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2. Geographical Association Between Basic Life Support Courses and Bystander Cardiopulmonary Resuscitation and Survival from OHCA in Denmark

Author

Jensen TW, Ersbøll AK, Folke F, Andersen MP, Blomberg SN, Holgersen MG, Andersen LB, Lippert F, Torp-Pedersen C, and Christensen HC

Subjects
basic life support, survival, geography, epidemology, conditional autoregressive regression, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Theo Walther Jensen,1– 3 Annette Kjær Ersbøll,3,4 Fredrik Folke,2,3,5 Mikkel Porsborg Andersen,6 Stig Nikolaj Blomberg,1– 3 Mathias Geldermann Holgersen,2,7 Lars Bredevang Andersen,1 Freddy Lippert,2,3 Christian Torp-Pedersen,6,8 Helle Collatz Christensen1,2,9 1Emergency Medical Services Region Zealand, Naestved, Denmark; 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Copenhagen Emergency Medical Services, University of Copenhagen, Copenhagen, Denmark; 4National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; 5Department of Cardiology, Herlev Gentofte University Hospital, Gentofte, Denmark; 6Department of Cardiology, Nordsjaellands Hospital, Hilleroed, Denmark; 7Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark; 8Aalborg University Hospital, Aalborg & Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 9Danish Clinical Quality Program (RKKP), National Clinical Registries & Department of Clinical Medicine, Copenhagen, DenmarkCorrespondence: Theo Walther Jensen, Emergency Medical Services, Region Zealand and University of Copenhagen, Ringstedgade 61, 13. etage, Naestved, 4700, Denmark, Tel +45 51 21 10 06, Email theje@regionsjaelland.dkIntroduction: Annually, approximately 4% of the entire adult population of Denmark participate in certified basic life support (BLS) courses. It is still unknown whether increases in BLS course participation in a geographical area increase bystander cardiopulmonary resuscitation (CPR) or survival from out-of-hospital cardiac arrest (OHCA). The aim of the study was to examine the geographical association between BLS course participation, bystander CPR, and 30-day survival from OHCA.Methods: This nationwide register-based cohort study includes all OHCAs from the Danish Cardiac Arrest Register. Data concerning BLS course participation were supplied by the major Danish BLS course providers. A total of 704,234 individuals with BLS course certificates and 15,097 OHCA were included from the period 2016– 2019. Associations were examined using logistic regression and Bayesian conditional autoregressive analyses conducted at municipality level.Results: A 5% increase in BLS course certificates at municipality level was significantly associated with an increased likelihood of bystander CPR prior to ambulance arrival with an adjusted odds ratio (OR) of 1.34 (credible intervals: 1.02;1.76). The same trends were observed for OHCAs in out-of-office hours (4pm-08am) with a significant OR of 1.43 (credible intervals: 1.09;1.89). Local clusters with low rate of BLS course participation and bystander CPR were identified.Conclusion: This study found a positive effect of mass education in BLS on bystander CPR rates. Even a 5% increase in BLS course participation at municipal level significantly increased the likelihood of bystander CPR. The effect was even more profound in out-of-office hours with an increase in bystander CPR rate at OHCA.Keywords: basic life support, survival, geography, epidemiology, conditional autoregressive regression

Published
2023

4. The National Danish Cardiac Arrest Registry for Out-of-Hospital Cardiac Arrest – A Registry in Transformation

Author

Jensen TW, Blomberg SN, Folke F, Mikkelsen S, Rostgaard-Knudsen M, Juelsgaard P, Christensen EF, Torp-Pedersen C, Lippert F, and Christensen HC

Subjects
cardiac arrest, ohca, cardiopulmonary resuscitation, denmark, quality, survival., Infectious and parasitic diseases, RC109-216
Abstract

Theo Walter Jensen,1,2 Stig Nikolaj Blomberg,1,2 Fredrik Folke,1– 3 Søren Mikkelsen,4,5 Martin Rostgaard-Knudsen,6 Palle Juelsgaard,7 Erika Frishknecht Christensen,6,8 Christian Torp-Pedersen,9,10 Freddy Lippert,1,2 Helle Collatz Christensen1,2,11,12 1Research, Copenhagen Emergency Medical Services, Copenhagen, Denmark; 2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 3Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen, Denmark; 4Emergency Medical Services, The Region of Southern Denmark, Odense, Denmark; 5Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; 6Emergency Medical Services, North Region of Denmark, Aalborg, Denmark; 7Emergency Medical Services, Central Denmark Region, Viborg, Denmark; 8Center for Prehospital and Emergency Research, Aalborg University Hospital and Aalborg University, Aalborg, Denmark; 9Department of Cardiology and Clinical Investigation, Nordsjaellands Hospital, Hillerød, Denmark; 10Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; 11Emergency Medical Services, Naestved, Region Zealand, Denmark; 12Danish Clinical Quality Program (RKKP) ▪ National Clinical Registries, Copenhagen, DenmarkCorrespondence: Helle Collatz Christensen, Email helle.collatz.christensen.02@regionh.dkAim of the Database: The aim of the Danish Cardiac Arrest Registry is to monitor the quality of prehospital cardiac arrest treatment, evaluate initiatives regarding prehospital treatment of cardiac arrest, and facilitate research.Study Population: All patients with prehospital cardiac arrest in Denmark treated by the emergency medical services in whom resuscitation or defibrillation has been attempted.Main Variables: The Danish Cardiac Arrest Register records descriptive and qualitative variables as outlined in the “Utstein” template for reporting out-of-hospital-cardiac arrest. Main variables include whether the case was witnessed, whether the cardiac arrest was electrocardiographically monitored, the timing of cardiopulmonary resuscitation, and the timing of the first analysis of the cardiac rhythm. The outcome measures are the status of the patient at handover to the hospital, return of spontaneous circulation, and 30-day survival after event.Database Status: The Danish Cardiac Arrest Registry was established in June 2001, and all Danish emergency medical services are reporting to the database.Conclusion: The Danish Cardiac Arrest Registry is among the oldest Danish national clinical registries, with a high quality of clinical data and coverage. This registry provides the prerequisite for all research on out-of-hospital cardiac arrest research in Denmark and is essential for monitoring and improving the quality of care for patients suffering from out-of-hospital cardiac arrest.Keywords: cardiac arrest, OHCA, cardiopulmonary resuscitation, Denmark, quality, survival

Published
2022

7. The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action

Author

Marijon, E, Narayanan, K, Smith, K, Barra, S, Basso, C, Blom, M, Crotti, L, D'Avila, A, Deo, R, Dumas, F, Dzudie, A, Farrugia, A, Greeley, K, Hindricks, G, Hua, W, Ingles, J, Iwami, T, Junttila, J, Koster, R, Le Polain De Waroux, J, Olasveengen, T, Ong, M, Papadakis, M, Sasson, C, Shin, S, Tse, H, Tseng, Z, Van Der Werf, C, Folke, F, Albert, C, Winkel, B, Marijon E., Narayanan K., Smith K., Barra S., Basso C., Blom M. T., Crotti L., D'Avila A., Deo R., Dumas F., Dzudie A., Farrugia A., Greeley K., Hindricks G., Hua W., Ingles J., Iwami T., Junttila J., Koster R. W., Le Polain De Waroux J. -B., Olasveengen T. M., Ong M. E. H., Papadakis M., Sasson C., Shin S. D., Tse H. -F., Tseng Z., Van Der Werf C., Folke F., Albert C. M., Winkel B. G., Marijon, E, Narayanan, K, Smith, K, Barra, S, Basso, C, Blom, M, Crotti, L, D'Avila, A, Deo, R, Dumas, F, Dzudie, A, Farrugia, A, Greeley, K, Hindricks, G, Hua, W, Ingles, J, Iwami, T, Junttila, J, Koster, R, Le Polain De Waroux, J, Olasveengen, T, Ong, M, Papadakis, M, Sasson, C, Shin, S, Tse, H, Tseng, Z, Van Der Werf, C, Folke, F, Albert, C, Winkel, B, Marijon E., Narayanan K., Smith K., Barra S., Basso C., Blom M. T., Crotti L., D'Avila A., Deo R., Dumas F., Dzudie A., Farrugia A., Greeley K., Hindricks G., Hua W., Ingles J., Iwami T., Junttila J., Koster R. W., Le Polain De Waroux J. -B., Olasveengen T. M., Ong M. E. H., Papadakis M., Sasson C., Shin S. D., Tse H. -F., Tseng Z., Van Der Werf C., Folke F., Albert C. M., and Winkel B. G.

Abstract

Despite major advancements in cardiovascular medicine, sudden cardiac death (SCD) continues to be an enormous medical and societal challenge, claiming millions of lives every year. Efforts to prevent SCD are hampered by imperfect risk prediction and inadequate solutions to specifically address arrhythmogenesis. Although resuscitation strategies have witnessed substantial evolution, there is a need to strengthen the organisation of community interventions and emergency medical systems across varied locations and health-care structures. With all the technological and medical advances of the 21st century, the fact that survival from sudden cardiac arrest (SCA) remains lower than 10% in most parts of the world is unacceptable. Recognising this urgent need, the Lancet Commission on SCD was constituted, bringing together 30 international experts in varied disciplines. Consistent progress in tackling SCD will require a completely revamped approach to SCD prevention, with wide-sweeping policy changes that will empower the development of both governmental and community-based programmes to maximise survival from SCA, and to comprehensively attend to survivors and decedents’ families after the event. International collaborative efforts that maximally leverage and connect the expertise of various research organisations will need to be prioritised to properly address identified gaps. The Commission places substantial emphasis on the need to develop a multidisciplinary strategy that encompasses all aspects of SCD prevention and treatment. The Commission provides a critical assessment of the current scientific efforts in the field, and puts forth key recommendations to challenge, activate, and intensify efforts by both the scientific and global community with new directions, research, and innovation to reduce the burden of SCD worldwide.

Published
2023

9. Development of video tutorials to help parents manage children with acute illnesses using a modified Delphi method

Author

Borch‐Johnsen, L., primary, Andrés‐Jensen, L., additional, Folke, F., additional, Espersen, M. M., additional, Amstrup, S. L., additional, Frederiksen, M. S., additional, Gjærde, L. K., additional, Hjelvang, B. R., additional, Kristoffersen, M. J., additional, Lundby‐Christensen, L., additional, Schrøder, M., additional, Spangenberg, K. B., additional, Lund, S., additional, and Cortes, D., additional

Published
2023
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10. Centralisation of post-resuscitation care after out-of-hospital cardiac arrest at heart centres - a nationwide follow-up study

Author

Rasalingam Mork, S, primary, Gregers, E, additional, Kragholm, K, additional, Kjaergaard, J, additional, Folke, F, additional, Torp-Pedersen, C, additional, Kober, L, additional, Boas Soja, A M, additional, Juhl Terkelsen, C, additional, Michalik, F, additional, Eifer Moller, J, additional, Lund Henriksen, F, additional, Bundgaard Ringgren, K, additional, Hassager, C, additional, and Soholm, H, additional

Published
2023
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12. Termination of resuscitation in out-of-hospital cardiac arrest in women and men:An ESCAPE-NET project

Author

Smits, R. L.A., Sødergren, S. T.F., van Schuppen, H., Folke, F., Ringh, M., Jonsson, M., Motazedi, E., van Valkengoed, I. G.M., Tan, H. L., Smits, R. L.A., Sødergren, S. T.F., van Schuppen, H., Folke, F., Ringh, M., Jonsson, M., Motazedi, E., van Valkengoed, I. G.M., and Tan, H. L.

Abstract

Aim: Women have less favorable resuscitation characteristics than men. We investigated whether the Advanced Life Support Termination of Resuscitation rule (ALS-TOR) performs equally in women and men. Additionally, we studied whether adding or removing criteria from the ALS-TOR improved classification into survivors and non-survivors. Methods: We analyzed 6,931 female and 14,548 male out-of-hospital cardiac arrest (OHCA) patients from Dutch and Swedish registries, and validated in 10,772 female and 21,808 male Danish OHCA patients. Performance measures were calculated for ALS-TOR in relation to 30-day survival. Recursive partitioning analysis was performed with the ALS-TOR criteria, as well as age, comorbidities, and additional resuscitation characteristics (e.g. initial rhythm, OHCA location). Finally, we explored if we could reduce the number of ALS-TOR criteria without loss of prognostic value. Results: The ALS-TOR had a specificity and positive predictive value (PPV) of ≥99% in both women and men (e.g. PPV 99.9 in men). Classification by recursive partitioning analysis showed a high sensitivity but a PPV below 99%, thereby exceeding the acceptable miss rate of 1%. A combination of no return of spontaneous circulation (ROSC) before transport to the hospital and unwitnessed OHCA resulted in nearly equal specificity and PPV, higher sensitivity, and a lower transport rate to the hospital than the ALS-TOR. Conclusion: For both women and men, the ALS-TOR has high specificity and low miss rate for predicting 30-day OHCA survival. We could not improve the classification with additional characteristics. Employing a simplified version may decrease the number of futile transports to the hospital.

Published
2023

13. Development of video tutorials to help parents manage children with acute illnesses using a modified Delphi method

Author

Borch-Johnsen, L., Andrés-Jensen, L., Folke, F., Espersen, M. M., Amstrup, S. L., Frederiksen, M. S., Gjærde, L. K., Hjelvang, B. R., Kristoffersen, M. J., Lundby-Christensen, L., Schrøder, M., Spangenberg, K. B., Lund, S., Cortes, D., Borch-Johnsen, L., Andrés-Jensen, L., Folke, F., Espersen, M. M., Amstrup, S. L., Frederiksen, M. S., Gjærde, L. K., Hjelvang, B. R., Kristoffersen, M. J., Lundby-Christensen, L., Schrøder, M., Spangenberg, K. B., Lund, S., and Cortes, D.

Abstract

Aim Children often fall sick, which causes concern among parents. Online health information can be confusing and difficult to understand. We aimed to produce simple, informative video tutorials on the symptoms ill children present. Methods We used a modified Delphi method to produce video tutorials on the symptoms of fever, vomiting and diarrhoea, abdominal pain, breathing difficulties, sore throat, red eyes, earache and rash. We identified the most common symptoms in acutely ill children. During the first consensus round, experts rated statements on out-of-hospital management from existing health information. Video tutorials were produced from statements rated to be included. The second consensus round involved video showings and editing. Two videos were evaluated in focus groups by parents. Results During the first round, experts rated a median of 79 (40–154) statements for each symptom. Panels consisted of a median of seven (6–11) experts, primarily. Panels reached a consensus on inclusion, neutrality or exclusion in 83% of statements. The second round led to adjustments to the videos and final approval by experts. Most parents evaluated the videos as ‘informative, easy to understand and calming’. Conclusion We produced video tutorials on the common symptoms ill children present using a modified Delphi method. Feedback from parents in focus groups was positive., Aim: Children often fall sick, which causes concern among parents. Online health information can be confusing and difficult to understand. We aimed to produce simple, informative video tutorials on the symptoms ill children present. Methods: We used a modified Delphi method to produce video tutorials on the symptoms of fever, vomiting and diarrhoea, abdominal pain, breathing difficulties, sore throat, red eyes, earache and rash. We identified the most common symptoms in acutely ill children. During the first consensus round, experts rated statements on out-of-hospital management from existing health information. Video tutorials were produced from statements rated to be included. The second consensus round involved video showings and editing. Two videos were evaluated in focus groups by parents. Results: During the first round, experts rated a median of 79 (40–154) statements for each symptom. Panels consisted of a median of seven (6–11) experts, primarily. Panels reached a consensus on inclusion, neutrality or exclusion in 83% of statements. The second round led to adjustments to the videos and final approval by experts. Most parents evaluated the videos as ‘informative, easy to understand and calming’. Conclusion: We produced video tutorials on the common symptoms ill children present using a modified Delphi method. Feedback from parents in focus groups was positive.

Published
2023

14. 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces

Author

Berg, K. M., Bray, J. E., Ng, K. -C., Liley, H. G., Greif, R., Carlson, J. N., Morley, P. T., Drennan, I. R., Smyth, M., Scholefield, B. R., Weiner, G. M., Cheng, A., Djarv, T., Abelairas-Gomez, C., Acworth, J., Andersen, L. W., Atkins, D. L., Berry, D. C., Bhanji, F., Bierens, J., Couto, T. B., Borra, V., Bottiger, B. W., Bradley, R. N., Breckwoldt, J., Cassan, P., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Dassanayake, V., Davis, P. G., Dawson, J. A., de Almeida, M. F., De Caen, A. R., Deakin, C. D., Dicker, B., Douma, M. J., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Fijacko, N., Finn, J. C., Flores, G. E., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M. E., Kloeck, D. A., Kudenchuk, P., Kule, A., Kurosawa, H., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y., Lockey, A. S., Macneil, F., Maconochie, I. K., Madar, R. J., Hansen, C. M., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Monnelly, V., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., Ohshimo, S., Olasveengen, T. M., Ong, Y. -K. G., Orkin, A. M., Parr, M. J., Patocka, C., Perkins, G. D., Perlman, J. M., Rabi, Y., Raitt, J., Ramachandran, S., Ramaswamy, V. V., Raymond, T. T., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Singletary, E. M., Skrifvars, M. B., Smith, C. M., Soar, J., Stassen, W., Sugiura, T., Tijssen, J. A., Topjian, A. A., Trevisanuto, D., Vaillancourt, C., Wyckoff, M. H., Wyllie, J. P., Yang, C. -W., Yeung, J., Zelop, C. M., Zideman, D. A., Nolan, J. P., Barcala-Furelos, R., Beerman, S. B., Bruckner, M., Castren, M., Chong, S., Claesson, A., Dunne, C. L., Finan, E., Fukuda, T., Ganesan, S. L., Gately, C., Gois, A., Gray, S., Halamek, L. P., Hoover, A. V., Hurst, C., Josephsen, J., Kollander, L., Kamlin, C. O., Kool, M., Li, L., Mecrow, T. S., Montgomery, W., Ristau, P., Jayashree, M., Schmidt, A., Scquizzato, T. -M., Seesink, J., Sempsrott, J., Solevag, A. L., Strand, M. L., Szpilman, D., Szyld, E., Thom, O., Tobin, J. M., Trang, J., Webber, J., Webster, H. K., Wellsford, M., Sandroni C. (ORCID:0000-0002-8878-2611), Berg, K. M., Bray, J. E., Ng, K. -C., Liley, H. G., Greif, R., Carlson, J. N., Morley, P. T., Drennan, I. R., Smyth, M., Scholefield, B. R., Weiner, G. M., Cheng, A., Djarv, T., Abelairas-Gomez, C., Acworth, J., Andersen, L. W., Atkins, D. L., Berry, D. C., Bhanji, F., Bierens, J., Couto, T. B., Borra, V., Bottiger, B. W., Bradley, R. N., Breckwoldt, J., Cassan, P., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Dassanayake, V., Davis, P. G., Dawson, J. A., de Almeida, M. F., De Caen, A. R., Deakin, C. D., Dicker, B., Douma, M. J., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Fijacko, N., Finn, J. C., Flores, G. E., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M. E., Kloeck, D. A., Kudenchuk, P., Kule, A., Kurosawa, H., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y., Lockey, A. S., Macneil, F., Maconochie, I. K., Madar, R. J., Hansen, C. M., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Monnelly, V., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., Ohshimo, S., Olasveengen, T. M., Ong, Y. -K. G., Orkin, A. M., Parr, M. J., Patocka, C., Perkins, G. D., Perlman, J. M., Rabi, Y., Raitt, J., Ramachandran, S., Ramaswamy, V. V., Raymond, T. T., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Singletary, E. M., Skrifvars, M. B., Smith, C. M., Soar, J., Stassen, W., Sugiura, T., Tijssen, J. A., Topjian, A. A., Trevisanuto, D., Vaillancourt, C., Wyckoff, M. H., Wyllie, J. P., Yang, C. -W., Yeung, J., Zelop, C. M., Zideman, D. A., Nolan, J. P., Barcala-Furelos, R., Beerman, S. B., Bruckner, M., Castren, M., Chong, S., Claesson, A., Dunne, C. L., Finan, E., Fukuda, T., Ganesan, S. L., Gately, C., Gois, A., Gray, S., Halamek, L. P., Hoover, A. V., Hurst, C., Josephsen, J., Kollander, L., Kamlin, C. O., Kool, M., Li, L., Mecrow, T. S., Montgomery, W., Ristau, P., Jayashree, M., Schmidt, A., Scquizzato, T. -M., Seesink, J., Sempsrott, J., Solevag, A. L., Strand, M. L., Szpilman, D., Szyld, E., Thom, O., Tobin, J. M., Trang, J., Webber, J., Webster, H. K., Wellsford, M., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

The International Liaison Committee on Resuscitation engages in a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation and first aid science. Draft Consensus on Science With Treatment Recommendations are posted online throughout the year, and this annual summary provides more concise versions of the final Consensus on Science With Treatment Recommendations from all task forces for the year. Topics addressed by systematic reviews this year include resuscitation of cardiac arrest from drowning, extracorporeal cardiopulmonary resuscitation for adults and children, calcium during cardiac arrest, double sequential defibrillation, neuroprognostication after cardiac arrest for adults and children, maintaining normal temperature after preterm birth, heart rate monitoring methods for diagnostics in neonates, detection of exhaled carbon dioxide in neonates, family presence during resuscitation of adults, and a stepwise approach to resuscitation skills training. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, using Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces list priority knowledge gaps for further research. Additional topics are addressed with scoping reviews and evidence updates.

Published
2023

15. Similar long-term survival of consecutive in-hospital and out-of-hospital cardiac arrest patients treated with targeted temperature management

Author

Engsig M, Søholm H, Folke F, Gadegaard PJ, Wiis JT, Molin R, Mohr T, and Engsig FN

Subjects
In-hospital cardiac arrest, long-term survival, targeted temperature management, out-of-hospital cardiac arrest, advanced life support, post-resuscitation care., Infectious and parasitic diseases, RC109-216
Abstract

Magaly Engsig,1 Helle Søholm,2 Fredrik Folke,3,4 Peter J Gadegaard,1 Julie Therese Wiis,5 Rune Molin,6 Thomas Mohr,1 Frederik N Engsig7 1Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital, Hellerup, 2Department of Cardiology, Copenhagen University Hospital, Herlev, 3Department of Cardiology, Copenhagen University Hospital, Hellerup, 4Pre-Hospital Emergency Medical Services, Capital Region of Denmark, Ballerup, 5Department of Intensive Care, Copenhagen University Hospital, Copenhagen, 6Department of Anaesthesiology, Copenhagen University Hospital, Hillerød, 7Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark Objective: The long-term survival of in-hospital cardiac arrest (IHCA) patients treated with targeted temperature management (TTM) is poorly described. The aim of this study was to compare the outcomes of consecutive IHCA with out-of-hospital cardiac arrest (OHCA) patients treated with TTM. Design, setting, and patients: Retrospectively collected data on all consecutive adult patients treated with TTM at a university tertiary heart center between 2005 and 2011 were analyzed. Measurements: Primary endpoints were survival to hospital discharge and long-term survival. Secondary endpoint was neurological outcome assessed using the Pittsburgh cerebral performance category (CPC). Results: A total of 282 patients were included in this study; 233 (83%) OHCA and 49 (17%) IHCA. The IHCA group presented more often with asystole, received bystander cardiopulmonary resuscitation (CPR) in all cases, and had shorter time to return of spontaneous circulation (ROSC). Survival to hospital discharge was 54% for OHCA and 53% for IHCA (adjusted odds ratio 0.98 [95% confidence interval {CI}; 0.43–2.24]). Age ≤60 years, bystander CPR, time to ROSC ≤10 min, and shockable rhythm at presentation were associated with survival to hospital discharge. Good neurologic outcome among survivors was achieved by 86% of OHCA and 92% of IHCA (P=0.83). After a median follow-up time of >5 years, 83% of OHCA and 77% of IHCA were alive (adjusted hazard ratio [HR] 1.51 [95% CI; 0.59–3.91]). Age ≤60 years was the only factor associated with long-term survival (adjusted HR 2.73 [95% CI; 1.36–5.52]). Conclusion: There was no difference in short- and long-term survival and no difference in neurologic outcome to hospital discharge between IHCA and OHCA patients treated with TTM despite higher frequency of asystole in IHCA. Keywords: retrospective observational study, in-hospital survival, neurological outcome, advanced life support, post-resuscitation care

Published
2016

16. Registered prodromal symptoms of out-of-hospital cardiac arrest among patients calling the medical helpline services

Author

Zylyftari, N, Lee CJY, Gnesin F, Lykkemark Møller A, Mills EHA, Møller SG, Jensen B, Bundgaard Ringgren K, Kragholm K, Collatz Christensen H, Fasmer Blomberg SN, Tan HL, Folke F, Køber L, Gislason G, and Torp Pedersen C

Abstract

Highlights Nearly 1 out of 5 patients called the medical helpline services within a month before their cardiac arrest. Despite prodromal symptoms being highly varied during these calls, breathing problems were the most registered symptom-specific category and nearly twice more common than chest pain. Almost half of the patients called within the week before their OHCA, where CNS-realted symptoms/unconsciousness was the most registered symptom-specific category. More patients called the non-emergency number than the emergency number. Abstract Background Early identification of warning symptoms among out-of-hospital cardiac arrest (OHCA) patients remains challenging. Thus, we examined the registered prodromal symptoms of patients who called medical helpline services within 30-days before OHCA. Methods Patients unwitnessed by emergency medical services (EMS) aged ≥18 years during their OHCA were identified from the Danish Cardiac Arrest Registry (2014–2018) and linked to phone records from the 24-h emergency helpline (1−1−2) and out-of-hours medical helpline (1813-Medical Helpline) in Copenhagen before the arrest. The registered symptoms were categorized into chest pain; breathing problems; central nervous system (CNS)-related/unconsciousness; abdominal/back/urinary; psychiatric/addiction; infection/fever; trauma/exposure; and unspecified (diverse from the beforementioned categories). Analyses were divided by the time-period of calls (0-7 days/8-30 days preceding OHCA) and call type (1–1-2/1813-Medical Helpline). Results Of all OHCA patients, 18% (974/5442) called helpline services (males 56%, median age 76 years[Q1-Q3:65–84]). Among these, 816 had 1145 calls with registered symptoms. The most common symptom categories (except for unspecified, 33%) were breathing problems (17%), trauma/exposure (17%), CNS/unconsciousness (15%), abdominal/back/urinary (12%), and chest pain (9%). Most patients (61%) called 1813-Medical Helpline, especially for abdominal/back/urinary (17%). Patients calling 1–1-2 had breathing problems (24%) and CNS/unconsciousness (23%). Nearly half of the patients called within 7 days before their OHCA, and CNS/unconsciousness (19%) was the most registered. The unspecified category remained the most common during both time periods (32%;33%) and call type (24%;39%). Conclusions Among patients who called medical helplines services up to 30-days before their OHCA, besides symptoms being highly varied (unspecified (33%)), breathing problems (17%) were the most registered symptom-specific category.

Published
2022

17. External validation of the simple NULL-PLEASE clinical score in predicting outcomes in men and women with out-of-hospital cardiac arrest

Author

Byrne, C, primary, Barcella, C, additional, Krogager, M L, additional, Pareek, M, additional, Ringgren, K B, additional, Wissenberg, M, additional, Folke, F, additional, Gislason, G, additional, Kober, L, additional, Lippert, F, additional, Kjaergaard, J, additional, Hassager, C, additional, Torp-Pedersen, C, additional, Lip, G Y H, additional, and Kragholm, K, additional

Published
2022
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22. Risk of worsening heart failure and all-cause mortality following mRNA COVID-19 vaccination in patients with heart failure: a Danish nationwide real-world safety study

Author

Sindet-Pedersen, C, primary, Michalik, F, additional, Emanuel Strange, J, additional, Moelager Christensen, D, additional, Alexander Gerds, T, additional, Andersson, C, additional, Folke, F, additional, Biering-Soerensen, T, additional, Fosboel, E, additional, Torp-Pedersen, C, additional, Hilmar Gislason, G, additional, Koeber, L, additional, and Schou, M, additional

Published
2022
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23. The challenges and possibilities of public access defibrillation

Author

Ringh, M., Hollenberg, J., Palsgaard‐Moeller, T., Svensson, L., Rosenqvist, M., Lippert, F. K., Wissenberg, M., Malta Hansen, C., Claesson, A., Viereck, S., Zijlstra, J. A., Koster, R. W., Herlitz, J., Blom, M. T., Kramer‐Johansen, J., Tan, H. L., Beesems, S. G., Hulleman, M., Olasveengen, T. M., and Folke, F.

Published
2018
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25. 2021 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations

Author

Wyckoff, MH, Singletary, EM, Soar, J, Olasveengen, TM, Greif, R, Liley, HG, Zideman, D, Bhanji, F, Andersen, LW, Avis, SR, Aziz, K, Bendall, JC, Berry, DC, Borra, V, Böttiger, BW, Bradley, R, Bray, JE, Breckwoldt, J, Carlson, JN, Cassan, P, Castrén, M, Chang, WT, Charlton, NP, Cheng, A, Chung, SP, Costa-Nobre, DT, Dainty, KN, Davis, PG, de Almeida, MF, de Caen, AR, de Paiva, EF, Deakin, CD, Djärv, T, Douma, MJ, Drennan, IR, Duff, JP, Eastwood, KJ, El-Naggar, W, Epstein, JL, Escalante, R, Fabres, JG, Fawke, J, Finn, JC, Foglia, EE, Folke, F, Freeman, K, Gilfoyle, E, Goolsby, CA, Grove, A, Guinsburg, R, Hatanaka, T, Hazinski, MF, Heriot, GS, Hirsch, KG, Holmberg, MJ, Hosono, S, Hsieh, MJ, Hung, KKC, Hsu, CH, Ikeyama, T, Isayama, T, Kapadia, VS, Kawakami, MD, Kim, HS, Kloeck, DA, Kudenchuk, PJ, Lagina, AT, Lauridsen, KG, Lavonas, EJ, Lockey, AS, Hansen, CM, Markenson, D, Matsuyama, T, McKinlay, CJD, Mehrabian, A, Merchant, RM, Meyran, D, Morley, PT, Morrison, LJ, Nation, KJ, Nemeth, M, Neumar, RW, Nicholson, T, Niermeyer, S, Nikolaou, N, Nishiyama, C, O’Neil, BJ, Orkin, AM, Osemeke, O, Parr, MJ, Patocka, C, Pellegrino, JL, Perkins, GD, Perlman, JM, Rabi, Y, Reynolds, JC, Ristagno, G, Roehr, CC, Sakamoto, T, Sandroni, C, Considine, Julie, Wyckoff, MH, Singletary, EM, Soar, J, Olasveengen, TM, Greif, R, Liley, HG, Zideman, D, Bhanji, F, Andersen, LW, Avis, SR, Aziz, K, Bendall, JC, Berry, DC, Borra, V, Böttiger, BW, Bradley, R, Bray, JE, Breckwoldt, J, Carlson, JN, Cassan, P, Castrén, M, Chang, WT, Charlton, NP, Cheng, A, Chung, SP, Costa-Nobre, DT, Dainty, KN, Davis, PG, de Almeida, MF, de Caen, AR, de Paiva, EF, Deakin, CD, Djärv, T, Douma, MJ, Drennan, IR, Duff, JP, Eastwood, KJ, El-Naggar, W, Epstein, JL, Escalante, R, Fabres, JG, Fawke, J, Finn, JC, Foglia, EE, Folke, F, Freeman, K, Gilfoyle, E, Goolsby, CA, Grove, A, Guinsburg, R, Hatanaka, T, Hazinski, MF, Heriot, GS, Hirsch, KG, Holmberg, MJ, Hosono, S, Hsieh, MJ, Hung, KKC, Hsu, CH, Ikeyama, T, Isayama, T, Kapadia, VS, Kawakami, MD, Kim, HS, Kloeck, DA, Kudenchuk, PJ, Lagina, AT, Lauridsen, KG, Lavonas, EJ, Lockey, AS, Hansen, CM, Markenson, D, Matsuyama, T, McKinlay, CJD, Mehrabian, A, Merchant, RM, Meyran, D, Morley, PT, Morrison, LJ, Nation, KJ, Nemeth, M, Neumar, RW, Nicholson, T, Niermeyer, S, Nikolaou, N, Nishiyama, C, O’Neil, BJ, Orkin, AM, Osemeke, O, Parr, MJ, Patocka, C, Pellegrino, JL, Perkins, GD, Perlman, JM, Rabi, Y, Reynolds, JC, Ristagno, G, Roehr, CC, Sakamoto, T, Sandroni, C, and Considine, Julie

Published
2022

26. 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations: Summary from the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; And First Aid Task Forces

Author

Wyckoff, M. H., Greif, R., Morley, P. T., Ng, K. -C., Olasveengen, T. M., Singletary, E. M., Soar, J., Cheng, A., Drennan, I. R., Liley, H. G., Scholefield, B. R., Smyth, M. A., Welsford, M., Zideman, D. A., Acworth, J., Aickin, R., Andersen, L. W., Atkins, D., Berry, D. C., Bhanji, F., Bierens, J., Borra, V., Bottiger, B. W., Bradley, R. N., Bray, J. E., Breckwoldt, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Couto, T. B., Dainty, K. N., Davis, P. G., De Almeida, M. F., De Caen, A. R., Deakin, C. D., Djarv, T., Donnino, M. W., Douma, M. J., Duff, J. P., Dunne, C. L., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Finn, J., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M., Kloeck, D. A., Kudenchuk, P. J., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y. (., Lockey, A. S., Maconochie, I. K., Madar, R. J., Malta Hansen, C., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Morgan, P., Morrison, L. J., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., O'Neill, B. J., Ong, Y. -K. G., Orkin, A. M., Paiva, E. F., Parr, M. J., Patocka, C., Pellegrino, J. L., Perkins, G. D., Perlman, J. M., Rabi, Y., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Skrifvars, M. B., Smith, C. M., Sugiura, T., Tijssen, J. A., Trevisanuto, D., Van De Voorde, P., Wang, T. -L., Weiner, G. M., Wyllie, J. P., Yang, C. -W., Yeung, J., Nolan, J. P., Berg, K. M., Burdick, M. C., Cartledge, S., Dawson, J. A., Elgohary, M. M., Ersdal, H. L., Finan, E., Flaatten, H. I., Flores, G. E., Fuerch, J., Garg, R., Gately, C., Goh, M., Halamek, L. P., Handley, A. J., Hatanaka, T., Hoover, A., Issa, M., Johnson, S., Kamlin, C. O., Ko, Y. -C., Kule, A., Leone, T. A., Mackenzie, E., Macneil, F., Montgomery, W., O'Dochartaigh, D., Ohshimo, S., Palazzo, F. S., Picard, C., Quek, B. H., Raitt, J., Ramaswamy, V. V., Scapigliati, Andrea, Shah, B. A., Stewart, C., Strand, M. L., Szyld, E., Thio, M., Topjian, A. A., Udaeta, E., Vaillancourt, C., Wetsch, W. A., Wigginton, J., Yamada, N. K., Yao, S., Zace, D., Zelop, C. M., Sandroni C. (ORCID:0000-0002-8878-2611), Scapigliati A. (ORCID:0000-0002-4044-2343), Wyckoff, M. H., Greif, R., Morley, P. T., Ng, K. -C., Olasveengen, T. M., Singletary, E. M., Soar, J., Cheng, A., Drennan, I. R., Liley, H. G., Scholefield, B. R., Smyth, M. A., Welsford, M., Zideman, D. A., Acworth, J., Aickin, R., Andersen, L. W., Atkins, D., Berry, D. C., Bhanji, F., Bierens, J., Borra, V., Bottiger, B. W., Bradley, R. N., Bray, J. E., Breckwoldt, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Couto, T. B., Dainty, K. N., Davis, P. G., De Almeida, M. F., De Caen, A. R., Deakin, C. D., Djarv, T., Donnino, M. W., Douma, M. J., Duff, J. P., Dunne, C. L., Eastwood, K., El-Naggar, W., Fabres, J. G., Fawke, J., Finn, J., Foglia, E. E., Folke, F., Gilfoyle, E., Goolsby, C. A., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hsu, C. H., Ikeyama, T., Isayama, T., Johnson, N. J., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kleinman, M., Kloeck, D. A., Kudenchuk, P. J., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lee, H. C., Lin, Y. (., Lockey, A. S., Maconochie, I. K., Madar, R. J., Malta Hansen, C., Masterson, S., Matsuyama, T., Mckinlay, C. J. D., Meyran, D., Morgan, P., Morrison, L. J., Nadkarni, V., Nakwa, F. L., Nation, K. J., Nehme, Z., Nemeth, M., Neumar, R. W., Nicholson, T., Nikolaou, N., Nishiyama, C., Norii, T., Nuthall, G. A., O'Neill, B. J., Ong, Y. -K. G., Orkin, A. M., Paiva, E. F., Parr, M. J., Patocka, C., Pellegrino, J. L., Perkins, G. D., Perlman, J. M., Rabi, Y., Reis, A. G., Reynolds, J. C., Ristagno, G., Rodriguez-Nunez, A., Roehr, C. C., Rudiger, M., Sakamoto, T., Sandroni, Claudio, Sawyer, T. L., Schexnayder, S. M., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Skrifvars, M. B., Smith, C. M., Sugiura, T., Tijssen, J. A., Trevisanuto, D., Van De Voorde, P., Wang, T. -L., Weiner, G. M., Wyllie, J. P., Yang, C. -W., Yeung, J., Nolan, J. P., Berg, K. M., Burdick, M. C., Cartledge, S., Dawson, J. A., Elgohary, M. M., Ersdal, H. L., Finan, E., Flaatten, H. I., Flores, G. E., Fuerch, J., Garg, R., Gately, C., Goh, M., Halamek, L. P., Handley, A. J., Hatanaka, T., Hoover, A., Issa, M., Johnson, S., Kamlin, C. O., Ko, Y. -C., Kule, A., Leone, T. A., Mackenzie, E., Macneil, F., Montgomery, W., O'Dochartaigh, D., Ohshimo, S., Palazzo, F. S., Picard, C., Quek, B. H., Raitt, J., Ramaswamy, V. V., Scapigliati, Andrea, Shah, B. A., Stewart, C., Strand, M. L., Szyld, E., Thio, M., Topjian, A. A., Udaeta, E., Vaillancourt, C., Wetsch, W. A., Wigginton, J., Yamada, N. K., Yao, S., Zace, D., Zelop, C. M., Sandroni C. (ORCID:0000-0002-8878-2611), and Scapigliati A. (ORCID:0000-0002-4044-2343)

Abstract

This is the sixth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. This summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. Topics covered by systematic reviews include cardiopulmonary resuscitation during transport; approach to resuscitation after drowning; passive ventilation; minimizing pauses during cardiopulmonary resuscitation; temperature management after cardiac arrest; use of diagnostic point-of-care ultrasound during cardiac arrest; use of vasopressin and corticosteroids during cardiac arrest; coronary angiography after cardiac arrest; public-access defibrillation devices for children; pediatric early warning systems; maintaining normal temperature immediately after birth; suctioning of amniotic fluid at birth; tactile stimulation for resuscitation immediately after birth; use of continuous positive airway pressure for respiratory distress at term birth; respiratory and heart rate monitoring in the delivery room; supraglottic airway use in neonates; prearrest prediction of in-hospital cardiac arrest mortality; basic life support training for likely rescuers of high-risk populations; effect of resuscitation team training; blended learning for life support training; training and recertification for resuscitation instructors; and recovery position for maintenance of breathing and prevention of cardiac arrest. Members from 6 task forces have assessed, discussed, and debated the quality of the evidence using Grading of Recommendations Assessment, Development, and Evaluation criteria and generated consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence-to-Decision Framework Highlights sections, and priority knowledge gaps for futu

Published
2022

27. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group

Author

Wyckoff, Mh, Singletary, Em, Soar, J, Olasveengen, Tm, Greif, R, Liley, Hg, Zideman, D, Bhanji, F, Andersen, Lw, Avis, Sr, Aziz, K, Bendall, Jc, Berry, Dc, Borra, V, Bottiger, Bw, Bradley, R, Bray, Je, Breckwoldt, J, Carlson, Jn, Cassan, P, Castren, M, Chang, Wt, Charlton, Np, Cheng, A, Chung, Sp, Considine, J, Costa-Nobre, Dt, Couper, K, Dainty, Kn, Davis, Pg, de Almeida, Mf, de Caen, Ar, de Paiva, Ef, Deakin, Cd, Djarv, T, Douma, Mj, Drennan, Ir, Duff, Jp, Eastwood, Kj, El-Naggar, W, Epstein, Jl, Escalante, R, Fabres, Jg, Fawke, J, Finn, Jc, Foglia, Ee, Folke, F, Freeman, K, Gilfoyle, E, Goolsby, Ca, Grove, A, Guinsburg, R, Hatanaka, T, Hazinski, Mf, Heriot, G, Hirsch, Kg, Holmberg, Mj, Hosono, S, Hsieh, Mj, Hung, Kkc, Hsu, Ch, Ikeyama, T, Isayama, T, Kapadia, V, Kawakami, Md, Kim, H, Kloeck, Da, Kudenchuk, Pj, Lagina, At, Lauridsen, Kg, Lavonas, Ej, Lockey, A, Hansen, Cm, Markenson, D, Matsuyama, T, McKinlay, Cjd, Mehrabian, A, Merchant, Rm, Meyran, D, Morley, Pt, Morrison, Lj, Nation, Kj, Nemeth, M, Neumar, Rw, Nicholson, T, Niermeyer, S, Nikolaou, N, Nishiyama, C, O'Neil, Bj, Orkin, Am, Osemeke, O, Parr, Mj, Patocka, C, Pellegrino, Jl, Perkins, Gd, Perlman, Jm, Rabi, Y, Reynolds, Jc, Ristagno, G, Roehr, Cc, Sakamoto, T, Sandroni, C, Sawyer, T, Schmolzer, Gm, Schnaubelt, S, Semeraro, F, Skrifvars, Mb, Smith, Cm, Smyth, Ma, Soll, Rf, Sugiura, T, Taylor-Phillips, S, Trevisanuto, D, Vaillancourt, C, Wang, Tl, Weiner, Gm, Welsford, M, Wigginton, J, Wyllie, Jp, Yeung, J, Nolan, Jp, Berg, Km, Sandroni, C (ORCID:0000-0002-8878-2611), Wyckoff, Mh, Singletary, Em, Soar, J, Olasveengen, Tm, Greif, R, Liley, Hg, Zideman, D, Bhanji, F, Andersen, Lw, Avis, Sr, Aziz, K, Bendall, Jc, Berry, Dc, Borra, V, Bottiger, Bw, Bradley, R, Bray, Je, Breckwoldt, J, Carlson, Jn, Cassan, P, Castren, M, Chang, Wt, Charlton, Np, Cheng, A, Chung, Sp, Considine, J, Costa-Nobre, Dt, Couper, K, Dainty, Kn, Davis, Pg, de Almeida, Mf, de Caen, Ar, de Paiva, Ef, Deakin, Cd, Djarv, T, Douma, Mj, Drennan, Ir, Duff, Jp, Eastwood, Kj, El-Naggar, W, Epstein, Jl, Escalante, R, Fabres, Jg, Fawke, J, Finn, Jc, Foglia, Ee, Folke, F, Freeman, K, Gilfoyle, E, Goolsby, Ca, Grove, A, Guinsburg, R, Hatanaka, T, Hazinski, Mf, Heriot, G, Hirsch, Kg, Holmberg, Mj, Hosono, S, Hsieh, Mj, Hung, Kkc, Hsu, Ch, Ikeyama, T, Isayama, T, Kapadia, V, Kawakami, Md, Kim, H, Kloeck, Da, Kudenchuk, Pj, Lagina, At, Lauridsen, Kg, Lavonas, Ej, Lockey, A, Hansen, Cm, Markenson, D, Matsuyama, T, McKinlay, Cjd, Mehrabian, A, Merchant, Rm, Meyran, D, Morley, Pt, Morrison, Lj, Nation, Kj, Nemeth, M, Neumar, Rw, Nicholson, T, Niermeyer, S, Nikolaou, N, Nishiyama, C, O'Neil, Bj, Orkin, Am, Osemeke, O, Parr, Mj, Patocka, C, Pellegrino, Jl, Perkins, Gd, Perlman, Jm, Rabi, Y, Reynolds, Jc, Ristagno, G, Roehr, Cc, Sakamoto, T, Sandroni, C, Sawyer, T, Schmolzer, Gm, Schnaubelt, S, Semeraro, F, Skrifvars, Mb, Smith, Cm, Smyth, Ma, Soll, Rf, Sugiura, T, Taylor-Phillips, S, Trevisanuto, D, Vaillancourt, C, Wang, Tl, Weiner, Gm, Welsford, M, Wigginton, J, Wyllie, Jp, Yeung, J, Nolan, Jp, Berg, Km, and Sandroni, C (ORCID:0000-0002-8878-2611)

Abstract

The International Liaison Committee on Resuscitation initiated a continuous review of new, peer-reviewed published cardiopulmonary resuscitation science. This is the fifth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations; a more comprehensive review was done in 2020. This latest summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation task force science experts. Topics covered by systematic reviews in this summary include resuscitation topics of video-based dispatch systems; head-up cardiopulmonary resuscitation; early coronary angiography after return of spontaneous circulation; cardiopulmonary resuscitation in the prone patient; cord management at birth for preterm and term infants; devices for administering positive-pressure ventilation at birth; family presence during neonatal resuscitation; self-directed, digitally based basic life support education and training in adults and children; coronavirus disease 2019 infection risk to rescuers from patients in cardiac arrest; and first aid topics, including cooling with water for thermal burns, oral rehydration for exertional dehydration, pediatric tourniquet use, and methods of tick removal. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, according to the Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations or good practice statements. Insights into the deliberations of the task forces are provided in Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces listed priority knowledge gaps for further research.

Published
2022

29. Association between serum potassium levels and short-term mortality in out-of-hospital cardiac arrest survivors

Author

Byrne, C, primary, Krogager, ML, additional, Kragholm, KH, additional, Pareek, M, additional, Mohr, GH, additional, Ringgren, KB, additional, Wissenberg, M, additional, Folke, F, additional, Gislason, G, additional, Koeber, L, additional, Lippert, F, additional, Torp-Pedersen, C, additional, Lip, GYH, additional, and Barcella, CA, additional

Published
2022
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33. External validation of the simple NULL-PLEASE clinical score in predicting outcomes of out-of-hospital cardiac arrest in the Danish population - a nationwide register-based study

Author

Byrne, C, primary, Barcella, CA, additional, Krogager, ML, additional, Pareek, M, additional, Ringgren, KB, additional, Wissenberg, M, additional, Folke, F, additional, Gislason, G, additional, Koeber, L, additional, Lippert, F, additional, Torp-Pedersen, C, additional, Kragholm, KH, additional, and Lip, GYH, additional

Published
2022
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40. Prodromal symptoms of out-of-hospital cardiac arrest among patients calling emergency and non-emergency medical help services

Author

Zylyftari, N, primary, Lee, C.J.-Y, additional, Gnesin, F, additional, Moeller, A.L, additional, Mills, E.H.A, additional, Moeller, S.G, additional, Jensen, B, additional, Ringgren, K.B, additional, Christensen, H.C, additional, Blomberg, N.F, additional, Tan, H.L, additional, Folke, F, additional, Koeber, L, additional, Gislason, G.H, additional, and Torp-Pedersen, C, additional

Published
2021
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45. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams

Author

Wyckoff, MH, Singletary, EM, Soar, J, Olasveengen, TM, Greif, R, Liley, HG, Zideman, D, Bhanji, F, Andersen, LW, Avis, SR, Aziz, K, Bendall, JC, Berry, DC, Borra, V, Böttiger, BW, Bradley, R, Bray, JE, Breckwoldt, J, Carlson, JN, Cassan, P, Castrén, M, Chang, WT, Charlton, NP, Cheng, A, Chung, SP, Considine, Julie, Costa-Nobre, DT, Couper, K, Dainty, KN, Davis, PG, de Almeida, MF, de Caen, AR, de Paiva, EF, Deakin, CD, Djärv, T, Douma, MJ, Drennan, IR, Duff, JP, Eastwood, KJ, El-Naggar, W, Epstein, JL, Escalante, R, Fabres, JG, Fawke, J, Finn, JC, Foglia, EE, Folke, F, Freeman, K, Gilfoyle, E, Goolsby, CA, Grove, A, Guinsburg, R, Hatanaka, T, Hazinski, MF, Heriot, GS, Hirsch, KG, Holmberg, MJ, Hosono, S, Hsieh, MJ, Hung, KKC, Hsu, CH, Ikeyama, T, Isayama, T, Kapadia, VS, Kawakami, MD, Kim, HS, Kloeck, DA, Kudenchuk, PJ, Lagina, AT, Lauridsen, KG, Lavonas, EJ, Lockey, AS, Malta Hansen, C, Markenson, D, Matsuyama, T, McKinlay, CJD, Mehrabian, A, Merchant, RM, Meyran, D, Morley, PT, Morrison, LJ, Nation, KJ, Nemeth, M, Neumar, RW, Nicholson, T, Niermeyer, S, Nikolaou, N, Nishiyama, C, O'Neil, BJ, Orkin, AM, Osemeke, O, Parr, MJ, Patocka, C, Pellegrino, JL, Perkins, GD, Perlman, JM, Rabi, Y, Reynolds, JC, Ristagno, G, Roehr, CC, Wyckoff, MH, Singletary, EM, Soar, J, Olasveengen, TM, Greif, R, Liley, HG, Zideman, D, Bhanji, F, Andersen, LW, Avis, SR, Aziz, K, Bendall, JC, Berry, DC, Borra, V, Böttiger, BW, Bradley, R, Bray, JE, Breckwoldt, J, Carlson, JN, Cassan, P, Castrén, M, Chang, WT, Charlton, NP, Cheng, A, Chung, SP, Considine, Julie, Costa-Nobre, DT, Couper, K, Dainty, KN, Davis, PG, de Almeida, MF, de Caen, AR, de Paiva, EF, Deakin, CD, Djärv, T, Douma, MJ, Drennan, IR, Duff, JP, Eastwood, KJ, El-Naggar, W, Epstein, JL, Escalante, R, Fabres, JG, Fawke, J, Finn, JC, Foglia, EE, Folke, F, Freeman, K, Gilfoyle, E, Goolsby, CA, Grove, A, Guinsburg, R, Hatanaka, T, Hazinski, MF, Heriot, GS, Hirsch, KG, Holmberg, MJ, Hosono, S, Hsieh, MJ, Hung, KKC, Hsu, CH, Ikeyama, T, Isayama, T, Kapadia, VS, Kawakami, MD, Kim, HS, Kloeck, DA, Kudenchuk, PJ, Lagina, AT, Lauridsen, KG, Lavonas, EJ, Lockey, AS, Malta Hansen, C, Markenson, D, Matsuyama, T, McKinlay, CJD, Mehrabian, A, Merchant, RM, Meyran, D, Morley, PT, Morrison, LJ, Nation, KJ, Nemeth, M, Neumar, RW, Nicholson, T, Niermeyer, S, Nikolaou, N, Nishiyama, C, O'Neil, BJ, Orkin, AM, Osemeke, O, Parr, MJ, Patocka, C, Pellegrino, JL, Perkins, GD, Perlman, JM, Rabi, Y, Reynolds, JC, Ristagno, G, and Roehr, CC

Published
2021

46. Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes

Author

van Dongen, L H, de Goede, P, Moeller, S, Eroglu, T E, Folke, F, Gislason, G, Blom, M T, Elders, P J M, Torp-Pedersen, C, Tan, H L, van Dongen, L H, de Goede, P, Moeller, S, Eroglu, T E, Folke, F, Gislason, G, Blom, M T, Elders, P J M, Torp-Pedersen, C, and Tan, H L

Abstract

Objective: Out-of-hospital cardiac arrest (OHCA) occurrence has been shown to exhibit a circadian rhythm, following the circadian rhythm of acute myocardial infarction (AMI) occurrence. Diabetes mellitus (DM) is associated with changes in circadian rhythm. We aimed to compare the temporal variation of OHCA occurrence over the day and week between OHCA patients with DM and those without.Methods: In two population-based OHCA registries (Amsterdam Resuscitation Studies [ARREST] 2010-2016, n = 4163, and Danish Cardiac Arrest Registry [DANCAR], 2010-2014, n = 12,734), adults (≥18y) with presumed cardiac cause of OHCA and available medical history were included. Single and double cosinor analysis was performed to model circadian variation of OHCA occurrence. Stratified analysis of circadian variation was performed in patients with AMI as immediate cause of OHCA.Results: DM patients (22.8% in ARREST, 24.2% in DANCAR) were older and more frequently had cardiovascular risk factors or previous cardiovascular disease. Both cohorts showed 24 h-rhythmicity, with significant amplitudes in single and double cosinor functions (P-range < 0.001). In both registries, a morning peak (10:00-11:00) and an evening peak (20:00-21:00) was observed in both DM and non-DM patients. No septadian variation was observed in either DM or non-DM patients (P-range 0.13-84).Conclusions: In these two population-based OHCA registries, we observed a similar circadian rhythm of OHCA occurrence in DM and non-DM patients.

Published
2021

47. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group

Author

Wyckoff, M. H., Singletary, E. M., Soar, J., Olasveengen, T. M., Greif, R., Liley, H. G., Zideman, D., Bhanji, F., Andersen, L. W., Avis, S. R., Aziz, K., Bendall, J. C., Berry, D. C., Borra, V., Bottiger, B. W., Bradley, R., Bray, J. E., Breckwoldt, J., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Cheng, A., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Davis, P. G., de Almeida, M. F., de Caen, A. R., de Paiva, E. F., Deakin, C. D., Djarv, T., Douma, M. J., Drennan, I. R., Duff, J. P., Eastwood, K. J., El-Naggar, W., Epstein, J. L., Escalante, R., Fabres, J. G., Fawke, J., Finn, J. C., Foglia, E. E., Folke, F., Freeman, K., Gilfoyle, E., Goolsby, C. A., Grove, A., Guinsburg, R., Hatanaka, T., Hazinski, M. F., Heriot, G. S., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hung, K. K. C., Hsu, C. H., Ikeyama, T., Isayama, T., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kloeck, D. A., Kudenchuk, P. J., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lockey, A. S., Malta Hansen, C., Markenson, D., Matsuyama, T., Mckinlay, C. J. D., Mehrabian, A., Merchant, R. M., Meyran, D., Morley, P. T., Morrison, L. J., Nation, K. J., Nemeth, M., Neumar, R. W., Nicholson, T., Niermeyer, S., Nikolaou, N., Nishiyama, C., O'Neil, B. J., Orkin, A. M., Osemeke, O., Parr, M. J., Patocka, C., Pellegrino, J. L., Perkins, G. D., Perlman, J. M., Rabi, Y., Reynolds, J. C., Ristagno, G., Roehr, C. C., Sakamoto, T., Sandroni, Claudio, Sawyer, T., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Skrifvars, M. B., Smith, C. M., Smyth, M. A., Soll, R. F., Sugiura, T., Taylor-Phillips, S., Trevisanuto, D., Vaillancourt, C., Wang, T. -L., Weiner, G. M., Welsford, M., Wigginton, J., Wyllie, J. P., Yeung, J., Nolan, J. P., Berg, K. M., Abelairas-Gomez, C., Barcala-Furelos, R., Beerman, S. B., Bierens, J., Cacciola, Sofia, Cellini, J., Claesson, A., Court, R., D'Arrigo, Sonia, De Brier, N., Dunne, C. L., Elsenga, H. E., Johnson, S., Kleven, G., Maconochie, I., Mecrow, T., Morgan, P., Otto, Q., Palmieri, T. L., Parnia, S., Pawar, R., Pereira, J., Rudd, S., Scapigliati, Andrea, Schmidt, A., Seesink, J., Sempsrott, J. R., Szpilman, D., Warner, D. S., Webber, J. B., West, R. L., Sandroni C. (ORCID:0000-0002-8878-2611), Cacciola S., D'Arrigo S. (ORCID:0000-0001-6740-3195), Scapigliati A. (ORCID:0000-0002-4044-2343), Wyckoff, M. H., Singletary, E. M., Soar, J., Olasveengen, T. M., Greif, R., Liley, H. G., Zideman, D., Bhanji, F., Andersen, L. W., Avis, S. R., Aziz, K., Bendall, J. C., Berry, D. C., Borra, V., Bottiger, B. W., Bradley, R., Bray, J. E., Breckwoldt, J., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Cheng, A., Chung, S. P., Considine, J., Costa-Nobre, D. T., Couper, K., Dainty, K. N., Davis, P. G., de Almeida, M. F., de Caen, A. R., de Paiva, E. F., Deakin, C. D., Djarv, T., Douma, M. J., Drennan, I. R., Duff, J. P., Eastwood, K. J., El-Naggar, W., Epstein, J. L., Escalante, R., Fabres, J. G., Fawke, J., Finn, J. C., Foglia, E. E., Folke, F., Freeman, K., Gilfoyle, E., Goolsby, C. A., Grove, A., Guinsburg, R., Hatanaka, T., Hazinski, M. F., Heriot, G. S., Hirsch, K. G., Holmberg, M. J., Hosono, S., Hsieh, M. -J., Hung, K. K. C., Hsu, C. H., Ikeyama, T., Isayama, T., Kapadia, V. S., Kawakami, M. D., Kim, H. -S., Kloeck, D. A., Kudenchuk, P. J., Lagina, A. T., Lauridsen, K. G., Lavonas, E. J., Lockey, A. S., Malta Hansen, C., Markenson, D., Matsuyama, T., Mckinlay, C. J. D., Mehrabian, A., Merchant, R. M., Meyran, D., Morley, P. T., Morrison, L. J., Nation, K. J., Nemeth, M., Neumar, R. W., Nicholson, T., Niermeyer, S., Nikolaou, N., Nishiyama, C., O'Neil, B. J., Orkin, A. M., Osemeke, O., Parr, M. J., Patocka, C., Pellegrino, J. L., Perkins, G. D., Perlman, J. M., Rabi, Y., Reynolds, J. C., Ristagno, G., Roehr, C. C., Sakamoto, T., Sandroni, Claudio, Sawyer, T., Schmolzer, G. M., Schnaubelt, S., Semeraro, F., Skrifvars, M. B., Smith, C. M., Smyth, M. A., Soll, R. F., Sugiura, T., Taylor-Phillips, S., Trevisanuto, D., Vaillancourt, C., Wang, T. -L., Weiner, G. M., Welsford, M., Wigginton, J., Wyllie, J. P., Yeung, J., Nolan, J. P., Berg, K. M., Abelairas-Gomez, C., Barcala-Furelos, R., Beerman, S. B., Bierens, J., Cacciola, Sofia, Cellini, J., Claesson, A., Court, R., D'Arrigo, Sonia, De Brier, N., Dunne, C. L., Elsenga, H. E., Johnson, S., Kleven, G., Maconochie, I., Mecrow, T., Morgan, P., Otto, Q., Palmieri, T. L., Parnia, S., Pawar, R., Pereira, J., Rudd, S., Scapigliati, Andrea, Schmidt, A., Seesink, J., Sempsrott, J. R., Szpilman, D., Warner, D. S., Webber, J. B., West, R. L., Sandroni C. (ORCID:0000-0002-8878-2611), Cacciola S., D'Arrigo S. (ORCID:0000-0001-6740-3195), and Scapigliati A. (ORCID:0000-0002-4044-2343)

Abstract

The International Liaison Committee on Resuscitation initiated a continuous review of new, peer-reviewed published cardiopulmonary resuscitation science. This is the fifth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations; a more comprehensive review was done in 2020. This latest summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation task force science experts. Topics covered by systematic reviews in this summary include resuscitation topics of video-based dispatch systems; head-up cardiopulmonary resuscitation; early coronary angiography after return of spontaneous circulation; cardiopulmonary resuscitation in the prone patient; cord management at birth for preterm and term infants; devices for administering positive-pressure ventilation at birth; family presence during neonatal resuscitation; self-directed, digitally based basic life support education and training in adults and children; coronavirus disease 2019 infection risk to rescuers from patients in cardiac arrest; and first aid topics, including cooling with water for thermal burns, oral rehydration for exertional dehydration, pediatric tourniquet use, and methods of tick removal. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, according to the Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations or good practice statements. Insights into the deliberations of the task forces are provided in Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces listed priority knowledge gaps for further research.

Published
2021

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