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3. Treat-to-Target Approach for the Management of Patients with Moderate-to-Severe Plaque Psoriasis: Consensus Recommendations

Author

Gisondi, Paolo, Talamonti, Marina, Chiricozzi, Andrea, Piaserico, Stefano, Amerio, Paolo, Balato, Anna, Bardazzi, Federico, Calzavara Pinton, Piergiacomo, Campanati, Anna, Cattaneo, Angelo, Dapavo, Paolo, De Simone, Clara, Dini, Valentina, Fargnoli, Maria C., Flori, Maria L., Galluzzo, Marco, Guarneri, Claudio, Lasagni, Claudia, Loconsole, Francesco, Lo Schiavo, Ada, Malagoli, Piergiorgio, Malara, Giovanna, Mercuri, Santo R., Musumeci, Maria L., Naldi, Luigi, Papini, Manuela, Parodi, Aurora, Potenza, Concetta, Prignano, Francesca, Rongioletti, Franco, Stingeni, Luca, Tiberio, Rossana, Venturini, Marina, Bianchi, Luca, Costanzo, Antonio, Cusano, Francesco, Girolomoni, Giampiero, Offidani, Anna M., and Peris, Ketty

Published
2021
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4. QUALITATIVE STUDY OF A COMPUTER MODEL IN THE CYBERNETIC FIELD

Author

FLORI Maria

Subjects
feedback, modeling, cybernetic system, information space, algebraic fractals, cellular automata, Business, HF5001-6182, Finance, HG1-9999
Abstract

The starting point of this study described in this paper is the desire to create a model that will be useful in various fields related to mathematical modeling and that will contain a new perspective of what we call and know about feedback. This feedback has appeared in cyber studies. The modeling of this computer system involves the transfer of information from the data of a problem written in a practical language to the language specific to the feedback contained in cellular automata and algebraic fractals. Both cellular automata and algebraic fractals are fundamental in the development of technical solutions used in the fields related to quantum mechanics. The bases of these researches are from the articles conceived by Prof. Dr. Colceag, in which he mentions information fields, structural fractals, but also about modeling and the models that emerge from this modeling. All this complex modeling structure will describe more complex objects with characteristics such as: feedback cycles, projective relationships in the projective space and specific transformations that describe how this model was obtained, these being common features for everything that means description and modeling the phenomena of physics, chemistry, biology, economy etc. At the beginning, such a model focuses on feedback cycles, and will also develop commutative diagrams based on automorphisms. After this first phase, the model is organized on progressive levels where its structure is divided into new and stable structures that self-determine, this leading to a fractalized modeling in which a feedback structure is inserted in the form of a loop.

Published
2020

8. Insider Trading: A Systematic Review

Author

Flori, Maria

Abstract

The major challenge facing human society in the 21st century is represented by the environmental crisis. In this context, the present article proposes a sustainable vector model for managing the environmental crisis. It focuses on social, economic, and ecological aspects, with the aim of providing a framework for analysis and adapted solutions. By integrating environmental factors into decision-making processes and public policies, this model aims to improve the quality of life and promote sustainable development. This study presents a comprehensive and cohesive framework for addressing environmental challenges by integrating the Context Triangle and Phenomenon Triangle to develop a sustainable vector model. This novel approach to crisis management aims to provide a holistic and adaptive response to the complex and evolving needs of society and the environment, acknowledging the interconnected nature of environmental issues. The proposed sustainable vector model seeks to understand the trade-offs and synergies between various dimensions of sustainability, ultimately facilitating the development and implementation of more robust and equitable strategies. By incorporating this vector-based approach, the integrated framework can be employed to examine the intricate relationships between different aspects of environmental challenges, fostering a deeper understanding of their interconnected nature and promoting more effective interventions. Moreover, potential advancements may involve fractalizing the integrated framework on multiple levels, allowing for a more elaborate and comprehensive sustainable management approach. By extending the system into a multi-level fractal structure, stakeholders can investigate the relationships between different aspects of environmental challenges, ultimately driving the development of innovative and adaptive strategies that can better address the ever-changing needs of our planet and its inhabitants.

Published
2023
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10. The GENDER ATTENTION Observational Study: Gender and Hormonal Status Differences in the Incidence of Adverse Events During Cyclosporine Treatment in Psoriatic Patients

Author

Colombo, Delia, Banfi, Giuseppe, Cassano, Nicoletta, Graziottin, Alessandra, Vena, Gino Antonio, Fiori, Giovanni Gualberto, Zagni, Emanuela, Stingeni, Luca, Chimenti, Sergio, Berardesca, Enzo, Micali, Giuseppe, Albertini, Giuseppe, De Simone, Clara, Bellia, Gilberto, Amato, Salvatore, Ayala, Fabio, Bardazzi, Ferderico, Bernengo, Maria Grazia, Bongiorno, Maria Rita, Borroni, Giovanni, Calvieri, Stefano, Pinton, Piergiacomo Calzavara, Cannarozzo, Calcedonio, Cannavò, Serafinella Patrizia, Cattaneo, Angelo, Ceschini, Rossella, Colombo, Enrico, Congedo, Maurizio, Cusano, Francesco, De Pità, Ornella, Di Nuzzo, Sergio, Donadio, Dario, Donelli, Stefano, Filotico, Raffaele, Flori, Maria Laura, Germino, Maurizio, Girolomoni, Giampiero, Kokelj, Franco, Lanzoni, Anna, Lembo, Giuseppe, Locatelli, Andrea, Magnoni, Cristina, Marconi, Marco, Motolese, Alberico, Papini, Manuela, Parodi, Aurora, Pau, Monica, Peris, Ketty, Piaserico, Stefano, Piccirillo, Angelo, Potenza, Concetta, Ricotti, Giuseppe, Sedona, Patrizio, Stinco, Giuseppe, Valenti, Giancarlo, Fornasa, Cleto Veller, Zichichi, Leonardo, Ori, Alessandra, Amici, Christian, Zullo, Alessandro, Simoni, Lucia, Lanci, Nicole, Longagnani, Chiara, Sala, Saide, Trevisan, Francesca, Magri, Giovanna, and On behalf of the GENDER ATTENTION study group

Published
2017
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12. Secukinumab for the treatment of palmoplantar psoriasis: a 2-year, multicenter, real-life observational study

Author

Galluzzo, Marco, primary, Talamonti, Marina, additional, Atzori, Laura, additional, Bardazzi, Federico, additional, Campanati, Anna, additional, Di Cesare, Antonella, additional, Diotallevi, Federico, additional, Flori, Maria Laura, additional, Mugheddu, Cristina, additional, Offidani, Annamaria, additional, Piaserico, Stefano, additional, Russo, Filomena, additional, Sacchelli, Lidia, additional, Bianchi, Luca, additional, and Prignano, Francesca, additional

Published
2022
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13. Pyoderma gangrenosum secondary to total hip replacement

Author

RUSSO, Filomena, primary, MANCINI, Virginia, additional, FLORI, Maria L., additional, PELOSI, Piergiorgio, additional, CARTA, Serafino, additional, PROVVIDENZIALE, Luca, additional, PELLEGRINO, Michele, additional, TADDEUCCI, Paolo, additional, and FIMIANI, Michele, additional

Published
2022
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22. Dupilumab in Elderly Patients With Severe Atopic Dermatitis

Author

Russo, Filomena, primary, Milanesi, Nicola, additional, Cartocci, Alessandra, additional, Bruzziches, Francesco, additional, Tronconi, Greta, additional, Lazzeri, Laura, additional, D'erme, Angelo Massimiliano, additional, Bagnoni, Giovanni, additional, Gola, Massimo, additional, Cinotti, Elisa, additional, Rubegni, Pietro, additional, and Flori, Maria Laura, additional

Published
2020
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23. Tuscan Consensus on the diagnosis, treatment and follow up of adult atopic dermatitis

Author

Russo, Filomena, primary, Milanesi, Nicola, additional, Iannone, Michela, additional, Bagnoni, Giovanni, additional, Bartoli, Laura, additional, Bellini, Mauro, additional, Brandini, Luca, additional, Buggiani, Gionata, additional, Cecchi, Roberto, additional, Cuccia, Aldo, additional, D'erme, Angelo M., additional, Dini, Valentina, additional, Gori, Alessia, additional, Grazzini, Marta, additional, Marsili, Franco, additional, Masci, Guia, additional, Mazzoli, Sabrina, additional, Peccianti, Camilla, additional, Pellegrino, Michele, additional, Pimpinelli, Nicola, additional, Rubegni, Pietro, additional, Taviti, Franca, additional, Tedeschi, Corrado, additional, Tonini, Giulia, additional, Mazzatenta, Carlo, additional, Flori, Maria L., additional, and Gola, Massimo, additional

Published
2020
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27. A paradoxical head and neck erythema: an adverse event due to dupilumab in adult patients with atopic dermatitis.

Author

Russo, Filomena, Rizzo, Arianna, Santi, Francesco, Lamberti, Arianna, Lazzeri, Laura, Flori, Maria Laura, and Rubegni, Pietro

Subjects
ATOPIC dermatitis, DUPILUMAB, ECZEMA, HEAD & neck cancer, ERYTHEMA, NECK, ADULTS
Abstract

Despite the presence of this erythema and although the lesions did not respond to treatment, all patients continued with their dupilumab treatment with spontaneous remission of erythema within two to three months. 1 and Table 1) with severe AD treated with dupilumab and with paradoxical head and neck erythema that appeared 8-20 weeks after the start of biological treatment while eczema on other body parts had greatly improved. Dear Editor, Atopic dermatitis (AD) is a chronic inflammatory dermatological disease with multifactorial etiology. [Extracted from the article]

Published
2022
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28. Eyelid Dermatitis: An Evaluation of 447 Patients

Author

Ayala, Fabio, Fabbrocini, Gabriella, Bacchilega, Roberto, Berardesca, Enzo, Caraffini, Stefano, Corazza, Monica, Flori, Maria Laura, Francalanci, Stefano, Guarrera, Marcella, Lisi, Paolo, Santucci, Baldassarre, Schena, Donatella, Suppa, Francesco, Valsecchi, Rossano, Vincenzi, Colombina, and Balato, Nicola

Published
2003

30. Pyoderma gangrenosum secondary to total hip replacement

Author

Russo, Filomena, primary, Mancini, Virginia, additional, Flori, Maria Laura, additional, Pelosi, Piergiorgio, additional, Carta, Serafino, additional, Provvidenziale, Luca, additional, Pellegrino, Michele, additional, Taddeucci, Paolo, additional, and Fimiani, Michele, additional

Published
2019
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37. Eyelid Dermatitis: An Evaluation of 447 Patients

Author

Ayala, Fabio, primary, Fabbrocini, Gabriella, additional, Bacchilega, Roberto, additional, Berardesca, Enzo, additional, Caraffini, Stefano, additional, Corazza, Monica, additional, Flori, Maria Laura, additional, Francalanci, Stefano, additional, Guarrera, Marcella, additional, Lisi, Paolo, additional, Santucci, Baldassarre, additional, Schena, Donatella, additional, Suppa, Francesco, additional, Valsecchi, Rossano, additional, Vincenzi, Colombina, additional, and Balato, Nicola, additional

Published
2003
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43. Altered expression of the α2 laminin chain in psoriatic skin: the effect of treatment with cyclosporin.

Author

Toti, Pellegrino, Villanova, Flori, Miracco, Bartolommei, Andreassi, and Laura Flori, Maria

Subjects
PSORIASIS treatment, CYCLOSPORINE, SKIN wound treatment
Abstract

The histopathological pattern of psoriasis is characterized by dermal inflammatory reaction and hyperproliferation of the epidermis. The mechanism of the epidermal hyperproliferation is not completely understood, but it is probably modulated by the basal lamina (BL), the alterations of which have not been described. We performed the present study to evaluate the expression of the α1, α2, β1 and γ1 laminin chains and collagen IV in the BL of active psoriasis vulgaris before and after cyclosporin treatment administered until the psoriasis was in remission. The results showed that the α2 chain is weak and irregular in the lesions, while the α1, β1 and γ1 chains and collagen IV are normal, with intense and continuous reaction. In the same subjects, this alteration was absent in skin that was clinically unaffected. After treatment with cyclosporin, the altered expression of the α2 chain returned to normal in the healing lesions. [ABSTRACT FROM AUTHOR]

Published
1998
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44. Treat-to-Target Approach for the Management of Patients with Moderate-to-Severe Plaque Psoriasis: Consensus Recommendations

Author

Luca Stingeni, Andrea Chiricozzi, Piergiorgio Malagoli, Anna Campanati, Marina Venturini, Antonio Costanzo, Anna Balato, Paolo Gisondi, Clara De Simone, Giampiero Girolomoni, Maria Letizia Musumeci, Aurora Parodi, Franco Rongioletti, Angelo Cattaneo, Claudia Lasagni, Santo Raffaele Mercuri, Valentina Dini, Francesca Prignano, Federico Bardazzi, Concetta Potenza, Claudio Guarneri, Ada Lo Schiavo, Ketty Peris, A. M. Offidani, Manuela Papini, Paolo Dapavo, Francesco Loconsole, Maria Laura Flori, Francesco Cusano, Maria Concetta Fargnoli, Stefano Piaserico, Marco Galluzzo, Paolo Amerio, Piergiacomo Calzavara Pinton, Luca Bianchi, Marina Talamonti, Luigi Naldi, Rossana Tiberio, G. Malara, Gisondi, Paolo, Talamonti, Marina, Chiricozzi, Andrea, Piaserico, Stefano, Amerio, Paolo, Balato, Anna, Bardazzi, Federico, Calzavara Pinton, Piergiacomo, Campanati, Anna, Cattaneo, Angelo, Dapavo, Paolo, De Simone, Clara, Dini, Valentina, Fargnoli, Maria C, Flori, Maria L, Galluzzo, Marco, Guarneri, Claudio, Lasagni, Claudia, Loconsole, Francesco, Lo Schiavo, Ada, Malagoli, Piergiorgio, Malara, Giovanna, Mercuri, Santo R, Musumeci, Maria L, Naldi, Luigi, Papini, Manuela, Parodi, Aurora, Potenza, Concetta, Prignano, Francesca, Rongioletti, Franco, Stingeni, Luca, Tiberio, Rossana, Venturini, Marina, Bianchi, Luca, Costanzo, Antonio, Cusano, Francesco, Girolomoni, Giampiero, Offidani, Anna M, Peris, Ketty, Gisondi, P., Talamonti, M., Chiricozzi, A., Piaserico, S., Amerio, P., Balato, A., Bardazzi, F., Calzavara Pinton, P., Campanati, A., Cattaneo, A., Dapavo, P., De Simone, C., Dini, V., Fargnoli, M. C., Flori, M. L., Galluzzo, M., Guarneri, C., Lasagni, C., Loconsole, F., Lo Schiavo, A., Malagoli, P., Malara, G., Mercuri, S. R., Musumeci, M. L., Naldi, L., Papini, M., Parodi, A., Potenza, C., Prignano, F., Rongioletti, F., Stingeni, L., Tiberio, R., Venturini, M., Bianchi, L., Costanzo, A., Cusano, F., Girolomoni, G., Offidani, A. M., and Peris, K.

Subjects
Quality of life, Moderate to severe, medicine.medical_specialty, Consensus, Delphi method, Consensu, Dermatology, Plaque psoriasis, Systemic inflammation, Treat-to-target, 030207 dermatology & venereal diseases, 03 medical and health sciences, Settore MED/35, 0302 clinical medicine, Quality of life (healthcare), Psoriasis Area and Severity Index, Psoriasis, consensus, plaque psoriasis, quality of life, systemic inflammation, treatto-target, medicine, Intensive care medicine, Original Research, business.industry, Treat to target, Dermatology Life Quality Index, medicine.disease, Plaque psoriasi, 030220 oncology & carcinogenesis, Settore MED/35 - MALATTIE CUTANEE E VENEREE, business
Abstract

Introduction: Treat-to-target strategies are used in several chronic diseases to improve outcomes. Treatment goals have also been suggested for psoriasis, but there is currently no consensus on targets, and guidance is needed to implement this strategy in clinical practice. The project ‘Treat to Target Italia’ was launched by a scientific board (SB) of 10 psoriasis experts to generate expert consensus recommendations. Methods: On the basis of the published literature, their clinical experience, and the results of a survey among Italian dermatologists, the SB identified four relevant topics: (1) clinical remission; (2) quality of life; (3) abrogation of systemic inflammation; (4) safety. They drafted 20 statements addressing these four topics and submitted them to a panel of 28 dermatologists, in a Delphi process, to achieve consensus (greater than 80% agreement). Results: Consensus was reached on all statements. Treatment goals defining clinical remission should include a 90% improvement from baseline in the Psoriasis Area and Severity Index (PASI90 response) or an absolute PASI score of less than or equal to 3. Patient’s quality of life and satisfaction are important targets. If PASI targets are achieved, there should be no or very low impact of psoriasis on quality of life [Dermatology Life Quality Index (DLQI) score less than or equal to 3]. If PASI or DLQI goals are not achieved within 3–4months, treatment should be changed. Abrogation of systemic inflammation may be crucial for preventing or delaying inflammatory comorbidities. Safety is an equally important target as efficacy. Conclusion: These 20 consensus statements define the parameters of a treat-to-target strategy for psoriasis in Italy. It is hoped that use of these in the management of patients with psoriasis will improve treatment outcomes and patient health-related quality of life.

Published
2021

45. Cyclosporine in psoriasis: comparison of a 25-year real-world Italian experience to current European guidelines

Author

Altomare, G., Ayala, F., Bardazzi, F., Bellia, G., Chimenti, S., Colombo, D., Flori, M. L., Girolomoni, G., Giuseppe MICALI, Parodi, A., Peris, K., Vena, G. A., Altomare, Gianfranco, Ayala, Fabio, Bardazzi, Federico, Bellia, Gilberto, Chimenti, Sergio, Colombo, Delia, Flori, Maria L, Girolomoni, Giampiero, Micali, Giuseppe, Parodi, Aurora, Peris, Ketty, and Vena, Gino A.

Subjects
Adult, Europe, Skin diseases, Italy, Practice Guidelines as Topic, Cyclosporine, Psoriasis, Humans, Dermatologic Agents, Child, Immunosuppressive Agents, Dermatitis, Atopic
Abstract

Cyclosporine (CsA) is an effective and safe therapeutic option in various dermatoses in both adults and children. Over the last 25 years, Italian dermatologists have gained relevant experience about the use of CsA in the treatment of psoriasis and atopic dermatitis, and an Italian Consensus Conference has recently provided recommendations in adult patients. A comparison between these real-world indications and current European guidelines is hereby provided.

46. Effect of dupilumab on sleep disturbances in adult patients with severe atopic dermatitis.

Author

Milanesi N, Gola M, Cartocci A, Tronconi G, Bruzziches F, Flori ML, Rubegni P, and Russo F

Subjects
Adult, Antibodies, Monoclonal, Humanized, Female, Humans, Infant, Male, Middle Aged, Pruritus drug therapy, Retrospective Studies, Sleep, Treatment Outcome, Dermatitis, Atopic complications, Sleep Wake Disorders drug therapy
Abstract

Background: Sleep disturbances are common in patients with atopic dermatitis (AD). Considering their relevant burden on health, routine screening of sleep disturbances seems to be very useful in AD adults' management. However, few studies have evaluated the association between sleep disturbances and AD in adults, and real-life data are lacking. The aim of this study was to assess the effect of treatment with dupilumab on sleep disturbances in adult patients with severe atopic dermatitis., Methods: This is a retrospective, multicenter study including patients (age ≥18 y) with severe atopic dermatitis treated with dupilumab for at least 8 months from January 2019 to January 2020. Patients were evaluated three times: at treatment initiation (T0), at 4 (T4) and 8 months (T8) from the start of treatment. At each visit disease activity was assessed by severity score (Eczema Area and Severity Index [EASI]), patient-reported outcomes (Pruritus Numerical Rating Scale [NRS], Dermatology Life Quality Index [DLQI], and Pittsburgh Sleep Quality Index [PSQI]). Kolmogorov-Smirnov Test was performed to evaluate the normality distribution, Bartlett's Test for homoscedasticity. Since the assumptions were met, ANOVA for repeated measures was performed to evaluate the mean difference of PSQI, EASI, DLQI and pruritus NRS between baseline, the 4 th month and the 8 th month. In addition, χ 2 for Trend Test was performed to evaluate the increasing/decreasing prevalence of poor sleepers., Results: A total of 36 patients (15 females and 21 males) with a mean age of 42.5±14.3 (range 20-67) were included in the study. The mean score for PSQI at TO was 9.0±3.6. At week 16 (T4) the mean score for PSQI was 4.92±2.99 and at week 32 (T8), the mean score for PSQI was 4.3±3.0. EASI, NRS pruritus and DLQI significantly improved during follow-up (P<0.001) whereas PSQI improved significantly at 16 weeks (T4); however, no significant further improvement was observed at 32 weeks. Of the 31 patients (86%) with baseline PSQI≥5, 17 (54%) experienced sleep quality improvement during treatment. Overall, we observed a total of 22 patients (61.1%) having a PSQI<5 at 32 weeks., Conclusions: Our data show effectiveness of dupilumab in improving sleep disturbances in adult patients with severe AD. However, further studies are required to understand if PSQI could serve as useful evaluating tool.

Published
2022
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48. Cyclosporine in psoriasis: comparison of a 25-year real-world Italian experience to current European guidelines.

Author

Altomare G, Ayala F, Bardazzi F, Bellia G, Chimenti S, Colombo D, Flori ML, Girolomoni G, Micali G, Parodi A, Peris K, and Vena GA

Subjects
Adult, Child, Dermatitis, Atopic drug therapy, Dermatitis, Atopic pathology, Europe, Humans, Immunosuppressive Agents therapeutic use, Italy, Practice Guidelines as Topic, Psoriasis pathology, Cyclosporine therapeutic use, Dermatologic Agents therapeutic use, Psoriasis drug therapy
Abstract

Cyclosporine (CsA) is an effective and safe therapeutic option in various dermatoses in both adults and children. Over the last 25 years, Italian dermatologists have gained relevant experience about the use of CsA in the treatment of psoriasis and atopic dermatitis, and an Italian Consensus Conference has recently provided recommendations in adult patients. A comparison between these real-world indications and current European guidelines is hereby provided.

Published
2016

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