391 results on '"Fleishman, Sarel J."'
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2. Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family
3. Designed active-site library reveals thousands of functional GFP variants
4. Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases
5. Stable Mammalian Serum Albumins Designed for Bacterial Expression
6. Computationally designed dual-color MRI reporters for noninvasive imaging of transgene expression
7. Structure and receptor recognition by the Lassa virus spike complex
8. Computationally designed hyperactive Cas9 enzymes
9. Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms
10. Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin
11. Addressing epistasis in the design of protein function.
12. A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen.
13. Functionally Diverse Peroxygenases by AlphaFold2, Design, and Signal Peptide Shuffling
14. Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies
15. Evolutionary paths that link orthogonal pairs of binding proteins
16. Design and in vitro realization of carbon-conserving photorespiration
17. Computational optimization of antibody humanness and stability by systematic energy-based ranking
18. Principles for computational design of binding antibodies
19. One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen
20. Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model
21. A Putative Molecular-Activation Switch in the Transmembrane Domain of erbB2
22. Computational design of BclxL inhibitors that target transmembrane domain interactions
23. Design of a stable human acid‐β‐glucosidase: towards improved Gaucher disease therapy and mutation classification
24. Repertoire of Computationally Designed Peroxygenases for Enantiodivergent C–H Oxyfunctionalization Reactions
25. Inspired by nature
26. Ultrahigh specificity in a network of computationally designed protein-interaction pairs
27. Rapid characterization of secreted recombinant proteins by native mass spectrometry
28. Computational design of BclxL inhibitors that target transmembrane domain interactions
29. Designed High-Redox Potential Laccases Exhibit High Functional Diversity
30. Combinatorial assembly and design of enzymes
31. Reliable energy-based antibody humanization and stabilization
32. Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals
33. Editorial overview: Engineering and design
34. Computational design of a pH-sensitive IgG binding protein
35. De novo-designed transmembrane domains tune engineered receptor functions
36. Emerging themes in the computational design of novel enzymes and protein–protein interfaces
37. Protein Quaternary Structures in Solution are a Mixture of Multiple forms
38. Author response: De novo-designed transmembrane domains tune engineered receptor functions
39. Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope
40. Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences
41. What Have We Learned from Design of Function in Large Proteins?
42. Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning
43. Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
44. The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
45. Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning
46. A Rationally and Computationally Designed Fluorescent Biosensor for d-Serine
47. Assessing and enhancing foldability in designed proteins
48. Extending the New Generation of Structure Predictors to Account for Dynamics and Allostery
49. Why reinvent the wheel? Building new proteins based on ready-made parts
50. PROTEIN DESIGN: Inspired by nature
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