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1. The comparative burden of chronic spontaneous urticaria, atopic dermatitis and psoriasis in five European countries

Author

Maria‐Magdalena Balp, Kathryn Krupsky, Shaloo Gupta, Bridget L. Balkaran, Ravneet K. Kohli, Clementine Lienhard, Jaclyn Loh, Jose M. Rodriguez Barrios, Dhaval Patil, Florence Tétart, Tariq El‐Shanawany, and John Reed

Subjects
atopic dermatitis, chronic spontaneous urticaria, disease burden, health‐related quality of life, patient‐reported outcome measure, psoriasis, Dermatology, RL1-803, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Skin diseases can have a significant impact on the physical, psychological and social well‐being of patients. Quantification of the burden of chronic spontaneous urticaria (CSU) compared to other dermatological conditions is limited. Objectives To evaluate the comparative humanistic and economic burden of CSU, atopic dermatitis (AD), and psoriasis (PSO) in five European countries (EU5). Methods This cross‐sectional analysis compared data from adult respondents with a physician diagnosis of CSU, AD and PSO from the 2020 National Health and Wellness Survey in EU5 (France, Germany, Italy, Spain and the United Kingdom). Outcomes included Short Form (SF)‐12v2 [mental (MCS) and physical component (PCS) summary scores], SF‐6D, EQ‐5D, EQ‐Visual Analogue Scale (VAS), Dermatology Life Quality Index (DLQI), General Anxiety Disorder‐7 (GAD‐7), Patient Health Questionnaire‐9 (PHQ‐9), Work Productivity and Activity Impairment (WPAI) and healthcare resource utilization (HRU). Multivariable analyses comparing CSU to AD and PSO, respectively, were conducted for each outcome. Results This analysis included 379 CSU, 788 AD and 2,636 PSO patients. Adjusted MCS and PCS scores were lower among CSU patients than AD (MCS, p = 0.006; PCS, p

Published
2024
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2. Ocular sequelae of epidermal necrolysis: French national audit of practices, literature review and proposed management

Author

Dhyna Thorel, Saskia Ingen-Housz-Oro, Daniel Benaïm, Vincent Daien, Eric Gabison, Valentine Saunier, Laurence Béral, David Touboul, Dominique Brémond-Gignac, Matthieu Robert, Robin Vasseur, Gérard Royer, Olivier Dereure, Brigitte Milpied, Claire Bernier, Anne Welfringer-Morin, Christine Bodemer, Nadège Cordel, Marie Tauber, Carole Burillon, Marion Servant, Chloe Couret, Bertrand Vabres, Florence Tétart, Myriam Cassagne, Marie-Ange Kuoch, Marc Muraine, Agnès Delcampe, and Julie Gueudry

Subjects
Stevens-Johnson syndrome, Toxic epidermal necrolysis, Management, Ocular involvement, Treatment, Drug reaction, Medicine
Abstract

Abstract Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious and rare diseases, most often drug-induced, and their incidence has been estimated at 6 cases/million/year in France. SJS and TEN belong to the same spectrum of disease known as epidermal necrolysis (EN). They are characterized by more or less extensive epidermal detachment, associated with mucous membrane involvement, and may be complicated during the acute phase by fatal multiorgan failure. SJS and TEN can lead to severe ophthalmologic sequelae. There are no recommendations for ocular management during the chronic phase. We conducted a national audit of current practice in the 11 sites of the French reference center for toxic bullous dermatoses and a review of the literature to establish therapeutic consensus guidelines. Ophthalmologists and dermatologists from the French reference center for epidermal necrolysis were asked to complete a questionnaire on management practices in the chronic phase of SJS/TEN. The survey focused on the presence of a referent ophthalmologist at the center, the use of local treatments (artificial tears, corticosteroid eye drops, antibiotic-corticosteroids, antiseptics, vitamin A ointment (VA), cyclosporine, tacrolimus), the management of trichiatic eyelashes, meibomian dysfunction, symblepharons, and corneal neovascularization, as well as the contactologic solutions implemented. Eleven ophthalmologists and 9 dermatologists from 9 of the 11 centers responded to the questionnaire. Based on questionnaire results, 10/11 ophthalmologists systematically prescribed preservative-free artificial tears, and 11/11 administered VA. Antiseptic or antibiotic eye drops or antibiotic-corticosteroid eye drops were recommended as needed by 8/11 and 7/11 ophthalmologists, respectively. In case of chronic inflammation, topical cyclosporine was consistently proposed by 11/11 ophthalmologists. The removal of trichiatic eyelashes was mainly performed by 10/11 ophthalmologists. Patients were referred to a reference center for fitting of scleral lenses (10/10,100%). Based on this practice audit and literature review, we propose an evaluation form to facilitate ophthalmic data collection in the chronic phase of EN and we also propose an algorithm for the ophthalmologic management of ocular sequelae.

Published
2023
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3. Agranulocytosis‐complicated DRESS with medullar HHV‐6 replication

Author

Margot Lehericey, Florence Tétart, Priscille Carvalho, Olivia Bauvin, Charles Hervouet, Pascal Joly, and Vivien Hébert

Subjects
agranulocytosis, bone marrow, drug reaction with eosinophilia and systemic symptoms, HHV‐6, Medicine, Medicine (General), R5-920
Abstract

Abstract HHV‐6B is the subtype most often involved in the systemic manifestations of the DRESS, but also in myelosuppression in bone marrow transplant. We report a new observation of its myelosuppressive effect: a case of DRESS complicated by agranulocytosis with detectable HHV‐6 RNA in bone marrow.

Published
2020
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4. Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials

Author

Rosana, Agondi, Ahmed, Al Waily, Fabio, Almerigogna, Miguel Angel Tejedor, Alonso, Alfred, Ammoury, Eng Kim, Anne Goh, Robert, Anolik, Ledit, Ardusso, Petr, Arenberger, Nandini, AS, Mohammad, Asefi, Natalia, Astafieva, Anil, Badhwar, Esther Serra, Baldrich, Christine, Bangert, Annick, Barbaud, Zsuzsanna, Bata-Csorgo, Andrea, Bauer, Frederic, Berard, Beata, Bergler-Czop, Gary D, Berman, Jonathan, Bernstein, Subhash Chandra, Bharija, Ramesh M, Bhat, Isabelle, Boccon-Gibod, Ivan, Botev, Knut, Brockow, Philipp, Buck, Paula, Busse, Regis, Campos, Giorgio Walter, Canonica, Irani, Carla, Julia Maria Del, Carmen, Jaime Del, Carpio, Mamatha, Chadalavada, Yoon-Seok, Chang, Amarjit, Cheema, Yi Hsing, Chen, Yuko, Chinuki, Soyun, Cho, Jeong-Hee, Choi, Chia-Yu, Chu, Ronit, Confino, Jonathan, Corren, Roberta, Criado, Claudia De La, Cruz, David M, Cypcar, Pramila, Daftary, Inna, Danilycheva, Kenneth, Dawes, Michelle Joy, De Vera, James, Deangelo, Stefano, Del Giacco, Diana, Deleanu, John, Delgado, Richard, DeMera, Mohamed, Denguezli, Heinrich, Dickel, Le Huu, Doanh, Sinan, Dogan, Marie Sylvie, Doutre, Anne Sophie, Dupond, Anton, Edin, Kent, EDWARD, Swarna, Ekanayake-Bohling, Daniel, Elbirt, David, Elkayam, Anne, Ellis, Shaunagh, Emanuel, Alexander, Emeliyanov, Burhan, Engin, Luis Felipe, Ensina, Ignacio Antepara, Ercoreca, Safiye, Ergun, Jose Luis Lopez, Estebaranz, Rustem, Fassakhov, Daria, Fomina, Linda, Ford, Mariangela, Francomano, Todd, Funkhouser, Remi, Gagnon, Ricardo, Galimberti, Cesar Alberto, Galvan Calle, Clovis, Galvao, Gabriel, Gattolin, Pierre-Dominique, Ghislain, Ana Maria, Gimenez Arnau, Elliot, Ginchansky, Francoise, Giordano-Labadie, Stanislav, Givirovsky, Kiran, Godse, Shaila, Gogate, Alan, Goldsobel, Francisca, Gomez, Rene Maximiliano, Gomez, Erika, Gonzalez, Paula Ribo, Gonzalez, Dimitar, Gospodinov, Clive, Grattan, Martine, Grosber, Gary, Gross, Francisco Jose Gomez, Guimera Martin-Neda, Rolland, Gyulai, Svetlana, Hadvabova, Suzana Ljubojevic, Hadzavdic, Hadi, Hamam, Daniela, Hasicova, Koremasa, Hayama, Pravin, Hissaria, Anna, Hjerppe, Ivan, Hlinka, Moises Labrador, Horrillo, Connie, Hsu, Yu-Huei, Huang, Iftikhar, Hussain, Atsuyuki, Igarashi, Beata, IMKO-WALCZUK, Huseyin Serhat, Inaloz, Rossella, Intravaia, Neal, Jain, Sanjeev, Jain, Thilo, Jakob, Ruth Cerino, Javier, Antonio, João, Luiza Marek, Jozefowicz, Chang-Gyu, Jung, Martin, Kaatz, Nida, Kacar, Henry, Kanarek, Iva, Karlova, Alexander, Kastanayan, Jana, Kazandjieva, Johannes, Kern, Aharon, Kessel, Neena, Khanna, HeeJoo, Kim, Nancy, Kim, Sang-Ha, Kim, Tae-bum, Kim, Kulli, Kingo, Andreas, Kleinheinz, Janka, Komova, Evangelia, Kompoti, Tomas, Kopal, Peter, Kozub, Dorota, Krasowska, Beata, Krecisz, Burkhard, Kreft, Satsuki, Kubota, Hitoshi, Kudo, Teja, Kulkarni, Kanokvalai, Kulthanan, Akihiro, Kume, Maciej, Kupczyk, Edward, Lain, Bobby, Lanier, Hilde, Lapeere, Griselle Ortiz, Lasanta, Svetlana, Lazareva, Laura, Lazzeri, Dennis, Ledford, Donghun, Lee, Haur Yueh, Lee, Jeffrey, Leflein, Nicolas, Leitz, Nancy, Levin, Hermenio, Lima, Undine, Lippert, Brian, Lipson, Paula, Luna, Gabriel, Magarinos, Satyaprakash, Mahajan, Michail, Makris, Alejandro, Malbran, Ahmed Manjra, Manjra, Michael, Manning, Maria, Manrique, Adriana, Marcipar, Mariano, Marini, Veronique Del, Marmol, Jorge, Maspero, Tomoko, Matsuda, Jonathan, Matz, Marcus, Maurer, Wendy, McFalda, Anne, Mclaughlin, Iris, Medina, Rajesh Dutt, Mehta, Stephan, Meller, Steven, MELTZER, Raisa, Meshkova, Dorin, Mihalache, Francisco Javier, Miquel, Mourad, Mokni, J, Molhoek, Efrain, Montano, Sabine, Mueller, Javier Pedraz, Munoz, Toshikazu, Nagakura, Joanna, Narbutt, Ignasi Figueras, Nart, Ma. Lourdes M, Nebrida-Idea, Trong Hao, Nguyen, Johannes, Niesmann, Violeta Zaragoza, Ninet, Hiromitsu, Noguchi, Yuko Chinuki, Nomura, Roman, Nowicki, Tokuya, Omi, Robert, Onder, Ivan, Orojan, Francisco Javier, Ortiz de Frutos, Kim, Papp, Claudio, Parisi, Chun Wook, Park, Heungwoo, Park, Jungwon, Park, Young Min, Park, Viviana, Parra, Thierry, Passeron, Justine, Pasteur, Shivakumar, Patil, Vergil, Patrascu, Sylvia, Pauser, Anna Wojas, Pelc, Jonathan Grant, Peter, Wolfgang, Pfuetzner, Nicola, Pimpinelli, Andreas, Pinter, Cristian, Pizarro, Karel, Pizinger, Jarmila, Plutinska, Todor, Popov, Veronika, Popova, Marta Ferrer, Puga, Lara Ferrandiz, Pulido, Anca, Purcaru, Ulrike, Raap, Anna, Rajchel, John, Ramey, Ma Deanna Santos, Ramiscal, German Dario, Ramon, Syed, Rehman, Adam, Reich, Norbert, Reider, Krista, Ress, Dimitrios, Rigopoulos, Enrique, Rivas, Heike, Rockmann, Pierre-Paul, Roquet-Gravy, Menachem, Rottem, Vermen Verallo, Rowell, Franziska, Rueff, Juan Alberto Ruano, Ruiz, Juan, Russo, Ronald, Saff, Sarbjit, Saini, Maria, Salazar, Juan Francisco Silvestre, Salvador, Jorge, Sanchez, Florica, Sandru, Mark, Scarupa, Knut, Schaekel, Sibylle, Schliemann, Rik, Schrijvers, Beate, Schwarz, Andreas, Schwinn, Sudhir, Sekhsaria, Nilgun, Senturk, Seong Jun, Seo, Mercedes Rodriguez, Serna, Faradiba, Serpa, Paul A, Shapero, Eriko, Shinkawa, Jan-Christoph, Simon, Rodney, Sinclair, Ralfi, Singer, Dareen D, Siri, Karl, Sitz, Adam, Smialowski, Andrew, Smith, Morten, Soerensen, Wiebke, Sondermann, Haejun, Song, Dmitrii, Sonin, Weily, Soong, Daniel, Soteres, Maria, Staevska-Kotasheva, Petra, Staubach-Renz, Nisha Su Yien, Subash, Gordon, Sussman, Ake Svensson, Svensson, Ekaterini, Syrigou, Andrea, Szegedi, Jacek, Szepietowski, Shunsuke, Takahagi, Yuval, Tal, Neetu, Talreja, Wooi Chiang, Tan, Ricardo, Tan, Jyh Jong, Tang, Tonny, Tanus, Martha, Tarpay, Shang Ian, Tee, Craig, Teller, Florence, Tetart, Aurelie Du, Thanh, Suganthi, Thevarajah, Simon Francis, Thomsen, Carl, Thornblade, Milan, Tjioe, Alberto, Tolcachier, Celeste, Tolentino, Athanasios, Tsianakas, Ilia, Tsingov, Hamida, Turki, Olga, Ukhanova, Jens, Ulrich, Meltem, Uslu, Fernando, Valenzuela, Solange, Valle, Martijn, van Doorn, Jirina, Vankova, Suneel, Vartak, Christine, Vidouria, Sebastian, Volc, Gerald, Volcheck, Nicola, Wagner, Irena, Walecka-Herniczek, Penpun, Wattanakrai, Bettina, Wedi, Steven, Weinstein, Vesarat, Wessagowit, Hugh, Windom, Akiko, Yagami, Aisaku, Yamamoto, Shinichiro, Yasumoto, Young Min, Ye, Jose Cevallos, Yepez, Sang Woong, Youn, Hana, Zelenkova, Oleg, Ziganshin, Matthew, Zook, Maurer, Marcus, Ensina, Luis Felipe, Gimenez-Arnau, Ana Maria, Sussman, Gordon, Hide, Michihiro, Saini, Sarbjit, Grattan, Clive, Fomina, Daria, Rigopoulos, Dimitrios, Berard, Frederic, Canonica, Giorgio Walter, Rockmann, Heike, Szepietowski, Jacek C, Leflein, Jeffrey, Bernstein, Jonathan A, Peter, Jonny G, Kulthanan, Kanokvalai, Godse, Kiran, Ardusso, Ledit, Ukhanova, Olga, Staubach, Petra, Sinclair, Rodney, Gogate, Shaila, Thomsen, Simon Francis, Tanus, Tonny, Ye, Young Min, Burciu, Alis, Barve, Avantika, Modi, Darshna, Scosyrev, Emil, Hua, Eva, Letzelter, Kerstin, Varanasi, Vineeth, Patekar, Manmath, and Severin, Thomas

Published
2024
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5. Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children

Author

Charlotte, Beaumont, Anne-Sophie, Darrigade, Annick, Barbaud, Evelyne, Collet, Nadia, Raison-Peyron, Jean-Luc, Bourrain, Haudrey, Assier, Françoise, Giordano-Labadie, Corina, Bara-Passot, Brigitte, Milpied, Florence, Tétart, Pierre, Armingaud, Florence, Castelain, Lamia, Benkalfate, Claire, Boulard, Juliette, Delaunay, Pascale, Mathelier-Fusade, Catherine, Pecquet, Pauline, Pralong, Dominique, Vital-Durand, Nathalie, Genillier Foin, Marine-Alexia, Lefèvre, Florence, Hacard, Audrey, Nosbaum, Justine, Pasteur, Aude, Valois, Martine, Vigan, Marie-Christine, Ferrier le Bouëdec, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Dermatologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), CHU Montpellier, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de dermatologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Toulouse [Toulouse], CHU Bordeaux [Bordeaux], Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de dermatologie, hôpital Jacques-Monod, Le Havre, Département d'allergie et d'immunologie clinique [CHU Lyon Sud], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
recidal-gerda, Adult, Chlorhexidine, contact dermatitis, Dermatology, Allergens, Patch Tests, allergy, benzalkonium chloride, Chlorides, antiseptic, Dermatitis, Allergic Contact, Anti-Infective Agents, Local, Humans, Immunology and Allergy, Benzalkonium Compounds, Child, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Benzyl Alcohols, benzyl alcohol, Retrospective Studies
Abstract

An aqueous antiseptic containing "chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol" (CBB) is widely used in France. The only previous documented study dealing with allergic contact dermatitis (ACD) to this antiseptic is one small case series in children. The French Vigilance Network for Dermatology and Allergy (REVIDAL-GERDA) has collected many cases in the last few years.To evaluate the clinical and sensitization profiles of patients diagnosed with ACD to CBB.We performed a retrospective study of patients with contact dermatitis to CBB and positive tests to CBB and/or at least one of its components. All patients had to be tested with all components of CBB.A total of 102 patients (71 adults and 31 children) were included. The lesions were extensive in 63% of patients and 55% had delayed time to diagnosis. CBB patch tests were positive in 93.8% of cases. The allergen was identified in 97% of patients, mainly benzyl alcohol in adults (81.7%) and chlorhexidine digluconate in children (54.8%). About 32.4% of the patients were sensitized to several components.CBB is a cause of ACD at all ages. The components of the antiseptic should be tested. The sensitization profile seems to be different between adults and children.

Published
2022
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7. Pustular Lichenoid Eruptions Induced by Immune Checkpoint Inhibitors: Two Case Reports and a Review of the Literature

Author

Charlotte Emonet, Florence Tétart, Olivia Bauvin, Lucie Cellier, Philippe Courville, Claire Mignard, Raphaël Janela-Lapert, Alexis Lefebvre, Samy Lachkar, Diane Lechevalier, Laurence Lagarce, Priscille Carvalho, and Billal Tedbirt

Subjects
Pharmacology, Cancer Research, Immunology, Immunology and Allergy
Abstract

Immune checkpoint inhibitors (ICIs) have become the standard treatment for many types of cancer. After several years of using these therapies, many adverse events related to ICIs have been observed. Dermatologic toxicities such as nonspecific morbilliform rash, vitiligo, Stevens-Johnson syndrome/toxic epidermal necrolysis, and more rarely, lichenoid eruptions have been described in the literature. We report 2 cases of pustular lichenoid eruptions, 1 in a patient with nonsmall cell lung carcinoma and 1 in a patient with metastatic melanoma, induced by pembrolizumab and nivolumab, respectively. The 2 patients were treated with topical corticosteroids, and complete healing of lesions was slowly obtained. Due to the severity of the cutaneous eruptions, pembrolizumab and nivolumab were discontinued. We identified 6 cases of pustular lichenoid eruptions induced by ICIs in the published literature and in the French Pharmacovigilance Database and reviewed their main clinical features and courses.

Published
2022

8. Skin Testing and Drug Provocation Tests in Epidermal Necrolysis: A French Experience

Author

Camille Roux, Benoit Ben Said, Brigitte Milpied, Claire Bernier, Delphine Staumont-Sallé, Frédéric Dezoteux, Angèle Soria, Annick Barbaud, Laurence Valeyrie-Allanore, Florence Tétart, Nathalia Bellon, Bénédicte Lebrun-Vignes, Gwendeline Gener, Muriel Paul, Saskia Ingen-Housz-Oro, Haudrey Assier, CHU Lille, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de Pharmacologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Henri Mondor, Service de dermatologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
[SDV]Life Sciences [q-bio], Stevens-Johnson Syndrome, Immunology and Allergy, Humans, Patch Tests, Retrospective Studies, Skin Tests
Abstract

There are limited data on the use of skin testing, other than patch testing, and challenges in the evaluation of epidermal necrolysis (EN), including Stevens-Johnson syndrome and toxic epidermal necrolysis.To report a French multicenter experience in skin testing and challenges in EN, and investigate the factors associated with tests' positivity.All patients who were evaluated by patch tests (PTs), skin prick tests, intradermal tests (IDTs), or drug provocation tests (DPTs) for EN between 2010 and 2020 were retrospectively included through 2 French drug reaction networks.In total, 113 patients were included from 8 centers. Median (interquartile range) time from EN to hypersensitivity workup was 7.9 months (5.1-15 months). All patients had PTs, 17 (15%) had skin prick tests or IDTs with delayed readings and 32 (28.3%) had DPTs. One mild reaction occurred after a DPT. Overall, 22 patients (19.5%) had positive PTs, and the only factors associated with positivity were Algorithm of Drug Causality for Epidermal Necrolysis (ALDEN) score and drug class. Only 1 IDT was positive but considered irrelevant. The DPTs were never performed to prove responsibility of a highly suspected drug but were used to confirm current tolerance of needed medications.Allergological workup in EN, performed by specialists involved in EN, seems safe. Skin tests, although of limited sensitivity, can be helpful for considering the reintroduction of essential drugs according to a benefit-to-risk decision. We propose an algorithm for approaching hypersensitivity testing in patients with EN, to be adapted to each patient.

Published
2022
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10. Contents Vol. 231, 2015

Author

Anne Janin, Luigi Naldi, David Swanson, Daniela Cattoni, Gunseli Ozturk, C. Lheure, Valerio De Vita, Maxime Battistella, Béatrice Flageul, Nora Kramkimel, Andrew T. Patterson, Angèle Soria, Koji Sayama, Olivier Sorg, Bengu Gerceker Turk, Frances T. Tian, Masamoto Murakami, Nathalie Franck, David C. Whiteman, Marie Masson Regnault, Yeliz Erdemoğlu, Pascal Girardin, Vincent Sibaud, François Goldwasser, Pasquale Ena, Michelle R. Iannacone, Martine Bagot, Aysin Kaya, Fumiko Oda, Fisard, Alex Llambrich, Chika Namba, H. Peter Soyer, Kana Masuda, Ryo Utsunomiya, Sylvie Fraitag, Nicolas Dupin, Marie-Françoise Avril, Rocco Micciolo, Werner Druck Medien Ag, Camille Francès, Marcia Davis, Diane Kottler, Banu Yaman, Annick Barbaud, Jean-Hilaire Saurat, Lydia Deschamps, Sebastiana Boi, Angel Pizarro, Steven C. Campbell, Sarah Guenounou, Christian Recher, Nicole M. Isbel, Gürkan Kaya, Patricia Caseiro Silverio, Satz Mengensatzproduktion, Mario Cristofolini, Miesha Merati, Naiara Fraga-Braghiroli, Henri Roche, Jonathan Fawcett, Dirk M. Elston, Astrid Queant, Nicolas Ortonne, Serge Boulinguez, Stéphane Barete, Benjamin H. Kaffenberger, Luis Javier del Pozo, Luca Ena, Nirmala Pandeya, Michel Rybojad, Lisa Ferguson, Florence Tétart, Laurence Gladieff, Agnès Carlotti, Laurence Lamant, Saskia Ingen-Housz-Oro, Harold S. Rabinovitz, Nikhil Yawalkar, Marco Ferrari, Martine Avenel-Audran, Haudrey Assier, Maria Cristina Sicher, Emilie Tournier, Pedro Zaballos, José Bañuls, Sara Laurent-Roussel, Christian Landi, Adèle C. Green, Karolina Gadaldi, Noémie Gadaud, Simone Cazzaniga, Fabienne Fontao, Gaëlle Quéreux, Nadia Raison-Peyron, Alon Scope, Béatrice Crickx, Mehdi Iskandarli, Stéphanie Amarger, Adriano Decarli, Gabriella Fabbrocini, Vittorio Mazzarello, and Angel Vera

Subjects
Dermatology
Published
2015

11. Acknowledgement to Referees for Dermatology 2015

Author

Béatrice Crickx, Jean-Hilaire Saurat, Banu Yaman, Maria Cristina Sicher, Rocco Micciolo, Camille Francès, Noémie Gadaud, Sarah Guenounou, Jonathan Fawcett, Marcia Davis, Andrew T. Patterson, Christian Recher, Aysin Kaya, Nirmala Pandeya, Florence Tétart, Gunseli Ozturk, Sara Laurent-Roussel, Christian Landi, Lisa Ferguson, Steven C. Campbell, C. Lheure, Lydia Deschamps, François Goldwasser, Agnès Carlotti, Angèle Soria, Koji Sayama, Gaëlle Quéreux, Gürkan Kaya, Simone Cazzaniga, Henri Roche, Fabienne Fontao, Werner Druck Medien Ag, Mehdi Iskandarli, Serge Boulinguez, Naiara Fraga-Braghiroli, Fisard, Luigi Naldi, Michelle R. Iannacone, Nadia Raison-Peyron, Stéphane Barete, Stéphanie Amarger, Nikhil Yawalkar, Martine Bagot, Valerio De Vita, Adriano Decarli, Nicole M. Isbel, Marie Masson Regnault, Saskia Ingen-Housz-Oro, Michel Rybojad, Gabriella Fabbrocini, David Swanson, Satz Mengensatzproduktion, Fumiko Oda, Masamoto Murakami, Karolina Gadaldi, Yeliz Erdemoğlu, David C. Whiteman, Annick Barbaud, Harold S. Rabinovitz, Daniela Cattoni, Vittorio Mazzarello, Bengu Gerceker Turk, Angel Vera, Marco Ferrari, Angel Pizarro, Luis Javier del Pozo, Nicolas Ortonne, Anne Janin, Benjamin H. Kaffenberger, Sylvie Fraitag, Kana Masuda, Alon Scope, Ryo Utsunomiya, H. Peter Soyer, Laurence Lamant, Luca Ena, Alex Llambrich, Nora Kramkimel, Vincent Sibaud, Adèle C. Green, Olivier Sorg, Miesha Merati, Mario Cristofolini, Marie-Françoise Avril, Maxime Battistella, Béatrice Flageul, Diane Kottler, Dirk M. Elston, Martine Avenel-Audran, Haudrey Assier, Emilie Tournier, Chika Namba, Sebastiana Boi, Pedro Zaballos, José Bañuls, Pasquale Ena, Astrid Queant, Patricia Caseiro Silverio, Laurence Gladieff, Frances T. Tian, Nathalie Franck, Pascal Girardin, and Nicolas Dupin

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2015
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12. Urticaire chronique spontanée : mise en perspective de la prise en charge par les acteurs de santé dans les parcours de soins

Author

Vasse, Élsa, UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Florence Tétart, and Gilles Gargala

Subjects
Papules, Dermatologue, Antihistaminique, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Oedèmes, Urticaire Chronique Spontanée
Abstract

L’Urticaire Chronique Spontanée est une pathologie dermatologique peu connue. Cependant, sa prévalence peut atteindre 1% de la population mondiale. Le parcours de soins des patients atteints d’Urticaire Chronique est majoritairement difficile car les diagnostiques différentiels ne sont pas toujours évidents. De plus, les multiples acteurs de santé : médecin généraliste, allergologue, dermatologues libéral et hospitalier, pharmacien peuvent accentuer la longévité de la prise en charge. Cette thèse a pour vocation de faire l’état de l’art de ce parcours et de mettre en lumière les possibilités pour chaque acteur de santé d’améliorer la prise en charge des patients. Enfin, elle permet de présenter les nouveaux acteurs en faveur de l’optimisation de la prise en charge des patients atteints d’Urticaire Chronique Spontanée.

Published
2020

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