Colloque avec actes et comité de lecture. Internationale.; International audience; In some highly demanding fluid dynamics simulations, as for instance in inertial confinement fusion applications, it appears necessary to simulate multi-fluid flows involving numerous constraints at the same time, such as (and non-limitatively): large number of fluids (typically 10 and above), both isentropic and strongly shocked compressible evolution, large heat sources, large deformations, transport over large distances, and highly variable or contrasted EOS (equation of state) stiffnesses. Fulfilling such a challenge in a robust and tractable way demands that thermodynamic consistency of the numerical scheme be carefully ensured. This is addressed here over an arbitrarily evolving computational grid (ALE or Arbitrary Lagrangian?Eulerian approach) by a three-step mimicking derivation: I) to ensure a compatible (approximately symplectic) exchange between internal and kinetic energies under isentropic conditions, a variational least action principle is used to generate the proper pressure forces in the momentum equations; ii) to generate the conservative internal energy equation, a tally is performed to match the kinetic energy, and iii) artificial dissipation is added to ensure shock stability, but other physical terms could also be included (drag, heat exchange, etc.). This mimicking derivation procedure has been developed by the authors in ""A novel GEEC (Geometry, Energy, and Entropy Compatible) procedure applied to a staggered direct-ALE scheme for hydrodynamics"" and applied as a proof of concept on a single-fluid direct ALE scheme named GEECS (Geometry, Energy, and Entropy Compatible Scheme). The resulting multi-fluid scheme named multiGEECS (Geometry, Energy, and Entropy Compatible multiphase Scheme) involves the following features: I) full conservation of mass, momentum, and total energy of the system at discrete level (up to round-off errors); ii) direct ALE formalism where mass, momentum, and internal energy fluxes are taken into account directly into the discrete evolution equations (without separation between Lagrangian evolution and remapping procedure); iii) thermodynamical consistency of the pressure work obtained by application of a variational principle; iv) pressure equilibrium through a simple and local (to the cells) procedure; and v) generic set of evolution equations written for an arbitrary number of fluids and derived without any constraint on structure or spatial dimension in order to simulate a broad category of multiphase flows. Multiphase numerical test cases?including Sod's shock tube, water-air shock tube, triple point test, and Ransom's water faucet problem?are performed in two-dimensions using various strenuous grid motion strategies. The results confirm the following properties: I) exact conservation at discrete level (proper capture of shock levels and shock velocities); ii) robust multi-material like behavior with small residual volume fractions; iii) stable multiphase behavior where each fluid has its own velocity in order to obtain drifting between fluids; iv) preservation of isentropic flows; and v) versatility regarding grid motions (including supersonic shearing, linear interpolation of contact discontinuity, near-Lagrangian motions, or randomly distorted mesh).