Search

Your search keyword '"Fogliarino S"' showing total 7 results
Start Over Author "Fogliarino S"
7 results on '"Fogliarino S"'

2. PEN-2 gene mutation in a familial Alzheimer's disease case

Author

SALA FRIGERIO, C, Piscopo, P, Calabrese, E, Crestini, A, MALVEZZI CAMPEGGI, L, CIVITA DI FAVA, R, Fogliarino, S, Albani, D, Marcon, Gabriella, Cherchi, R, Piras, R, Forloni, G, Confaloni, A., SALA FRIGERIO, C, Piscopo, P, Calabrese, E, Crestini, A, MALVEZZI CAMPEGGI, L, CIVITA DI FAVA, R, Fogliarino, S, Albani, D, Marcon, Gabriella, Cherchi, R, Piras, R, Forloni, G, and Confaloni, A.

Published
2005

6. MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels.

Author

Fenoglio C, Galimberti D, Lovati C, Guidi I, Gatti A, Fogliarino S, Tiriticco M, Mariani C, Forloni G, Pettenati C, Baron P, Conti G, Bresolin N, and Scarpini E

Subjects
Age of Onset, Aged, Alzheimer Disease blood, Alzheimer Disease immunology, Chemokine CCL2 blood, Chemokines immunology, Chemotaxis, Leukocyte immunology, DNA Mutational Analysis, Encephalitis blood, Encephalitis immunology, Female, Gene Frequency genetics, Genetic Testing, Genotype, Humans, Italy, Male, Mutation genetics, Risk Factors, Sex Factors, Up-Regulation genetics, Up-Regulation immunology, Alzheimer Disease genetics, Chemokine CCL2 genetics, Chemotaxis, Leukocyte genetics, Encephalitis genetics, Genetic Predisposition to Disease genetics, Polymorphism, Genetic genetics
Abstract

MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed. The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD.

Published
2004
Full Text
View/download PDF

7. Tumor necrosis factor alpha polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population.

Author

Terreni L, Fogliarino S, Quadri P, Ruggieri RM, Piccoli F, Tettamanti M, Lucca U, and Forloni G

Subjects
Aged, Aged, 80 and over, Alzheimer Disease genetics, Female, Genotype, Humans, Italy, Male, Polymorphism, Genetic, Risk Factors, Dementia genetics, Tumor Necrosis Factor-alpha genetics
Abstract

A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) alpha as a genetic risk factor for VD and, associated with apolipoprotein E epsilon 4, for AD. We have assessed the association between TNF-alpha polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-alpha polymorphism on dementia has not been confirmed in this segment of the Italian population.

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results