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540 results on '"Flavell, A. J."'

2. Rare dosage abnormalities flanking the SHOX gene

Author

Bunyan, David J., Gevers, Evelien, Hobbs, James I., Duncan-Flavell, Philippa J., Howarth, Rachel J., Holder-Espinasse, Muriel, Klee, Philippe, Van-Heurk, Roxane, Lemmens, Laure, Carminho-Rodrigues, Maria Teresa, Mohamed, Zainaba, Goturu, Aruna, Hughes, Claire R., Ajzensztejn, Michal, and Thomas, N. Simon

Published
2021
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10. Saporin Immunotoxins

Author

Flavell, D. J., Compans, R. W., editor, Cooper, M., editor, Hogle, J. M., editor, Ito, Y., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Seadler, H., editor, Vogt, P. K., editor, Wagner, H., editor, and Frankel, Arthur E., editor

Published
1998
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12. The chromosomal distributions of Ty1-copia group retrotransposable elements in higher plants and their implications for genome evolution

Author

Heslop-Harrison, J. S. Pat, Brandes, Andrea, Taketa, Shin, Schmidt, Thomas, Vershinin, Alexander V., Alkhimova, Elena G., Kamm, Anette, Doudrick, Robert L., Schwarzacher, Trude, Katsiotis, Andreas, Kubis, Sybille, Kumar, Amar, Pearce, Steven R., Flavell, Andrew J., Harrison, Gill E., and Capy, Pierre, editor

Published
1997
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26. Gene-based sequence diversity analysis of field pea (Pisum)

Author

Jing, Runchun, Johnson, Richard, Seres, Andrea, Kiss, Gyorgy, Ambrose, Mike J., Knox, Maggie R., Ellis, T.H. Noel, and Flavell, Andrew J.

Subjects
Peas -- Genetic aspects, Gene expression -- Research, Biological sciences
Abstract

Sequence diversity of 39 dispersed gene loci was analyzed in 48 diverse individuals representative of the genus Pisum. The different genes show large variation in diversity parameters, suggesting widely differing levels of selection and a high overall diversity level for the species. The data set yields a genetic diversity tree whose deep branches, involving wild samples, are preserved in a tree derived from a polymorphic retrotransposon insertions in an identical sample set. Thus, gene regions and intergenic 'junk DNA' share a consistent picture for the genomic diversity of Pisum, despite low linkage disequilibrium in wild and landrace germplasm, which might be expected to allow independent evolution of these very different DNA classes. Additional lines of evidence indicate that recombination has shuffled gene haplotypes efficiently within Pisum, despite its high level of inbreeding and widespread geographic distribution. Trees derived from individual gene loci show marked differences from each other, and genetic distance values between sample pairs show high standard deviations. Sequence mosaic analysis of aligned sequences identifies nine loci showing evidence for intragenic recombination. Lastly, phylogenetic network analysis confirms the non-treelike structure of Pisum diversity and indicates the major germplasm classes involved. Overall, these data emphasize the artificiality of simple tree structures for representing genomic sequence variation within Pisum and emphasize the need for fine structure haplotype analysis to accurately define the genetic structure of the species.

Published
2007

33. Insertional polymorphism and antiquity of PDR1 retrotransposon insertions in pisum species

Author

Jing, Runchun, Knox, Maggie R., Lee, Jennifer M., Vershinin, Alexander V., Ambrose, Michael, Ellis, T.H. Noel, and Flavell, Andrew J.

Subjects
Genetic polymorphisms -- Research, Peas -- Genetic aspects, Peas -- Research, Retrotransposons -- Research, Genetic research, Biological sciences
Abstract

Sequences flanking 73 insertions of the retrotransposon PDR1 have been characterized, together with an additional 270 flanking regions from one side alone, from a diverse collection of Pisum germ plasm. Most of the identified flanking sequences are repetitious DNAs but more than expected (7%) lie within nuclear gene protein-coding regions. The approximate age of 52 of the PDR1 insertions has been determined by measuring sequence divergence among LTR pairs. These data show that PDR1 transpositions occurred within the last 5 MY, with a peak at 1-2.5 MYA. The insertional polymorphism of 68 insertions has been assessed across 47 selected Pisum accessions, representing the diversity of the genus. None of the insertions are fixed, showing that PDR1 insertions can persist in a polymorphic state for millions of years in Pisum. The insertional polymorphism data have been compared with the age estimations to ask what rules control the proliferation of PDR1 insertions in Pisum. Relatively recent insertions (< ~1.5MYA) tend to be found in small subsets of the Piston accessions set, 'middle-aged' insertions (between ~1.5 and 2.5 MYA) vary greatly in their occurrence, and older insertions (> ~2.5 MYA) are mostly found in small subsets of Pisum. Finally, the average age estimate for PDRI insertions, together with an existing data set for PDR1 retrotransposon SSAP markers, has been used to derive an estimate of the effective population size for Pisum of ~7.5 X [10.sup.5].

Published
2005

35. Barley whole exome capture: a tool for genomic research in the genus Hordeum and beyond

Author

Mascher, Martin, Richmond, Todd A., Gerhardt, Daniel J., Himmelbach, Axel, Clissold, Leah, Sampath, Dharanya, Ayling, Sarah, Steuernagel, Burkhard, Pfeifer, Matthias, DʼAscenzo, Mark, Akhunov, Eduard D., Hedley, Pete E., Gonzales, Ana M., Morrell, Peter L., Kilian, Benjamin, Blattner, Frank R., Scholz, Uwe, Mayer, Klaus F.X., Flavell, Andrew J., Muehlbauer, Gary J., Waugh, Robbie, Jeddeloh, Jeffrey A., and Stein, Nils

Published
2013
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36. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

Author

Otterbein, Leo E., Zuckerbraun, Brian S., Haga, Manabu, Liu, Fang, Song, Ruiping, Usheva, Anny, Stachulak, Christina, Bodyak, Natalya, Smith, R. Neal, Csizmadia, Eva, Tyagi, Shivraj, Akamatsu, Yorihiro, Flavell, Richard J., Billiar, Timothy R., Tzeng, Edith, Bach, Fritz H., Choi, Augustine M.K., and Soares, Miguel P.

Abstract

Carbon monoxide (CO), one of the products of heme oxygenase action on heme, prevents arteriosclerotic lesions that occur following aorta transplantation; pre-exposure to 250 parts per million of CO for 1 hour before injury suppresses stenosis after carotid balloon injury in rats as well as in mice. The protective effect of CO is associated with a profound inhibition of graft leukocyte infiltration/activation as well as with inhibition of smooth muscle cell proliferation. The anti-proliferative effect of CO in vitro requires the activation of guanylate cyclase, the generation of cGMP, the activation of p38 mitogen-activated protein kinases and the expression of the cell cycle inhibitor p21[sup.Cip1]. These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent., Author(s): Leo E. Otterbein [1, 7]; Brian S. Zuckerbraun [2, 7]; Manabu Haga [3, 7]; Fang Liu [1]; Ruiping Song [1]; Anny Usheva [4]; Christina Stachulak [4]; Natalya Bodyak [4]; [...]

Published
2003
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41. Antibody-Drug Conjugates: The New Frontier of Chemotherapy

Author

Ponziani, Sara, primary, Di Vittorio, Giulia, additional, Pitari, Giuseppina, additional, Cimini, Anna Maria, additional, Ardini, Matteo, additional, Gentile, Roberta, additional, Iacobelli, Stefano, additional, Sala, Gianluca, additional, Capone, Emily, additional, Flavell, David J., additional, Ippoliti, Rodolfo, additional, and Giansanti, Francesco, additional

Published
2020
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