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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an increasingly used mediastinal sampling technique. The purpose of the study is the evaluation of the tolerance during EBUS-TBNA according to the choice of anesthesia. Methods: this is a prospective two-center observational study extended form january 2012 to April 2014. We conducted a systematic review of patients undergoing EBUS-TBNA in the hospitals of Amiens and Saint Quentin where we practiced respectively under conscious sedation or under general anesthesia with propofol and laryngeal mask. The main objectives were the hemodynamic tolerance and the subjective tolerance collected by a questionnaire. Results: Eighty eight patients were included in our study, forty one in the general anesthesia group and forty seven in the conscious sedation group. Arterial blood pressure and heart rate increased in midazolam group, and decreased in propofol group. No incident occured in the general anesthesia group.The subjective tolerance seemed better in the general anesthesia group with an visual analogue scale estimated at 3/100 versus 32,6/100 in the conscious sedation group (p Conclusion: the tolerance is better under general anesthesia but the choice of anesthesia does not affect the profitability of the examination,.