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131 results on '"FitzGerald, Mark J."'

5. Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma

Author

Gauvreau, Gail M, primary, Hohlfeld, Jens M, additional, FitzGerald, Mark J, additional, Boulet, Louis-Philippe, additional, Cockcroft, Donald W, additional, Davis, Beth E, additional, Korn, Stephanie, additional, Kornmann, Oliver, additional, Leigh, Richard, additional, Mayers, Irvin, additional, Watz, Henrik, additional, Grant, Sarah S, additional, Jain, Monish, additional, Cabanseki, Maciej, additional, Pertel, Peter E, additional, Jones, Ieuan, additional, Lecot, Jean R, additional, Cao, Hui, additional, and O'Byrne, Paul M, additional

Published
2023
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41. Antibiotic consumption in children prior to diagnosis of asthma

Author

FitzGerald Mark J, Lynd Larry D, Richardson Kathryn, Marra Carlo A, and Marra Fawziah

Subjects
Diseases of the respiratory system, RC705-779
Abstract

ABSTRACT Background Asthma is difficult to diagnose in children and at times misdiagnosis of an infection can occur. However, little is known about the magnitude and patterns of antibiotic consumption in children with asthma relative to those without asthma. Methods Using population-based data, 128,872 children were identified with at least 6 years of follow-up. The adjusted rate-ratio (RR) of antibiotics dispensed to asthmatic as compared to non-asthmatic children was determined. Results At age six, the RR of antibiotic consumption for asthmatics compared to non-asthmatics varied between, 1.66 to 2.32, depending on the year of asthma diagnosis. Of the 18,864 children with asthma at ages 2-8, 52% (n = 9,841) had antibiotics dispensed in the 6 months prior to their index date of asthma diagnosis. The RR of antibiotic consumption in the 1 month prior to asthma diagnosis compared to 5 months prior was 1.66 (95% CI 1.60-1.71). The RR was lower in males compared to females (1.58 vs 1.77), and lower in those who received antibiotics in the first year of life relative to those that did not (1.60 vs. 1.76). Conclusions There is higher antibiotic consumption in children with asthma compared to those without asthma. The pattern of antibiotic use suggests that diagnosis guidelines are difficult to follow in young children leading to misdiagnosis and over treatment with antibiotics.

Published
2011
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45. Delay in admission for elective coronary-artery bypass grafting is associated with increased in-hospital mortality

Author

Levy Adrian R, Kuramoto Lisa, Hayden Robert, Fradet Guy, Sobolev Boris G, and FitzGerald Mark J

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Many health care systems now use priority wait lists for scheduling elective coronary artery bypass grafting (CABG) surgery, but there have not yet been any direct estimates of reductions in in-hospital mortality rate afforded by ensuring that the operation is performed within recommended time periods. Methods We used a population-based registry to identify patients with established coronary artery disease who underwent isolated CABG in British Columbia, Canada. We studied whether postoperative survival during hospital admission for CABG differed significantly among patients who waited for surgery longer than the recommended time, 6 weeks for patients needing semi-urgent surgery and 12 weeks for those needing non-urgent surgery. Results Among 7316 patients who underwent CABG, 97 died during the same hospital admission, for a province-wide death rate at discharge of 1.3%. The observed proportion of patients who died during the same admission was 1.0% (27 deaths among 2675 patients) for patients treated within the recommended time and 1.5% (70 among 4641) for whom CABG was delayed. After adjustment for age, sex, anatomy, comorbidity, calendar period, hospital, and mode of admission, patients with early CABG were only 2/3 as likely as those for whom CABG was delayed to experience in-hospital death (odds ratio 0.61; 95% confidence interval [CI] 0.39 to 0.96). There was a linear trend of 5% increase in the odds of in-hospital death for every additional month of delay before surgery, adjusted OR = 1.05 (95% CI 1.00 to 1.11). Conclusion We found a significant survival benefit from performing surgical revascularization within the time deemed acceptable to consultant surgeons for patients requiring the treatment on a semi-urgent or non-urgent basis.

Published
2008
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46. Survival benefit of coronary-artery bypass grafting accounted for deaths in those who remained untreated

Author

Levy Adrian R, Kuramoto Lisa, Hayden Robert, Fradet Guy, Sobolev Boris G, and FitzGerald Mark J

Subjects
Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background Currently there are no direct estimates of mortality reduction afforded by coronary-artery bypass grafting (CABG) that take into account the deaths among patients for whom coronary revascularization was indicated but who did not undergo the treatment. The objective of this analysis was to compare survival after the treatment decision between patients who underwent CABG and those who remained untreated. Methods We used a population-based registry to identify patients with established coronary artery disease who were to undergo first-time isolated CABG. We measured the effect of surgical revascularization on survival after the treatment decision in two cohorts of patients categorized by symptoms, coronary anatomy, and left ventricular function. Results One in 10 patients died during the five years after treatment decision. The hazard of death among patients who underwent CABG was 51 percent of that for the untreated group, the adjusted hazard ratio was 0.51 (95 percent confidence interval, 0.43 to 0.61). The effect was stronger when CABG was performed within the recommended time: adjusted hazard ratios were 0.43 (95 percent confidence interval, 0.35 to 0.53) and 0.58 (95 percent confidence interval, 0.48 to 0.70) for early and late intervention, respectively; chi-square for the difference between hazard ratios was 12.2 (P < 0.001). Conclusion Estimates that account for patients who died before they could undergo a required CABG indicate a significant survival benefit of performing early surgical revascularization even for patients registered to undergo the operation on the non-urgent basis.

Published
2008
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