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1. A scoping review of cerebral reperfusion therapies in childhood and adolescence with arterial ischemic stroke

Author

Ana Lúcia de Paula Garcia, Flávia Guirro Zuliani, Cristiane Lara Mendes‐Chillof, Silméia Garcia Zanati Bazan, Carlos Clayton Macedo deFreitas, Gabriel Pinheiro Modolo, Vitor Mendes Pereira, Gustavo José Luvizutto, and Rodrigo Bazan

Subjects
adolescence, cerebral reperfusion therapies, childhood, stroke, Neurology. Diseases of the nervous system, RC346-429, Pediatrics, RJ1-570
Abstract

Abstract Background Management of pediatric stroke is challenging because of the paucity of data supporting the efficacy of interventions. This scoping review details the treatments available for the acute phase of stroke in pediatric patients with arterial ischemic stroke. Summary of Review Overall, 68 relevant articles were published between 2001 and 2023. The primary study included 48 case reports (n = 48). Eleven articles reported the use of intravenous thrombolysis (IVT) with alteplase, eight used intra‐arterial (IA) alteplase, and 52 reported mechanical thrombectomy (MT). IVT was administered to 195 patients with a median of 5.5 h of stroke onset, and only four (2.0%) had intracranial hemorrhage after alteplase treatment. Of the 11 articles, nine used 0.9 mg/kg IVT administered as a 10% bolus, with the remaining 90% administered over one hour, and one study used 0.54 mg/kg. IA was performed in 17 patients with a median of 5.05 h of stroke onset, and three individuals (17.6%) had intracranial hemorrhage. Of the eight reports that document IA, two used 0.9 mg/kg; one each used 0.16 mg/kg, 0.1 mg/kg, 0.6 mg/kg, 100 mg/day, and 10 mg/day; and one article documented the use of urokinase 750 000 IU. MT was used in 434 and 215 individuals in a previous systematic review, with a median of 11.82 h of stroke onset, and only 2.9% had intracranial hemorrhage after the treatment. Stent retrievers were used in 33 reports (63.5%) and aspiration retrievers were mentioned in 15 articles (28.8%). Overall, the outcomes ranged from complete to moderate recovery for all modalities. Conclusions IVT and MT are safer than IA; however, despite the lack of clinical trials, all modalities seem effective in improving clinical recovery. To guide clinical practice and determine better intervention modalities, clinicians should note the key messages from this review, such as using magnetic resonance imaging in the acute phase and identifying key risk factors and presenting symptoms.

Published
2024
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2. 365 Dias de pandemia de COVID-19 e a realidade brasileira: pesquisas e reflexões

Author

Alzielma Oliveira de Araujo, Ana Paula Dias Barbosa, Antonia Gleiciane Silva Farias, Caio Gabriel Silva Campelo, Erika Costa Sousa, Esmailyn Castillo Santana, Geilson Silva Pereira, Giovana Milla Oliveira Santos, Hugo Vinícius de Oliveira Silva, Ligianara Veloso de Moura, Lorena Roas Ribeiro Ilze Costa Santos, Luana da Cunha Lopes, Lucas Holanda Galvão Rodrigues, Neirigelson Ferreira de Barros Leite, Roseneide dos Santos Tavares, Ruthe de Carvalho Brito, Ruthy Lemos Gomes, Thiago Luis Aguayo de Castro, Adriano Boettcher Brandes, Adriely Lais de Souza Pereira, Alexandre Lemos Medeiros, Aline Sarturi Ponte, Allan Pinheiro Holanda, Altair Meirelles de Sousa Maia, Aluísio Francisco Oliveira de Sousa, Amanda Lima de Oliveira, Amanda Carolina Aguilar, Amara Lúcia Holanda Tavares Battistel, Ana Martins Fabris, Ana Beatriz S ouza Oliveira, Ana Carolina Araujo Mazeto, Ana Carolina Cavalcanti Pessoa de Souza, Ana Carolina Souza Galvão, Ana Caroline Czerner Volkart, Ana Inês Dias Alves, André Haiske, Andressa Santana Arce, Andrey Oeiras Pedroso, Anna Amélia de Faria, Anny Carolina Nogueira Lods da Silva, Antonio Edson Ribeiro de Almada, Ariadne Celinne de Souza e Silva, Augusto de França Maia, Barbara Cordeiro da Silva, Bernardo Ebbres Bernardi, Bruna Pimentel de Lima, Bruno Félix Lustosa Oliveira, Caique Anizio Santos da Rosa, Carina Braz Cristo de Souza, Carlos Augusto Gomes Silva, Carmem Cícera Maria da Silva, Carulina Cardoso Batista, Cassandra Vargas Ascarrunz, Celsa Karolayne Silva Cruz, Clarice Castro Reis Dantas, Clebes Iolanda Leodice Alves, Daniel da Costa Araújo, Danilo Santos Rocha, Dariely de Carvalho Monte, Débora de Almeida Silva, Débora Maria Vilela, Deborah Aline Medeiros Souza, Deborah Helena Pimentel de Araújo, Dernival Bertoncello, Diego Mendonça Viana, Diogo Pinto Mendes Carlos, Dora Letícia Nascimento Dogbe, Eddie Carlos Saraiva da Silva, Ediane Tamiles Souza de Souza, Eduardo Sousa da Silva, Elcio Domingues de Silva, Emanuella Castro Murad da Cruz, Erika Ernestina Bezerra Pinheiro, Fabiana Jucineide Coelho, Fábio França Silva, Fábio Peron Carballo, Felipe Nicori Pereira, Fernanda Nunes de Castro Veríssimo, Fernando Willliam de Melo, Flávia Guirro Zuliani, Flávio de Souza Melo, Francisca Ielly Oliveira Marques, Gabriel Vinícius Silva de Carvalho, Gabriela Carvalho, Gabriela Cardoso Araújo, Gleyce Hellen de Almeida de Souza, Grazielle Cristina Gomes da Silva, Helen Carvalho Silva, Isadora Regina Huk dos Santos, Ivna Diógenes da Silva, Izabella Mariane Ramos dos Santos, Izabella Barufaldi Prette, Jaqueline Rocha Borges dos Santos, Jardel Pessoa Medeiros, Jessica de Andrade Santos, João Erikes Almeida Marques, João Leonardo Lima Araújo, João Lucas Caldas Minervino, João Matheus Ferreira do Nascimento, João Pedro Felipe Godoi, João Samuel Carvalho Dias, João Victor da Costa Nunes, Joedna Vasconcelos Menezes Andrade, José Gomes do Amaral Neto, José Gabriel Fontenele Gomes, José Marciel Araújo Porcino, Josiane Bertoldo Piovesan, Juliana da Silva Avelar, Júlio César Couto Bem Siqueira Telles, Karine da Silva Oliveira, Karoline de Macêdo Gonçalves Frota, Karoline Silva Gomes Barbosa, Kátia J. Brandão Amaral, Larissa Mayra da Silva Patrício, Larissa Carvalho Ribeiro de Sá Lustosa, Laura Melo Zanella Felipe, Leandra Costa Matos, Leila Cristina Konradt Moraes, Leonice Aparecida de Fátima Alves Pereira Mourad, Lídia da Silva Azevedo, Lorena Couto de Azevedo, Luciana de Andrade Amoroso Remer, Luciana Sabbatine Neves, Luis Felipe de Oliveira, Lurdiane Gabriel Pereira, Manoel Matias Medeiros de Araújo, Mara Dantas Pereira, Marcela Dias Parreira, Maria Aparecida Turci, Maria Bernadete de Sousa Carvalho Monte, Maria dos Remédios Magalhães Santos, Maria Clara Feijó de Figueiredo, Maria Denise de Melo Machado, Maria Dilma Felizardo Ferreira, Maria Eliane da Costa Macêdo, Maria Letícia Cerqueira Santos, Maria Neiliane da Silva Souza, Maria Paula de Lemos Franco, Maria Victoria Santos Sousa, Maria Vitória da Silva Sousa, Maria Zenaide de Lima Arantes, Mariana Brito Simões, Mariana Marrara Barros Nonato, Mariana Mozzaquatro, Mariana Silveira Silva, Marília Graziele de Sousa Melo, Marisa de Sousa Alencar, Marli Ferreira de Carvalho Damasceno, Matheus Moacir Perinazzo, Míria Dantas Pereira, Natália Barreto de Mesquita, Nicolas Guimarães Novais Pinto Mendes, Paloma Lealdini Luis, Pâmella Priscila Manhani da Silva, Paola Fernanda Santos Antunes, Paolla Clayr de Arruda Silveira, Paula Boettcher Brandes, Paula Cristina Albuquerque de Souza Medeiros, Priscilla Duarte Guerra Machado, Priscilla de Oliveira Reis Alencastro, Raiane Miranda da Fonseca, Raissa Bandeira Fernandes, Raquel Nunes Mota, Rayane Alexandrino Caiana, Renata Rezende Pinheiro Castro, Renata Josiane Cavalcante Carvalho de Marins, Roberto Magno Reis Netto, Rodrigo Higino Mar e Silva, Ronilson Ferreira Xavier, Rosimar Soares de Brito Silva, Sabrina de Lucas Ramos Necy, Sabrina Gabriela Noronha Silva, Samira Paredes Sampaio Barreto, Silmaria Bezerra Porcino, Sofia Guerra Machado, Stella Regina Arcanjo Medeiros, Suanny da Silva Alves, Talyta Eduardo Oliveira, Tamara Cecília Rangel Gomes, Thais Leite Nascimento, Thais Pereira Costa Magalhães, Thayane Rose Cavalcante de Queiroz, Thiago Chagas de Amorim, Túlio Dias Duarte Sales, Valdemar Lacerda Júnior, Valéria Amanda Jerônimo Pereira, Vinícius Jordão Silva, Virgínia Souza Galvão, Vitoria Souza Cavalcante, Yasmim de Sousa Esteves Foggia, and Yure Victor Nogueira da Silva

Published
2021
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