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327 results on '"Fischer, Dagmar-Christiane"'

1. No substantial neurocognitive impact of COVID-19 across ages and disease severity: a multicenter biomarker study of SARS-CoV-2 positive and negative adult and pediatric patients with acute respiratory tract infections

Author

Ehler, Johannes, Klawitter, Felix, von Möllendorff, Friedrich, Zacharias, Maike, Fischer, Dagmar-Christiane, Danckert, Lena, Bajorat, Rika, Hackenberg, Johanna, Bertsche, Astrid, Loebermann, Micha, Geerdes-Fenge, Hilte, Fleischmann, Robert, Klinkmann, Gerd, Schramm, Patrick, Schober, Sarah, Petzold, Axel, Perneczky, Robert, and Saller, Thomas

Published
2024
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3. Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on Vascular Calcification in Hemodialysis Patients (Trevasc-HDK)

Author

Haroon, Sabrina, Davenport, Andrew, Ling, Lieng-Hsi, Tai, Bee-Choo, Teo, Lynette-Li-San, Schurgers, Leon, Chen, Zhaojin, Shroff, Rukshana, Fischer, Dagmar-Christiane, Khatri, Priyanka, Low, Sanmay, Tan, Jia-Neng, Chua, Horng-Ruey, Teo, Boon-Wee, Ong, Ching-Ching, Subramanian, Srinivas, Yeo, Xi-Er, Wong, Weng-Kin, and Lau, Titus-Wai-Leong

Published
2023
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4. Naturally occurring stable calcium isotope ratios are a novel biomarker of bone calcium balance in chronic kidney disease

Author

Shroff, Rukshana, Lalayiannis, Alexander D., Fewtrell, Mary, Schmitt, Claus Peter, Bayazit, Aysun, Askiti, Varvara, Jankauskiene, Augustina, Bacchetta, Justine, Silva, Selmy, Goodman, Nadine, McAlister, Louise, Biassoni, Lorenzo, Crabtree, Nicola, Rahn, Anja, Fischer, Dagmar-Christiane, Heuser, Alexander, Kolevica, Ana, and Eisenhauer, Anton

Published
2022
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7. Hemodiafiltration Is Associated With Reduced Inflammation and Increased Bone Formation Compared With Conventional Hemodialysis in Children: The HDF, Hearts and Heights (3H) Study

Author

Fischer, Dagmar-Christiane, Smith, Colette, De Zan, Francesca, Bacchetta, Justine, Bakkaloglu, Sevcan A., Agbas, Ayse, Anarat, Ali, Aoun, Bilal, Askiti, Varvara, Azukaitis, Karolis, Bayazit, Aysun, Bulut, Ipek Kaplan, Canpolat, Nur, Borzych-Dużałka, Dagmara, Duzova, Ali, Habbig, Sandra, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Obrycki, Lukasz, Paglialonga, Fabio, Rahn, Anja, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish D., Spasojevic, Brankica, Stefanidis, Constantinos J., Vidal, Enrico, Yilmaz, Alev, Fischbach, Michel, Schaefer, Franz, Schmitt, Claus Peter, and Shroff, Rukshana

Published
2021
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11. Force loss and distribution of load in the hands of patients with cubital tunnel syndrome.

Author

Garkisch, Angelina, Rohmfeld, Kristina, Fischer, Dagmar-Christiane, Prommersberger, Karl-Josef, and Mühldorfer-Fodor, Marion

Subjects
CUBITAL tunnel syndrome, ULNAR neuropathies, HAND-foot syndrome
Abstract

Manugraphy with three different cylinder sizes was used to quantify the contribution of fingers, thumb and palm to grip force in patients with unilateral cubital tunnel syndrome. Forces in the affected and contralateral hands differed by up to 29%. Although grip force is usually maximal when gripping small handles, ulnar nerve palsy resulted in similar absolute grip forces using the 100-mm and 200-mm cylinders. The contact area between the affected hand and the cylinders was reduced by 5%–9%. We noted a high correlation between the contact area and grip force, visible atrophy and permanently impaired sensibility. The load distribution differed significantly between both hands for all cylinder sizes. When gripping large objects, the main functional impairment in cubital tunnel syndrome is weakness in positioning and stabilizing the thumb. Weak intrinsic finger muscles are responsible for loss of force when gripping small objects. Level of evidence: III [ABSTRACT FROM AUTHOR]

Published
2024
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15. Efficacy of dietary vitamin D3 and 25(OH)D3 on reproductive capacities, growth performance, immunity and bone development in pigs.

Author

Hasan, Maruf, Oster, Michael, Reyer, Henry, Wimmers, Klaus, and Fischer, Dagmar-Christiane

Subjects
SWINE physiology, HUMAN growth, NATURAL immunity, BONE growth, NUTRITIONAL assessment, CALCITRIOL, NUTRITION, SERUM, PHOSPHORUS, CHOLECALCIFEROL, DIETARY supplements, VITAMIN D, TREATMENT effectiveness, IMMUNITY, MICRONUTRIENTS, BONE density, CALCIUM, REPRODUCTIVE health, PHENOTYPES
Abstract

Vitamin D3 (Vit D3) and 25(OH)D3 are used as dietary sources of active vitamin D (1,25(OH)2D3) in pig husbandry. Although acting primarily on intestine, kidney and bone, their use in pig nutrition has shown a wide range of effects also in peripheral tissues. However, there is an ambiguity in the existing literature about whether the effects of Vit D3 and 25(OH)D3 differ in attributing the molecular and phenotypic outcomes in pigs. We searched Web of Science and PubMed databases concerning the efficacy of Vit D3 in comparison with 25(OH)D3 on pig physiology, i.e. reproductive capacities, growth performance, immunity and bone development. Dietary intake of Vit D3 or 25(OH)D3 did not influence the reproductive capacity of sows. Unlike Vit D3, the maternal intake of 25(OH)D3 significantly improved the growth performance of piglets, which might be attributed to maternally induced micronutrient efficiency. Consequently, even in the absence of maternal vitamin D supplementation, 25(OH)D3-fed offspring also demonstrated better growth than the offspring received Vit D3. Moreover, a similar superior impact of 25(OH)D3 was seen with respect to serum markers of innate and humoral immunity. Last but not least, supplements containing 25(OH)D3 were found to be more effective than Vit D3 to improve bone mineralisation and formation, especially in pigs receiving basal diets low in Ca and phosphorus. The insights are of particular value in determining the principal dietary source of vitamin D to achieve its optimum utilisation efficiency, nutritional benefits and therapeutic potency and to further improve animal welfare across different management types. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Endothelial dysfunction during long-term follow-up in children with STEC hemolytic-uremic syndrome

Author

Kreuzer, Martin, Sollmann, Laura, Ruben, Stephan, Leifheit-Nestler, Maren, Fischer, Dagmar-Christiane, Pape, Lars, and Haffner, Dieter

Subjects
Health
Abstract

Background Shiga-toxin-producing Escherichia coli (STEC)-associated hemolytic-uremic syndrome (HUS) is a major cause of acute kidney injury (AKI), especially in children. Its long-term outcome with respect to endothelial damage remains largely elusive. Methods This was a cross-sectional study in 26 children who had suffered from STEC-HUS in the past and achieved a complete recovery of renal function (eGFR >90 ml/min/1.73 m.sup.2). Skin microcirculation after local heating was assessed by laser Doppler fluximetry, carotid-femoral pulse wave velocity (PWV), carotid intima media thickness (cIMT), 24-h ambulatory blood pressure, and angiopoietin (Ang) 1 and 2 serum levels after a median follow-up period of 6.1 years. The results were compared to those of healthy controls. Results All patients were normotensive, mean eGFR was 102 (range 91-154) ml/min/1.73 m.sup.2, and 13 of the 26 patients showed albuminuria. Endothelial dysfunction was present in 13 patients, and the mean serum Ang2/Ang1 ratio was increased compared to healthy children (each p < 0.05). In contrast, mean values for PWV and cIMT in the patients did not differ from those of the controls. Endothelial dysfunction was significantly associated with younger age at STEC-HUS manifestation, time after HUS, and presence of albuminuria. Conclusion The results of this study highlight the need for long-term follow-up of STEC-HUS patients even after complete recovery of eGFR and lack of hypertension with respect to microvascular damage., Author(s): Martin Kreuzer [sup.1] , Laura Sollmann [sup.1] , Stephan Ruben [sup.1] , Maren Leifheit-Nestler [sup.1] , Dagmar-Christiane Fischer [sup.2] , Lars Pape [sup.1] , Dieter Haffner [sup.1] Author Affiliations: [...]

Published
2017
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23. FC 133HEMODIAFILTRATION IS ASSOCIATED WITH REDUCED INFLAMMATION AND INCREASED BONE TURNOVER COMPARED TO CONVENTIONAL HEMODIALYSIS IN CHILDREN - THE HDF, HEART AND HEIGHT (3H) STUDY

Author

Fischer, Dagmar-Christiane, primary, Smith, Colette, additional, De Zan, Francesca, additional, Askiti, Varvara, additional, Bayazit, Aysun Karabay, additional, Canpolat, Nur, additional, Litwin, Mieczyslaw, additional, Paglialonga, Fabio, additional, Schaefer, Franz, additional, Schmitt, Claus, additional, and Shroff, Rukshana, additional

Published
2021
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24. Arterial stiffness is increased in asthmatic children

Author

Steinmann, Markus, Abbas, Chiara, Singer, Florian, Casaulta, Carmen, Regamey, Nicolas, Haffner, Dieter, Fischer, Dagmar-Christiane, Simonetti, Giacomo, Steinmann, Markus, Abbas, Chiara, Singer, Florian, Casaulta, Carmen, Regamey, Nicolas, Haffner, Dieter, Fischer, Dagmar-Christiane, and Simonetti, Giacomo

Abstract

Altered arterial stiffness is a recognized risk factor of poor cardiovascular health. Chronic inflammation may increase arterial stiffness. We tested whether arterial stiffness is increased children with asthma, a chronic disease characterized by fluctuating airway and systemic inflammation. Arterial stiffness, expressed as carotid-femoral pulse wave velocity (PWVcf), was measured in 37 mild-to-moderate asthmatic children: 11 girls, median (range) age 11.1years (6-15). PWVcf in asthma was compared to PWVcf in 65 healthy controls matched for age, height, and gender previously studied in Germany and was correlated with airway inflammation and obstruction. PWVcf was higher in asthmatic children compared to controls: PWVcf median (interquartile range) was 4.7m/s (4.5-4.9) vs. 4.3m/s (4.1-4.7), p < 0.0001. In asthmatic children, PWVcf was inversely associated (r 2 = 0.20, p = 0.004) with forced expiratory volume in 1s (FEV1). This association remained significant after adjusting for possible confounders including body mass index, blood pressure, steroid use, and FeNO. Conclusion: Arterial stiffness is increased in children with mild-to-moderate asthma. The association between impaired lung function and increased arterial stiffness suggests that severity of disease translates into detrimental effects on the cardiovascular system.

Published
2021

41. Naturally Occurring Stable Calcium Isotope Ratios in Body Compartments Provide a Novel Biomarker of Bone Mineral Balance in Children and Young Adults

Author

Shroff, Rukshana, primary, Fewtrell, Mary, additional, Heuser, Alexander, additional, Kolevica, Ana, additional, Lalayiannis, Alexander, additional, McAlister, Louise, additional, Silva, Selmy, additional, Goodman, Nadine, additional, Schmitt, Claus P, additional, Biassoni, Lorenzo, additional, Rahn, Anja, additional, Fischer, Dagmar‐Christiane, additional, and Eisenhauer, Anton, additional

Published
2020
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45. Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis

Author

Prakasam, Ruby Kala, primary, Matuszewska-Iwanicka, Aleksandra, additional, Fischer, Dagmar-Christiane, additional, Schumann, Heidrun, additional, Tschöpe, Diethelm, additional, Stratmann, Bernd, additional, Hettlich, Hans-Joachim, additional, Guthoff, Rudolf F., additional, Stachs, Oliver, additional, and Röhlig, Martin, additional

Published
2020
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46. MO055STABLE CALCIUM ISOTOPES: A NOVEL BIOMARKER OF BONE MINERAL CONTENT IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Author

Shroff, Rukshana, primary, Heuser, Alex, primary, Lalayiannis, Alex, primary, Karabay Bayazit, Aysun, primary, Jankauskiene, Augustina, primary, BACCHETTA, JUSTINE, primary, Askiti, Varvara, primary, Schmitt, Claus, primary, Mitsioni, Andromachi, primary, Crabtree, Nicola, primary, Fewtrell, Mary, primary, Biassoni, Lorenzo, primary, Fischer, Dagmar-Christiane, primary, and Eisenhauer, Anton, primary

Published
2020
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