11 results on '"Foix L’Hélias, Laurence"'
Search Results
2. Neonatal Outcomes in Extremely Preterm Newborns Admitted to Intensive Care after No Active Antenatal Management: A Population-Based Cohort Study
- Author
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Diguisto, Caroline, Foix L'Helias, Laurence, Morgan, Andrei S., Ancel, Pierre-Yves, Kayem, Gilles, Kaminski, Monique, Perrotin, Franck, Khoshnood, Babak, and Goffinet, Francois
- Published
- 2018
- Full Text
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3. Five‐year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model
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Diguisto, Caroline, primary, Morgan, Andrei Scott, additional, Foix L’Hélias, Laurence, additional, Pierrat, Veronique, additional, Ancel, Pierre‐Yves, additional, Cohen, Jérémie F., additional, and Goffinet, Francois, additional
- Published
- 2023
- Full Text
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4. Five‐year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model.
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Diguisto, Caroline, Morgan, Andrei Scott, Foix L'Hélias, Laurence, Pierrat, Veronique, Ancel, Pierre‐Yves, Cohen, Jérémie F., and Goffinet, Francois
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PREMATURE infants ,PREDICTION models ,ASPHYXIA neonatorum ,GESTATIONAL age ,NEWBORN infants ,SURVIVAL rate - Abstract
Objective: To develop and validate a clinical prediction model for outcomes at 5 years of age for children born extremely preterm and receiving active perinatal management. Design: The EPIPAGE‐2 national prospective cohort. Setting: France, 2011. Population: Live‐born neonates between 24+0 and 26+6 weeks of gestation who received active perinatal management (i.e. birth in a tertiary‐level hospital, with antenatal steroids and resuscitation at birth). Methods: A prediction model using logistic modelling, including gestational age, small‐for gestational‐age (SGA) status and sex, was developed. Model performance was assessed through calibration and discrimination, with bootstrap internal validation. Main outcome measures: Survival without moderate or severe neurodevelopmental disability (NDD) at 5 years. Results: Among the 557 neonates included, 401 (72%) survived to 5 years, of which 59% survived without NDD (95% CI 54% to 63%). Predicted rates of survival without NDD ranged from 45% (95% CI 33% to 57%), to 56% (95% CI 49% to 64%) to 64% (95% CI 57% to 70%) for neonates born at 24, 25 and 26 weeks of gestation, respectively. Predicted rates of survival without NDD were 47% (95% CI 18% to 76%) and 62% (95% CI 49% to 76%) for SGA and non‐SGA children, respectively. The model showed good calibration (calibration slope 0.85, 95% CI 0.54 to 1.16; calibration‐in‐the‐large −0.0123, 95% CI −0.25 to 0.23) and modest discrimination (C‐index 0.59, 95% CI 0.53 to 0.65). Conclusions: A simple prediction model using three factors easily known antenatally may help doctors and families in their decision‐making for extremely preterm neonates receiving active perinatal management. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Prenatal parental involvement in decision for delivery room management at 22-26 weeks of gestation in France - The EPIPAGE-2 Cohort Study
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Levaillant, Cerise, Caeymaex, Laurence, Behal, Hélène, Kaminski, Monique, Diguisto, Caroline, Tosello, Barthélémy, Azria, Elie, Claris, Olivier, Bétrémieux, Pierre, Foix L'Hélias, Laurence, Truffert, Patrick, Gestionnaire, Hal Sorbonne Université, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Intercommunal de Créteil (CHIC), Centre d'Etudes des discours, Images, Textes, Ecrits, Communications (CEDITEC), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Lille, Université Sorbonne Paris Cité (USPC), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU), EFS, Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, CHU Pontchaillou [Rennes], Service de néonatologie [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Trousseau [APHP], CHU Lille, Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Centre d'Etudes des discours, Images, Textes, Ecrits, Communications [CEDITEC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153], Université Claude Bernard Lyon 1 [UCBL], Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Groupe hospitalier Paris Saint-Joseph - Hôpital, and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP]-Sorbonne Université (SU)
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Male ,Parents ,Critical Care and Emergency Medicine ,Physiology ,Maternal Health ,Resuscitation ,Decision Making ,Social Sciences ,Gestational Age ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Pediatrics ,Families ,Labor and Delivery ,Cognition ,Pregnancy ,Medicine and Health Sciences ,Humans ,Psychology ,Birth Weight ,Public Health Surveillance ,Children ,Delivery Rooms ,Body Weight ,Infant, Newborn ,Cognitive Psychology ,Disease Management ,Infant ,Biology and Life Sciences ,Neonates ,Obstetrics and Gynecology ,Delivery, Obstetric ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Physiological Parameters ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Age Groups ,Infant, Extremely Premature ,People and Places ,Birth ,Cognitive Science ,Women's Health ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Population Groupings ,France ,Infants ,Research Article ,Developmental Biology ,Neuroscience - Abstract
International audience; OBJECTIVE: Our main objective was to examine if parental prenatal preferences predict delivery-room management of extremely preterm periviable infants. The secondary objectives were to describe parental involvement and the content of prenatal counseling given to parents for this prenatal decision.DESIGN: Prospective study of neonates liveborn between 22 and 26 weeks of gestation in France in 2011 among the neonates included in the EPIPAGE-2 study.SETTING: 18 centers participating in the "Extreme Prematurity Group" substudy of the EPIPAGE-2 study.PATIENTS: 302 neonates liveborn between 22-26 weeks among which 113 with known parental preferences while parental preferences were unknown or unavailable for 186 and delivery room management was missing for 3.RESULTS: Data on prenatal counseling and parental preferences were collected by a questionnaire completed by professionals who cared for the baby at birth; delivery room (DR) management, classified as stabilization or initiation of resuscitation (SIR) vs comfort care (CC). The 113 neonates studied had a mean (SD) gestational age of 24 (0.1) weeks. Parents of neonates in the CC group preferred SIR less frequently than those with neonates in the SIR group (16% vs 88%, p < .001). After multivariate analysis, preference for SIR was an independent factor associated with this management. Professionals qualified decisions as shared (81%), exclusively medical (16%) or parental (3%). Information was described as medical with no personal opinion (71%), complete (75%) and generally pessimistic (54%).CONCLUSION: Parental involvement in prenatal decision-making did not reach satisfying rates in the studied setting. When available, prenatal parental preference was a determining factor for DR management of extremely preterm neonates. Potential biases in the content of prenatal counselling given to parents need to be evaluated.
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- 2019
6. Tocolysis in the management of preterm prelabor rupture of membranes at 22-33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM).
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Lorthe, Elsa, Kayem, Gilles, on behalf of the TOCOPROM Study Group and the GROG (Groupe de Recherche en Obstétrique et Gynécologie), Ancel, Pierre-Yves, Abdoul, Hendy, Briand, Nelly, Lehmann, Blandine, Cabanne, Clémence, Marret, Stéphane, Foix l'Hélias, Laurence, Goffinet, François, Schmitz, Thomas, Charlier, Caroline, Autret, Fanny, Azria, Elie, Balitalike, Jadot, Billiemaz, Kareen, Bohec, Caroline, Bolot, Pascal, and Bornes, Marie
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PREMATURE labor ,TOCOLYTIC agents ,NIFEDIPINE ,PREGNANCY ,NEONATAL nursing - Abstract
Background: Preterm prelabor rupture of membranes (PPROM) before 34 weeks of gestation complicates 1% of pregnancies and accounts for one-third of preterm births. International guidelines recommend expectant management, along with antenatal steroids before 34 weeks and antibiotics. Up-to-date evidence about the risks and benefits of administering tocolysis after PPROM, however, is lacking. In theory, reducing uterine contractility could delay delivery and reduce the risks of prematurity and its adverse short- and long-term consequences, but it might also prolong fetal exposure to inflammation, infection, and acute obstetric complications, potentially associated with neonatal death or long-term sequelae. The primary objective of this study is to assess whether short-term (48 h) tocolysis reduces perinatal mortality/morbidity in PPROM at 22 to 33 completed weeks of gestation.Methods: A randomized, double-blind, placebo-controlled, superiority trial will be performed in 29 French maternity units. Women with PPROM between 220/7 and 336/7 weeks of gestation, a singleton pregnancy, and no condition contraindicating expectant management will be randomized to receive a 48-hour oral treatment by either nifedipine or placebo (1:1 ratio). The primary outcome will be the occurrence of perinatal mortality/morbidity, a composite outcome including fetal death, neonatal death, or severe neonatal morbidity before discharge. If we assume an alpha-risk of 0.05 and beta-risk of 0.20 (i.e., a statistical power of 80%), 702 women (351 per arm) are required to show a reduction of the primary endpoint from 35% (placebo group) to 25% (nifedipine group). We plan to increase the required number of subjects by 20%, to replace any patients who leave the study early. The total number of subjects required is thus 850. Data will be analyzed by the intention-to-treat principle.Discussion: This trial will inform practices and policies worldwide. Optimized prenatal management to improve the prognosis of infants born preterm could benefit about 50,000 women in the European Union and 40,000 in the United States each year.Trial Registration: ClinicalTrials.gov identifier: NCT03976063 (registration date June 5, 2019). [ABSTRACT FROM AUTHOR]- Published
- 2021
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7. Effect of maternal obesity on birthweight and neonatal fat mass: A prospective clinical trial
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Mitanchez, Delphine, primary, Jacqueminet, Sophie, additional, Nizard, Jacky, additional, Tanguy, Marie-Laure, additional, Ciangura, Cécile, additional, Lacorte, Jean-Marc, additional, De Carne, Céline, additional, Foix L’Hélias, Laurence, additional, Chavatte-Palmer, Pascale, additional, Charles, Marie-Aline, additional, and Dommergues, Marc, additional
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- 2017
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8. Cognitive Training for Visuospatial Processing in Children Aged 5½ to 6 Years Born Very Preterm With Working Memory Dysfunction: A Randomized Clinical Trial.
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Gire, Catherine, Beltran Anzola, Any, Marret, Stéphane, Foix L'Hélias, Laurence, Roze, Jean-Christophe, Granier, Michèle, Patural, Hugues, Lecomte, Bénédicte, Guillois, Bernard, Souksi Medioni, Isabelle, Bednarek Weirauch, Nathalie, Claris, Olivier, Hascoët, Jean-Michel, Kuhn, Pierre, Zahed, Meriem, Boucekine, Mohamed, Ancel, Pierre-Yves, Arnaud, Catherine, Cambonie, Gilles, and Dorriere Datin, Valérie
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- 2023
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9. Exclusive and mixed breastfeeding in maternity unit: situation in France in 2003
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Bonet, Mercedes, Foix L'Hélias, Laurence, Blondel, Béatrice, Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pédiatrie et Réanimations néonatales [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), L'enquête National Périnatale a été financée en partie par la Direction Générale de la Santé, and Debs, Nayla
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mixed breastfeeding ,MESH: Humans ,breastfeeding ,MESH: Infant, Newborn ,MESH: Parity ,regional disparities ,MESH: Adult ,social disparites ,MESH: Bottle Feeding ,MESH: France ,MESH: Pregnancy ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,exclusive breastfeeding ,MESH: Breast Feeding ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,France ,MESH: Hospital Units ,MESH: Educational Status ,MESH: Female - Abstract
International audience; PURPOSE: To assess how exclusive and mixed breastfeeding varied depending on the characteristics of the mother, the newborn, and place of birth. METHODS: A national representative sample of births included 14,580 live births. During the hospital stay, mothers were asked if the infant was exclusively breastfed, breast and bottle-fed (mixed), or only bottle-fed. The factors associated with exclusive breastfeeding and those associated with mixed breastfeeding were compared using a multinomial logistic regression model. RESULTS: Of the women studied, 56.3% breastfed exclusively and 6.3% used mixed breastfeeding. Exclusive and mixed breastfeeding were higher among primiparous, non-French, and highly educated women. Non-French nationality had a stronger effect on mixed breastfeeding than on exclusive breastfeeding (adjusted odds ratio [aOR], 9.9 and 5.2, respectively, among women from North Africa). A high level of education played a greater role in exclusive breastfeeding (aOR, 2.5) than mixed breastfeeding (aOR, 1.8). Breastfeeding was higher in the Ile-de-France, East, Central-East, and Mediterranean regions, with stronger variations in mixed breastfeeding than in exclusive breastfeeding. CONCLUSION: Clear social disparities in exclusive and mixed breastfeeding exist depending on maternal social class and nationality, and region of birth. Particular breastfeeding promotion actions could target groups or regions where women are less likely to breastfeed.
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- 2008
10. Effect of maternal obesity on birthweight and neonatal fat mass: a prospective clinical trial.
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Mitanchez, Delphine, Jacqueminet, Sophie, Nizard, Jacky, Tanguy, Marie-Laure, Ciangura, Cecile, Lacorte, Jean-Marc, De Carne, Celine, Foix L'Hélias, Laurence, Chavatte-Palmer, Pascale, Charles, Marie-Aline, and Dommergues, Marc
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- 2017
11. Five-year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model.
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Diguisto C, Morgan AS, Foix L'Hélias L, Pierrat V, Ancel PY, Cohen JF, and Goffinet F
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- Infant, Newborn, Infant, Child, Humans, Pregnancy, Female, Prospective Studies, Prognosis, Gestational Age, Infant, Extremely Premature, Models, Statistical
- Abstract
Objective: To develop and validate a clinical prediction model for outcomes at 5 years of age for children born extremely preterm and receiving active perinatal management., Design: The EPIPAGE-2 national prospective cohort., Setting: France, 2011., Population: Live-born neonates between 24
+0 and 26+6 weeks of gestation who received active perinatal management (i.e. birth in a tertiary-level hospital, with antenatal steroids and resuscitation at birth)., Methods: A prediction model using logistic modelling, including gestational age, small-for gestational-age (SGA) status and sex, was developed. Model performance was assessed through calibration and discrimination, with bootstrap internal validation., Main Outcome Measures: Survival without moderate or severe neurodevelopmental disability (NDD) at 5 years., Results: Among the 557 neonates included, 401 (72%) survived to 5 years, of which 59% survived without NDD (95% CI 54% to 63%). Predicted rates of survival without NDD ranged from 45% (95% CI 33% to 57%), to 56% (95% CI 49% to 64%) to 64% (95% CI 57% to 70%) for neonates born at 24, 25 and 26 weeks of gestation, respectively. Predicted rates of survival without NDD were 47% (95% CI 18% to 76%) and 62% (95% CI 49% to 76%) for SGA and non-SGA children, respectively. The model showed good calibration (calibration slope 0.85, 95% CI 0.54 to 1.16; calibration-in-the-large -0.0123, 95% CI -0.25 to 0.23) and modest discrimination (C-index 0.59, 95% CI 0.53 to 0.65)., Conclusions: A simple prediction model using three factors easily known antenatally may help doctors and families in their decision-making for extremely preterm neonates receiving active perinatal management., (© 2023 John Wiley & Sons Ltd.)- Published
- 2024
- Full Text
- View/download PDF
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