therapy of preterm infants

Author

Bianchi, Maria, Giannantonio, Carmen, Spartano, Serena, Fioretti, Maria, Landini, Alessandra, Molisso, A, Tesfagabir, Gm, Tornesello, Assunta, Barbagallo, O, Valentini, Cg, Vento, Giovanni, Zini Tanzi, Gina, Romagnoli, Costantino, Papacci, Patrizia, Teofili, L., and Teofili, Luciana

Subjects
Male, Erythrocyte transfusion, medicine.medical_specialty, Adult red blood cells, Availability of umbilical cord blood, Preterm infants, Safety of umbilical cord blood, Umbilical cord blood transfusion, Birth Weight, Feasibility Studies, Female, Fetal Blood, Follow-Up Studies, Gestational Age, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Prospective Studies, Erythrocyte Transfusion, Infant, Premature, Pediatrics, Perinatology and Child Health, Developmental Biology, Umbilical cord, Pediatrics, Blood product, Neonatal, Medicine, Prospective cohort study, Premature, Red Cell, business.industry, Obstetrics, TransfusionTherapy, Follow up studies, Gestational age, Infant, Perinatology and Child Health, Newborn, Intensive Care Units, Settore MED/15 - MALATTIE DEL SANGUE, medicine.anatomical_structure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Transfusion therapy, business
Abstract

Background: Preterm infants often receive blood transfusions early in life. In this setting, umbilical cord blood (UCB) might be safer than adult blood (A) with respect to infectious and immunologic threats. Objectives: To evaluate, as a first objective, the feasibility of fulfilling transfusion needs of preterm infants with allogeneic UCB red blood cell (RBC) concentrates and, as a secondary objective, to assess the safety of allogeneic cord blood transfusions. Methods: At the Neonatal Intensive Care Unit and the UNICATT Cord Blood Bank of ‘A. Gemelli' Hospital in Rome, a prospective study was carried out over a 1-year period, enrolling newborns with gestational age ≤30 weeks and/or birth weight ≤1,500 g requiring RBC transfusions within the first 28 days of life. At first transfusion, patients were assigned to receive UCB-RBCs or A-RBCs depending on the availability of ABO-Rh(D)-matched UCB-RBC units. The same regimen (UCB-RBC or A-RBC units) was thereafter maintained, unless ABO-Rh(D)-matched UCB-RBC units were not available. Results: Overall, 23 UCB-RBC units were transfused to 9 patients; the requests for UCB-RBC units were met in 45% of patients at the first transfusion and in 78% at the subsequent transfusions. At a median follow-up of 57 days (range 6-219), no acute or delayed transfusion-related adverse events occurred. Hematocrit gain after transfusion and time intervals between transfusions were similar in the UCB-RBC and A-RBC group, as well. Conclusions: Transfusing allogeneic UCB-RBC units in preterm infants appears a feasible and safe approach, although the transfusion needs of our study population were not completely covered. More data are necessary to validate this novel transfusion practice. © 2014 S. Karger AG, Basel

Published
2015

42. Water stress and temperature effects on germination and early seedling growth of Digitaria eriantha

Author

Brevedan, Roberto, Busso, Carlos Alberto, Fioretti, Maria Nelida, Toribio, Mirta Susana, Baioni, Sandra Sonia, Torres, Yanina Alejandra, Fernandez, Osvaldo Alberto, Giorgetti, Hugo Dosindo, Bentivegna, Diego Javier, Entio, Lisandro Jose, Ithurrart, Leticia Soledad, Montenegro, Oscar Alberto, Mujica, Maria de la Merced, Rodriguez, Gustavo Dionisio, Tucat, Guillermo, and Busso, Carlos Alberto

Subjects
Ciencias Biológicas, Water potential, Germination, Ecología, Digitaria eriantha, CIENCIAS NATURALES Y EXACTAS, Early growth
Abstract

We assessed seed germination and seedling survival of the grass Digitaria eriantha cv. Irene to determine its potential for re-vegetation in the arid parts of Argentina. We evaluated the effects of (1) water stress and temperature on the germination, and (2) water stress on the early seedling growth under controlled conditions. During the first 24 hrs the germination at constant temperature exceeded by 50 % (one-way ANOVA: F3,20=67.40, p

Published
2013

43. Efecto fitotóxico de Baccharis ulicina sobre la germinación y crecimiento inicial de Avena sativa, Lolium perenne y Raphanus sativus

Author

Tucat, Guillermo, Bentivegna, Diego Javier, Fernandez, Osvaldo Alberto, Busso, Carlos Alberto, Brevedan, Roberto, Mujica, Maria de la Merced, Torres, Yanina Alejandra, Daddario, Juan Facundo Fabian, Ithurrart, Leticia Soledad, Giorgetti, Hugo Dosindo, Rodriguez, Gustavo Dionisio, Montenegro, Oscar Alberto, Baioni, Sandra Sonia, Entio, Lisandro Jose, and Fioretti, Maria Nelida

Subjects
purl.org/becyt/ford/1 [https], Ciencias Biológicas, Baccharis ulicina, Alelopatía, Ecología, purl.org/becyt/ford/1.6 [https], germinación, CIENCIAS NATURALES Y EXACTAS
Abstract

Baccharis ulicina es una maleza ampliamente distribuida en los pastizales de la zona semiárida argentina. A fin de evaluar sus posibles efectos alelopáticos, se utilizaron extractos acuosos de B. ulicina (hoja, tallo, raíz y planta entera) a dos concentraciones (50 y 150 g tejido/L agua) sobre la germinación y crecimiento inicial de Avena sativa , Lolium perenne y Raphanus sativus . Para cada especie se regaron 100 semillas y se mantuvieron a 25°C y oscuridad. Se registraron la germinación de las semillas y la longitud de coleóptilo / hipocótile (C/H) y radícula (R). Con los datos obtenidos se determinó: porcentaje de germinación, coeficiente de velocidad de germinación, vigor de la germinación, inhibición de la germinación, inhibición de la longitud de la radícula y del coleóptilo / hipocótile e índice de vigor de radícula y de coleóptilo / hipocótile. Los extractos con alta concentración redujeron la germinación en promedio 65% mientras que inhibieron la longitud en 58,8% (C/H) y 93,3% (R) para A. sativa , 71,5% (C/H) y 87,9% (R) para L. perenne , y 93,8% (C/H) y 94,5% (R) para R. sativus . Se registró un evidente efecto fitotóxico de B. ulicina sobre las especies evaluadas, indicando que la alelopatía sería una estrategia ecológica de la especie. Baccharis ulicina is a weed widely distributed in pastures of the semiarid zone of Argentina. With the aim of evaluate potential allelopathic effects, aqueous extracts of B. ulicina (leaf, stem, root and whole plant) at two concentrations (50 and 150 g tissue/L water) were used on germination and initial growth of Avena sativa, Lolium perenne and Raphanus sativus. For each species, 100 seeds were watered and maintained at 25°C at darkness. Seed germination and length of coleoptile / hypocotyl (C/H) and radicle (R) was measured. Then, germination percentage, germination rate coefficient, germination vigor, inhibition of germination, inhibition of radicle length and coleoptile / hypocotyl length, radicle vigor index and the coleoptile / hypocotyl vigor index were calculated. High concentration extracts reduced germination an average of 65%, in addition, they produced a length inhibition of 58.8% (C/H) and 93.3% (R) to A. sativa, 71.5% (C/H) and 87.9% (R) to L. perenne, and 93.8% (C/H) and 94.5% (R) to R. sativus. There was an evident phytotoxic effect of B. ulicina on evaluated species, indicating that allelopathy would be an ecological strategy of the species. Fil: Tucat, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Bentivegna, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Fernandez, Osvaldo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Busso, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Brevedan, Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Mujica, Maria de la Merced. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Ambiente y Recursos Naturales. Cat.introduccion de Mejoramiento Genético; Argentina; Fil: Torres, Yanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Daddario, Juan Facundo Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahia Blanca. Centro Rec.nat.renovables de Zona Semiarida(i); Argentina; Fil: Ithurrart, Leticia Soledad. Universidad Nacional del Sur; Argentina; Fil: Giorgetti, Hugo Dosindo. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fil: Rodriguez, Gustavo Dionisio. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fil: Montenegro, Oscar Alberto. Provincia de Buenos Aires. Ministerio de Asuntos Agrarios. Chacra Experimental de Patagones; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fil: Baioni, Sandra Sonia. Universidad Nacional del Sur; Argentina; Fil: Entio, Lisandro Jose. Universidad Nacional de la Plata. Facultad de Cs.agrarias y Forestales. Departamento de Ambiente y Recursos Naturales. Cat.introduccion de Mejoramiento Genético; Argentina; Fil: Fioretti, Maria Nelida. Universidad Nacional del Sur; Argentina

Published
2013

44. Yield and stability of safflower varieties (Carthamus tinctorius L.) in the Semiarid Pampean Region

Author

Mirassón, H.R., Palomo, Iris Rosana, Brevedan, Roberto, and Fioretti, Maria Nelida

Subjects
CARTAMO, REGIÓN SEMIÁRIDA, CIENCIAS AGRÍCOLAS, Agricultura, purl.org/becyt/ford/4.1 [https], ESTABILIDAD, RENDIMIENTO, Agricultura, Silvicultura y Pesca, purl.org/becyt/ford/4 [https]
Abstract

El cultivo de cártamo se realiza actualmente en el noroeste de la Argentina, aunque el área más apta para el mismo es la Región Pampeana Central Semiárida. Se estudió el comportamiento de diferentes variedades en distintos ambientes para determinar aquellas capaces de producir un rendimiento más estable y productivo, para ser utilizadas en programas de difusión del cultivo en esa región. A tal fin se efectuaron seis ensayos comparativos de rendimiento en dos localidades: Santa Rosa (La Pampa, 36° 39 ’S, 64° 16 ’O) y Tres Picos (Buenos Aires, 38° 16’ S, 62° 13’ O), durante varios años. Para el estudio de la estabilidad del rendimiento se utilizó el análisis de los rendimientos relativos. Las variedades S-541, S-200 y S-400 fueron las más estables y las de mayor rendimiento en grano y aceite. Safflower production is mainly concentrated in northwestern Argentina although the most suitable area for its production is the central, Semiarid Pampean Region. The response of different varieties able to produce high sustainable yields was studied under different environments, with the idea of promoting these varieties in the study region. Six variety trials were carried out at two locations in the study area, Santa Rosa (La Pampa, 36° 39’ S, 64° 16’ W) and Tres Picos (Buenos Aires, 38° 16’ S, 62° 13’ W), during several years. Relative yield was used as a measure of safflower stability. Varieties S-541, S-200 and S-400 were the most stable and showed the highest grain and oil yields. Fil: Mirassón, H.R.. Universidad Nacional de La Pampa. Facultad de Agronomía; Argentina Fil: Palomo, Iris Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina Fil: Brevedan, Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina Fil: Fioretti, Maria Nelida. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina

Published
2011

48. Phosphorus nutrition on nitrogen metabolism of non-nodulated soybean

Author

Brevedan, Roberto, Aveldaño, Marta Isabel, Fioretti, Maria Nelida, Varillas, María Alejandra, Baioni, Sandra Sonia, Mirasson, H. R., and Palomo, Iris Rosana

Subjects
Otras Agricultura, Silvicultura y Pesca, MOVILIZACIÓN DE NITRATOS, CIENCIAS AGRÍCOLAS, purl.org/becyt/ford/4.1 [https], INTERACCION FOSFORO-NITROGENO, Agricultura, Silvicultura y Pesca, DEFICIENCIA DE FOSFORO, NITRATO REDUCTASA, ABSORCIÓN DE NITRATOS, purl.org/becyt/ford/4 [https]
Abstract

Se realizaron dos experimentos en el invernáculo para estudiar la influencia de la deficiencia de P en la nutrición con nitrógeno de plantas de soja no nodulada. Hubo una reducción en el contenido de N y P en las plantas deficientes en P (P-) de casi el 50% y del 33% en la materia seca, luego de 50 días. La actividad de la nitrato reductasa y el contenido de nitratos en tallos fueron menores en plantas P- que en aquellas P+. Del total de nitratos en las plantas P-, 75% estuvo en las raíces. La acumulación de nitratos en las raíces sería debido a la menor actividad de la nitrato reductasa en las mismas, y a una disminución en el flujo de agua hacia el vástago. El incremento en la concentración de nitratos en la raíz causaría una retroalimentación negativa que reduciría su absorción por la planta. Two experiments were conducted under greenhouse conditions to study the influence of P deficiency on nitrogen nutrition of non-nodulated soybean. There was a reduction of N and P content in P deficient (P-) plants of almost 50% after 50 days. During this period, dry matter of these plants was reduced by 33%. Nitrate reductase activity and shoot nitrate content were lower in Pthan in P+ plants. Seventy five percent of nitrates in P- plants were in the roots. Nitrate accumulation in roots would be due to the lower nitrate reductase activity in this organ and a reduced water flux to shoots. Root nitrate concentration increases would cause a negative feedback which would reduce plant nitrate uptake. Fil: Brevedan, Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina Fil: Aveldaño, Marta Isabel. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fioretti, Maria Nelida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina Fil: Varillas, María Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Cátedra de Control de Calidad de Medicamentos; Argentina Fil: Baioni, Sandra Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina Fil: Mirasson, H. R.. Universidad Nacional de la Pampa. Facultad de Agronomia. Cátedra de Fisiología Vegetal; Argentina Fil: Palomo, Iris Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiárida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiárida; Argentina

Published
2009

49. Respuesta del coriandro a dos distanciamientos entre líneas, con y sin riego, en dos fechas de siembra en el sudoeste de la provincia de Buenos Aires

Author

Palomo, Iris Rosana, Castro, A., Brevedan, Roberto, Fioretti, Maria Nelida, and Oyola, Jorge Mario

Subjects
Fechas de Siembra, Distancia entre Lineas, CIENCIAS AGRÍCOLAS, Coriandro, Agricultura, purl.org/becyt/ford/4.1 [https], Agricultura, Silvicultura y Pesca, purl.org/becyt/ford/4 [https], Riego
Abstract

El proceso de reconversión productiva en el cual se encuentra inmerso el sector agropecuario de nuestro país ha llevado en los últimos años a la búsqueda de nuevas alternativas de producción con la finalidad de incrementar la rentabilidad de las empresas agropecuarias. Esto se manifiesta más agudamente en zonas marginales. Dentro de este marco los cultivos aromáticos han resurgido como alternativas de tal diversificación. La vuelta a lo natural, la posibilidad de incorporar valor agregado a la producción primaria, el interés por las medicinas alternativas, etc. ha incitado a un renovado interés por el sector de las plantas fitoterapéuticas lo que se detecta a través de las numerosas consultas que se reciben a diario de productores y profesionales interesados en incursionar en este tipo de cultivos. Las condiciones de suelo y clima de la región son adecuadas para el cultivo de diferentes especies aromáticas, entre las que se cuenta el coriandro (Coriandrum sativum L.), que es una planta aromática anual de ciclo invernal perteneciente a la familia Apiaceae (ex Umbeliferae), cuyos frutos (granos) y la esencia que se obtiene de ellos tienen diversos usos en distintas industrias. En la industria alimenticia se usan los granos como condimento, siendo la base del polvo curry. La esencia tiene usos en productos medicinales y en perfumería. También son consumidas las hojas frescas de estas plantas en ensaladas y sopas. Aunque existen algunos estudios previos sobre este cultivo, éste no está muy difundido en el sudoeste de la provincia de Buenos Aires por lo que se busca investigar su adaptación agronómica y las técnicas de manejo más adecuado para incluirlo dentro de los sistemas de producción de esta zona. El análisis del margen bruto y retorno del cultivo realizados para la región, indican que el coriandro podría ser una alternativa interesante a considerar en secano y más aún con riego complementario, en lotes de alta fertilidad, de acuerdo a los valores de margen bruto y retorno obtenidos (Castro et al, 2009). El objetivo de este estudio fue obtener información referida a las distancias de siembra más apropiadas, en cultivos regados y sin regar, sembrados en distintas fechas, en las condiciones agroecológicas del sudoeste de la provincia de Bs. As. Fil: Palomo, Iris Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina Fil: Castro, A.. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Bordenave; Argentina Fil: Brevedan, Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina Fil: Fioretti, Maria Nelida. Universidad Nacional del Sur. Departamento de Agronomía; Argentina Fil: Oyola, Jorge Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; Argentina

Published
2009

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