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1. Large Interferometer For Exoplanets (LIFE)

Author

Quanz, SP, Ottiger, M, Fontanet, E, Kammerer, J, Menti, F, Dannert, F, Gheorghe, A, Absil, O, Airapetian, VS, Alei, E, Allart, R, Angerhausen, D, Blumenthal, S, Buchhave, LA, Cabrera, J, Carrión-González, Ó, Chauvin, G, Danchi, WC, Dandumont, C, Defrére, D, Dorn, C, Ehrenreich, D, Ertel, S, Fridlund, M, Muñoz, A García, Gascón, C, Girard, JH, Glauser, A, Grenfell, JL, Guidi, G, Hagelberg, J, Helled, R, Ireland, MJ, Janson, M, Kopparapu, RK, Korth, J, Kozakis, T, Kraus, S, Léger, A, Leedjärv, L, Lichtenberg, T, Lillo-Box, J, Linz, H, Liseau, R, Loicq, J, Mahendra, V, Malbet, F, Mathew, J, Mennesson, B, Meyer, MR, Mishra, L, Molaverdikhani, K, Noack, L, Oza, AV, Pallé, E, Parviainen, H, Quirrenbach, A, Rauer, H, Ribas, I, Rice, M, Romagnolo, A, Rugheimer, S, Schwieterman, EW, Serabyn, E, Sharma, S, Stassun, KG, Szulágyi, J, Wang, HS, Wunderlich, F, and Wyatt, MC

Subjects
planets and satellites, terrestrial planets, telescopes, instrumentation, high angular resolution, methods, numerical, detection, infrared, planetary systems, Astronomical and Space Sciences, Astronomy & Astrophysics
Abstract

Context. One of the long-term goals of exoplanet science is the atmospheric characterization of dozens of small exoplanets in order to understand their diversity and search for habitable worlds and potential biosignatures. Achieving this goal requires a space mission of sufficient scale that can spatially separate the signals from exoplanets and their host stars and thus directly scrutinize the exoplanets and their atmospheres.Aims. We seek to quantify the exoplanet detection performance of a space-based mid-infrared (MIR) nulling interferometer that measures the thermal emission of exoplanets. We study the impact of various parameters and compare the performance with that of large single-aperture mission concepts that detect exoplanets in reflected light.Methods. We have developed an instrument simulator that considers all major astrophysical noise sources and coupled it with Monte Carlo simulations of a synthetic exoplanet population around main-sequence stars within 20 pc of the Sun. This allows us to quantify the number (and types) of exoplanets that our mission concept could detect. Considering single visits only, we discuss two different scenarios for distributing 2.5 yr of an initial search phase among the stellar targets. Different apertures sizes and wavelength ranges are investigated.Results. An interferometer consisting of four 2 m apertures working in the 4–18.5 μ.m wavelength range with a total instrument throughput of 5% could detect up to ≈550 exoplanets with radii between 0.5 and 6 R⊕ with an integrated S/N ≥ 7. At least ≈160 of the detected exoplanets have radii ≤1.5 R⊕. Depending on the observing scenario, ≈25–45 rocky exoplanets (objects with radii between 0.5 and 1.5 R⊕) orbiting within the empirical habitable zone (eHZ) of their host stars are among the detections. With four 3.5 m apertures, the total number of detections can increase to up to ≈770, including ≈60–80 rocky eHZ planets. With four times 1 m apertures, the maximum detection yield is ≈315 exoplanets, including ≤20 rocky eHZ planets. The vast majority of small, temperate exoplanets are detected around M dwarfs. The impact of changing the wavelength range to 3–20 μm or 6–17 μm on the detection yield is negligible.Conclusions. A large space-based MIR nulling interferometer will be able to directly detect hundreds of small, nearby exoplanets, tens of which would be habitable world candidates. This shows that such a mission can compete with large single-aperture reflected light missions. Further increasing the number of habitable world candidates, in particular around solar-type stars, appears possible via the implementation of a multi-visit strategy during the search phase. The high median S/N of most of the detected planets will allow for first estimates of their radii and effective temperatures and will help prioritize the targets for a second mission phase to obtain high-S/N thermal emission spectra, leveraging the superior diagnostic power of the MIR regime compared to shorter wavelengths.

Published
2022

2. Large Interferometer For Exoplanets (LIFE): I. Improved exoplanet detection yield estimates for a large mid-infrared space-interferometer mission

Author

Quanz, S. P., Ottiger, M., Fontanet, E., Kammerer, J., Menti, F., Dannert, F., Gheorghe, A., Absil, O., Airapetian, V. S., Alei, E., Allart, R., Angerhausen, D., Blumenthal, S., Buchhave, L. A., Cabrera, J., Carrión-González, Ó., Chauvin, G., Danchi, W. C., Dandumont, C., Defrère, D., Dorn, C., Ehrenreich, D., Ertel, S., Fridlund, M., Muñoz, A. García, Gascón, C., Girard, J. H., Glauser, A., Grenfell, J. L., Guidi, G., Hagelberg, J., Helled, R., Ireland, M. J., Janson, M., Kopparapu, R. K., Korth, J., Kozakis, T., Kraus, S., Léger, A., Leedjärv, L., Lichtenberg, T., Lillo-Box, J., Linz, H., Liseau, R., Loicq, J., Mahendra, V., Malbet, F., Mathew, J., Mennesson, B., Meyer, M. R., Mishra, L., Molaverdikhani, K., Noack, L., Oza, A. V., Pallé, E., Parviainen, H., Quirrenbach, A., Rauer, H., Ribas, I., Rice, M., Romagnolo, A., Rugheimer, S., Schwieterman, E. W., Serabyn, E., Sharma, S., Stassun, K. G., Szulágyi, J., Wang, H. S., Wunderlich, F., Wyatt, M. C., and collaboration, the LIFE

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

One of the long-term goals of exoplanet science is the atmospheric characterization of dozens of small exoplanets in order to understand their diversity and search for habitable worlds and potential biosignatures. Achieving this goal requires a space mission of sufficient scale. We seek to quantify the exoplanet detection performance of a space-based mid-infrared nulling interferometer that measures the thermal emission of exoplanets. For this, we have developed an instrument simulator that considers all major astrophysical noise sources and coupled it with Monte Carlo simulations of a synthetic exoplanet population around main-sequence stars within 20 pc. This allows us to quantify the number (and types) of exoplanets that our mission concept could detect over a certain time period. Two different scenarios to distribute the observing time among the stellar targets are discussed and different apertures sizes and wavelength ranges are considered. Within a 2.5-year initial search phase, an interferometer consisting of four 2 m apertures with a total instrument throughput of 5% covering a wavelength range between 4 and 18.5 $\mu$m could detect up to ~550 exoplanets with radii between 0.5 and 6 R$_\oplus$ with an integrated SNR$\ge$7. At least ~160 of the detected exoplanets have radii $\le$1.5 R$_\oplus$. Depending on the observing scenario, ~25-45 rocky exoplanets (objects with radii between 0.5 and 1.5 $_{\oplus}$) orbiting within the empirical habitable zone (eHZ) of their host stars are among the detections. With an aperture size of 3.5 m, the total number of detections can increase to up to ~770, including ~60-80 rocky, eHZ planets. With 1 m aperture size, the maximum detection yield is ~315 exoplanets, including $\le$20 rocky, eHZ planets. In terms of predicted detection yield, such a mission can compete with large single-aperture reflected light missions. (abridged), Comment: Accepted for publication by A&A - some typos corrected and affiliations updated; 14 pages main text (incl. 14 figures); first paper in the LIFE paper series; papers II (arXiv:2203.00471) and III (arXiv:2112.02054) are also available

Published
2021
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3. Chirurgie : ce qui a changé en 2022 [Surgery: what's new in 2022]

Author

Lázaro-Fontanet, E., Deslarzes, P., Grass, F., Mantziari, S., Demartines, N., and Teixeira Farinha, H.

Subjects
Humans, Endoscopy, Robotic Surgical Procedures/methods, Colectomy/methods, Health Care Costs, Bariatric Surgery, Laparoscopy
Abstract

During 2022 a lot of efforts were developed to reduce health-costs by reducing complications and length of hospital stay. Same-day surgery is becoming the standard for all patients scheduled for elective surgery in CHUV. Outpatient colectomy also become a new standard. During 2022, endoscopic bariatric surgery became increasingly used. Not widely performed yet in Switzerland, these treatments deserve to be recognized and considered in various situations. Finally, 2022 saw a promising development of robotic surgery with the acquisition of Da Vinci and Dexter robots after allowing various high-precision surgical procedures.

Published
2023

4. Large Interferometer For Exoplanets (LIFE):I. Improved exoplanet detection yield estimates for a large mid-infrared space-interferometer mission

Author

Quanz, S. P., Ottiger, M., Fontanet, E., Kammerer, J., Menti, F., Dannert, F., Gheorghe, A., Absil, O., Airapetian, V. S., Alei, E., Allart, R., Angerhausen, D., Blumenthal, S., Buchhave, L. A., Cabrera, J., Carrión-González, Ó., Chauvin, G., Danchi, W. C., Dandumont, C., Defrére, D., Dorn, C., Ehrenreich, D., Ertel, S., Fridlund, M., García Muñoz, A., Gascón, C., Girard, J. H., Glauser, A., Grenfell, J. L., Guidi, G., Hagelberg, J., Helled, R., Ireland, M. J., Janson, M., Kopparapu, R. K., Korth, J., Kozakis, T., Kraus, S., Léger, A., Leedjärv, L., Lichtenberg, T., Lillo-Box, J., Linz, H., Liseau, R., Loicq, J., Mahendra, V., Malbet, F., Mathew, J., Mennesson, B., Meyer, M. R., Mishra, L., Molaverdikhani, K., Noack, L., Oza, A. V., Pallé, E., Parviainen, H., Quirrenbach, A., Rauer, H., Ribas, I., Rice, M., Romagnolo, A., Rugheimer, S., Schwieterman, E. W., Serabyn, E., Sharma, S., Stassun, K. G., Szulágyi, J., Wang, H. S., Wunderlich, F., Wyatt, M. C., Collaboration, the LIFE, Quanz, S. P., Ottiger, M., Fontanet, E., Kammerer, J., Menti, F., Dannert, F., Gheorghe, A., Absil, O., Airapetian, V. S., Alei, E., Allart, R., Angerhausen, D., Blumenthal, S., Buchhave, L. A., Cabrera, J., Carrión-González, Ó., Chauvin, G., Danchi, W. C., Dandumont, C., Defrére, D., Dorn, C., Ehrenreich, D., Ertel, S., Fridlund, M., García Muñoz, A., Gascón, C., Girard, J. H., Glauser, A., Grenfell, J. L., Guidi, G., Hagelberg, J., Helled, R., Ireland, M. J., Janson, M., Kopparapu, R. K., Korth, J., Kozakis, T., Kraus, S., Léger, A., Leedjärv, L., Lichtenberg, T., Lillo-Box, J., Linz, H., Liseau, R., Loicq, J., Mahendra, V., Malbet, F., Mathew, J., Mennesson, B., Meyer, M. R., Mishra, L., Molaverdikhani, K., Noack, L., Oza, A. V., Pallé, E., Parviainen, H., Quirrenbach, A., Rauer, H., Ribas, I., Rice, M., Romagnolo, A., Rugheimer, S., Schwieterman, E. W., Serabyn, E., Sharma, S., Stassun, K. G., Szulágyi, J., Wang, H. S., Wunderlich, F., Wyatt, M. C., and Collaboration, the LIFE

Published
2022

7. Large Interferometer For Exoplanets (LIFE): I. Improved exoplanet detection yield estimates for a large mid-infrared space-interferometer mission

Author

Quanz, Sascha P., Ottiger, Marcel, Fontanet, E., Kammerer, Jens, Menti, Franziska, Dannert, Felix, Gheorghe, A., Absil, O., Airapetian, Vladimir S., Alei, Eleonora, Allart, Romain, Angerhausen, Daniel, Blumenthal, S., Buchhave, Lars, Cabrera, J., Carrión-González, Óscar, Chauvin, Gaël, Danchi, William C., Dandumont, Colin, Defrère, Denis, Dorn, Caroline, Ehrenreich, David, Ertel, Steve, Fridlund, Malcolm C.V., García Muñoz, Antonio, Gascón, C., Girard, Julien H., Glauser, Adrian, Grenfell, John Lee, Guidi, Greta, Hagelberg, Janis, Helled, Ravit, Ireland, M. J., Kopparapu, Ravi K., Korth, Judith, Kozakis, Thea, Kraus, Stefan, Léger, Alain, Leedjärv, Laurits, Lichtenberg, Tim, Lillo-Box, Jorge, Linz, Hendrik, Liseau, René, Loicq, Jérôme, Mahendra, Vishal, Malbet, Fabien, Mathew, J., Mennesson, Bertrand, Meyer, Michael R., Mishra, Lokesh, Molaverdikhani, K., Noack, Lena, Pallé, Enric, Parviainen, Hannu, Quirrenbach, Andreas, Rauer, Heike, Ribas, Ignasi, Rice, M., Romagnolo, A., Rugheimer, Sarah, Schwieterman, Edward W., Serabyn, Eugene, Sharma, S., Stassun, Keivan G., Szulágyi, Judit, Wang, H. S., Wunderlich, Fabian, and Wyatt, Mark C.

Subjects
interferometric, Infrared: planetary systems, Techniques: high angular resolution, Methods: numerical, Planets and satellites: detection, Planets and satellites: terrestrial planets [Telescopes, Techniques], Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Earth and Planetary Astrophysics
Abstract

One of the long-term goals of exoplanet science is the atmospheric characterization of dozens of small exoplanets in order to understand their diversity and search for habitable worlds and potential biosignatures. Achieving this goal requires a space mission of sufficient scale. We seek to quantify the exoplanet detection performance of a space-based mid-infrared nulling interferometer that measures the thermal emission of exoplanets. For this, we have developed an instrument simulator that considers all major astrophysical noise sources and coupled it with Monte Carlo simulations of a synthetic exoplanet population around main-sequence stars within 20 pc. This allows us to quantify the number (and types) of exoplanets that our mission concept could detect over a certain time period. Two different scenarios to distribute the observing time among the stellar targets are discussed and different apertures sizes and wavelength ranges are considered. Within a 2.5-year initial search phase, an interferometer consisting of four 2 m apertures covering a wavelength range between 4 and 18.5 μm could detect up to ~550 exoplanets with radii between 0.5 and 6 R⊕ with an integrated SNR≥7. At least ~160 of the detected exoplanets have radii ≤1.5 R⊕. Depending on the observing scenario, ~25-45 rocky exoplanets (objects with radii between 0.5 and 1.5 ⊕) orbiting within the empirical habitable zone (eHZ) of their host stars are among the detections. With four times 3.5 m aperture size, the total number of detections can increase to up to ~770, including ~60-80 rocky, eHZ planets. With four times 1 m aperture size, the maximum detection yield is ~315 exoplanets, including ≤20 rocky, eHZ planets. In terms of predicted detection yield, such a mission can compete with large single-aperture reflected light missions.

Published
2021

9. Large Interferometer For Exoplanets (LIFE): I. Improved exoplanet detection yield estimates for a large mid-infrared space-interferometer mission

Author

Quanz, Sascha P., Ottiger, Marcel, Fontanet, E., Kammerer, Jens, Menti, Franziska, Dannert, Felix, Gheorghe, A., Absil, O., Airapetian, Vladimir S., Alei, Eleonora, Allart, Romain, Angerhausen, Daniel, Blumenthal, S., Buchhave, Lars, Cabrera, J., Carrión-González, Óscar, Chauvin, Gaël, Danchi, William C., Dandumont, Colin, Defrère, Denis, Dorn, Caroline, Ehrenreich, David, Ertel, Steve, Fridlund, Malcolm C.V., García Muñoz, Antonio, Gascón, C., Girard, Julien H., Glauser, Adrian, Grenfell, John Lee, Guidi, Greta, Hagelberg, Janis, Helled, Ravit, Ireland, M. J., Kopparapu, Ravi K., Korth, Judith, Kozakis, Thea, Kraus, Stefan, Léger, Alain, Leedjärv, Laurits, Lichtenberg, Tim, Lillo-Box, Jorge, Linz, Hendrik, Liseau, René, Loicq, Jérôme, Mahendra, Vishal, Malbet, Fabien, Mathew, J., Mennesson, Bertrand, Meyer, Michael R., Mishra, Lokesh, Molaverdikhani, K., Noack, Lena, Pallé, Enric, Parviainen, Hannu, Quirrenbach, Andreas, Rauer, Heike, Ribas, Ignasi, Rice, M., Romagnolo, A., Rugheimer, Sarah, Schwieterman, Edward W., Serabyn, Eugene, Sharma, S., Stassun, Keivan G., Szulágyi, Judit, Wang, H. S., Wunderlich, Fabian, and Wyatt, Mark C.

Subjects
Techniques: high angular resolution, Infrared: planetary systems, Planets and satellites: terrestrial planets, Methods: numerical, Techniques: interferometric, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Planets and satellites: detection, 7. Clean energy, Telescopes
Abstract

One of the long-term goals of exoplanet science is the atmospheric characterization of dozens of small exoplanets in order to understand their diversity and search for habitable worlds and potential biosignatures. Achieving this goal requires a space mission of sufficient scale. We seek to quantify the exoplanet detection performance of a space-based mid-infrared nulling interferometer that measures the thermal emission of exoplanets. For this, we have developed an instrument simulator that considers all major astrophysical noise sources and coupled it with Monte Carlo simulations of a synthetic exoplanet population around main-sequence stars within 20 pc. This allows us to quantify the number (and types) of exoplanets that our mission concept could detect over a certain time period. Two different scenarios to distribute the observing time among the stellar targets are discussed and different apertures sizes and wavelength ranges are considered. Within a 2.5-year initial search phase, an interferometer consisting of four 2 m apertures covering a wavelength range between 4 and 18.5 μm could detect up to ~550 exoplanets with radii between 0.5 and 6 R⊕ with an integrated SNR≥7. At least ~160 of the detected exoplanets have radii ≤1.5 R⊕. Depending on the observing scenario, ~25-45 rocky exoplanets (objects with radii between 0.5 and 1.5 ⊕) orbiting within the empirical habitable zone (eHZ) of their host stars are among the detections. With four times 3.5 m aperture size, the total number of detections can increase to up to ~770, including ~60-80 rocky, eHZ planets. With four times 1 m aperture size, the maximum detection yield is ~315 exoplanets, including ≤20 rocky, eHZ planets. In terms of predicted detection yield, such a mission can compete with large single-aperture reflected light missions., arXiv

10. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

Author

Hiddo J L Heerspink, Hans-Henrik Parving, Dennis L Andress, George Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, Dalane W Kitzman, Donald Kohan, Hirofumi Makino, John J V McMurray, Joel Z Melnick, Michael G Miller, Pablo E Pergola, Vlado Perkovic, Sheldon Tobe, Tingting Yi, Melissa Wigderson, Dick de Zeeuw, Alicia Elbert, Augusto Vallejos, Andres Alvarisqueta, Laura Maffei, Luis Juncos, Javier de Arteaga, Gustavo Greloni, Eduardo Farias, Alfredo Zucchini, Daniel Vogel, Ana Cusumano, Juan Santos, Margaret Fraenkel, Martin Gallagher, Tim Davis, Shamasunder Acharya, Duncan Cooke, Michael Suranyi, Simon Roger, Nigel Toussaint, Carol Pollock, Doris Chan, Stephen Stranks, Richard MacIsaac, Zoltan Endre, Alice Schmidt, Rudolf Prager, Gert Mayer, Xavier Warling, Michel Jadoul, Jean Hougardy, Chris Vercammen, Bruno Van Vlem, Pieter Gillard, Adriana Costa e Forti, Joao Lindolfo Borges, Luis Santos Canani, Freddy Eliaschewitz, Silmara Leite, Fadlo Fraige Filho, Raphael Paschoalin, Jose Andrade Moura Neto, Luciane Deboni, Irene de Lourdes Noronha, Cintia Cercato, Carlos Alberto Prompt, Maria Zanella, Nelson Rassi, Domingos D'Avila, Rosangela Milagres, Joao Felicio, Roberto Pecoits Filho, Miguel Carlos Riella, Joao Salles, Elizete Keitel, Sergio Draibe, Celso Amodeo, Joseph Youmbissi, Louise Roy, Serge Cournoyer, Shivinder Jolly, Vincent Pichette, Gihad Nesrallah, Harpreet Singh Bajaj, Hasnain Khandwala, Ronnie Aronson, Richard Goluch, Paul Tam, Christian Rabbat, Gordon Bailey, Stephen Chow, Alvaro Castillo, Alfredo Danin Vargas, Fernando Gonzalez, Rodrigo Munoz, Vicente Gutierrez, Gonzalo Godoy, Hongwen Zhao, Zhangsuo Liu, Minghui Zhao, Xiaohui Guo, Benli Su, Shuxia Fu, Yan Xu, Jinkui Yang, Bingyin Shi, Guanqing Xiao, Wei Shi, Chuanming Hao, Changying Xing, Fanfan Hou, Qun Luo, Yuxiu Li, Linong Ji, Li Zuo, Song Wang, Zhaohui Ni, Guohua Ding, Nan Chen, Jiajun Zhao, Weiping Jia, Shengqiang Yu, Jian Weng, Gang Xu, Ping Fu, Shiren Sun, Bicheng Liu, Xiaoqiang Ding, Ivan Rychlik, Alexandra Oplustilova, Dagmar Bartaskova, Vaclava Honova, Hana Chmelickova, Martin Petr, Petr Bucek, Vladimir Tesar, Emil Zahumensky, Johan Povlsen, Kenneth Egstrup, Anna Oczachowska-Kulik, Peter Rossing, Jorma Lahtela, Jorma Strand, Ilkka Kantola, Catherine Petit, Christian Combe, Philippe Zaoui, Vincent Esnault, Pablo Urena Torres, Jean-Michel Halimi, Bertrand Dussol, Tasso Bieler, Klemens Budde, Frank Dellanna, Thomas Segiet, Christine Kosch, Hans Schmidt-Guertler, Isabelle Schenkenberger, Volker Vielhauer, Frank Pistrosch, Mark Alscher, Christoph Hasslacher, Christian Hugo, Anja Muehlfeld, Christoph Wanner, Ploumis Passadakis, Theofanis Apostolou, Nikolaos Tentolouris, Ioannis Stefanidis, Konstantinos Mavromatidis, Vasilios Liakopoulos, Dimitrios Goumenos, Konstantinos Siamopoulos, Vincent Yeung, Risa Ozaki, Samuel Fung, Kathryn Tan, Sydney Tang, Sing Leung Lui, Siu Fai Cheung, Seamus Sreenan, Joseph Eustace, Donal O'Shea, Peter Lavin, Austin Stack, Yoram Yagil, Julio Wainstein, Hilla Knobler, Josef Cohen, Irina Kenis, Deeb Daoud, Yosefa Bar-Dayan, Victor Frajewicki, Faiad Adawi, Loreto Gesualdo, Domenico Santoro, Francesco Marino, Andrea Galfre, Chiara Brunati, Piero Ruggenenti, Giuseppe Rombola, Giuseppe Pugliese, Maura Ravera, Fabio Malberti, Giuseppe Pontoriero, Teresa Rampino, Salvatore De Cosmo, Ciro Esposito, Felice Nappi, Cataldo Abaterusso, Giuseppe Conte, Vincenzo Panichi, Davide Lauro, Giovambattista Capasso, Domenico Russo, Jiichi Anzai, Motoji Naka, Keita Ato, Tetsuro Tsujimoto, Toshinori Nimura, Eitaro Nakashima, Tetsuro Takeda, Shinya Fujii, Kunihisa Kobayashi, Hideaki Iwaoka, Koji Nagayama, Hiroyuki Harada, Hajime Maeda, Rui Kishimoto, Tadashi Iitsuka, Naoki Itabashi, Ryuichi Furuya, Yoshitaka Maeda, Daishiro Yamada, Nobuhiro Sasaki, Hiromitsu Sasaki, Shinichiro Ueda, Naoki Kashihara, Shuichi Watanabe, Takehiro Nakamura, Hidetoshi Kanai, Yuichiro Makita, Keiko Ono, Noriyuki Iehara, Daisuke Goto, Keiichiro Kosuge, Kenichi Tsuchida, Toshiaki Sato, Takashi Sekikawa, Hideki Okamoto, Tsuyoshi Tanaka, Naoko Ikeda, Takenobu Tadika, Koji Mukasa, Takeshi Osonoi, Fuminori Hirano, Motonobu Nishimura, Yuko Yambe, Yukio Tanaka, Makoto Ujihara, Takashi Sakai, Mitsuo Imura, Yutaka Umayahara, Shinya Makino, Jun Nakazawa, Yukinari Yamaguchi, Susumu Kashine, Hiroaki Miyaoka, Katsunori Suzuki, Toshihiko Inoue, Sou Nagai, Nobuyuki Sato, Masahiro Yamamoto, Noriyasu Taya, Akira Fujita, Akira Matsutani, Yugo Shibagaki, Yuichi Sato, Akira Yamauchi, Masahiro Tsutsui, Tamayo Ishiko, Shizuka Kaneko, Nobuyuki Azuma, Hirofumi Matsuda, Yasuhiro Hashiguchi, Yukiko Onishi, Mikiya Tokui, Munehide Matsuhisa, Arihiro Kiyosue, Junji Shinoda, Kazuo Ishikawa, Ghazali Ahmad, Shalini Vijayasingham, Nor Azizah Aziz, Zanariah Hussein, Yin Khet Fung, Wan Hasnul Halimi Wan Hassan, Hin Seng Wong, Bak Leong Goh, Norhaliza Mohd Ali, Nor Shaffinaz Yusuf Azmi Merican, Indralingam Vaithilingam, Nik Nur Fatnoon Nik Ahmad, Noor Adam, Norlela Sukor, V Paranthaman P Vengadasalam, Khalid Abdul Kadir, Mafauzy Mohamed, Karina Renoirte Lopez, Aniceto Leguizamo-Dimas, Alfredo Chew Wong, Jose Chevaile-Ramos, Jose Gonzalez Gonzalez, Raul Rico Hernandez, Jose Nino-Cruz, Leobardo Sauque Reyna, Guillermo Gonzalez-Galvez, Magdalena Madero Rovalo, Tomasso Bochicchio-Ricardelli, Jorge Aldrete, Jaime Carranza-Madrigal, Liffert Vogt, Peter Smak Gregoor, JNM Barendregt, Peter Luik, Ronald Gansevoort, Gozewijn Laverman, Helen Pilmore, Helen Lunt, John Baker, Steven Miller, Kannaiyan Rabindranath, Luis Zapata-Rincon, Rolando Vargas-Gonzales, Jorge Calderon Ticona, Augusto Dextre Espinoza, Jose Burga Nunez, Carlos Antonio Zea-Nunez, Benjamin Herrada Orue, Boris Medina-Santander, Cesar Delgado-Butron, Julio Farfan-Aspilcueta, Stanislaw Mazur, Miroslaw Necki, Michal Wruk, Katarzyna Klodawska, Grazyna Popenda, Ewa Skokowska, Malgorzata Arciszewska, Andrzej Wiecek, Kazimierz Ciechanowski, Michal Nowicki, Rita Birne, Antonio Cabrita, Aura Ramos, Manuel Anibal Antunes Ferreira, Evelyn Matta Fontanet, Altagracia Aurora Alcantara-Gonzalez, Angel Comulada-Rivera, Eugenia Galindo Ramos, Jose Cangiano, Luis Quesada-Suarez, Ricardo Calderon Ortiz, Jose Vazquez-Tanus, Rafael Burgos-Calderon, Carlos Rosado, Nicolae Hancu, Ella Pintilei, Cristina Mistodie, Gabriel Bako, Lavinia Ionutiu, Ligia Petrica, Romulus Timar, Liliana Tuta, Livia Duma, Adriana Tutescu, Svetlana Ivanova, Ashot Essaian, Konstantin Zrazhevskiy, Natalia Tomilina, Elena Smolyarchuk, Anatoly Kuzin, Olga Lantseva, Irina Karpova, Minara Shamkhalova, Natalia Liberanskaya, Andrey Yavdosyuk, Yuri Shvarts, Tatiana Bardymova, Olga Blagoveshchenskaya, Oleg Solovev, Elena Rechkova, Natalia Pikalova, Maria Pavlova, Elena Kolmakova, Rustam Sayfutdinov, Svetlana Villevalde, Natalya Koziolova, Vladimir Martynenko, Vyacheslav Marasaev, Adelya Maksudova, Olga Sigitova, Viktor Mordovin, Vadim Klimontov, Yulia Samoylova, Tatiana Karonova, Lee Ying Yeoh, Boon Wee Teo, Marjorie Wai Yin Foo, Adrian Liew, Ivan 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Isabel Garcia Mendez, Juan Navarro Gonzalez, Jose Herrero Calvo, Secundino Cigarran Guldris, Mario Prieto Velasco, Jose Ignacio Minguela Pesquera, Antonio Galan, Julio Pascual, Maria Marques Vidas, Judith Martins Munoz, Jose Rodriguez-Perez, Cristina Castro-Alonso, Josep Bonet Sol, Daniel Seron, Elvira Fernandez Giraldez, Javier Arrieta Lezama, Nuria Montero, Julio Hernandez-Jaras, Rafael Santamaria Olmo, Jose Ramon Molas Coten, Olof Hellberg, Bengt Fellstrom, Andreas Bock, Dee Pei, Ching-Ling Lin, Kai-Jen Tien, Ching-Chu Chen, Chien-Ning Huang, Ju-Ying Jiang, Du-An Wu, Chih-Hsun Chu, Shih-Ting Tseng, Jung-Fu Chen, Cho-Tsan Bau, Wayne Sheu, Mai-Szu Wu, Ramazan Sari, Siren Sezer, Alaattin Yildiz, Ilhan Satman, Betul Kalender, Borys Mankovskyy, Ivan Fushtey, Mykola Stanislavchuk, Mykola Kolenyk, Iryna Dudar, Viktoriia Zolotaikina, Orest Abrahamovych, Tetyana Kostynenko, Olena Petrosyan, Petro Kuskalo, Olga Galushchak, Oleg Legun, Ivan Topchii, Liliya Martynyuk, Vasyl Stryzhak, Svitlana 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A., Herrada Orue, B., Medina-Santander, B., Delgado-Butron, C., Farfan-Aspilcueta, J., Mazur, S., Necki, M., Wruk, M., Klodawska, K., Popenda, G., Skokowska, E., Arciszewska, M., Wiecek, A., Ciechanowski, K., Nowicki, M., Birne, R., Cabrita, A., Ramos, A., Antunes Ferreira, M. A., Matta Fontanet, E., Alcantara-Gonzalez, A. A., Comulada-Rivera, A., Galindo Ramos, E., Cangiano, J., Quesada-Suarez, L., Calderon Ortiz, R., Vazquez-Tanus, J., Burgos-Calderon, R., Rosado, C., Hancu, N., Pintilei, E., Mistodie, C., Bako, G., Ionutiu, L., Petrica, L., Timar, R., Tuta, L., Duma, L., Tutescu, A., Ivanova, S., Essaian, A., Zrazhevskiy, K., Tomilina, N., Smolyarchuk, E., Kuzin, A., Lantseva, O., Karpova, I., Shamkhalova, M., Liberanskaya, N., Yavdosyuk, A., Shvarts, Y., Bardymova, T., Blagoveshchenskaya, O., Solovev, O., Rechkova, E., Pikalova, N., Pavlova, M., Kolmakova, E., Sayfutdinov, R., Villevalde, S., Koziolova, N., Martynenko, V., Marasaev, V., Maksudova, A., Sigitova, O., Mordovin, V., Klimontov, V., Samoylova, Y., Karonova, T., Yeoh, L. Y., Teo, B. W., Foo, M. W. Y., Liew, A., Tkac, I., Oroszova, A., Fekete, J., Rosenberger, J., Obetkova, I., Fulopova, A., Kolesarova, E., Raslova, K., Smolko, P., Oksa, A., Distiller, L., Trokis, J., Adams, L., Makan, H., Ramlachan, P., Mitha, E., Coetzee, K., Punt, Z., Bhorat, Q., Naiker, P., Ellis, G., Van Zyl, L., Lee, K. W., Kim, M. S., Yoo, S. -J., Yoon, K. H., Cho, Y. -W., Park, T. -S., Kim, S. Y., Choi, M. -G., Oh, T. K., Lee, K. -W., Shon, H. S., Suh, S. H., Kim, B. -J., Doo-Man, K., Yi, J. H., Lee, S. A., Cho, H. C., Kim, S. -G., Cha, D. -R., Seo, J. A., Choi, K. M., Woo, J. -T., Ahn, K. J., Lee, J. H., Kim, I. -J., Lee, M. -K., Jang, H. C., Park, K. -S., Kim, B. S., Mok, J. O., Shin, M., Yoon, S. A., Nam-Goong, I. -S., Chung, C. H., Yu, T. Y., Lee, H. W., Soto Gonzalez, A., Almirall, J., Egido, J., Calero Gonzalez, F., Fernandez Fresnedo, G., Valera Cortes, I., Praga Terente, M., Garcia Mendez, I., Navarro Gonzalez, J., Herrero Calvo, J., Cigarran Guldris, S., Prieto Velasco, M., Minguela Pesquera, J. I., Galan, A., Pascual, J., Marques Vidas, M., Martins Munoz, J., Rodriguez-Perez, J., Castro-Alonso, C., Bonet Sol, J., Seron, D., Fernandez Giraldez, E., Arrieta Lezama, J., Montero, N., Hernandez-Jaras, J., Santamaria Olmo, R., Molas Coten, J. R., Hellberg, O., Fellstrom, B., Bock, A., Pei, D., Lin, C. -L., Tien, K. -J., Chen, C. -C., Huang, C. -N., Jiang, J. -Y., Wu, D. -A., Chu, C. -H., Tseng, S. -T., Chen, J. -F., Bau, C. -T., Sheu, W., Wu, M. -S., Sari, R., Sezer, S., Yildiz, A., Satman, I., Kalender, B., Mankovskyy, B., Fushtey, I., Stanislavchuk, M., Kolenyk, M., Dudar, I., Zolotaikina, V., Abrahamovych, O., Kostynenko, T., Petrosyan, O., Kuskalo, P., Galushchak, O., Legun, O., Topchii, I., Martynyuk, L., Stryzhak, V., Panina, S., Tkach, S., Korpachev, V., Maxwell, P., Gnudi, L., Kon, S. 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Subjects
Male, endothelin, albuminuria, nephropathy, inhibition, Diabetes Mellitus, Type 2/drug therapy, Endocrinology, Diabetes and Metabolism, Placebo-controlled study, Administration, Oral, 030204 cardiovascular system & hematology, Settore MED/13 - Endocrinologia, chemistry.chemical_compound, 0302 clinical medicine, ENDOTHELIN, 80 and over, Diabetic Nephropathies, 030212 general & internal medicine, Renal Insufficiency, Chronic, Aged, 80 and over, Diabetic Nephropathies/blood, General Medicine, Middle Aged, Atrasentan/administration & dosage, Editorial Commentary, Treatment Outcome, Nephrology, Creatinine, Administration, young adult, Female, medicine.symptom, Glomerular filtration rate, Type 2, Endothelin A Receptor Antagonists/administration & dosage, medicine.drug, Glomerular Filtration Rate, Human, Oral, Adult, medicine.medical_specialty, ALBUMINURIA, Endothelin A Receptor Antagonists, NEPHROPATHY, Urology, INHIBITION, Renal function, Serum Albumin, Human, Placebo, Nephropathy, 03 medical and health sciences, Young Adult, Double-Blind Method, Atresentan, diabetes, chronic kidney disease, medicine, Diabetes Mellitus, Aged, Atrasentan, Diabetes Mellitus, Type 2, Humans, Renal Insufficiency, Chronic, Serum Albumin, business.industry, Creatinine/blood, medicine.disease, Serum Albumin, Human/urine, n/a OA procedure, chemistry, Albuminuria, Renal Insufficiency, Chronic/blood, business, aged, 80 and over, Kidney disease
Abstract

Background Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.Methods We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18-85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR) 25-75 mL/min per 1.73 m(2) of body surface area, and a urine albumin-to-creatinine ratio (UACR) of 300-5000 mg/g who had received maximum labelled or tolerated renin-angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0.75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders) were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0.75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for >= 30 days) or end-stage kidney disease (eGFR = 90 days, chronic dialysis for >= 90 days, kidney transplantation, or death from kidney failure) in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials. gov, number NCT01858532.Findings Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325) or placebo group (n=1323). Median follow-up was 2.2 years (IQR 1.4-2.9). 79 (6.0%) of 1325 patients in the atrasentan group and 105 (7.9%) of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR] 0.65 [95% CI 0.49-0.88]; p=0.0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3.5%) of 1325 patients in the atrasentan group and 34 (2.6%) of 1323 patients in the placebo group (HR 1.33 [95% CI 0.85-2.07]; p=0.208). 58 (4.4%) patients in the atrasentan group and 52 (3.9%) in the placebo group died (HR 1.09 [95% CI 0.75-1.59]; p=0.65).Interpretation Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Copyright (C) 2019 Elsevier Ltd. All rights reserved.

Published
2019
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11. Quantitative T2 Mapping of Acute Pancreatitis.

Author

Porões F, Vietti Violi N, Piazza G, Uldry E, Lázaro-Fontanet E, Gaspar-Figueiredo S, Hilbert T, Ledoux JB, Denys A, Schütz F, and Schmidt S

Subjects
Humans, Female, Male, Middle Aged, Adult, Aged, Aged, 80 and over, Prospective Studies, Acute Disease, Young Adult, Tomography, X-Ray Computed, Pancreas diagnostic imaging, Severity of Illness Index, Contrast Media, Reproducibility of Results, Pancreatitis diagnostic imaging, Magnetic Resonance Imaging methods
Abstract

Background: Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable assessment of AP., Purpose: To evaluate MR-derived pancreatic T2 mapping values in AP and correlate them with markers of disease severity., Study Type: Prospective single-center study., Population: 76 adults with AP (20-91 years, females/males: 39/37)., Field Strength/sequence: Fat suppressed multiecho spin-echo prototype sequence to quantify T2 signal at 3T MRI., Assessment: The severity of AP was assessed clinically, biologically, and by contrast-enhanced CT (CECT) performed 48-72 hours after symptom onset. MRI was then performed ≤24 hours after CT. Two readers blinded to any clinical information independently evaluated the T2 values by placing three regions of interest inside the pancreatic head, body, and tail on the T2 mapping MR sequence. Results were compared with corresponding CECT images as the standard and clinical severity parameters, using the length of hospital stay as our primary endpoint., Statistical Tests: Continuous variables were compared using the Spearman's rank correlation coefficient, analysis of variance (ANOVA) or Student's t-test., Results: T2 values significantly correlated with the length of hospital stay (r s (74) = 0.29), CT severity index (CTSI) (r s (73) = 0.61; CTSI 0-3: 72 ± 14 msec, CTSI 4-10: 88 ± 15), intensive care unit (ICU) admission (t(2.77) = -3.41) and presence of organ failure (t(6.72) = -3.42), whereas the CTSI and Ranson score were not significantly related with ICU admission (CTSI: P = 0.24; Ranson score: P = 0.24) and organ failure (CTSI: P = 0.11; Ranson score P = 0.11)., Conclusion: T2 mapping correlates with AP severity parameters and is useful for assessing the severity of AP with higher sensitivity than the usual clinical and radiological scoring systems., Level of Evidence: 1 TECHNICAL EFFICACY: Stage 2., (© 2024 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Published
2024
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13. Endoscopic ultrasound-guided modification of surgical anatomy (from Roux-en-Y gastrectomy to Billroth II-like anatomy) for endoscopic treatment of malignant biliary stenosis.

Author

Piazza G, Lázaro-Fontanet E, Cotton A, Godat S, and Galasso D

Subjects
Humans, Constriction, Pathologic etiology, Constriction, Pathologic surgery, Anastomosis, Roux-en-Y, Ultrasonography, Interventional, Postoperative Complications, Gastrectomy, Gastroenterostomy
Abstract

Competing Interests: The authors declare that they have no conflict of interest.

Published
2023
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14. [Surgery: what's new in 2022].

Author

Lázaro-Fontanet E, Deslarzes P, Grass F, Mantziari S, Demartines N, and Teixeira Farinha H

Subjects
Humans, Endoscopy, Colectomy methods, Health Care Costs, Robotic Surgical Procedures methods, Bariatric Surgery, Laparoscopy
Abstract

During 2022 a lot of efforts were developed to reduce health-costs by reducing complications and length of hospital stay. Same-day surgery is becoming the standard for all patients scheduled for elective surgery in CHUV. Outpatient colectomy also become a new standard. During 2022, endoscopic bariatric surgery became increasingly used. Not widely performed yet in Switzerland, these treatments deserve to be recognized and considered in various situations. Finally, 2022 saw a promising development of robotic surgery with the acquisition of Da Vinci and Dexter robots after allowing various high-precision surgical procedures., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.

Published
2023
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15. A hypervascular liver mass.

Author

Lázaro-Fontanet E, Maillard M, Fasquelle F, Vietti-Violi N, Labgaa I, and Uldry E

Subjects
Contrast Media, Humans, Magnetic Resonance Imaging, Carcinoma, Hepatocellular, Liver Neoplasms diagnostic imaging, Liver Neoplasms surgery
Published
2022
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