Search

Your search keyword '"Flynt, Erin"' showing total 229 results
Start Over Author "Flynt, Erin"
229 results on '"Flynt, Erin"'

6. Supplementary Table S1 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

7. Supplementary Data 4 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

8. Supplementary Data 1 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

9. Supplementary Figures S1-S11 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

10. Data from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

11. Supplementary Data 5 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

12. Supplementary Data 3 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

13. Supplementary Data 2 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

14. Supplementary Data 7 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

15. Supplementary Data 6 from ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., primary, Jung, David, primary, Patton, Jonathan C., primary, Maity, Ranjan, primary, Tagoug, Ines, primary, Stein, Caleb K., primary, Tilmont, Remi, primary, Leblay, Noemie, primary, Ahn, Sungwoo, primary, Lee, Holly, primary, Welsh, Seth J., primary, Riggs, Daniel L., primary, Stong, Nicholas, primary, Flynt, Erin, primary, Thakurta, Anjan, primary, Keats, Jonathan J., primary, Lonial, Sagar, primary, Bergsagel, P. Leif, primary, Boise, Lawrence H., primary, and Bahlis, Nizar J., primary

Published
2024
Full Text
View/download PDF

16. ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Author

Neri, Paola, primary, Barwick, Benjamin G., additional, Jung, David, additional, Patton, Jonathan C., additional, Maity, Ranjan, additional, Tagoug, Ines, additional, Stein, Caleb K., additional, Tilmont, Remi, additional, Leblay, Noemie, additional, Ahn, Sungwoo, additional, Lee, Holly, additional, Welsh, Seth J., additional, Riggs, Daniel L., additional, Stong, Nicholas, additional, Flynt, Erin, additional, Thakurta, Anjan, additional, Keats, Jonathan J., additional, Lonial, Sagar, additional, Bergsagel, P. Leif, additional, Boise, Lawrence H., additional, and Bahlis, Nizar J., additional

Published
2023
Full Text
View/download PDF

17. Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Author

Walker, Brian A., Mavrommatis, Konstantinos, Wardell, Christopher P., Ashby, T. Cody, Bauer, Michael, Davies, Faith E., Rosenthal, Adam, Wang, Hongwei, Qu, Pingping, Hoering, Antje, Samur, Mehmet, Towfic, Fadi, Ortiz, Maria, Flynt, Erin, Yu, Zhinuan, Yang, Zhihong, Rozelle, Dan, Obenauer, John, Trotter, Matthew, Auclair, Daniel, Keats, Jonathan, Bolli, Niccolo, Fulciniti, Mariateresa, Szalat, Raphael, Moreau, Philippe, Durie, Brian, Stewart, A. Keith, Goldschmidt, Hartmut, Raab, Marc S., Einsele, Hermann, Sonneveld, Pieter, San Miguel, Jesus, Lonial, Sagar, Jackson, Graham H., Anderson, Kenneth C., Avet-Loiseau, Herve, Munshi, Nikhil, Thakurta, Anjan, and Morgan, Gareth J.

Published
2018
Full Text
View/download PDF

18. P-381 Mezigdomide (CC-92480) activates innate and adaptive immune populations in the bone marrow microenvironment of heavily pre-treated multiple myeloma patients

Author

Chen, Lucia, primary, Amatangelo, Michael, additional, van Oekelen, Oliver, additional, Upadhyaya, Bhaskar, additional, Lagana, Alessandro, additional, Kelly, Geoffrey, additional, Kim-Schulze, Seunghee, additional, Aleman, Adolfo, additional, Chow, Tracy, additional, Kurtova, Antonina, additional, Gandhi, Anita, additional, Gooding, Sarah, additional, Jagannath, Sundar, additional, Thakurta, Anjan, additional, Flynt, Erin, additional, Oppermann, Udo, additional, and Parekh, Samir, additional

Published
2023
Full Text
View/download PDF

19. P-179 Altered lipid metabolism in IMiD/CELMoD resistant multiple myeloma confers novel and targetable vulnerabilities

Author

Bird, Sarah, primary, Xu, Yitao, additional, Sialana, Fernando, additional, Licciardello, Marco, additional, Che, Harvey, additional, Tamin, Saleh, additional, Bouguenina, Habib, additional, Grabovska, Yura, additional, Liu, Enze, additional, Morales, Salomon, additional, Chrisochoidou, Yakinthi, additional, Li, Yigen, additional, Martin, Shannon, additional, Wilson, Amy, additional, Flynt, Erin, additional, Walker, Brian, additional, Choudhary, Jyoti, additional, Clarke, Paul, additional, Keun, Hector, additional, and Pawlyn, Charlotte, additional

Published
2023
Full Text
View/download PDF

20. A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis

Author

Walker, Brian A., Mavrommatis, Konstantinos, Wardell, Christopher P., Ashby, T. Cody, Bauer, Michael, Davies, Faith, Rosenthal, Adam, Wang, Hongwei, Qu, Pingping, Hoering, Antje, Samur, Mehmet, Towfic, Fadi, Ortiz, Maria, Flynt, Erin, Yu, Zhinuan, Yang, Zhihong, Rozelle, Dan, Obenauer, John, Trotter, Matthew, Auclair, Daniel, Keats, Jonathan, Bolli, Niccolo, Fulciniti, Mariateresa, Szalat, Raphael, Moreau, Phillipe, Durie, Brian, Stewart, A. Keith, Goldschmidt, Hartmut, Raab, Marc S., Einsele, Hermann, Sonneveld, Pieter, San Miguel, Jesus, Lonial, Sagar, Jackson, Graham H., Anderson, Kenneth C., Avet-Loiseau, Herve, Munshi, Nikhil, Thakurta, Anjan, and Morgan, Gareth

Published
2019
Full Text
View/download PDF

21. Supplementary Data from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Table from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure from Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, primary, Ashby, Cody, primary, Kausar, Tasneem, primary, Khera, Akhil, primary, Kazeroun, Mohammad H., primary, Hsu, Chih-Chao, primary, Wang, Lin, primary, Fitzsimons, Evelyn, primary, Salminen, Outi, primary, Blaney, Patrick, primary, Czader, Magdalena, primary, Williams, Jonathan, primary, Abu Zaid, Mohammad I., primary, Ansari-Pour, Naser, primary, Yong, Kwee L., primary, van Rhee, Frits, primary, Pierceall, William E., primary, Morgan, Gareth J., primary, Flynt, Erin, primary, Gooding, Sarah, primary, Abonour, Rafat, primary, Ramasamy, Karthik, primary, Thakurta, Anjan, primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Data from BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma

Author

Boyle, Eileen M., primary, Ashby, Cody, primary, Tytarenko, Ruslana G., primary, Deshpande, Shayu, primary, Wang, Hongwei, primary, Wang, Yan, primary, Rosenthal, Adam, primary, Sawyer, Jeffrey, primary, Tian, Erming, primary, Flynt, Erin, primary, Hoering, Antje, primary, Johnson, Sarah K., primary, Rutherford, Michael W., primary, Wardell, Christopher P., primary, Bauer, Michael A., primary, Dumontet, Charles, primary, Facon, Thierry, primary, Thanendrarajan, Sharmilan, primary, Schinke, Carolina D., primary, Zangari, Maurizio, primary, van Rhee, Frits, primary, Barlogie, Bart, primary, Cairns, David, primary, Jackson, Graham, primary, Thakurta, Anjan, primary, Davies, Faith E., primary, Morgan, Gareth J., primary, and Walker, Brian A., primary

Published
2023
Full Text
View/download PDF

25. Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma

Author

Gooding, Sarah, primary, Ansari-Pour, Naser, additional, Kazeroun, Mohammad, additional, Karagoz, Kubra, additional, Polonskaia, Ann, additional, Salazar, Mirian, additional, Fitzsimons, Evie, additional, Sirinukunwattana, Korsuk, additional, Chavda, Selina, additional, Ortiz Estevez, Maria, additional, Towfic, Fadi, additional, Flynt, Erin, additional, Pierceall, William, additional, Royston, Daniel, additional, Yong, Kwee, additional, Ramasamy, Karthik, additional, Vyas, Paresh, additional, and Thakurta, Anjan, additional

Published
2022
Full Text
View/download PDF

26. P-065: Development of a mass cytometry-based toolkit to investigate myeloma therapeutic responses ex vivo

Author

Gooding, Sarah, primary, Guo, Manman, additional, Van Oekelen, Oliver, additional, Al-Hourani, Kinda, additional, Watson, Edmund, additional, Palmer, Charlotte, additional, Philpott, Martin, additional, Baker, Warren, additional, Ahern, David, additional, Updahyaya, Bhaskar, additional, Kim-Schulze, Seunghee, additional, Flynt, Erin, additional, Pierceall, William, additional, Ramasamy, Karthik, additional, Cribbs, Adam, additional, Parekh, Samir, additional, Thakurta, Anjan, additional, and Oppermann, Udo, additional

Published
2022
Full Text
View/download PDF

27. P-093: Iberdomide induces activation and proliferation of innate and adaptive immune cell subsets in the tumor microenvironment of relapsed/refractory myeloma patients

Author

Van Oekelen, Oliver, primary, Amatangelo, Michael, additional, Guo, Manman, additional, Updahyaya, Bhaskar, additional, Cribbs, Adam, additional, Kelly, Geoffrey, additional, Patel, Manishkumar, additional, Kim-Schulze, Seunghee, additional, Flynt, Erin, additional, Lagana, Alessandro, additional, Gooding, Sarah, additional, Jagannath, Sundar, additional, Pierceall, William, additional, Thakurta, Anjan, additional, Oppermann, Udo, additional, and Parekh, Samir, additional

Published
2022
Full Text
View/download PDF

28. P-016: Tumor profiling of idecabtagene vicleucel (ide-cel, bb2121) patients in KarMMa showed comparable responses in existing molecular high-risk subsets and preliminary gene signature of durable response

Author

Martin, Nathan, primary, Xu, Amy, additional, Stong, Nicholas, additional, Rytlewski, Julie, additional, Finney, Olivia, additional, Campbell, Timothy, additional, Pierceall, William, additional, Flynt, Erin, additional, Thompson, Ethan, additional, and Kaiser, Shari, additional

Published
2022
Full Text
View/download PDF

30. Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, additional, Ashby, Cody, additional, Kausar, Tasneem, additional, Khera, Akhil, additional, Kazeroun, Mohammad H., additional, Hsu, Chih-Chao, additional, Wang, Lin, additional, Fitzsimons, Evelyn, additional, Salminen, Outi, additional, Blaney, Patrick, additional, Czader, Magdalena, additional, Williams, Jonathan, additional, Abu Zaid, Mohammad I., additional, Ansari-Pour, Naser, additional, Yong, Kwee L., additional, van Rhee, Frits, additional, Pierceall, William E., additional, Morgan, Gareth J., additional, Flynt, Erin, additional, Gooding, Sarah, additional, Abonour, Rafat, additional, Ramasamy, Karthik, additional, Thakurta, Anjan, additional, and Walker, Brian A., additional

Published
2022
Full Text
View/download PDF

32. A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma

Author

Sudha, Parvathi, primary, Ahsan, Aarif, additional, Khera, Akhil, additional, Kazeroun, Mohammad H, additional, Kausar, Tasneem, additional, Wang, Lin, additional, Angulo Salazar, Mirian, additional, Fitzsimons, Evelyn, additional, Salminen, Outi, additional, Ashby, Timothy Cody, additional, Blaney, Patrick, additional, Czader, Magdalena, additional, Vance, Gail, additional, Williams, Jon, additional, Abu Zaid, Mohammad Issam, additional, Ramasamy, Karthik, additional, Yong, Kwee, additional, Morgan, Gareth J., additional, van Rhee, Frits, additional, Abonour, Rafat, additional, Flynt, Erin, additional, Ansari-Pour, Naser, additional, Gooding, Sarah, additional, Thakurta, Anjan, additional, and Walker, Brian A, additional

Published
2021
Full Text
View/download PDF

33. Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination

Author

Ahsan, Aarif, primary, Polonskaia, Ann, additional, Hsu, Chih-Chao, additional, Bjorklund, Chad C, additional, Ortiz Estevez, Maria, additional, Towfic, Fadi, additional, Bahlis, Nizar J., additional, Pourdehnad, Michael, additional, Flynt, Erin, additional, Ahsan, Aarif, additional, and Thakurta, Anjan, additional

Published
2021
Full Text
View/download PDF

35. Loss of COP9 Signalosome Gene-Containing 2q Region Is Associated with Lenalidomide and Pomalidomide Resistance in Myeloma Patients

Author

Gooding, Sarah, primary, Ansari-Pour, Naser, additional, Kazeroun, Mohammad H, additional, Karagoz, Kubra, additional, Angulo Salazar, Mirian, additional, Fitzsimons, Evelyn, additional, Ortiz Estevez, Maria, additional, Towfic, Fadi, additional, Flynt, Erin, additional, Pierceall, William E., additional, Yong, Kwee, additional, Vyas, Paresh, additional, and Thakurta, Anjan, additional

Published
2021
Full Text
View/download PDF

41. The location of the t(4;14) translocation breakpoint within the NSD2gene identifies a subset of patients with high-risk NDMM

Author

Stong, Nicholas, Ortiz-Estévez, María, Towfic, Fadi, Samur, Mehmet, Agarwal, Amit, Corre, Jill, Flynt, Erin, Munshi, Nikhil, Avet-Loiseau, Hervé, and Thakurta, Anjan

Abstract

•High-risk t(4;14) MM patients can be identified by using the coordinates of the translocation breakpoints in NSD2gene on chromosome 4.•Large-scale genomic analysis of NDMM patient data identifies mutations and copy number aberrations enriched in t(4;14) patients.

Published
2023
Full Text
View/download PDF

47. BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma

Author

Boyle, Eileen M., primary, Ashby, Cody, additional, Tytarenko, Ruslana G., additional, Deshpande, Shayu, additional, Wang, Hongwei, additional, Wang, Yan, additional, Rosenthal, Adam, additional, Sawyer, Jeffrey, additional, Tian, Erming, additional, Flynt, Erin, additional, Hoering, Antje, additional, Johnson, Sarah K., additional, Rutherford, Michael W., additional, Wardell, Christopher P., additional, Bauer, Michael A., additional, Dumontet, Charles, additional, Facon, Thierry, additional, Thanendrarajan, Sharmilan, additional, Schinke, Carolina D., additional, Zangari, Maurizio, additional, van Rhee, Frits, additional, Barlogie, Bart, additional, Cairns, David, additional, Jackson, Graham, additional, Thakurta, Anjan, additional, Davies, Faith E., additional, Morgan, Gareth J., additional, and Walker, Brian A., additional

Published
2020
Full Text
View/download PDF

48. Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

Author

Computer Science, Mason, Mike J., Schinke, Carolina, Eng, Christine L. P., Towfic, Fadi, Gruber, Fred, Dervan, Andrew, White, Brian S., Pratapa, Aditya, Guan, Yuanfang, Chen, Hongjie, Cui, Yi, Li, Bailiang, Yu, Thomas, Neto, Elias Chaibub, Mavrommatis, Konstantinos, Ortiz, Maria, Lyzogubov, Valeriy, Bisht, Kamlesh, Dai, Hongyue Y., Schmitz, Frank, Flynt, Erin, Rozelle, Dan, Danziger, Samuel A., Ratushny, Alexander, Dalton, William S., Goldschmidt, Hartmut, Avet-Loiseau, Herve, Samur, Mehmet, Hayete, Boris, Sonneveld, Pieter, Shain, Kenneth H., Munshi, Nikhil, Auclair, Daniel, Hose, Dirk, Morgan, Gareth, Trotter, Matthew, Bassett, Douglas, Goke, Jonathan, Walker, Brian A., Thakurta, Anjan, Guinney, Justin, Computer Science, Mason, Mike J., Schinke, Carolina, Eng, Christine L. P., Towfic, Fadi, Gruber, Fred, Dervan, Andrew, White, Brian S., Pratapa, Aditya, Guan, Yuanfang, Chen, Hongjie, Cui, Yi, Li, Bailiang, Yu, Thomas, Neto, Elias Chaibub, Mavrommatis, Konstantinos, Ortiz, Maria, Lyzogubov, Valeriy, Bisht, Kamlesh, Dai, Hongyue Y., Schmitz, Frank, Flynt, Erin, Rozelle, Dan, Danziger, Samuel A., Ratushny, Alexander, Dalton, William S., Goldschmidt, Hartmut, Avet-Loiseau, Herve, Samur, Mehmet, Hayete, Boris, Sonneveld, Pieter, Shain, Kenneth H., Munshi, Nikhil, Auclair, Daniel, Hose, Dirk, Morgan, Gareth, Trotter, Matthew, Bassett, Douglas, Goke, Jonathan, Walker, Brian A., Thakurta, Anjan, and Guinney, Justin

Abstract

While the past decade has seen meaningful improvements in clinical outcomes for multiple myeloma patients, a subset of patients does not benefit from current therapeutics for unclear reasons. Many gene expression-based models of risk have been developed, but each model uses a different combination of genes and often involves assaying many genes making them difficult to implement. We organized the Multiple Myeloma DREAM Challenge, a crowdsourced effort to develop models of rapid progression in newly diagnosed myeloma patients and to benchmark these against previously published models. This effort lead to more robust predictors and found that incorporating specific demographic and clinical features improved gene expression-based models of high risk. Furthermore, post-challenge analysis identified a novel expression-based risk marker, PHF19, which has recently been found to have an important biological role in multiple myeloma. Lastly, we show that a simple four feature predictor composed of age, ISS, and expression of PHF19 and MMSET performs similarly to more complex models with many more gene expression features included.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results