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137 results on '"Flores, Kristina"'

1. Carbapenem-Resistant and Extended-Spectrum [beta]-Lactamase-Producing Enterobacterales in Children, United States, 2016-2020

Author

Grome, Heather N., Grass, Julian E., Duffy, Nadezhda, Bulens, Sandra N., Ansari, Uzma, Campbell, Davina, Lutgring, Joseph D., Gargis, Amy S., Masters, Thao, Kent, Alyssa G., McKay, Susannah L., Smith, Gillian, Wilson, Lucy E., Vaeth, Elisabeth, Evenson, Bailey, Dumyati, Ghinwa, Tsay, Rebecca, Phipps, Erin, Flores, Kristina, Wilson, Christopher D., Czaja, Christopher A., Johnston, Helen, Janelle, Sarah J., Lynfield, Ruth, OMalley, Sean, Vagnone, Paula Snippes, Maloney, Meghan, Nadle, Joelle, and Guh, Alice Y.

Subjects
Drug therapy, Diagnosis, Testing, Pediatric communicable diseases -- Drug therapy -- Diagnosis, Microbial drug resistance -- Testing, Medical research, Enterobacteriaceae infections -- Drug therapy -- Diagnosis, Medicine, Experimental, Drug resistance in microorganisms -- Testing, Communicable diseases in children -- Drug therapy -- Diagnosis
Abstract

Medscape CME Activity In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is jointly accredited with commendation [...]

Published
2024
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2. Predictors and Consequences of Math Course Repetition: The Role of Horizontal and Vertical Repetition in Success among Community College Transfer Students

Author

Bicak, Ibrahim, Schudde, Lauren, and Flores, Kristina

Abstract

Delays in meeting math requirements can impede the progress among community college students who aspire to earn a baccalaureate degree. To investigate this issue, we used state administrative data from Texas to examine the prevalence and predictors of math course repetition and how math course repetition predicts transfer students' outcomes. More than a third of community college transfer students take additional introductory mathematics coursework despite having fulfilled the requirement--a phenomenon we referred to as "horizontal repetition"--and one sixth of community college students take redundant coursework within a given mathematics course sequence, referred to as "vertical repetition." Using regression models controlling for student backgrounds, academic experiences, and institutional fixed effects, we found that horizontal repetition was linked to lower GPA and, among degree recipients, increased time to degree and excess credits. Vertical repetition was negatively associated with GPA and degree completion and positively linked to increased time to degree and excess credits. Location of course repetition shaped student outcomes, where math course repetitions occurring at the university appear to drive many of the negative associations between both horizontal and vertical repetition and student outcomes. As community colleges and universities across the country consider the efficacy of course sequences and transfer pathways, our research offers insights into patterns and implications of course repetition in core math courses.

Published
2023
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3. Carbapenem-resistant Acinetobacter baumannii complex in the United States—An epidemiological and molecular description of isolates collected through the Emerging Infections Program, 2019

Author

Bulens, Sandra N., Campbell, Davina, McKay, Susannah L., Vlachos, Nicholas, Burgin, Alex, Burroughs, Mark, Padila, Jasmine, Grass, Julian E., Jacob, Jesse T., Smith, Gillian, Muleta, Daniel B., Maloney, Meghan, Macierowski, Bobbie, Wilson, Lucy E., Vaeth, Elisabeth, Lynfield, Ruth, O’Malley, Sean, Snippes Vagnone, Paula M., Dale, Jennifer, Janelle, Sarah J., Czaja, Christopher A., Johnson, Helen, Phipps, Erin C., Flores, Kristina G., Dumyati, Ghinwa, Tsay, Rebecca, Beldavs, Zintars G., Maureen Cassidy, P., Hall, Amanda, Walters, Maroya S., Guh, Alice Y., Magill, Shelley S., and Lutgring, Joseph D.

Published
2024
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4. Hospitalization Rates and Characteristics of Children Aged <18 Years Hospitalized with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 1–July 25, 2020

Author

Kim, Lindsay, Whitaker, Michael, O’Halloran, Alissa, Kambhampati, Anita, Chai, Shua J, Reingold, Arthur, Armistead, Isaac, Kawasaki, Breanna, Meek, James, Yousey-Hindes, Kimberly, Anderson, Evan J, Openo, Kyle P, Weigel, Andy, Ryan, Patricia, Monroe, Maya L, Fox, Kimberly, Kim, Sue, Lynfield, Ruth, Bye, Erica, Shrum Davis, Sarah, Smelser, Chad, Barney, Grant, Spina, Nancy L, Bennett, Nancy M, Felsen, Christina B, Billing, Laurie M, Shiltz, Jessica, Sutton, Melissa, West, Nicole, Talbot, H Keipp, Schaffner, William, Risk, Ilene, Price, Andrea, Brammer, Lynnette, Fry, Alicia M, Hall, Aron J, Langley, Gayle E, Garg, Shikha, Coates, Ashley, Daily Kirley, Pam, Libby, Tanya, Roland, Jeremy, Alden, Nisha, Herlihy, Rachel, McLafferty, Sarah, Clogher, Paula, Kayalioglu, Hazal, Maslar, Amber, Misiorski, Adam, Niccolai, Linda, Olson, Danyel, Parisi, Christina, Fawcett, Emily, Gretzinger, Siyeh, Lengacher, Katelyn, Williams, Jeremiah, Blythe, David, Brooks, Alicia, Park, Rachel, Wilson, Michelle, Como-Sabetti, Kathryn, Danila, Richard, Cline, Cory, Angeles, Kathy, Eisenberg, Nancy, Flores, Kristina, Habrun, Caroline, Hancock, Emily, Khanlian, Sarah, Novi, Meaghan, Phipps, Erin, Salazar-Sanchez, Yadira, Dufort, Elizabeth, Muse, Alison, Bushey, Sophrena, Gaitan, Maria, Kurtz, RaeAnne, Owusu-Dommey, Ama, Snyder, Lindsey, Michaelis, Katherine, Seeley, Kylie, Markus, Tiffanie, Chatelain, Ryan, George, Andrea, Hill, Mary, McCullough, Laine, Spencer, Melanie, Swain, Ashley, McCaffrey, Keegan, Holstein, Rachel, Meador, Seth, and Wortham, Jonathan

Subjects
Pediatric, Patient Safety, Infectious Diseases, Clinical Trials and Supportive Activities, Lung, Prevention, Clinical Research, Pediatric Research Initiative, Aetiology, 2.4 Surveillance and distribution, Good Health and Well Being, Adolescent, Betacoronavirus, COVID-19, Child, Child, Preschool, Chronic Disease, Clinical Laboratory Services, Coronavirus Infections, Ethnicity, Female, Hospitalization, Humans, Infant, Infant, Newborn, Male, Pandemics, Pediatric Obesity, Pneumonia, Viral, Risk Factors, SARS-CoV-2, Severity of Illness Index, United States, COVID-NET Surveillance Team, General & Internal Medicine
Abstract

Most reported cases of coronavirus disease 2019 (COVID-19) in children aged

Published
2020

5. Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences

Author

Guh, Alice Y, primary, Li, Rongxia, additional, Korhonen, Lauren, additional, Winston, Lisa G, additional, Parker, Erin, additional, Czaja, Christopher A, additional, Johnston, Helen, additional, Basiliere, Elizabeth, additional, Meek, James, additional, Olson, Danyel, additional, Fridkin, Scott K, additional, Wilson, Lucy E, additional, Perlmutter, Rebecca, additional, Holzbauer, Stacy M, additional, D’Heilly, Paige, additional, Phipps, Erin C, additional, Flores, Kristina G, additional, Dumyati, Ghinwa K, additional, Pierce, Rebecca, additional, Ocampo, Valerie L S, additional, Wilson, Christopher D, additional, Watkins, Jasmine J, additional, Gerding, Dale N, additional, and McDonald, L Clifford, additional

Published
2024
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6. Carbapenem-Resistant and Extended-Spectrum β-Lactamase-Producing Enterobacterales in Children, United States, 2016-2020.

Author

Grome, Heather N., Grass, Julian E., Duffy, Nadezhda, Bulens, Sandra N., Ansari, Uzma, Campbell, Davina, Lutgring, Joseph D., Gargis, Amy S., Masters, Thao, Kent, Alyssa G., McKay, Susannah L., Smith, Gillian, Wilson, Lucy E., Vaeth, Elisabeth, Evenson, Bailey, Dumyati, Ghinwa, Tsay, Rebecca, Phipps, Erin, Flores, Kristina, and Wilson, Christopher D.

Subjects
CHILD patients, AGE groups, URINE, INFANTS
Abstract

We conducted surveillance for carbapenem-resistant Enterobacterales (CRE) during 2016-2020 at 10 US sites and extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) during 2019-2020 at 6 US sites. Among 159 CRE cases in children (median age 5 years), CRE was isolated from urine for 131 (82.4%) and blood from 20 (12.6%). Annual CRE incidence rate (cases/100,000 population) was 0.47-0.87. Among 207 ESBLE cases in children (median age 6 years), ESBL-E was isolated from urine of 196 (94.7%) and blood of 8 (3.9%). Annual ESBL-E incidence rate was 26.5 in 2019 and 19.63 in 2020. CRE and ESBL-E rates were >2-fold higher among infants than other age groups. Most CRE and ESBL-E cases were healthcare-associated community-onset (68 [43.0%] for CRE vs. 40 [23.7%] for ESBL-E) or community- associated (43 [27.2%] for CRE vs. 109 [64.5%] for ESBL-E). Programs to detect, prevent, and treat multidrugresistant infections must include pediatric populations (particularly the youngest) and outpatient settings. [ABSTRACT FROM AUTHOR]

Published
2024
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8. 684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences

Author

Guh, Alice, primary, Li, Rongxia, additional, Korhonen, Lauren C, additional, Winston, Lisa Gail, additional, Parker, Erin, additional, Czaja, Christopher A, additional, Johnston, Helen, additional, Basiliere, Elizabeth, additional, Meek, James, additional, Olson, Danyel M, additional, Fridkin, Scott, additional, Wilson, Lucy E, additional, Perlmutter, Rebecca, additional, Holzbauer, Stacy, additional, D’Heilly, Paige, additional, Phipps, Erin, additional, Flores, Kristina, additional, Dumyati, Ghinwa, additional, Pierce, Rebecca, additional, Ocampo, Valerie, additional, Wilson, Christopher, additional, Watkins, Jasmine, additional, Gerding, Dale, additional, and Clifford McDonald, L, additional

Published
2023
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11. Epidemiology of carbapenem-resistant and extended-spectrum beta-lactamase-producing Enterobacterales in US children, 2016–2020

Author

Grome, Heather, primary, Grass, Julian, additional, Duffy, Nadezhda, additional, Bulens, Sandra, additional, Jacob, Jesse, additional, Smith, Gillian, additional, Wilson, Lucy, additional, Vaeth, Elisabeth, additional, Evenson, Bailey, additional, Dumyati, Ghinwa, additional, Tsay, Rebecca, additional, Phipps, Erin C., additional, Flores, Kristina, additional, Wilson, Christopher, additional, Czaja, Christopher, additional, Johnston, Helen, additional, Lynfield, Ruth, additional, O’Malley, Sean, additional, Maloney, Meghan, additional, Stabach, Nicole, additional, Nadle, Joelle, additional, and Guh, Alice, additional

Published
2023
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14. Data from The A/G Allele of Rs16906252 Predicts for MGMT Methylation and Is Selectively Silenced in Premalignant Lesions from Smokers and in Lung Adenocarcinomas

Author

Leng, Shuguang, primary, Bernauer, Amanda M., primary, Hong, Chibo, primary, Do, Kieu C., primary, Yingling, Christin M., primary, Flores, Kristina G., primary, Tessema, Mathewos, primary, Tellez, Carmen S., primary, Willink, Randall P., primary, Burki, Elizabeth A., primary, Picchi, Maria A., primary, Stidley, Christine A., primary, Prados, Michael D., primary, Costello, Joseph F., primary, Gilliland, Frank D., primary, Crowell, Richard E., primary, and Belinsky, Steven A., primary

Published
2023
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15. Supplementary Data from The A/G Allele of Rs16906252 Predicts for MGMT Methylation and Is Selectively Silenced in Premalignant Lesions from Smokers and in Lung Adenocarcinomas

Author

Leng, Shuguang, primary, Bernauer, Amanda M., primary, Hong, Chibo, primary, Do, Kieu C., primary, Yingling, Christin M., primary, Flores, Kristina G., primary, Tessema, Mathewos, primary, Tellez, Carmen S., primary, Willink, Randall P., primary, Burki, Elizabeth A., primary, Picchi, Maria A., primary, Stidley, Christine A., primary, Prados, Michael D., primary, Costello, Joseph F., primary, Gilliland, Frank D., primary, Crowell, Richard E., primary, and Belinsky, Steven A., primary

Published
2023
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16. FOXC1 plays a crucial role in the growth of pancreatic cancer

Author

Subramani, Ramadevi, Camacho, Fernando A., Levin, Carly Ivy, Flores, Kristina, Clift, Alexa, Galvez, Adriana, Terres, Mauricio, Rivera, Servando, Kolli, Sai Navana, Dodderer, Joshua, Miranda, Megan, Rodriguez, Alejandro, Pedroza, Diego A., Chatterjee, Animesh, and Lakshmanaswamy, Rajkumar

Published
2018
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17. 86. Antibiotic-resistant gram-negative bacterial infections among persons with or without a prior positive test for SARS-CoV-2 in 10 U.S. sites, 2020

Author

Bulens, Sandra N, primary, Grass, Julian E, additional, Duffy, Nadezhda, additional, Tola, Jigsa, additional, Jacob, Jesse T, additional, Smith, Gillian, additional, Vaeth, Elisabeth, additional, Dumyati, Ghinwa, additional, Looi, Hsioa Che, additional, Phipps, Erin C, additional, Flores, Kristina, additional, Wilson, Christopher, additional, Muleta, Daniel, additional, Czaja, Christopher A, additional, Driscoll, Jennifer, additional, Lynfield, Ruth, additional, O'Malley, Sean M, additional, Maloney, Meghan, additional, Stabach, Nicole, additional, Nadle, Joelle, additional, Pierce, Rebecca, additional, Hertzel, Heather, additional, and Guh, Alice, additional

Published
2022
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18. Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Author

Guh, Alice Y, primary, Yi, Sarah H, additional, Baggs, James, additional, Winston, Lisa, additional, Parker, Erin, additional, Johnston, Helen, additional, Basiliere, Elizabeth, additional, Olson, Danyel, additional, Fridkin, Scott K, additional, Mehta, Nirja, additional, Wilson, Lucy, additional, Perlmutter, Rebecca, additional, Holzbauer, Stacy M, additional, D’Heilly, Paige, additional, Phipps, Erin C, additional, Flores, Kristina G, additional, Dumyati, Ghinwa K, additional, Hatwar, Trupti, additional, Pierce, Rebecca, additional, Ocampo, Valerie L S, additional, Wilson, Christopher D, additional, Watkins, Jasmine J, additional, Korhonen, Lauren, additional, Paulick, Ashley, additional, Adamczyk, Michelle, additional, Gerding, Dale N, additional, and Reddy, Sujan C, additional

Published
2022
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21. Epidemiology of extended-spectrum β-lactamase–producing Enterobacterales in five US sites participating in the Emerging Infections Program, 2017

Author

Duffy, Nadezhda, primary, Karlsson, Maria, additional, Reses, Hannah E., additional, Campbell, Davina, additional, Daniels, Jonathan, additional, Stanton, Richard A., additional, Janelle, Sarah J., additional, Schutz, Kyle, additional, Bamberg, Wendy, additional, Rebolledo, Paulina A., additional, Bower, Chris, additional, Blakney, Rebekah, additional, Jacob, Jesse T., additional, Phipps, Erin C., additional, Flores, Kristina G., additional, Dumyati, Ghinwa, additional, Kopin, Hannah, additional, Tsay, Rebecca, additional, Kainer, Marion A., additional, Muleta, Daniel, additional, Byrd-Warner, Benji, additional, Grass, Julian E., additional, Lutgring, Joseph D., additional, Rasheed, J. Kamile, additional, Elkins, Christopher A., additional, Magill, Shelley S., additional, and See, Isaac, additional

Published
2022
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22. Carbapenem-resistant Acinetobacter baumannii and Carbapenem-resistant Enterobacterales in US Dialysis Populations, 2016-2021.

Author

Gomes, Danica, Grass, Julian, Bulens, Sandra, Duffy, Nadezhda, Brandenburg, Joshua, Jacob, Jesse, Smith, Gillian, Vaeth, Elisabeth, Dumyati, Ghinwa, Flores, Kristina, Wilson, Christopher, Muleta, Daniel, Czaja, Christopher, Johnston, Helen, Lynfield, Ruth, Snippes Vagnone, Paula, O'Malley, Sean, Stabach, Nicole, Nadle, Joelle, and Pierce, Rebecca

Published
2024
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27. 780. How Much Does Prior Hospitalization Contribute to Readmission with Community-onset Clostridioides difficile Infection?

Author

Guh, Alice, primary, Korhonen, Lauren C, additional, Winston, Lisa Gail, additional, Martin, Brittany, additional, Johnston, Helen, additional, Brousseau, Geoffrey, additional, Basiliere, Elizabeth, additional, Olson, Danyel M, additional, Fridkin, Scott, additional, Wilson, Lucy E, additional, Perlmutter, Rebecca, additional, Holzbauer, Stacy, additional, Bye, Maria, additional, Phipps, Erin C, additional, Flores, Kristina, additional, Dumyati, Ghinwa, additional, Nelson, Deborah, additional, Hatwar, Trupti, additional, Ocampo, Valerie, additional, Kainer, Marion, additional, and McDonald, Clifford, additional

Published
2020
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28. Evaluation of Discrepancies in Carbapenem Minimum Inhibitory Concentrations Obtained at Clinical Laboratories Compared to a Public Health Laboratory

Author

Grass, Julian E., primary, Magill, Shelley S., additional, See, Isaac, additional, Ansari, Uzma, additional, Wilson, Lucy E., additional, Vaeth, Elisabeth, additional, Vagnone, Paula Snippes, additional, Pattee, Brittany, additional, Jacob, Jesse T., additional, Program, Georgia Emerging Infections, additional, Bower, Chris, additional, Center, Atlanta Veterans Affairs Medical, additional, Research, Foundation for Atlanta Veterans Education and, additional, Satola, Sarah W., additional, Janelle, Sarah J., additional, Schutz, Kyle, additional, Tsay, Rebecca, additional, Kainer, Marion A., additional, Muleta, Daniel, additional, Cassidy, P. Maureen, additional, Leung, Vivian H., additional, Maloney, Meghan, additional, Phipps, Erin C., additional, Program, New Mexico Emerging Infections, additional, Flores, Kristina G., additional, Epson, Erin, additional, Nadle, Joelle, additional, Karlsson, Maria, additional, and Lutgring, Joseph D., additional

Published
2020
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34. Epidemiology of carbapenem-resistant and extended-spectrum beta-lactamase-producing Enterobacterales in US children, 2016–2020.

Author

Grome, Heather, Grass, Julian, Duffy, Nadezhda, Bulens, Sandra, Jacob, Jesse, Smith, Gillian, Wilson, Lucy, Vaeth, Elisabeth, Evenson, Bailey, Dumyati, Ghinwa, Tsay, Rebecca, Phipps, Erin C., Flores, Kristina, Wilson, Christopher, Czaja, Christopher, Johnston, Helen, Lynfield, Ruth, O'Malley, Sean, Maloney, Meghan, and Stabach, Nicole

Published
2024
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35. Genetic Testing in a Population-Based Sample of Breast and Ovarian Cancer Survivors from the REACH Randomized Trial: Cost Barriers and Moderators of Counseling Mode

Author

Steffen, Laurie E., primary, Du, Ruofei, additional, Gammon, Amanda, additional, Mandelblatt, Jeanne S., additional, Kohlmann, Wendy K., additional, Lee, Ji-Hyun, additional, Buys, Saundra S., additional, Stroup, Antoinette M., additional, Campo, Rebecca A., additional, Flores, Kristina G., additional, Vicuña, Belinda, additional, Schwartz, Marc D., additional, and Kinney, Anita Y., additional

Published
2017
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37. Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up

Author

Kinney, Anita Y., primary, Steffen, Laurie E., additional, Brumbach, Barbara H., additional, Kohlmann, Wendy, additional, Du, Ruofei, additional, Lee, Ji-Hyun, additional, Gammon, Amanda, additional, Butler, Karin, additional, Buys, Saundra S., additional, Stroup, Antoinette M., additional, Campo, Rebecca A., additional, Flores, Kristina G., additional, Mandelblatt, Jeanne S., additional, and Schwartz, Marc D., additional

Published
2016
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39. Efficacy of a Telehealth Intervention on Colonoscopy Uptake When Cost Is a Barrier: The Family CARE Cluster Randomized Controlled Trial

Author

Steffen, Laurie E., primary, Boucher, Kenneth M., additional, Damron, Barbara H., additional, Pappas, Lisa M., additional, Walters, Scott T., additional, Flores, Kristina G., additional, Boonyasiriwat, Watcharaporn, additional, Vernon, Sally W., additional, Stroup, Antoinette M., additional, Schwartz, Marc D., additional, Edwards, Sandra L., additional, Kohlmann, Wendy K., additional, Lowery, Jan T., additional, Wiggins, Charles L., additional, Hill, Deirdre A., additional, Higginbotham, John C., additional, Burt, Randall, additional, Simmons, Rebecca G., additional, and Kinney, Anita Y., additional

Published
2015
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40. Preferences for multigene panel testing for hereditary breast cancer risk among ethnically diverse BRCA-uninformative families.

Author

Vicuña, Belinda, Delaney, Harold, Flores, Kristina, Ballinger, Lori, Royce, Melanie, Dayao, Zoneddy, Pal, Tuya, and Kinney, Anita

Abstract

Until recently, genetic testing for hereditary breast cancer has primarily focused on pathogenic variants in the BRCA1 and BRCA2 ( BRCA) genes. However, advances in DNA sequencing technologies have made simultaneous testing for multiple genes possible. We examined correlates of interest in multigene panel testing and risk communication preferences in an ethnically diverse sample of women who tested negative for BRCA mutations previously but remain at high risk based on their family history (referred to as ' BRCA-uninformative') and their at-risk female family members. Two-hundred and thirteen women with a previous breast cancer diagnosis and a BRCA-uninformative test result and their first-degree relatives completed a survey on interest in multigene panel testing, communication preferences, and sociodemographic, psychological, and clinical factors. Stepwise logistic regression was used to identify factors associated with testing interest. Chi-square analyses were used to test differences in risk communication preferences. Interest in multigene panel testing was high (84%) and did not considerably differ by cancer status or ethnicity. In multivariable analysis, factors significantly associated with interest in genetic testing were having had a mammogram in the past 2 years (odds ratio (OR) = 4.04, 95% confidence interval (CI) 1.80-9.02) and high cancer worry (OR = 3.77, 95% CI 1.34-10.60). Overall, the most commonly preferred genetic communication modes were genetic counselors, oncologists, and print materials. However, non-Hispanic women were more likely than Hispanic women to prefer web-based risk communication ( p < 0.001). Hispanic and non-Hispanic women from BRCA-uninformative families have a high level of interest in gene panel testing. Cancer-related emotions and communication preferences should be considered in developing targeted genetic risk communication strategies. [ABSTRACT FROM AUTHOR]

Published
2018
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42. Telehealth Personalized Cancer Risk Communication to Motivate Colonoscopy in Relatives of Patients With Colorectal Cancer: The Family CARE Randomized Controlled Trial

Author

Kinney, Anita Y., primary, Boonyasiriwat, Watcharaporn, additional, Walters, Scott T., additional, Pappas, Lisa M., additional, Stroup, Antoinette M., additional, Schwartz, Marc D., additional, Edwards, Sandra L., additional, Rogers, Amy, additional, Kohlmann, Wendy K., additional, Boucher, Kenneth M., additional, Vernon, Sally W., additional, Simmons, Rebecca G., additional, Lowery, Jan T., additional, Flores, Kristina, additional, Wiggins, Charles L., additional, Hill, Deirdre A., additional, Burt, Randall W., additional, Williams, Marc S., additional, and Higginbotham, John C., additional

Published
2014
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46. Abstract 2633: Single nucleotide polymorphisms in one carbon metabolism genes are associated with methylation patterns and plasma metabolites in high risk smokers based on gender

Author

Flores, Kristina G., primary, Stidley, Christine A., additional, Picchi, Maria A., additional, Mackey, Amanda J., additional, Stabler, Sally P., additional, Byers, Tim, additional, Berwick, Marianne, additional, Belinsky, Steven A., additional, and Leng, Shuguang, additional

Published
2012
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48. The A/G Allele of Rs16906252 Predicts for MGMT Methylation and Is Selectively Silenced in Premalignant Lesions from Smokers and in Lung Adenocarcinomas

Author

Leng, Shuguang, primary, Bernauer, Amanda M., additional, Hong, Chibo, additional, Do, Kieu C., additional, Yingling, Christin M., additional, Flores, Kristina G., additional, Tessema, Mathewos, additional, Tellez, Carmen S., additional, Willink, Randall P., additional, Burki, Elizabeth A., additional, Picchi, Maria A., additional, Stidley, Christine A., additional, Prados, Michael D., additional, Costello, Joseph F., additional, Gilliland, Frank D., additional, Crowell, Richard E., additional, and Belinsky, Steven A., additional

Published
2011
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50. Vascular CD44 Expression and Breast Cancer Angiogenesis and Metastasis

Author

DUKE UNIV MEDICAL CENTER DURHAM NC, Flores, Kristina G., Hale, Laura, DUKE UNIV MEDICAL CENTER DURHAM NC, Flores, Kristina G., and Hale, Laura

Abstract

The breast cancer susceptibility gene, BRCA2, is thought to function during cellular proliferation, differentiation and DNA repair. Several lines of evidence suggest that BRCA2 may play a vital role in these processes particularly in the human thymus. First, whereas BRCA2 is expressed at relatively low levels in most tissues, it is highly expressed in normal thymus, a tissue having elevated levels of proliferation, differentiation, and DNA break and repair compared to other tissues. Second, mice carrying a truncating mutation in the 5' region of BRCA2 exon Ii often develop thymic lymphomas. These lymphomas may be the result of defects in DNA repair in thymocytes similar to the DNA repair defects found in embryonic fibroblasts from these mice. Finally, BRCA2 binds to RAD51, the eukaryotic RecA homologue involved in double stranded DNA repair. Taken together, this evidence suggests that BRCA2 may be an important mediator of thymic proliferation, differentiation or DNA repair within the thymus. In this study, BRCA2 was differentially expressed in thymocyte subsets with different rates of DNA repair, proliferation and differentiation. BRCA2 RNA was also found to increase in thymocytes with induced DNA breaks and in stimulated, proliferating cells. Further studies in the human thymus are needed to differentiate the role of BRCA2 in thymic processes., Original contains color plates: All DTIC reproductions will be in black and white.

Published
2000

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