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20 results on '"Firmino-Cruz, Luan"'

1. IL-17A/IFN-γ producing γ δ T cell functional dichotomy impacts cutaneous leishmaniasis in mice

Author

Dos-Santos, Julio Souza, primary, Firmino-Cruz, Luan, additional, Oliveira-Maciel, Diogo, additional, da Fonseca-Martins, Alessandra M, additional, Ramos, Tadeu Diniz, additional, Nunes-Souza, Leticia, additional, Soares, Rodrigo Pedro, additional, Gomes, Daniel Claudio Oliveira, additional, Mengel, Jose O., additional, Silva-Santos, Bruno, additional, and de Matos Guedes, Herbert L, additional

Published
2024
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2. B-1 lymphocytes are able to produce IL-10, but is not pathogenic during Leishmania (Leishmania) amazonensis infection

Author

Firmino-Cruz, Luan, Ramos, Tadeu Diniz, da Fonseca-Martins, Alessandra Marcia, Oliveira-Maciel, Diogo, Oliveira-Silva, Gabriel, dos Santos, Júlio Souza, Cavazzoni, Cecília, Morrot, Alexandre, Gomes, Daniel Claudio Oliveira, Vale, André Macedo, Decoté-Ricardo, Debora, Freire-de-Lima, Celio G., and de Matos Guedes, Herbert Leonel

Published
2020
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3. The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection

Author

da Silva-Junior, Elias Barbosa, Firmino-Cruz, Luan, Guimarães-de-Oliveira, Joyce Cristina, De-Medeiros, Juliana Valente Rodrigues, de Oliveira Nascimento, Danielle, Freire-de-Lima, Matheus, de Brito-Gitirana, Lycia, Morrot, Alexandre, Previato, Jose Osvaldo, Mendonça-Previato, Lucia, Decote-Ricardo, Debora, de Matos Guedes, Herbert Leonel, and Freire-de-Lima, Celio Geraldo

Published
2021
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4. Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis

Author

Ramos, Tadeu Diniz, Silva, Johnatas Dutra, da Fonseca-Martins, Alessandra Marcia, da Silveira Pratti, Juliana Elena, Firmino-Cruz, Luan, Maciel-Oliveira, Diogo, Dos-Santos, Julio Souza, Tenorio, João Ivo Nunes, de Araujo, Almair Ferreira, Freire-de-Lima, Célio Geraldo, Diaz, Bruno Lourenço, Cruz, Fernanda Ferreira, Rocco, Patricia Rieken Macedo, and de Matos Guedes, Herbert Leonel

Published
2020
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6. Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice

Author

Firmino-Cruz, Luan, primary, dos-Santos, Júlio Souza, additional, da Fonseca-Martins, Alessandra Marcia, additional, Oliveira-Maciel, Diogo, additional, Guadagnini-Perez, Gustavo, additional, Roncaglia-Pereira, Victor A., additional, Dumard, Carlos H., additional, Guedes-da-Silva, Francisca H., additional, Vicente Santos, Ana C., additional, Alvim, Renata G. F., additional, Lima, Tulio M., additional, Marsili, Federico F., additional, Abreu, Daniel P. B., additional, Rossi-Bergmann, Bartira, additional, Vale, Andre M., additional, Filardy, Alessandra D’Almeida, additional, Silva, Jerson Lima, additional, de Oliveira, Andrea Cheble, additional, Gomes, Andre M. O., additional, and de Matos Guedes, Herbert Leonel, additional

Published
2022
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7. Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

Author

dos-Santos, Júlio Souza, primary, Firmino-Cruz, Luan, additional, da Fonseca-Martins, Alessandra Marcia, additional, Oliveira-Maciel, Diogo, additional, Perez, Gustavo Guadagnini, additional, Roncaglia-Pereira, Victor A., additional, Dumard, Carlos H., additional, Guedes-da-Silva, Francisca H., additional, Santos, Ana C. Vicente, additional, Leandro, Monique dos Santos, additional, Ferreira, Jesuino Rafael Machado, additional, Guimarães-Pinto, Kamila, additional, Conde, Luciana, additional, Rodrigues, Danielle A. S., additional, Silva, Marcus Vinicius de Mattos, additional, Alvim, Renata G. F., additional, Lima, Tulio M., additional, Marsili, Federico F., additional, Abreu, Daniel P. B., additional, Ferreira Jr., Orlando C., additional, Mohana Borges, Ronaldo da Silva, additional, Tanuri, Amilcar, additional, Souza, Thiago Moreno L., additional, Rossi-Bergmann, Bartira, additional, Vale, André M., additional, Silva, Jerson Lima, additional, de Oliveira, Andréa Cheble, additional, Filardy, Alessandra D’Almeida, additional, Gomes, Andre M. O., additional, and de Matos Guedes, Herbert Leonel, additional

Published
2022
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9. Immunogenicity of SARS-CoV-2 trimetric spike protein associated to Poly(I:C) plus Alum

Author

dos-Santos, Júlio Souza, primary, Firmino-Cruz, Luan, additional, Fonseca-Martins, Alessandra Marcia da, additional, Oliveira-Maciel, Diogo, additional, Perez, Gustavo Guadagini, additional, Pereira, Victor A. R., additional, Dumard, Carlos H., additional, Guedes-da-Silva, Francisca H., additional, Santos, Ana C. Vicente, additional, Leandro, Monique dos Santos, additional, Machado Ferreira, Jesuino Rafael, additional, Guimarães-Pinto, Kamila, additional, Conde, Luciana, additional, Rodrigues, Danielle A. S., additional, de Mattos Silva, Marcus Vinicius, additional, Alvim, Renata G. F., additional, Lima, Tulio M., additional, Marsili, Federico F., additional, Abreu, Daniel P. B., additional, Ferreira, Orlando, additional, Borges, Ronaldo da Silva Mohana, additional, Tanuri, Amilcar, additional, Souza, Thiago Moreno L., additional, Rossi-Bergamnn, Bartira, additional, Vale, André M., additional, Silva, Jerson Lima, additional, de Oliveira, Andrea Cheble, additional, Filardy, Alessandra D’Almeida, additional, Gomes, Andre M. O., additional, and Leonel de Matos Guedes, Herbert, additional

Published
2021
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10. MPLA and AddaVax® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis

Author

Oliveira-Maciel, Diogo, primary, dos-Santos, Júlio Souza, additional, Oliveira-Silva, Gabriel, additional, Mello, Mirian França de, additional, da Fonseca-Martins, Alessandra Marcia, additional, Carneiro, Monique Pacheco Duarte, additional, Ramos, Tadeu Diniz, additional, Firmino-Cruz, Luan, additional, Gomes, Daniel Claudio Oliveira, additional, Rossi-Bergmann, Bartira, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2021
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11. Additional file 1 of Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis

Author

Tadeu Diniz Ramos, Johnatas Dutra Silva, Fonseca-Martins, Alessandra Marcia Da, Pratti, Juliana Elena Da Silveira, Firmino-Cruz, Luan, Maciel-Oliveira, Diogo, Dos-Santos, Julio Souza, Tenorio, João Ivo Nunes, Almair Ferreira De Araujo, Célio Geraldo Freire-De-Lima, Diaz, Bruno Lourenço, Cruz, Fernanda Ferreira, Rocco, Patricia Rieken Macedo, and Guedes, Herbert Leonel De Matos

Subjects
integumentary system, sense organs, equipment and supplies, skin and connective tissue diseases
Abstract

Additional file 1 : Figure S1. Wound healing scratch assay controls. 3 T3 cells were cultured until reaching 80% confluence. The cell monolayers were scratched, and the medium of the culture was changed as follows: RPMI (negative control); DMEM + FBS (positive control). Values show the mean ± standard deviation.

Published
2020
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12. Additional file 2 of Combined therapy with adipose tissue-derived mesenchymal stromal cells and meglumine antimoniate controls lesion development and parasite load in murine cutaneous leishmaniasis caused by Leishmania amazonensis

Author

Tadeu Diniz Ramos, Johnatas Dutra Silva, Fonseca-Martins, Alessandra Marcia Da, Pratti, Juliana Elena Da Silveira, Firmino-Cruz, Luan, Maciel-Oliveira, Diogo, Dos-Santos, Julio Souza, Tenorio, João Ivo Nunes, Almair Ferreira De Araujo, Célio Geraldo Freire-De-Lima, Diaz, Bruno Lourenço, Cruz, Fernanda Ferreira, Rocco, Patricia Rieken Macedo, and Guedes, Herbert Leonel De Matos

Abstract

Additional file 2 : Figure S2. Detection of T CD8+ lymphocytes by flow cytometry (FACS). Cells were collected from the draining popliteal lymph node macerate, counted under a microscope (40× magnification), and analyzed by flow cytometry (FACS CANTO BD) for T CD8+ lymphocyte expression after 52 days of infection. Results shown as percentage and total population of cells positive for these markers in CD3+ marker-positive lymphocytes. (A) Percentage of CD8+ T lymphocytes; (B) Total CD8+ T lymphocyte population; Values show the mean ± standard deviation for each group. * P

Published
2020
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15. Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis

Author

dos-Santos, Júlio Souza, primary, Firmino-Cruz, Luan, additional, Ramos, Tadeu Diniz, additional, Fonseca-Martins, Alessandra Marcia da, additional, Oliveira-Maciel, Diogo, additional, De-Medeiros, Juliana Valente Rodrigues, additional, Chaves, Suzana Passos, additional, Gomes, Daniel Claudio Oliveira, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2019
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16. Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice

Author

Bezerra, Izabella Pereira da Silva, primary, Oliveira-Silva, Gabriel, additional, Braga, Danielle Sophia Ferreira Santos, additional, de Mello, Mirian França, additional, Pratti, Juliana Elena Silveira, additional, Pereira, Joyce Carvalho, additional, da Fonseca-Martins, Alessandra Marcia, additional, Firmino-Cruz, Luan, additional, Maciel-Oliveira, Diogo, additional, Ramos, Tadeu Diniz, additional, Vale, André Macedo, additional, Gomes, Daniel Claudio Oliveira, additional, Rossi-Bergmann, Bartira, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2019
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17. The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy

Author

Pratti, Juliana Elena Silveira, primary, da Fonseca Martins, Alessandra Marcia, additional, da Silva, Juliana Paiva, additional, Ramos, Tadeu Diniz, additional, Pereira, Joyce Carvalho, additional, Firmino-Cruz, Luan, additional, Oliveira-Maciel, Diogo, additional, Vieira, Thiago Soares de Souza, additional, Lacerda, Leandra Linhares, additional, Vale, Andre Macedo, additional, Freire-de-Lima, Celio G., additional, Gomes, Daniel C. Oliveira, additional, Saraiva, Elvira M., additional, Rossi-Bergmann, Bartira, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2019
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18. Immunomodulating role of IL-10-producing B cells in Leishmania amazonensis infection

Author

Firmino-Cruz, Luan, primary, Ramos, Tadeu Diniz, additional, da Fonseca-Martins, Alessandra Marcia, additional, Maciel-Oliveira, Diogo, additional, Oliveira-Silva, Gabriel, additional, Pratti, Juliana Elena Silveira, additional, Cavazzoni, Cecília, additional, Chaves, Suzana Passos, additional, Oliveira Gomes, Daniel Claudio, additional, Morrot, Alexandre, additional, Freire-de-Lima, Leonardo, additional, Vale, André M., additional, Freire-de-Lima, Celio Geraldo, additional, Decote-Ricardo, Debora, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2018
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19. Effects of Bone Marrow Mesenchymal Stromal Cell Therapy in Experimental Cutaneous Leishmaniasis in BALB/c Mice Induced by Leishmania amazonensis

Author

Pereira, Joyce Carvalho, primary, Ramos, Tadeu Diniz, additional, Silva, Johnatas Dutra, additional, de Mello, Mirian França, additional, Pratti, Juliana Elena Silveira, additional, da Fonseca-Martins, Alessandra Marcia, additional, Firmino-Cruz, Luan, additional, Kitoko, Jamil Zola, additional, Chaves, Suzana Passos, additional, Gomes, Daniel Claudio De Oliveira, additional, Diaz, Bruno Lourenço, additional, Rocco, Patricia R. M., additional, and de Matos Guedes, Herbert Leonel, additional

Published
2017
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20. MPLA and AddaVax ® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis.

Author

Oliveira-Maciel, Diogo, dos-Santos, Júlio Souza, Oliveira-Silva, Gabriel, Mello, Mirian França de, da Fonseca-Martins, Alessandra Marcia, Carneiro, Monique Pacheco Duarte, Ramos, Tadeu Diniz, Firmino-Cruz, Luan, Gomes, Daniel Claudio Oliveira, Rossi-Bergmann, Bartira, and de Matos Guedes, Herbert Leonel

Subjects
CUTANEOUS leishmaniasis, LEISHMANIASIS, VACCINES, VACCINE effectiveness, IMMUNIZATION, LEISHMANIA
Abstract

There is so far no vaccine approved for human leishmaniasis, mainly because of the lack of appropriate adjuvants. This study aimed to evaluate in mice the capacity of a mixture of monophosphoryl lipid A (MPLA) and AddaVax® adjuvants in enhancing the efficacy of a Leishvacin®-like vaccine comprised of Leishmania amazonensis whole antigens (LaAg). For that, mice were immunized with LaAg plus MPLA/AddaVax® by the intramuscular route (i.m.) prior to challenge with 2 × 105 and 2 × 106 living parasites. Immunization with LaAg alone reduced the lesion growth of the 2 × 105-challenged mice only in the peak of infection, but that was not accompanied by reduced parasite load, and thus not considered protective. Mice given a 2 × 106 -challenge were not protected by LaAg. The association of LaAg with MPLA/AddaVax® was able to enhance the cutaneous hypersensitivity response compared with LaAg alone. Despite this, there was no difference in proliferative cell response to antigen ex vivo. Moreover, regardless of the parasite challenge, association of LaAg with MPL/AddaVax® did not significantly enhance protection in comparison with LaAg alone. This work demonstrated that MPL/AddaVax® is not effective in improving the efficacy of i.m. LaAg vaccine against cutaneous leishmaniasis. [ABSTRACT FROM AUTHOR]

Published
2021
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