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1. The Five Periampullary Cancers, not Just Different Siblings but Different Families: An International Multicenter Cohort Study

Author

Uijterwijk, Bas A., Lemmers, Daniël H., Ghidini, Michele, Wilmink, Hanneke, Zaniboni, Alberto, Salvia, Roberto, Kito Fusai, Giuseppe, Groot Koerkamp, Bas, Koek, Sharnice, Ghorbani, Poya, Zerbi, Alessandro, Nappo, Gennaro, Luyer, Misha, Goh, Brian K. P., Roberts, Keith J., Boggi, Ugo, Mavroeidis, Vasileios K., White, Steven, Kazemier, Geert, Björnsson, Bergthor, Serradilla-Martín, Mario, House, Michael G., Alseidi, Adnan, Ielpo, Benedetto, Mazzola, Michele, Jamieson, Nigel, Wellner, Ulrich, Soonawalla, Zahir, Cabús, Santiago Sánchez, Dalla Valle, Raffaele, Pessaux, Patrick, Vladimirov, Miljana, Kent, Tara S., Tang, Chung N., Fisher, William E., Kleeff, Jorg, Mazzotta, Alessandro, Suarez Muñoz, Miguel Angel, Berger, Adam C., Ball, Chad G., Korkolis, Dimitris, Bannone, Elisa, Ferarri, Clarissa, Besselink, Marc G., and Abu Hilal, Mohammed

Published
2024
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2. The road to tailored adjuvant chemotherapy for all four non-pancreatic periampullary cancers: An international multimethod cohort study

Author

Uijterwijk, Bas A., Lemmers, Daniël H., Ghidini, Michele, Wilmink, Johanna W., Zaniboni, Alberto, Fusai, Giuseppe Kito, Zerbi, Alessandro, Koerkamp, Bas Groot, Luyer, Misha, Ghorbani, Poya, Salvia, Roberto, White, Steven, Ielpo, Benedetto, Goh, Brian K. P., Boggi, Ugo, Kazemier, Geert, House, Michael G., Mavroeidis, Vasileios K., Björnsson, Bergthor, Mazzola, Michele, Serradilla, Mario, Korkolis, Dimitris, Alseidi, Adnan, Roberts, Keith J., Soonawalla, Zahir, Pessaux, Patrick, Fisher, William E., Koek, Sharnice, Kent, Tara S., Vladimirov, Miljana, Bolm, Louisa, Jamieson, Nigel, Dalla Valle, Raffaele, Kleeff, Jorg, Mazzotta, Alessandro, Suarez Muñoz, Miguel Angel, Cabús, Santiago Sánchez, Ball, Chad G., Berger, Adam C., Ferarri, Clarissa, Besselink, Marc G., and Hilal, Mohammed Abu

Published
2024
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4. Tackling challenges in rare diseases: The ISGACA approach on non-pancreatic cancers in the periampullary region

Author

Berger, Adam C., Alseidi, Adnan, Pisanu, Adolfo, Ramirez-Del Val, Alejandro, Serrablo, Alejandro, Anselmo, Alessandro, Ferrero, Alessandro, Giani, Alessandro, Mazzotta, Alessandro, Zerbi, Alessandro, Moekotte, Alma, Zureikat, Amer H., Cacciaguerra, Andrea Benedetti, de Wilde, Anouk, Koerkamp, Bas Groot, Ielpo, Bennedetto, Björnsson, Bergthor, Al, Bilal, Sarireh, Goh, Brian K.P., Gayet, Brice, Ball, Chad G., Vollmer, Charles M., Tang, Chung N., van Dam, Coen, Ricci, Claudio, Droogh, Daphne, Korkolis, Dimitris, Sparrelid, Ernesto, Ausania, Fabio, di Benedetto, Fabrizio, Lancelotti, Francesco, Berevoet, Frederik, Kazemier, Geert, Nappo, Gennaro, Poya, Ghorbani, Marchegiani, Giovanni, Fusai, Giuseppe Kito, Malleo, Giuseppe, Seppanen, Hanna, Wilmink, Hanneke, Han, Ho-Seong, Frigerio, Isabella, Halle, James, Christein, John D., Kleeff, Jorg, de Vos Geelen, Judith, Johansen, Karin, Roberts, Keith J., Hayek, Kevin el, Khalil, Khalid, Webber, Laurence, Siragusa, Leandro, Bolm, Louisa, Maglione, Manuel, Ramaekers, Mark, Giuffrida, Mario, Gruppo, Mario, Serradilla, Mario, Ramaeckers, Mark, Fontana, Martina, Guerra, Martina, Dillhoff, Mary E., Mortimer, Matthew C.M., House, Michael G., Mazzola, Michele, Suarez Muñoz, Miguel Angel, Vladimirov, Miljana, Luyer, Misha, Bonds, Morgan, Kerem, Mustafa, Napoli, Niccolò, Mowbray, Nicholas, Jamieson, Nigel B., Soubrane, Olivier, Pessaux, Patrick, Mauro, Podda, Valle, Raffaele Dalla, Zheng, Richard, Casadei, Riccardo, Bhogal, Ricky, Salvia, Roberto, Salem, Ronald R., Cabús, Santiago Sánchez, Koek, Sharnice, Delis, Spiros, Bouwense, Stefan, Dreyer, Stephan, Behrman, Stephen W., White, Steven, Robinson, Stuart, Mieog, Sven, S.Kent, Tara, Vanagas, Tomas, Boggi, Ugo, Wellner, Ulrich, Mavroeidis, Vasileios K., Fisher, William E., Koh, Ye Xin, Soonawalla, Zahir, Uijterwijk, Bas A., Lemmers, Daniël H., Moekotte, Alma L., Zaniboni, Alberto, Ghidini, Michele, Milella, Michele, Scarpa, Aldo, Luchini, Claudio, Baboeram, Nigel, Klei, Dorine S., Manzoni, Alberto, Bannone, Elisa, Oneda, Ester, Besselink, Marc G., and Abu Hilal, Mohammed

Published
2024
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5. Circulating immune signatures in chronic pancreatitis with and without preceding acute pancreatitis: A pilot study

Author

Hagn-Meincke, Rasmus, Yadav, Dhiraj, Andersen, Dana K., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Bellin, Melena D., Topazian, Mark D., Conwell, Darwin L., Li, Liang, Van Den Eeden, Stephen K., Drewes, Asbjørn M., Pandol, Stephen J., Forsmark, Chris E., Fisher, William E., Hart, Phil A., Olesen, Søren S., and Park, Walter G.

Published
2024
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6. Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis

Author

Saloman, Jami L., Li, Yan, Stello, Kimberly, Li, Wenhao, Li, Shuang, Phillips, Anna Evans, Hall, Kristen, Fogel, Evan L., Vege, Santhi Swaroop, Li, Liang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Topazian, Mark D., Van Den Eeden, Stephen K., Serrano, Jose, Conwell, Darwin L., and Yadav, Dhiraj

Published
2023
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8. Distinct Serum Immune Profiles Define the Spectrum of Acute and Chronic Pancreatitis From the Multicenter Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) Study

Author

Li, Liang, Yadav, Dhiraj, Conwell, Darwin L., Hart, Phil A., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Andersen, Dana, Bellin, Melena D., Topazian, Mark, Van Den Eeden, Stephen K., Pandol, Stephen J., Forsmark, Chris, Fisher, William E., Park, Walter G., Lee, Bomi, Jones, Elaina K., Manohar, Murli, Topazian, Mark D., Forsmark, Chris E., Husain, Sohail Z., and Habtezion, Aida

Published
2023
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9. T1 signal intensity ratio of the pancreas as an imaging biomarker for the staging of chronic pancreatitis

Author

Tirkes, Temel, Dasyam, Anil K., Shah, Zarine K., Fogel, Evan L., Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Chang, Stephanie T., Farinas, Carlos A., Grajo, Joseph R., Mawad, Kareem, Takahashi, Naoki, Venkatesh, Sudhakar K., Wachsman, Ashley, Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Van Den Eeden, Stephen K., Yang, Yunlong, Topazian, Mark, Andersen, Dana K., Serrano, Jose, Conwell, Darwin L., and Yadav, Dhiraj

Published
2022
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11. Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design

Author

Yadav, Dhiraj, primary, Conwell, Darwin L., additional, Pandol, Stephen J., additional, Steen, Hanno, additional, Feng, Ziding, additional, Li, Liang, additional, Andersen, Dana, additional, Bellin, Melena, additional, Chari, Suresh T., additional, Cruz-Monserrate, Zobeida, additional, Fisher, William E., additional, Fogel, Evan L., additional, Forsmark, Christopher E., additional, Hart, Phil A., additional, Lesinski, Gregory B., additional, Park, Walter G., additional, Rinaudo, Jo Ann, additional, Saloman, Jami L., additional, Serrano, Jose, additional, Tirkes, Temel, additional, Topazian, Mark D., additional, van Den Eeden, Stephen, additional, Vege, Santhi Swaroop, additional, and Whitcomb, David C., additional

Published
2024
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12. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage

Author

Fisher, William E, Cruz-Monserrate, Zobeida, McElhany, Amy L, Lesinski, Gregory B, Hart, Phil A, Ghosh, Ria, Van Buren, George, Fishman, Douglas S, Rinaudo, Jo Ann S, Serrano, Jose, Srivastava, Sudhir, Mace, Thomas, Topazian, Mark, Feng, Ziding, Yadav, Dhiraj, Pandol, Stephen J, Hughes, Steven J, Liu, Robert Y, Lu, Emily, Orr, Robert, Whitcomb, David C, Abouhamze, Amer S, Steen, Hanno, Sellers, Zachary M, Troendle, David M, Uc, Aliye, Lowe, Mark E, and Conwell, Darwin L

Subjects
Digestive Diseases, Cancer, Rare Diseases, Clinical Research, Diabetes, Pancreatic Cancer, Metabolic and endocrine, Biological Specimen Banks, Biomedical Research, Child, Diabetes Mellitus, Guidelines as Topic, Humans, Pancreatic Neoplasms, Pancreatitis, Chronic, Preservation, Biological, Specimen Handling, biorepository, biospecimens, pancreas, standard operating procedures, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Gastroenterology & Hepatology
Abstract

High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.

Published
2018

13. A Prospective Study to Establish a New-Onset Diabetes Cohort

Author

Maitra, Anirban, Sharma, Ayush, Brand, Randall E, Van Den Eeden, Stephen K, Fisher, William E, Hart, Phil A, Hughes, Steven J, Mather, Kieren J, Pandol, Stephen J, Park, Walter G, Feng, Ziding, Serrano, Jose, Rinaudo, Jo Ann S, Srivastava, Sudhir, and Chari, Suresh T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Prevention, Cancer, Rare Diseases, Pancreatic Cancer, Digestive Diseases, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Metabolic and endocrine, Good Health and Well Being, Biomedical Research, Blood Specimen Collection, Carcinoma, Pancreatic Ductal, Diabetes Mellitus, Type 2, Early Diagnosis, Humans, Middle Aged, Pancreatic Neoplasms, Pancreatitis, Chronic, Prospective Studies, Research Design, Young Adult, screening, sporadic pancreatic cancer, diabetes, high-risk group, biomarker, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Gastroenterology & Hepatology, Clinical sciences
Abstract

The National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases initiated the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) in 2015 (the CPDPC's origin, structure, governance, and research objectives are described in another article in this journal). One of the key objectives of CPDPC is to assemble a cohort of 10,000 subjects 50 years or older with new-onset diabetes, called the NOD cohort. Using a define, enrich, and find early detection approach, the aims of the NOD study are to (a) estimate the 3-year probability of pancreatic ductal adenocarcinoma (PDAC) in NOD (define), (b) establish a biobank of clinically annotated biospecimens from presymptomatic PDAC and control new-onset type 2 diabetes mellitus subjects, (c) conduct phase 3 validation studies of promising biomarkers for identification of incident PDAC in NOD patients (enrich), and (d) provide a platform for development of a future interventional screening protocol for early detection of PDAC in patients with NOD that incorporates imaging studies and/or clinical algorithms (find). It is expected that 85 to 100 incidences of PDAC will be diagnosed during the study period in this cohort of 10,000 patients.

Published
2018

14. PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Yadav, Dhiraj, Park, Walter G, Fogel, Evan L, Li, Liang, Chari, Suresh T, Feng, Ziding, Fisher, William E, Forsmark, Christopher E, Jeon, Christie Y, Habtezion, Aida, Hart, Phil A, Hughes, Steven J, Othman, Mohamed O, Rinaudo, Jo Ann S, Pandol, Stephen J, Tirkes, Temel, Serrano, Jose, Srivastava, Sudhir, Van Den Eeden, Stephen K, Whitcomb, David C, Topazian, Mark, and Conwell, Darwin L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pancreatic Cancer, Prevention, Digestive Diseases, Rare Diseases, Cancer, Clinical Research, 2.1 Biological and endogenous factors, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aetiology, Oral and gastrointestinal, Adult, Biomarkers, Blood Specimen Collection, Diabetes Mellitus, Disease Progression, Humans, Longitudinal Studies, Observational Studies as Topic, Outcome Assessment, Health Care, Pancreatic Neoplasms, Pancreatitis, Chronic, Prospective Studies, Research Design, Specimen Handling, Translational Research, Biomedical, United States, pancreas, alcohol, tobacco, genetic, biorepository, cohort, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Gastroenterology & Hepatology, Clinical sciences
Abstract

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.

Published
2018

15. A risk-adjusted analysis of drain use in pancreaticoduodenectomy: Some is good, but more may not be better

Author

Brubaker, Lisa S., Casciani, Fabio, Fisher, William E., Wood, Amy L., Cagigas, Martha Navarro, Trudeau, Maxwell T., Parikh, Viraj J., Baugh, Katherine A., Asbun, Horacio J., Ball, Chad G., Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Christein, John D., Fernandez-del Castillo, Carlos, Dillhoff, Mary E., Dixon, Elijah, House, Michael G., Hughes, Steven J., Kent, Tara S., Kunstman, John W., Wolfgang, Christopher L., Zureikat, Amer H., Vollmer, Charles M., Jr., and Van Buren, George, II

Published
2022
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16. Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies

Author

Saloman, Jami L., Conwell, Darwin L., Fogel, Evan, Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Phillips, Anna Evans, Topazian, Mark, Van Den Eeden, Stephen K., Serrano, Jose, and Yadav, Dhiraj

Published
2023
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18. The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation

Author

Abbruzzese, James L, Andersen, Dana K, Borrebaeck, Carl AK, Chari, Suresh T, Costello, Eithne, Cruz-Monserrate, Zobeida, Eibl, Guido, Engleman, Edgar G, Fisher, William E, Habtezion, Aida, Kim, Seung K, Korc, Murray, Logsdon, Craig, Lyssiotis, Costas A, Pandol, Stephen J, Rustgi, Anil, Wolfe, Bruce M, Zheng, Lei, and Powers, Alvin C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Diabetes, Prevention, Pancreatic Cancer, Digestive Diseases, Rare Diseases, Nutrition, Cancer, Obesity, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Biomedical Research, Carcinoma, Pancreatic Ductal, Comorbidity, Diabetes Mellitus, Energy Metabolism, Humans, Inflammation, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Pancreatic Neoplasms, Risk Factors, United States, diabetes, inflammation, obesity, pancreatic cancer, research gaps, Clinical Sciences, Gastroenterology & Hepatology, Clinical sciences
Abstract

A workshop on "The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities" was held by the National Institute of Diabetes and Digestive and Kidney Diseases on October 12, 2017. The purpose of the workshop was to explore the relationship and possible mechanisms of the increased risk of pancreatic ductal adenocarcinoma (PDAC) related to diabetes, the role of altered intracellular energy metabolism in PDAC, the mechanisms and biomarkers of diabetes caused by PDAC, the mechanisms of the increased risk of PDAC associated with obesity, and the role of inflammatory events and mediators as contributing causes of the development of PDAC. Workshop faculty reviewed the state of the current knowledge in these areas and made recommendations for future research efforts. Further knowledge is needed to elucidate the basic mechanisms contributing to the role of hyperinsulinemia, hyperglycemia, adipokines, and acute and chronic inflammatory events on the development of PDAC.

Published
2018

19. Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer

Author

Eibl, Guido, Cruz-Monserrate, Zobeida, Korc, Murray, Petrov, Maxim S, Goodarzi, Mark O, Fisher, William E, Habtezion, Aida, Lugea, Aurelia, Pandol, Stephen J, Hart, Phil A, Andersen, Dana K, and Consortium for the Study of Chronic Pancreatitis, Diabetes

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Diabetes, Pancreatic Cancer, Cancer, Prevention, Rare Diseases, Nutrition, Obesity, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Good Health and Well Being, Carcinoma, Pancreatic Ductal, Diabetes Mellitus, Type 2, Humans, Incidence, Pancreatic Neoplasms, Risk Factors, United States, Pancreatic cancer, Type 2 diabetes mellitus, Review, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Nutrition and Dietetics, Anthropology, Biomedical and clinical sciences, Health sciences
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030. Considering the failure to date to efficiently treat existing PDAC, increased effort should be undertaken to prevent this disease. A better understanding of the risk factors leading to PDAC development is of utmost importance to identify and formulate preventive strategies. Large epidemiologic and cohort studies have identified risk factors for the development of PDAC, including obesity and type 2 diabetes mellitus. This review highlights the current knowledge of obesity and type 2 diabetes as risk factors for PDAC development and progression, their interplay and underlying mechanisms, and the relation to diet. Research gaps and opportunities to address this deadly disease are also outlined.

Published
2018

21. The effect of high intraoperative blood loss on pancreatic fistula development after pancreatoduodenectomy: An international, multi-institutional propensity score matched analysis

Author

Fisher, William E., Van Buren, George, II, Callery, Mark P., Kent, Tara S., Pratt, Wande B., Vollmer, Charles M., Jr., Watkins, Ammara A., House, Michael G., Beane, Joal D., Berger, Adam C., Wolfgang, Christopher L., Javed, Ammar A., Poruk, Katherine E., Soares, Kevin C., Valero, Vicente, III, Fernandez-del Castillo, Carlos, Fong, Zhi V., Asbun, Horacio J., Stauffer, John A., Bloomston, Mark P., Dilhoff, Mary E., Haverick, Ericka N., Schmidt, Carl R., Christein, John D., Hollis, Robert H., Ball, Chad G., Dixon, Elijah, Hughes, Steven J., Drebin, Jeffrey A., Ecker, Brett, Lewis, Russell, Jr., McMillan, Matthew, Miller, Benjamin, Puri, Priya, Seykora, Thomas, Sprys, Michael J., Zureikat, Amer H., Kowalsky, Stacy J., Behrman, Stephen W., Bassi, Claudio, Casciani, Fabio, Maggino, Laura, Malleo, Giuseppe, Salvia, Roberto, Savegnago, Giulia, Cinelli, Lorenzo, Falconi, Massimo, Partelli, Stefano, Dickson, Euan J., Jamieson, Nigel B., Velu, Lavanniya K.P., Salem, Ronald R., Kunstman, John W., Trudeau, Maxwell T., Dillhoff, Mary E., and Vollmer, Charles M.

Published
2021
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22. The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Maggino, Laura, Seykora, Thomas F., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2022
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23. Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROCEED study.

Author

Saloman, Jami L., Conwell, Darwin L., Fogel, Evan, Vege, Santhi Swaroop, Li, Liang, Li, Shuang, Andersen, Dana K., Fisher, William E., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Phillips, Anna Evans, Topazian, Mark, Van Den Eeden, Stephen K., Serrano, Jose, and Yadav, Dhiraj

Published
2022
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24. Surgeon experience contributes to improved outcomes in pancreatoduodenectomies at high risk for fistula development

Author

Fisher, William E., Van Buren, George, II, Callery, Mark P., Kent, Tara S., Pratt, Wande B., Vollmer, Charles M., Jr., Watkins, Ammara A., House, Michael G., Beane, Joal D., Berger, Adam C., Wolfgang, Christopher L., Javed, Ammar A., Poruk, Katherine E., Soares, Kevin C., Valero, Vicente, III, Fernandez-del Castillo, Carlos, Fong, Zhi V., Asbun, Horacio J., Stauffer, John A., Bloomston, Mark P., Dilhoff, Mary E., Haverick, Ericka N., Schmidt, Carl R., Christein, John D., Hollis, Robert H., Ball, Chad G., Dixon, Elijah, Hughes, Steven J., Drebin, Jeffrey A., Ecker, Brett, Lewis, Russell, Jr., McMillan, Matthew, Miller, Benjamin, Puri, Priya, Seykora, Thomas, Sprys, Michael J., Zureikat, Amer H., Kowalsky, Stacy J., Behrman, Stephen W., Bassi, Claudio, Casciani, Fabio, Maggino, Laura, Malleo, Giuseppe, Salvia, Roberto, Savegnago, Giulia, Cinelli, Lorenzo, Falconi, Massimo, Partelli, Stefano, Dickson, Euan J., Jamieson, Nigel B., Velu, Lavanniya K.P., Salem, Ronald R., Kunstman, John W., Trudeau, Maxwell T., and Dillhoff, Mary E.

Published
2021
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25. Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma

Author

Moekotte, Alma L., van Roessel, Stijn, Malleo, Giuseppe, Rajak, Rushda, Ecker, Brett L., Fontana, Martina, Han, Ho-Seong, Rabie, Mohamed, Roberts, Keith J., Khalil, Khalid, White, Steven A., Robinson, Stuart, Halimi, Asif, Zarantonello, Laura, Fusai, Giuseppe K., Gradinariu, George, Alseidi, Adnan, Bonds, Morgan, Dreyer, Stephan, Jamieson, Nigel B., Mowbray, Nicholas, Al-Sarireh, Bilal, Mavroeidis, Vasileios K., Soonawalla, Zahir, Napoli, Niccolò, Boggi, Ugo, Kent, Tara S., Fisher, William E., Tang, Chung N., Bolm, Louisa, House, Michael G., Dillhoff, Mary E., Behrman, Stephen W., Nakamura, Masafumi, Ball, Chad G., Berger, Adam C., Christein, John D., Zureikat, Amer H., Salem, Ronald R., Vollmer, Charles M., Salvia, Roberto, Besselink, Marc G., Abu Hilal, Mohammed, Aljarrah, Ra'ed, Barrows, Courtney, Cagigas, Martha Navarro, Lai, Eric C.H., Wellner, Ulrich, Aversa, John, Dickson, Paxton V., Ohtsuka, Takao, Dixon, Elijah, Zheng, Richard, Kowalski, Stacy, and Freedman-Weiss, Mollie

Published
2020
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30. The Influence of Intraoperative Blood Loss on Fistula Development Following Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Maggino, Laura, Seykora, Thomas F., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2020
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31. Diagnostic and Prognostic Biomarkers of Chronic Pancreatitis: A Conceptual Framework Based on the PRoBE Design

Author

Andersen, Dana, Bellin, Melena, Chari, Suresh T., Cruz-Monserrate, Zobeida, Fisher, William E., Fogel, Evan L., Forsmark, Christopher E., Hart, Phil A., Lesinski, Gregory B., Park, Walter G., Rinaudo, Jo Ann, Saloman, Jami L., Serrano, Jose, Tirkes, Temel, Topazian, Mark D., van Den Eeden, Stephen, Vege, Santhi Swaroop, Whitcomb, David C., Yadav, Dhiraj, Conwell, Darwin L., Pandol, Stephen J., Steen, Hanno, Feng, Ziding, and Li, Liang

Published
2024
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34. The Fistula Risk Score Catalog: Toward Precision Medicine for Pancreatic Fistula After Pancreatoduodenectomy

Author

Trudeau, Maxwell T., Casciani, Fabio, Ecker, Brett L., Maggino, Laura, Seykora, Thomas F., Puri, Priya, McMillan, Matthew T., Miller, Benjamin, Pratt, Wande B., Asbun, Horacio J., Ball, Chad G., Bassi, Claudio, Behrman, Stephen W., Berger, Adam C., Bloomston, Mark P., Callery, Mark P., Castillo, Carlos Fernandez-del, Christein, John D., Dillhoff, Mary E., Dickson, Euan J., Dixon, Elijah, Fisher, William E., House, Michael G., Hughes, Steven J., Kent, Tara S., Malleo, Giuseppe, Salem, Ronald R., Wolfgang, Christopher L., Zureikat, Amer H., and Vollmer, Charles M.

Published
2020
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35. Notch1 activation up-regulates pancreatic and duodenal homeobox-1.

Author

Liu, Shi-He, Zhou, Guisheng, Yu, Juehua, Wu, James, Nemunaitis, John, Senzer, Neil, Dawson, David, Li, Min, Fisher, William E, and Brunicardi, F Charles

Subjects
Notch1, NICD, PDX-1, insulin, hyperinsulinemia, hypoglycemia, Genetics
Abstract

Transcription factor pancreatic and duodenal homeobox-1 (PDX-1) plays an essential role in pancreatic development, β-cell differentiation, maintenance of normal β-cell function and tumorigenesis. PDX-1 expression is tightly controlled through a variety of mechanisms under different cellular contexts. We report here that overexpression of Notch1 intracellular domain (NICD), an activated form of Notch1, enhanced PDX-1 expression in both PDX-1 stable HEK293 cells and mouse insulinoma β-TC-6 cells, while NICD shRNA inhibited the enhancing effect. NICD-enhanced PDX-1 expression was accompanied by increased insulin expression/secretion and cell proliferation in β-TC-6 cells, which was reversed by NICD shRNA. Cre activation-induced specific expression of NICD in islet β cells of transgenic βNICD+/+ mice induced increased expression of PDX-1, insulin and proliferating cell nuclear antigen (PCNA) and decreased expression of p27 with accompanied fasting hyperinsulinemia and hypoglycemia and altered responses to intraperitoneal glucose tolerance test. Systemically delivered NICD shRNA suppressed islet expression of PDX-1 and reversed the hypoglycemia and hyperinsulinemia. Moreover, expression levels of NICD were correlated with those of PDX-1 in human pancreatic neuroendocrine tumor. Thus, Notch1 acts as a positive regulator for PDX-1 expression, cooperates with PDX-1 in the development of insulin overexpression and islet cell neoplasia and represents a potential therapeutic target for islet neoplasia.

Published
2013

39. Distinct Serum Immune Profiles Define the Spectrum of Acute and Chronic Pancreatitis From the Multicenter Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) Study

Author

Lee, Bomi, primary, Jones, Elaina K., additional, Manohar, Murli, additional, Li, Liang, additional, Yadav, Dhiraj, additional, Conwell, Darwin L., additional, Hart, Phil A., additional, Vege, Santhi Swaroop, additional, Fogel, Evan L., additional, Serrano, Jose, additional, Andersen, Dana, additional, Bellin, Melena D., additional, Topazian, Mark D., additional, Van Den Eeden, Stephen K., additional, Pandol, Stephen J., additional, Forsmark, Chris E., additional, Fisher, William E., additional, Park, Walter G., additional, Husain, Sohail Z., additional, Habtezion, Aida, additional, Topazian, Mark, additional, and Forsmark, Chris, additional

Published
2023
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