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Thirty-two patients with acute leukemia, chronic granulocytic leukemia, or multiple myeloma received a T lympho-cyte-depleted HLA-identical marrow. After being treated with pan-T monoclonal antibodies (MoAbs) and one round of baby rabbit complement, the mean percentage of T cell depletion was 94% ± 4%. The number of residual viable T cell infused to the patient was 0.99 ± 0.65 × 106per kg body weight. The patients were conditioned with fractionated total body irradiation (TBI) (12 Gy) preceding high doses of cyclophosphamide (120 mg/kg). Methotrexate was used as an additional immunosuppressant in the first ten patients. For the following 22 patients no posttrans-plant immunoprophylaxis was administered. Eight patients died within three months due to complications related to transplantation. Engraftment was achieved in all evaluable patients, and no patient has a late graft failure. The proof of total chimerism was established in 24 patients. Twenty-four of 27 evaluable patients (88%) did not have an acute graft-v-host disease (GVHD) greater than grade 0 to 1. Two patients had a grade 2 (skin only), and one patient had a grade 4 acute GVHD (the latter had only 80% of T cell depletion). A medullary relapse occured in 11 patients (nine of them had previously been defined as “high risk leukemia”). Our data suggest that it may not be necessary to deplete nearly all T cells to prevent acute GVHD in recipients of HLA-identical marrow. © 1987 by Grune & Stratton, Inc.

To the Editor.—We read with interest the letter by Balcells-Gorina et al (1981;246:1659) about a case of periarteritis nodosa manifested as polyserositis. In this letter, we attempt to demonstrate that serositis can be observed in other forms of inflammatory angiitis, such as temporal arteritis.Report of a Case.—A 66-year-old woman was admitted to the hospital after a three-week illness, which consisted of a temperature reaching 39 °C, weight loss, and thoracic pain. A pericardial rub was noted. There was no history of viral or bacterial infection in the upper respiratory tract. The patient complained of neither arthralgia nor diffuse muscular stiffness of the shoulders and pelvic girdle. The skin was normal. No sign of Raynaud's phenomenon was noted. The liver and the spleen were of normal size. There was no pain in the temporal arteries, and palpation was normal. The chest x-ray film revealed a mild cardiomegaly. The