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1. Radio Pulse Profile Evolution of Magnetar Swift J1818.0-1607

Author

Fisher, Rebecca, Butterworth, Elliot, Rajwade, Kaustubh, Stappers, Ben, Desvignes, Gregory, Karuppusamy, Ramesh, Kramer, Michael, Liu, Kuo, Lyne, Andrew, Mickaliger, Mitchell, Shaw, Benjamin, and Weltevrede, Patrick

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The shape and polarisation properties of the radio pulse profiles of radio-loud magnetars provide a unique opportunity to investigate their magnetospheric properties. Gaussian Process Regression analysis was used to investigate the variation in the total intensity shape of the radio pulse profiles of the magnetar Swift J1818.0-1607. The observed profile shape was found to evolve through three modes between MJDs 59104 and 59365. The times at which these transitions occurred coincided with changes in the amplitude of modulations in the spin-down rate. The amount of linear and circular polarisation was also found to vary significantly with time. Lomb-Scargle periodogram analysis of the spin-down rate revealed three possibly harmonically related frequencies. This could point to the magnetar experiencing seismic activity. However, no profile features exhibited significant periodicity, suggesting no simple correlations between the profile variability and fluctuations of the spin-down on shorter timescales within the modes. Overall, this implies the mode changes seen are a result of local magnetospheric changes, with other theories, such as precession, less able to explain these observations., Comment: 11 pages, 6 figures, accepted for publication in MNRAS

Published
2024

4. Directed conservation of the world’s reef sharks and rays

Author

Goetze, Jordan S., Heithaus, Michael R., MacNeil, M. Aaron, Harvey, Euan, Simpfendorfer, Colin A., Heupel, Michelle R., Meekan, Mark, Wilson, Shaun, Bond, Mark E., Speed, Conrad W., Currey-Randall, Leanne M., Fisher, Rebecca, Sherman, C. Samantha, Kiszka, Jeremy J., Rees, Matthew J., Udyawer, Vinay, Flowers, Kathryn I., Clementi, Gina M., Asher, Jacob, Beaufort, Océane, Bernard, Anthony T. F., Berumen, Michael L., Bierwagen, Stacy L., Boslogo, Tracey, Brooks, Edward J., Brown, J. Jed, Buddo, Dayne, Cáceres, Camila, Casareto, Sara, Charloo, Venkatesh, Cinner, Joshua E., Clua, Eric E. G., Cochran, Jesse E. M., Cook, Neil, D’Alberto, Brooke M., de Graaf, Martin, Dornhege-Lazaroff, Mareike C., Fanovich, Lanya, Farabaugh, Naomi F., Fernando, Daniel, Ferreira, Carlos Eduardo Leite, Fields, Candace Y. A., Flam, Anna L., Floros, Camilla, Fourqurean, Virginia, Barcia, Laura García, Garla, Ricardo, Gastrich, Kirk, George, Lachlan, Graham, Rory, Hagan, Valerie, Hardenstine, Royale S., Heck, Stephen M., Heithaus, Patricia, Henderson, Aaron C., Hertler, Heidi, Hueter, Robert E., Johnson, Mohini, Jupiter, Stacy D., Kaimuddin, Muslimin, Kasana, Devanshi, Kelley, Megan, Kessel, Steven T., Kiilu, Benedict, Kyne, Fabian, Langlois, Tim, Lawe, Jaedon, Lédée, Elodie J. I., Lindfield, Steve, Maggs, Jade Q., Manjaji-Matsumoto, B. Mabel, Marshall, Andrea, Matich, Philip, McCombs, Erin, McLean, Dianne, Meggs, Llewelyn, Moore, Stephen, Mukherji, Sushmita, Murray, Ryan, Newman, Stephen J., O’Shea, Owen R., Osuka, Kennedy E., Papastamatiou, Yannis P., Perera, Nishan, Peterson, Bradley J., Pina-Amargós, Fabián, Ponzo, Alessandro, Prasetyo, Andhika, Quamar, L. M. Sjamsul, Quinlan, Jessica R., Razafindrakoto, Christelle F., Rolim, Fernanda A., Ruiz-Abierno, Alexei, Ruiz, Hector, Samoilys, Melita A., Sala, Enric, Sample, William R., Schärer-Umpierre, Michelle, Schoen, Sara N., Schlaff, Audrey M., Smith, Adam N. H., Sparks, Lauren, Stoffers, Twan, Tanna, Akshay, Torres, Rubén, Travers, Michael J., Valentin-Albanese, Jasmine, Warren, Joseph D., Watts, Alexandra M., Wen, Colin K., Whitman, Elizabeth R., Wirsing, Aaron J., Zarza-González, Esteban, and Chapman, Demian D.

Published
2024
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5. Incorporating uncertainty in Indigenous sea Country monitoring with Bayesian statistics: Towards more informed decision-making

Author

Cure, Katherine, Barneche, Diego R., Depczynski, Martial, Fisher, Rebecca, Warne, David J., McGree, James, Underwood, Jim, Weisenberger, Frank, Evans-Illidge, Elizabeth, Ford, Brendan, Oades, Daniel, Howard, Azton, McCarthy, Phillip, Pyke, Damon, Edgar, Zac, Maher, Rodney, Sampi, Trevor, Dougal, Kevin, and Bardi Jawi Traditional Owners

Published
2024
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6. Communicating uncertainty in Indigenous sea Country monitoring with Bayesian statistics: towards more informed decision-making

Author

Cure, Katherine, Barneche, Diego R, Depczynski, Martial, Fisher, Rebecca, Warne, David J, McGree, James M, Underwood, Jim, Weisenberger, Frank, Evans-Illidge, Elizabeth, Oades, Daniel, Howard, Azton, McCarthy, Phillip, Pyke, Damon, Edgar, Zac, Maher, Rodney, Sampi, Trevor, and Owners, Bardi Jawi Traditional

Subjects
Statistics - Applications
Abstract

First Nations Australians have a cultural obligation to look after land and sea Country, and Indigenous-partnered science is beginning to drive socially inclusive initiatives in conservation. The Australian Institute of Marine Science has partnered with Indigenous communities in systematically collecting monitoring data to understand the natural variability of ecological communities and better inform sea Country management. Monitoring partnerships are centred around the 2-way sharing of Traditional Ecological Knowledge, training in science and technology, and developing communication products that can be accessed across the broader community. We present a case study with the Bardi Jawi Rangers in northwest Australia focusing on a 3-year co-developed and co-delivered monitoring dataset for culturally important fish in coral reef ecosystems. We show how uncertainty estimated by Bayesian statistics can be incorporated into monitoring indicators and facilitate fuller communication between scientists and First Nations partners about the limitations of monitoring to identify change.

Published
2023

7. Estimated Effectiveness of JYNNEOS Vaccine in Preventing Mpox: A Multijurisdictional Case-Control Study — United States, August 19, 2022–March 31, 2023

Author

Dalton, Alexandra F, Diallo, Alpha Oumar, Chard, Anna N, Moulia, Danielle L, Deputy, Nicholas P, Fothergill, Amy, Kracalik, Ian, Wegner, Christopher W, Markus, Tiffanie M, Pathela, Preeti, Still, William L, Hawkins, Sam, Mangla, Anil T, Ravi, Nivedita, Licherdell, Erin, Britton, Amber, Lynfield, Ruth, Sutton, Melissa, Hansen, AmberJean P, Betancourt, Gabriela S, Rowlands, Jemma V, Chai, Shua J, Fisher, Rebecca, Danza, Phoebe, Farley, Monica, Zipprich, Jennifer, Prahl, Gregory, Wendel, Karen A, Niccolai, Linda, Castilho, Jessica L, Payne, Daniel C, Cohn, Amanda C, Feldstein, Leora R, Group, CDC Multijurisdictional Mpox Case-Control Study, Group, CDC Multijurisdictional Mpox Case Control Study, Saadeh, Kayla, Snyder, Robert E, Anderson, Madeline, Anguiano, Vanessa Aryana, Nadle, Joelle, Rothrock, Gretchen, Jones, Sydney, Duval, Lauren, Herlihy, Rachel, Stringer, Ginger, Weber, Robyn, Phan, Quyen, Sosa, Lynn, Meek, James, Lee, Michelle, Morrow, Allison S, Willut, Christina, Carlson, Jesse, Kamis, Kevin, Nishiyama, Masayo, Simien, Gena, Colasanti, Jonathan, van der Woude, Tamsin M, Archer, Roxanne, Finn, Lauren, Lam, Jane, Moulton, Bret, Peterson, Erin, Bolan, Robert, Garcia-Lopez, Gabriel, Como-Sabetti, Kathryn, Ruff, Anna, Schneider, Dakota, Robinson, Tracy, Anderson, Bridget J, Engesser, Kerianne, McGuire, Suzanne, Rowe, Adam, Pride, Christopher, Mitchell, Jaxon, Tourkina, Yelena, Cieslak, Paul R, Fill, Mary Margaret, Wiedeman, Caleb, Dumyati, Ghinwa, Felsen, Christina, Lewnard, Joseph A, Akoko, Bentley, Mansilla-Dubon, Kristyne, Ndi, Danielle, Talbot, H Keipp, Tiwari, Sweta, and Wyatt, Dayna

Subjects
Rare Diseases, Immunization, Infectious Diseases, Vaccine Related, Emerging Infectious Diseases, Prevention, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Infection, Good Health and Well Being, Adult, Male, Humans, United States, Homosexuality, Male, Case-Control Studies, Monkeypox, Sexual and Gender Minorities, Smallpox Vaccine, CDC Multijurisdictional Mpox Case-Control Study Group, CDC Multijurisdictional Mpox Case Control Study Group, General & Internal Medicine
Abstract

As of March 31, 2023, more than 30,000 monkeypox (mpox) cases had been reported in the United States in an outbreak that has disproportionately affected gay, bisexual, and other men who have sex with men (MSM) and transgender persons (1). JYNNEOS vaccine (Modified Vaccinia Ankara vaccine, Bavarian Nordic) was approved by the Food and Drug Administration (FDA) in 2019 for the prevention of smallpox and mpox via subcutaneous injection as a 2-dose series (0.5 mL per dose, administered 4 weeks apart) (2). To expand vaccine access, an Emergency Use Authorization was issued by FDA on August 9, 2022, for dose-sparing intradermal injection of JYNNEOS as a 2-dose series (0.1 mL per dose, administered 4 weeks apart) (3). Vaccination was available to persons with known or presumed exposure to a person with mpox (postexposure prophylaxis [PEP]), as well as persons at increased risk for mpox or who might benefit from vaccination (preexposure mpox prophylaxis [PrEP]) (4). Because information on JYNNEOS vaccine effectiveness (VE) is limited, a matched case-control study was conducted in 12 U.S. jurisdictions,† including nine Emerging Infections Program sites and three Epidemiology and Laboratory Capacity sites,§ to evaluate VE against mpox among MSM and transgender adults aged 18-49 years. During August 19, 2022-March 31, 2023, a total of 309 case-patients were matched to 608 control patients. Adjusted VE was 75.2% (95% CI = 61.2% to 84.2%) for partial vaccination (1 dose) and 85.9% (95% CI = 73.8% to 92.4%) for full vaccination (2 doses). Adjusted VE for full vaccination by subcutaneous, intradermal, and heterologous routes of administration was 88.9% (95% CI = 56.0% to 97.2%), 80.3% (95% CI = 22.9% to 95.0%), and 86.9% (95% CI = 69.1% to 94.5%), respectively. Adjusted VE for full vaccination among immunocompromised participants was 70.2% (95% CI = -37.9% to 93.6%) and among immunocompetent participants was 87.8% (95% CI = 57.5% to 96.5%). JYNNEOS is effective at reducing the risk for mpox. Because duration of protection of 1 versus 2 doses remains unknown, persons at increased risk for mpox exposure should receive the 2-dose series as recommended by the Advisory Committee on Immunization Practices (ACIP),¶ regardless of administration route or immunocompromise status.

Published
2023

8. Model-robust Bayesian design through Generalised Additive Models for monitoring submerged shoals

Author

De Silva, Dilishiya, Fisher, Rebecca, Radford, Ben, Thompson, Helen, and McGree, James

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

Optimal sampling strategies are critical for surveys of deeper coral reef and shoal systems, due to the significant cost of accessing and field sampling these remote and poorly understood ecosystems. Additionally, well-established standard diver-based sampling techniques used in shallow reef systems cannot be deployed because of water depth. Here we develop a Bayesian design strategy to optimise sampling for a shoal deep reef system using three years of pilot data. Bayesian designs are generally found by maximising the expectation of a utility function with respect to the joint distribution of the parameters and the response conditional on an assumed statistical model. Unfortunately, specifying such a model a priori is difficult as knowledge of the data generating process is typically incomplete. To address this, we present an approach to find Bayesian designs that are robust to unknown model uncertainty. This is achieved through couching the specified model within a Generalised Additive Modelling framework and formulating prior information that allows the additive component to capture discrepancies between what is assumed and the underlying data generating process. The motivation for this is to enable Bayesian designs to be found under epistemic model uncertainty; a highly desirable property of Bayesian designs. Our approach is demonstrated initially on an exemplar design problem where a theoretic result is derived and used to explore the properties of optimal designs. We then apply our approach to design future monitoring of sub-merged shoals off the north-west coast of Australia with the aim of significantly improving on current monitoring designs.

Published
2022

10. Designing Formative Assessments to Improve Anatomy Exam Performance

Author

Kingston, Amanda K., Garofalo, Evan M., Cardoza, Kristinmae, and Fisher, Rebecca E.

Abstract

Formative assessments are primarily used as a tool to gauge learning throughout an anatomy course. They have also been demonstrated to improve student mastery and exam performance, although the precise nature of this relationship is poorly understood. In this study, it is hypothesized that formative assessment questions targeting higher cognitive levels, integrating topics from multiple lessons, and including visuospatial elements will increase student exam performance. Formative and summative questions provided to students during the Clinical Anatomy block at the University of Arizona College of Medicine--Phoenix between 2015 and 2018 were assessed for cognitive level, integration of targeted learning objectives, and presence or absence of visuospatial elements. These variables were entered into a hierarchical linear model along with demographic variables for each cohort to assess the relationships between these variables and cohort performance on exam questions. The best predictor of exam performance was the inclusion of constituent learning objectives within the formative assessment. Additionally, students performed better on exam questions with visuospatial elements when the targeted learning objectives were also associated with visuospatial elements on the formative assessment. Surprisingly, the cognitive level of formative questions and the integration of learning objectives within them were not correlated with student exam performance. This study demonstrates the importance of including a broad range of topics in formative assessments and highlights a potential benefit of adopting consistent question formats for formative assessments and exams.

Published
2023
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11. Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells

Author

Renda, Fioranna, Miles, Christopher, Tikhonenko, Irina, Fisher, Rebecca, Carlini, Lina, Kapoor, Tarun M, Mogilner, Alex, and Khodjakov, Alexey

Subjects
Bioengineering, Genetics, Chromosome Segregation, Humans, Kinetochores, Microtubules, Mitosis, Spindle Apparatus, agent-based simulation, chromosome segregation, computational model, kinetochore, mitosis, spindle assembly, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology
Abstract

Proper segregation of chromosomes during mitosis depends on "amphitelic attachments"-load-bearing connections of sister kinetochores to the opposite spindle poles via bundles of microtubules, termed as the "K-fibers." Current models of spindle assembly assume that K-fibers arise largely from stochastic capture of microtubules, which occurs at random times and locations and independently at sister kinetochores. We test this assumption by following the movements of all kinetochores in human cells and determine that most amphitelic attachments form synchronously at a specific stage of spindle assembly and within a spatially distinct domain. This biorientation domain is enriched in bundles of antiparallel microtubules, and perturbation of microtubule bundling changes the temporal and spatial dynamics of amphitelic attachment formation. Structural analyses indicate that interactions of kinetochores with microtubule bundles are mediated by non-centrosomal short microtubules that emanate from most kinetochores during early prometaphase. Computational analyses suggest that momentous molecular motor-driven interactions with antiparallel bundles rapidly convert these short microtubules into nascent K-fibers. Thus, load-bearing connections to the opposite spindle poles form simultaneously on sister kinetochores. In contrast to the uncoordinated sequential attachments of sister kinetochores expected in stochastic models of spindle assembly, our model envisions the formation of amphitelic attachments as a deterministic process in which the chromosomes connect with the spindle poles synchronously at a specific stage of spindle assembly and at a defined location determined by the spindle architecture. Experimental analyses of changes in the kinetochore behavior in cells with perturbed activity of molecular motors CenpE and dynein confirm the predictive power of the model.

Published
2022

17. Risk of Clade II Mpox Associated with Intimate and Nonintimate Close Contact Among Men Who Have Sex with Men and Transgender Adults-United States, August 2022-July 2023

Author

Chard, Anna N., Dalton, Alexandra F., Diallo, Alpha Oumar, Moulia, Danielle L., Deputy, Nicholas P., Zecca, Italo B., Quilter, Laura A.S., Kachur, Rachel E., McCollum, Andrea M., Rowlands, Jemma V., Britton, Amber N., Fisher, Rebecca, Chai, Shua J., Licherdell, Erin, Still, William L., Morris, Adeline L., Castilho, Jessica L., Markus, Tiffanie M., Morrow, Allison S., Danza, Phoebe, Hansen, AmberJean P., Ali, Sophia Ibrahim, Wegner, Christopher W., Weber, Robyn, Betancourt, Gabriela S., Zipprich, Jennifer, Sutton, Melissa, Pathela, Preeti, Hawkins, Sam, Wendel, Karen A., and Feldstein, Leora R.

Subjects
Vaccination, Medical research, Medicine, Experimental, Transgender people -- Sexual behavior, Vaccines
Abstract

Introduction In May 2022, an unprecedented worldwide outbreak of clade II mpox, caused by monkeypox virus (MPXV), was detected among persons in countries with no history of sustained community transmission. [...]

Published
2024

18. Epidemiologic Characteristics of Mpox among People Experiencing Homelessness, Los Angeles County, California, USA, 2022

Author

Brosnan, Hannah K., Yeh, Karen W., Jones, Padma S., Gokhale, Sohum, Regos-Stewart, Dalia, Tran, Hang, Poortinga, Kathleen, Danza, Phoebe, Fisher, Rebecca, Finn, Lauren E., Foo, Chelsea, and Chang, Alicia H.

Subjects
Los Angeles, California -- Health aspects, Human monkeypox -- Statistics -- Risk factors -- Demographic aspects, Homeless persons -- Statistics -- Health aspects, Health
Abstract

Since May 2022, laboratory-confirmed cases of mpox have been reported across nonendemic countries including the United States, mostly among men who have sex with men (1,2). Persons experiencing homelessness (PEH) [...]

Published
2023
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25. Effects of malleable kinetochore morphology on measurements of intrakinetochore tension

Author

Renda, Fioranna, Magidson, Valentin, Tikhonenko, Irina, Fisher, Rebecca, Miles, Christopher, Mogilner, Alex, and Khodjakov, Alexey

Subjects
Biochemistry and Cell Biology, Biological Sciences, Bioengineering, Animals, Centromere Protein A, Chromosome Segregation, Chromosomes, Cytoskeletal Proteins, Humans, Kinetochores, Metaphase, Microtubules, Mitosis, Muntjacs, Nuclear Proteins, Paclitaxel, Spindle Apparatus, mitosis, kinetochores, intrakinetochore tension, Taxol, mitotic spindle, Microbiology, Immunology, Biological sciences, Biomedical and clinical sciences
Abstract

The distance between fluorescent spots formed by various kinetochore proteins (delta) is commonly interpreted as a manifestation of intrakinetochore tension (IKT) caused by microtubule-mediated forces. However, large-scale changes of the kinetochore architecture (such as its shape or dimensions) may also contribute to the value of delta. To assess contributions of these non-elastic changes, we compare behaviour of delta values in human kinetochores with small yet mechanically malleable kinetochores against compound kinetochores in Indian muntjac (IM) cells whose architecture remains constant. Due to the micrometre-scale length of kinetochore plates in IM, their shape and orientation are discernible in conventional light microscopy, which enables precise measurements of IKT independent of contributions from changes in overall architecture of the organelle. We find that delta in IM kinetochores remains relatively constant when microtubule-mediated forces are suppressed by Taxol, but it prominently decreases upon detachment of microtubules. By contrast, large decreases of delta observed in Taxol-treated human cells coincide with prominent changes in length and curvature of the kinetochore plate. These observations, supported by computational modelling, suggest that at least 50% of the decrease in delta in human cells reflects malleable reorganization of kinetochore architecture rather than elastic recoil due to IKT.

Published
2020

26. Successful Distribution of Tecovirimat During the Peak of the Mpox Outbreak--Los Angeles County, June 2022-January 2023

Author

O'Neil, Margaret J., Archer, Roxanne, Danza, Phoebe, Fisher, Rebecca, Bagwell, Dee Ann, Younis, Ibrahim, Kulkarni, Sonali, Rubin, Zachary, Kim, Moon, Balter, Sharon, Terashita, Dawn, Kim, Jee, Singhal, Rita, Hancz, Daniel, Gausche-Hill, Marianne, and Shah, Naman K.

Subjects
Public health -- Analysis, Pharmacy -- Analysis, Disease susceptibility -- Care and treatment, Emergency management -- Analysis, Health
Abstract

Introduction In May 2022, clade II mpox, historically endemic in West and Central Africa, became a widespread outbreak, with a public health emergency declared in the United States in August [...]

Published
2024

30. Monitoring Incidence of COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Status — 13 U.S. Jurisdictions, April 4–July 17, 2021

Author

Scobie, Heather M., Johnson, Amelia G., Suthar, Amitabh B., Severson, Rachel, Alden, Nisha B., Balter, Sharon, Bertolino, Daniel, Blythe, David, Brady, Shane, Cadwell, Betsy, Cheng, Iris, Davidson, Sherri, Delgadillo, Janelle, Devinney, Katelynn, Duchin, Jeff, Duwell, Monique, Fisher, Rebecca, Fleischauer, Aaron, Grant, Ashley, Griffin, Jennifer, Haddix, Meredith, Hand, Julie, Hanson, Matt, Hawkins, Eric, Herlihy, Rachel K., Hicks, Liam, Holtzman, Corinne, Hoskins, Mikhail, Hyun, Judie, Kaur, Ramandeep, Kay, Meagan, Kidrowski, Holly, Kim, Curi, Komatsu, Kenneth, Kugeler, Kiersten, Lewis, Melissa, Lyons, B. Casey, Lyons, Shelby, Lynfield, Ruth, McCaffrey, Keegan, McMullen, Chelsea, Milroy, Lauren, Meyer, Stephanie, Nolen, Leisha, Patel, Monita R., Pogosjans, Sargis, Reese, Heather E., Saupe, Amy, Sell, Jessica, Sokol, Theresa, Sosin, Daniel, Stanislawski, Emma, Stevens, Kelly, Vest, Hailey, White, Kelly, Wilson, Erica, MacNeil, Adam, Ritchey, Matthew D., and Silk, Benjamin J.

Published
2021

38. Outstanding Challenges in the Transferability of Ecological Models

Author

Yates, Katherine L, Bouchet, Phil J, Caley, M Julian, Mengersen, Kerrie, Randin, Christophe F, Parnell, Stephen, Fielding, Alan H, Bamford, Andrew J, Ban, Stephen, Barbosa, A Márcia, Dormann, Carsten F, Elith, Jane, Embling, Clare B, Ervin, Gary N, Fisher, Rebecca, Gould, Susan, Graf, Roland F, Gregr, Edward J, Halpin, Patrick N, Heikkinen, Risto K, Heinänen, Stefan, Jones, Alice R, Krishnakumar, Periyadan K, Lauria, Valentina, Lozano-Montes, Hector, Mannocci, Laura, Mellin, Camille, Mesgaran, Mohsen B, Moreno-Amat, Elena, Mormede, Sophie, Novaczek, Emilie, Oppel, Steffen, Crespo, Guillermo Ortuño, Peterson, A Townsend, Rapacciuolo, Giovanni, Roberts, Jason J, Ross, Rebecca E, Scales, Kylie L, Schoeman, David, Snelgrove, Paul, Sundblad, Göran, Thuiller, Wilfried, Torres, Leigh G, Verbruggen, Heroen, Wang, Lifei, Wenger, Seth, Whittingham, Mark J, Zharikov, Yuri, Zurell, Damaris, and Sequeira, Ana MM

Subjects
Ecology, Models, Biological, Predictive modeling, extrapolation, generality, habitat models, model transfers, species distribution models, uncertainty, Environmental Sciences, Biological Sciences, Evolutionary Biology
Abstract

Predictive models are central to many scientific disciplines and vital for informing management in a rapidly changing world. However, limited understanding of the accuracy and precision of models transferred to novel conditions (their 'transferability') undermines confidence in their predictions. Here, 50 experts identified priority knowledge gaps which, if filled, will most improve model transfers. These are summarized into six technical and six fundamental challenges, which underlie the combined need to intensify research on the determinants of ecological predictability, including species traits and data quality, and develop best practices for transferring models. Of high importance is the identification of a widely applicable set of transferability metrics, with appropriate tools to quantify the sources and impacts of prediction uncertainty under novel conditions.

Published
2018

46. Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol

Author

Chouliara, Niki, primary, Cameron, Trudi, additional, Ballard-Ridley, Scott, additional, Fisher, Rebecca J., additional, Kettlewell, Jade, additional, Kidd, Lisa, additional, Luxton, Leanna, additional, Pomeroy, Valerie, additional, Stockley, Rachel C., additional, Thomas, Shirley, additional, and Gordon, Adam L., additional

Published
2024
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47. Effectiveness of JYNNEOS vaccine against symptomatic mpox disease in adult men in Los Angeles County, August 29, 2022 to January 1, 2023

Author

Yeganeh, Nava, primary, Yin, Sherry, additional, Moir, Olivia, additional, Danza, Phoebe, additional, Kim, Moon, additional, Finn, Lauren, additional, Fisher, Rebecca, additional, Kulkarni, Sonali, additional, Perez, Mario, additional, Poortinga, Kathleen, additional, Garland, Wendy, additional, Foo, Chelsea, additional, Haddix, Meredith, additional, Archer, Roxanne, additional, Frey, Natalie, additional, Balter, Sharon, additional, Singhal, Rita, additional, and Kim, Andrea, additional

Published
2024
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