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2. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Callejas, José Luis, Caminal-Montero, Luis, Corbera-Bellalta, Marc, de Miguel, Eugenio, Díaz-López, J. Bernardino, García-Villanueva, María Jesús, Gómez-Vaquero, Carmen, Guijarro-Rojas, Mercedes, Hidalgo-Conde, Ana, Marí-Alfonso, Begoña, Martínez-Berriochoa, Agustín, Morado, Inmaculada C., Narváez, Javier, Ramentol-Sintas, Marc, Martínez-Zapico, Aleida, Martínez-Taboada, Víctor Manuel, Miranda-Filloy, José A., Monfort, Jordi, Pérez-Conesa, Mercedes, Prieto-González, Sergio, Raya, Enrique, Ríos-Fenández, Raquel, Sánchez-Martín, Julio, Sopeña, Bernardo, Tío, Laura, Unzurrunzaga, Ainhoa, Wordsworth, Oliver, Whitwell, Isobel, Brock, Jessica, Douglas, Victoria, Hettiarachchi, Chamila, Bartholomew, Jacqui, Jarrett, Stephen, Smithson, Gayle, Green, Michael, Brown, Pearl Clark, Lawson, Cathy, Gordon, Esther, Lane, Suzanne, Francis, Rebecca, Dasgupta, Bhaskar, Masunda, Bridgett, Calver, Jo, Patel, Yusuf, Thompson, Charlotte, Gregory, Louise, Levy, Sarah, Menon, Ajit, Thompson, Amy, Dyche, Lisa, Martin, Michael, Li, Charles, Laxminarayan, Ramasharan, Wilcox, Louise, de Guzman, Ralph, Isaacs, John, Lorenzi, Alice, Farley, Ross, Hinchcliffe-Hume, Helain, Bejarano, Victoria, Hope, Susan, Nandi, Pradip, Stockham, Lynne, Wilde, Catherine, Durrant, Donna, Lloyd, Mark, Ye, Chee-Seng, Stevens, Rob, Jilani, Amjad, Collins, David, Pegler, Suzannah, Rivett, Ali, Price, Liz, McHugh, Neil, Skeoch, Sarah, O'Kane, Diana, Kirkwood, Sue, Vadivelu, Saravanan, Pugmire, Susan, Sultan, Shabina, Dooks, Emma, Armstrong, Lisa, Sadik, Hala, Nandagudi, Anupama, Abioye, Tolu, Ramos, Angelo, Gumus, Steph, Sofat, Nidhi, Harrison, Abiola, Seward, Abi, Mollan, Susan, Rahan, Ray, Hawkins, Helen, Emsley, Hedley, Bhargava, Anna, Fleming, Vicki, Hare, Marianne, Raj, Sonia, George, Emmanuel, Allen, Nicola, Hunter, Karl, O'Sullivan, Eoin, Bird, Georgina, Magliano, Malgorzata, Manzo, Katarina, Sanghera, Bobbie, Hutchinson, David, Hammonds, Fiona, Sharma, Poonam, Cooper, Richard, McLintock, Graeme, Al-Saffar, Zaid S., Green, Mike, Elliott, Kerry, Neale, Tania, Mallinson, Janine, Lanyon, Peter, Pradere, Marie-Josephe, Jordan, Natasha, Htut, Ei Phyu, Mushapaidzi, Thelma, Abercrombie, Donna, Wright, Sam, Rowlands, Jane, Mukhtyar, Chetan, Kennedy, James, Makkuni, Damodar, Wilhelmsen, Elva, Kouroupis, Michael, John, Lily, Hughes, Rod, Walsh, Margaret, Buckley, Marie, Mackay, Kirsten, Camden-Woodley, Tracey, Redome, Joan, Pearce, Kirsty, Marianayagam, Thiraupathy, Cruz, Carina, Warner, Elizabeth, Atchia, Ishmael, Walker, Claire, Black, Karen, Duffy, Stacey, Fothergill, Lynda, Jefferey, Rebecca, Toomey, Jackie, Rhys-Dillon, Ceril, Pothecary, Carla, Green, Lauren, Toms, Tracey, Maher, Linda, Davis, Diana, Sayan, Amrinder, Thankachen, Mini, Abusalameh, Mahdi, Record, Jessica, Khan, Asad, Stafford, Sam, Hussein, Azza, Williams, Clare, Fletcher, Alison, Johson, Laura, Burnett, Richard, Moots, Robert, Frankland, Helen, Dale, James, Moar, Kirsten, Hollas, Carol, Parker, Ben, Ridings, Derek, Eapen, Sandhya, John, Sindhu, Robson, Jo, Guthrie, Lucy Belle, Fyfe, Rose, Tait, Moira, Marks, Jonathan, Gunter, Emma, Hernandez, Rochelle, Bhat, Smita, Johnston, Paul, Khurshid, Muhammad, Barclay, Charlotte, Kapur, Deepti, Jeffrey, Helen, Hughes, Anna, Slack, Lauren, Thomas, Eleri, Royon, Anna, Hall, Angela, King, Jon, Nyathi, Sindi, Morris, Vanessa, Castelino, Madhura, Hawkins, Ellie, Tomson, Linda, Singh, Animesh, Nunag, Annalyn, O'Connor, Stella, Rushby, Nathan, Hewitson, Nicola, O'Sunmboye, Kenny, Lewszuk, Adam, Boyles, Louise, Perry, Martin, Williams, Emma, Graver, Christine, Defever, Emmanuel, Kamanth, Sanjeet, Kay, Dominic, Ogor, Joe, Winter, Louise, Horton, Sarah, Welch, Gillian, Hollinshead, Kath, Peters, James, Labao, Julius, Dmello, Andrea, Dawson, Julie, Graham, Denise, De Lord, Denise, Deery, Jo, Hazelton, Tracy, Carette, Simon, Chung, Sharon, Cuthbertson, David, Forbess, Lindsy J., Gewurz-Singer, Ora, Hoffman, Gary S., Koening, Curry L., Maksimowicz-McKinnon, Kathleen M., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Spiera, Robert F., Sreih, Antoine, Warrington, Kenneth J., Monach, Paul A., Weisman, Michael, Borrego-Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Madrid-Paredes, Adela, Kerick, Martin, Hernández-Rodríguez, José, Mackie, Sarah L, Vaglio, Augusto, Castañeda, Santos, Solans, Roser, Mestre-Torres, Jaume, Khalidi, Nader, Langford, Carol A, Ytterberg, Steven, Beretta, Lorenzo, Govoni, Marcello, Emmi, Giacomo, Cimmino, Marco A, Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Øyvind, Diamantopoulos, Andreas P, Voskuyl, Alexandre, Daikeler, Thomas, Berger, Christoph T, Molloy, Eamonn S, Blockmans, Daniel, van Sleen, Yannick, Iles, Mark, Sorensen, Louise, Luqmani, Raashid, Reynolds, Gary, Bukhari, Marwan, Bhagat, Shweta, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A, Cid, María C, González-Gay, Miguel A, Morgan, Ann W, Martin, Javier, and Márquez, Ana

Published
2024
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3. The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial

Author

Paizis, Kathy, Walters, Giles, Jardine, Meg, Milton, Caroline, Ibraham, Abu, Siva, Brian, Desmond, Michael, Perkovic, Vlado, Kurtkoti, Jadadeesh, Vilayur, Eswari, Cass, Alan, Summers, Shaun, Brown, Fiona, Ryan, Jessica, Kerr, Peter, Noble, Euan, Luxton, Grant, Mudge, David W., Hawley, Carmel, Johnson, David W., Peh, Chen Au, Faull, Randall J., Ranganathan, Dwarakanathan, Jeffs, Lisa, Nicholls, Kathy, Hughes, Peter, Cooper, Bruce, Boudville, Neil, Ford, Sharon, Langham, Robyn, Reidlinger, Donna, AliciaMorrish, Badve, Sunil V., Pascoe, Elaine, Paul-Brent, Peta-Anne, Robison, Laura, Valks, Andrea, Blockmans, Daniel, Henckaerts, Liesbet, Sprangers, Ben, Suri, Rita, Brachemi, Soumeya, Clark, William, Garg, Amit, Carette, Simon, Pagnoux, Christian, Reich, Heather, Barth, David, Walsh, Michael, Khalidi, Nader, Cox, Gerry, Mazzetti, Andrea, Robins, Diane, Wald, Ron, Perl, Jeffrey, Pavenski, Katerina, Dacouris, Niki, Levin, Adeera, Copland, Michael, Fairhead, Todd, Pannu, Neesh, Qarni, Muhammad Uwais, Habib, Syed, Girard, Louis, Manns, Braden, Tesar, Vladimir, Hruskova, Zdenka, Chocova, Zdenka, Povlsen, Johan, Gregersen, Jon, Ivarsen, Per, Birn, Henrik, Krarup, Elizabeth, Pedersen, Erling B., Thomsen, Ingrid, Bech, Jesper Nørgaard, Szpirt, Wladmir, Egfjord, Martin, Mesbah, Rafik, Bataille, Pierre, Rey, Isabelle, Chantrel, François, Vanhille, Philipe, Quémeneur, Thomas, Carron, Pierre-Louis, Zaoui, Philippe, de Moreuil, Claire, Gosselin, Morgane, Delluc, Aurélien, Hanrotel-Saliou, Catherine, Le Jeune, Mathilde, Ficheux, Maxence, Aniort, Julien, Lavigne, Christian, Augusto, Jean Francois, Chauveau, Dominique, Guitard, Joëlle, Huart, Antoine, Ribes, David, Gatault, Philippe, Becmeur, Camille, Muller, Sandrine, Betz, Valérie, Klein, Alexandre, Blaison, Gilles, Seror, Raphaele, Francois, Hélène, Mariette, Xavier, Aubrun, Aurore, Coustet, Baptiste, Palazzo, Elisabeth, Ottaviani, Sébastien, Goulenok, Tiphaine, Daugas, Eric, Dieudé, Philipe, Papo, Thomas, Lebas, Céline, Lionet, Arnaud, Guillevin, Loïc, Mouthon, Luc, Puéchal, Xavier, Jourde-Chiche, Noémie, Ruivard, Marc, Karras, Alexandre, Limal, Nicolas, Kofman, Thomas, Le Quellec, Alain, Maurier, François, Gibelin, Aude, Parrot, Antoine, Bachmeyer, Claude, Gombert, Bruno, Nouvier, Mathilde, Lega, Jean-Christophe, Fain, Olivier, Andrès, Emmanuel, Cottet, Rachel, Gregorini, Gina, Jeannin, Guido, Possenti, Stefano, Buzio, Carlo, Vaglio, Augusto, Oliva, Elena, Makino, Hirofumi, Muso, Eri, Endo, Tomomi, Kakita, Hiroko, Suzuki, Hiroyuki, Handa, Takaya, Kang, Youngna, Ariyasu, Yuki, Tsukamoto, Tatsuo, Endo, Shuichiro, Miyata, Hitomi, Yamada, Hiroyuki, Ito-Ihara, Toshiko, Uchida, Shunya, Kono, Hajime, Fujigaki, Yoshihide, Kikuchi, Hirotoshi, Nanki, Toshihiro, Kato, Hideki, Okamoto, Akiko, Asako, Kurumi, Suzuki, Kazuo, Hamano, Yoshitomo, Yamagata, Kunihiro, Usui, Joichi, Fujimoto, Shouichi, Sato, Yuji, Kikuchi, Masao, Flores-Suárez, Luis Felipe, Sánchez-Guerrero, Sergio A., Collins, Michael, Schollum, John, de Zoysa, Janak, Quincy, Vicki, Sizeland, Peter, Aasarod, Knut, Solbu, Marit, Bruun, Trude Jannecke, Koldingsnes, Wenche, Wludarczyk, Anna, Nowak, Ilona, Gorka, Jacek, Sznajd, Jan, Padjas, Agnieszka, Jankowski, Milosz, Widawska, Agnieszka, Szczeklik, Wojciech, Ballarin, Jose, Bruchfeld, Annette, Efvergren, Mats, Eriksson, Per, Westman, Kerstin, Selga, Daina, Heijl, Caroline, Ohlsson, Sophie, Segelmark, Marten, Basu, Neil, Kidder, Dana, Fluck, Nicholas, Jayne, David R.W., Smith, Rona, Wilcocks, Lisa, McClure, Mark, Jones, Rachel, Trivedi, Sapna, Gopaluni, Seerapani, Brettell, Elizabeth, Crump, Paul, Feilbach, Annika, Hewitt, Catherine, Hilken, Nick, Howman, Andrew, Hughes, Terry, Ives, Natalie, Jarrett, Hugh, Mehta, Samir, Record, Rebecca, Ryan, Gemma, Sidile, Chaka, Wheatley, Keith, Sheerin, Brown, Alison, Baines, Laura Anne, Lordan, Jim, Pusey, Charles, Tanna, Anisha, McAdoo, Stephen, Levy, Jeremy, Griffith, Megan, Klebe, Bernhard, Doulton, Timothy, Warwick, Graham, Burton, James, Barratt, Jonathon, Topham, Peter, Baines, Richard, Brunskill, Nigel, Al-Jayyousi, Reem, Hamilton, Patrick, Patel, Mumtaz, Mitra, Sandip, Brown, Nina, Sharples, Edward, Luqmani, Raashid, Harper, Lorraine, Rhodes, Benjamin, Chanouzas, Dimitrios, Morgan, Matthew, Hewins, Peter, Floßmann, Oliver, Bhandary, Nitin, Foxton, Julie, Jones, Linda, King, Jenny, Smyth, Lucy, D’Souza, Richard, Haigh, Richard, Hough, Maxine, Salama, Alan, Burns, Aine, Little, Mark, Dhaun, Neeraj, Dhaygude, Ajay, Basnayake, Kolitha, Iggo, Neil, Jones, Daniel, Oliveira, David, MacPhee, Iain A.M., Dunn, Emma, Lewington, Andrew J.P., Fan, Stanley Linsun, Rajakariar, Ravindra, Yaqoob, Magdi, Short, Andrew, Geddes, Colin, Mackinnon, Bruce, Jardine, Alan G., Monach, Paul, Merkel, Peter A., Amudala, Naomi, Quillen, Karen, Weisman, Michael, Wallace, Daniel, Forbess, Lindsy, Venuturupalli, Swamy, Langford, Carol, Hajj-Ali, Rula, Koo, Anna, Hoffman, Gary, Specks, Ulrich, Keogh, Karina, Ytterberg, Steven, Winters, Jeff, Warrington, Kenneth, Cartin-Ceba, Rodrigo, Peikert, Tobias, Fervenza, Fernando, Baqir, Misbah, Nachman, Patrick, Detwiler, Randy, Mottl, Amy, Derebail, Vimal, McGregor, JulieAnne, Sreih, Antoine, Rhee, Rennie, McAlear, Carol, Aqui, Nicole, Moreland, Larry, Kiss, Joseph, Liang, Kimberly, Mohan, Niveditha, Balogun, Rasheed, Li, Tingting, Brasington, Richard, Odler, Balazs, Riedl, Regina, Geetha, Duvuru, Szpirt, Wladimir M., Uchida, Lisa, Wallace, Zachary S., Pusey, Charles D., Little, Mark A., and Kronbichler, Andreas

Published
2024
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4. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A

Published
2023
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6. Magnetic resonance multitasking for multidimensional assessment of cardiovascular system: Development and feasibility study on the thoracic aorta

Author

Hu, Zhehao, Christodoulou, Anthony G, Wang, Nan, Shaw, Jaime L, Song, Shlee S, Maya, Marcel M, Ishimori, Mariko L, Forbess, Lindsy J, Xiao, Jiayu, Bi, Xiaoming, Han, Fei, Li, Debiao, and Fan, Zhaoyang

Subjects
Engineering, Biomedical Engineering, Clinical Research, Biomedical Imaging, Vaccine Related, Cardiovascular, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Aorta, Thoracic, Aortic Diseases, Feasibility Studies, Humans, Magnetic Resonance Spectroscopy, Reproducibility of Results, MR multitasking, multicontrast imaging, phase-resolved imaging, thoracic aorta, Nuclear Medicine & Medical Imaging, Biomedical engineering
Abstract

PurposeTo develop an MR multitasking-based multidimensional assessment of cardiovascular system (MT-MACS) with electrocardiography-free and navigator-free data acquisition for a comprehensive evaluation of thoracic aortic diseases.MethodsThe MT-MACS technique adopts a low-rank tensor image model with a cardiac time dimension for phase-resolved cine imaging and a T2 -prepared inversion-recovery dimension for multicontrast assessment. Twelve healthy subjects and 2 patients with thoracic aortic diseases were recruited for the study at 3 T, and both qualitative (image quality score) and quantitative (contrast-to-noise ratio between lumen and wall, lumen and wall area, and aortic strain index) analyses were performed in all healthy subjects. The overall image quality was scored based on a 4-point scale: 3, excellent; 2, good; 1, fair; and 0, poor. Statistical analysis was used to test the measurement agreement between MT-MACS and its corresponding 2D references.ResultsThe MT-MACS images reconstructed from acquisitions as short as 6 minutes demonstrated good or excellent image quality for bright-blood (2.58 ± 0.46), dark-blood (2.58 ± 0.50), and gray-blood (2.17 ± 0.53) contrast weightings, respectively. The contrast-to-noise ratios for the three weightings were 49.2 ± 12.8, 20.0 ± 5.8 and 2.8 ± 1.8, respectively. There were good agreements in the lumen and wall area (intraclass correlation coefficient = 0.993, P < .001 for lumen; intraclass correlation coefficient = 0.969, P < .001 for wall area) and strain (intraclass correlation coefficient = 0.947, P < .001) between MT-MACS and conventional 2D sequences.ConclusionThe MT-MACS technique provides high-quality, multidimensional images for a comprehensive assessment of the thoracic aorta. Technical feasibility was demonstrated in healthy subjects and patients with thoracic aortic diseases. Further clinical validation is warranted.

Published
2020

7. Arterial lesions in giant cell arteritis: A longitudinal study.

Author

Kermani, Tanaz, Diab, Sehriban, Sreih, Antoine, Cuthbertson, David, Borchin, Renée, Carette, Simon, Forbess, Lindsy, Koening, Curry, McAlear, Carol, Monach, Paul, Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Warrington, Kenneth, Ytterberg, Steven, Langford, Carol, Merkel, Peter, and Khalidi, Nader

Subjects
Aortic aneurysm, Computed tomography angiography, Disease activity, Giant cell arteritis, Large-artery stenosis, Magnetic resonance angiography, Aged, Aorta, Thoracic, Axillary Artery, Computed Tomography Angiography, Female, Giant Cell Arteritis, Humans, Longitudinal Studies, Magnetic Resonance Angiography, Male, Middle Aged, Subclavian Artery
Abstract

OBJECTIVES: To evaluate large-vessel (LV) abnormalities on serial imaging in patients with giant cell arteritis (GCA) and discern predictors of new lesions. METHODS: Clinical and imaging data from patients with GCA (including subjects diagnosed by LV imaging) enrolled in a prospective, multicenter, longitudinal study and/or a randomized clinical trial were included. New arterial lesions were defined as a lesion in a previously unaffected artery. RESULTS: The study included 187 patients with GCA, 146 (78%) female, mean (±SD) age at diagnosis 68.5 ± 8.5 years; 39% diagnosed by LV imaging. At least one arterial lesion was present in 123 (66%) on the first study. The most frequently affected arteries were subclavian (42%), axillary (32%), and thoracic aorta (20%). In 106 patients (57%) with serial imaging, new arterial lesions were noted in 41 patients (39%), all of whom had a baseline abnormality, over a mean (±SD) follow-up of 4.39 (2.22) years. New abnormalities were observed in 33% patients by year 2; clinical features of active disease were present at only 50% of these cases. There were no differences in age, sex, temporal artery biopsy positivity, or disease activity in patients with or without new lesions. CONCLUSIONS: In this cohort of patients with GCA, LV abnormalities on first imaging were common. Development of new arterial lesions occurred in patients with arterial abnormalities at first imaging, often in the absence of symptoms of active disease. Arterial imaging should be considered in all patients with GCA at diagnosis and serial imaging at least in patients with baseline abnormalities.

Published
2019

8. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Borrego-Yaniz, Gonzalo, primary, Ortiz-Fernández, Lourdes, additional, Madrid-Paredes, Adela, additional, Kerick, Martin, additional, Hernández-Rodríguez, José, additional, Mackie, Sarah L, additional, Vaglio, Augusto, additional, Castañeda, Santos, additional, Solans, Roser, additional, Mestre-Torres, Jaume, additional, Khalidi, Nader, additional, Langford, Carol A, additional, Ytterberg, Steven, additional, Beretta, Lorenzo, additional, Govoni, Marcello, additional, Emmi, Giacomo, additional, Cimmino, Marco A, additional, Witte, Torsten, additional, Neumann, Thomas, additional, Holle, Julia, additional, Schönau, Verena, additional, Pugnet, Gregory, additional, Papo, Thomas, additional, Haroche, Julien, additional, Mahr, Alfred, additional, Mouthon, Luc, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P, additional, Voskuyl, Alexandre, additional, Daikeler, Thomas, additional, Berger, Christoph T, additional, Molloy, Eamonn S, additional, Blockmans, Daniel, additional, van Sleen, Yannick, additional, Iles, Mark, additional, Sorensen, Louise, additional, Luqmani, Raashid, additional, Reynolds, Gary, additional, Bukhari, Marwan, additional, Bhagat, Shweta, additional, Ortego-Centeno, Norberto, additional, Brouwer, Elisabeth, additional, Lamprecht, Peter, additional, Klapa, Sebastian, additional, Salvarani, Carlo, additional, Merkel, Peter A, additional, Cid, María C, additional, González-Gay, Miguel A, additional, Morgan, Ann W, additional, Martin, Javier, additional, Márquez, Ana, additional, Callejas, José Luis, additional, Caminal-Montero, Luis, additional, Corbera-Bellalta, Marc, additional, de Miguel, Eugenio, additional, Díaz-López, J. Bernardino, additional, García-Villanueva, María Jesús, additional, Gómez-Vaquero, Carmen, additional, Guijarro-Rojas, Mercedes, additional, Hidalgo-Conde, Ana, additional, Marí-Alfonso, Begoña, additional, Martínez-Berriochoa, Agustín, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Ramentol-Sintas, Marc, additional, Martínez-Zapico, Aleida, additional, Martínez-Taboada, Víctor Manuel, additional, Miranda-Filloy, José A., additional, Monfort, Jordi, additional, Pérez-Conesa, Mercedes, additional, Prieto-González, Sergio, additional, Raya, Enrique, additional, Ríos-Fenández, Raquel, additional, Sánchez-Martín, Julio, additional, Sopeña, Bernardo, additional, Tío, Laura, additional, Unzurrunzaga, Ainhoa, additional, Wordsworth, Oliver, additional, Whitwell, Isobel, additional, Brock, Jessica, additional, Douglas, Victoria, additional, Hettiarachchi, Chamila, additional, Bartholomew, Jacqui, additional, Jarrett, Stephen, additional, Smithson, Gayle, additional, Green, Michael, additional, Brown, Pearl Clark, additional, Lawson, Cathy, additional, Gordon, Esther, additional, Lane, Suzanne, additional, Francis, Rebecca, additional, Dasgupta, Bhaskar, additional, Masunda, Bridgett, additional, Calver, Jo, additional, Patel, Yusuf, additional, Thompson, Charlotte, additional, Gregory, Louise, additional, Levy, Sarah, additional, Menon, Ajit, additional, Thompson, Amy, additional, Dyche, Lisa, additional, Martin, Michael, additional, Li, Charles, additional, Laxminarayan, Ramasharan, additional, Wilcox, Louise, additional, de Guzman, Ralph, additional, Isaacs, John, additional, Lorenzi, Alice, additional, Farley, Ross, additional, Hinchcliffe-Hume, Helain, additional, Bejarano, Victoria, additional, Hope, Susan, additional, Nandi, Pradip, additional, Stockham, Lynne, additional, Wilde, Catherine, additional, Durrant, Donna, additional, Lloyd, Mark, additional, Ye, Chee-Seng, additional, Stevens, Rob, additional, Jilani, Amjad, additional, Collins, David, additional, Pegler, Suzannah, additional, Rivett, Ali, additional, Price, Liz, additional, McHugh, Neil, additional, Skeoch, Sarah, additional, O'Kane, Diana, additional, Kirkwood, Sue, additional, Vadivelu, Saravanan, additional, Pugmire, Susan, additional, Sultan, Shabina, additional, Dooks, Emma, additional, Armstrong, Lisa, additional, Sadik, Hala, additional, Nandagudi, Anupama, additional, Abioye, Tolu, additional, Ramos, Angelo, additional, Gumus, Steph, additional, Sofat, Nidhi, additional, Harrison, Abiola, additional, Seward, Abi, additional, Mollan, Susan, additional, Rahan, Ray, additional, Hawkins, Helen, additional, Emsley, Hedley, additional, Bhargava, Anna, additional, Fleming, Vicki, additional, Hare, Marianne, additional, Raj, Sonia, additional, George, Emmanuel, additional, Allen, Nicola, additional, Hunter, Karl, additional, O'Sullivan, Eoin, additional, Bird, Georgina, additional, Magliano, Malgorzata, additional, Manzo, Katarina, additional, Sanghera, Bobbie, additional, Hutchinson, David, additional, Hammonds, Fiona, additional, Sharma, Poonam, additional, Cooper, Richard, additional, McLintock, Graeme, additional, Al-Saffar, Zaid S., additional, Green, Mike, additional, Elliott, Kerry, additional, Neale, Tania, additional, Mallinson, Janine, additional, Lanyon, Peter, additional, Pradere, Marie-Josephe, additional, Jordan, Natasha, additional, Htut, Ei Phyu, additional, Mushapaidzi, Thelma, additional, Abercrombie, Donna, additional, Wright, Sam, additional, Rowlands, Jane, additional, Mukhtyar, Chetan, additional, Kennedy, James, additional, Makkuni, Damodar, additional, Wilhelmsen, Elva, additional, Kouroupis, Michael, additional, John, Lily, additional, Hughes, Rod, additional, Walsh, Margaret, additional, Buckley, Marie, additional, Mackay, Kirsten, additional, Camden-Woodley, Tracey, additional, Redome, Joan, additional, Pearce, Kirsty, additional, Marianayagam, Thiraupathy, additional, Cruz, Carina, additional, Warner, Elizabeth, additional, Atchia, Ishmael, additional, Walker, Claire, additional, Black, Karen, additional, Duffy, Stacey, additional, Fothergill, Lynda, additional, Jefferey, Rebecca, additional, Toomey, Jackie, additional, Rhys-Dillon, Ceril, additional, Pothecary, Carla, additional, Green, Lauren, additional, Toms, Tracey, additional, Maher, Linda, additional, Davis, Diana, additional, Sayan, Amrinder, additional, Thankachen, Mini, additional, Abusalameh, Mahdi, additional, Record, Jessica, additional, Khan, Asad, additional, Stafford, Sam, additional, Hussein, Azza, additional, Williams, Clare, additional, Fletcher, Alison, additional, Johson, Laura, additional, Burnett, Richard, additional, Moots, Robert, additional, Frankland, Helen, additional, Dale, James, additional, Moar, Kirsten, additional, Hollas, Carol, additional, Parker, Ben, additional, Ridings, Derek, additional, Eapen, Sandhya, additional, John, Sindhu, additional, Robson, Jo, additional, Guthrie, Lucy Belle, additional, Fyfe, Rose, additional, Tait, Moira, additional, Marks, Jonathan, additional, Gunter, Emma, additional, Hernandez, Rochelle, additional, Bhat, Smita, additional, Johnston, Paul, additional, Khurshid, Muhammad, additional, Barclay, Charlotte, additional, Kapur, Deepti, additional, Jeffrey, Helen, additional, Hughes, Anna, additional, Slack, Lauren, additional, Thomas, Eleri, additional, Royon, Anna, additional, Hall, Angela, additional, King, Jon, additional, Nyathi, Sindi, additional, Morris, Vanessa, additional, Castelino, Madhura, additional, Hawkins, Ellie, additional, Tomson, Linda, additional, Singh, Animesh, additional, Nunag, Annalyn, additional, O'Connor, Stella, additional, Rushby, Nathan, additional, Hewitson, Nicola, additional, O'Sunmboye, Kenny, additional, Lewszuk, Adam, additional, Boyles, Louise, additional, Perry, Martin, additional, Williams, Emma, additional, Graver, Christine, additional, Defever, Emmanuel, additional, Kamanth, Sanjeet, additional, Kay, Dominic, additional, Ogor, Joe, additional, Winter, Louise, additional, Horton, Sarah, additional, Welch, Gillian, additional, Hollinshead, Kath, additional, Peters, James, additional, Labao, Julius, additional, Dmello, Andrea, additional, Dawson, Julie, additional, Graham, Denise, additional, De Lord, Denise, additional, Deery, Jo, additional, Hazelton, Tracy, additional, Carette, Simon, additional, Chung, Sharon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Gewurz-Singer, Ora, additional, Hoffman, Gary S., additional, Koening, Curry L., additional, Maksimowicz-McKinnon, Kathleen M., additional, McAlear, Carol A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert F., additional, Sreih, Antoine, additional, Warrington, Kenneth J., additional, Monach, Paul A., additional, and Weisman, Michael, additional

Published
2024
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9. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

Author

Ortiz-Fernández, Lourdes, Saruhan-Direskeneli, Güher, Alibaz-Oner, Fatma, Kaymaz-Tahra, Sema, Coit, Patrick, Kong, Xiufang, Kiprianos, Allan P., Maughan, Robert T., Aydin, Sibel Z., Aksu, Kenan, Keser, Gokhan, Kamali, Sevil, Inanc, Murat, Springer, Jason, Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Forbess, Lindsy, Langford, Carol A., McAlear, Carol A., Ozbalkan, Zeynep, Yavuz, Sule, Çetin, Gozde Yildirim, Alpay-Kanitez, Nilufer, Chung, Sharon, Ates, Askin, Karaaslan, Yasar, McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Ozer, Hüseyin T.E., Seyahi, Emire, Fresko, Izzet, Cefle, Ayse, Seo, Philip, Warrington, Kenneth J., Ozturk, Mehmet A., Ytterberg, Steven R., Cobankara, Veli, Onat, Ahmet Mesut, Duzgun, Nurşen, Bıcakcıgil, Muge, Yentür, Sibel P., Lally, Lindsay, Manfredi, Angelo A., Baldissera, Elena, Erken, Eren, Yazici, Ayten, Kısacık, Bünyamin, Kaşifoğlu, Timuçin, Dalkilic, Ediz, Cuthbertson, David, Pagnoux, Christian, Sreih, Antoine, Reales, Guillermo, Wallace, Chris, Wren, Jonathan D., Cunninghame-Graham, Deborah S., Vyse, Timothy J., Sun, Ying, Chen, Huiyong, Grayson, Peter C., Tombetti, Enrico, Jiang, Lindi, Mason, Justin C., Merkel, Peter A., Direskeneli, Haner, and Sawalha, Amr H.

Published
2021
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11. Contributors

Author

Agmon-Levin, Nancy, primary, Alarcón, Graciela S., additional, Amengual, Olga, additional, Ardoin, Stacy P., additional, Arora, Swati, additional, Atisha-Fregoso, Yemil, additional, Atkinson, John P., additional, Atsumi, Tatsuya, additional, Ayoub, Isabelle, additional, Barilla-LaBarca, Maria-Louise, additional, Bermas, Bonnie L., additional, Bernatsky, Sasha, additional, Bertsias, George, additional, Bichile, Tanmayee, additional, Blanco, Patrick, additional, Bohgaki, Miyuki, additional, Bonsmann, Gisela, additional, Borghi, Maria Orietta, additional, Boumpas, Dimitrios T., additional, Bourn, Rebecka, additional, Buyon, Jill P., additional, Caricchio, Roberto, additional, Chan, Edward K.L., additional, Chang, Christopher, additional, Charrier, Manon, additional, Chighizola, Cecilia Beatrice, additional, Clarke, Ann E., additional, Crispín, José C., additional, Cuneo, Bettina, additional, Dörner, Thomas, additional, Damato, Erika M., additional, Denniston, Alastair K.O., additional, Devlin, Amy, additional, Diamond, Betty, additional, Ernandez, T., additional, Falasinnu, Titilola, additional, Fernandez-Ruiz, Ruth, additional, Fitzpatrick, Brianna, additional, Forbess, Lindsy, additional, Frangou, Eleni A., additional, Fritzler, Marvin J., additional, Fu, Shu Man, additional, Furie, Richard, additional, Gaskin, Felicia, additional, Gladman, Dafna, additional, Gordon, Caroline, additional, Grammer, Amrie C., additional, Greidinger, Eric L., additional, Greiling, Teri M., additional, Han, Shuhong, additional, Hansen, James E., additional, Hasni, Sarfaraz A., additional, Hassan, Fadi, additional, Hedrich, Christian M., additional, Hiromura, Keiju, additional, Horowitz, Diane, additional, Huang, Xin, additional, Hunt, David, additional, Izmirly, Peter M., additional, James, Judith A., additional, Jarjour, Wael N., additional, Jefferies, Caroline A., additional, Jefferies, Caroline, additional, Jiang, Xiaoyue, additional, Kaplan, Mariana J., additional, Katsuyama, Takayuki, additional, Khamashta, Munther, additional, Kingsmore, Kathryn M., additional, Koike, Takao, additional, Kono, Dwight H., additional, Kriegel, Martin A., additional, Kuhn, Annegret, additional, Kyttaris, Vasileios C, additional, La Cava, Antonio, additional, Ladouceur, Alexandra, additional, Lahita, Robert G., additional, Landmann, Aysche, additional, Lazaro, Estibaliz, additional, Lennard Richard, Mara L., additional, Lino, Andreia C., additional, Lipsky, Peter E., additional, Liszewski, M. Kathryn, additional, Lo, Mindy S., additional, Lu, Qianjin, additional, Mahieu, Mary, additional, Malkiel, Susan, additional, Manzi, Susan, additional, Marder, Galina, additional, Mayadas, T.N., additional, Meroni, Pier Luigi, additional, Merrill, Joan T., additional, Mohan, Chandra, additional, Mok, Chi Chiu, additional, Moulton, Vaishali R., additional, Murray, Philip I., additional, Naffaa, Mohammad E., additional, Nangaku, Masaomi, additional, Niewold, Timothy, additional, Okubo, K., additional, Olsen, Nancy J., additional, Pal, Trina, additional, Paz, Ziv, additional, Perl, Andras, additional, Pons-Estel, Guillermo J., additional, Qu, Bo, additional, Rahman, Anisur, additional, Raman, Ziaur S.M., additional, Ramsey-Goldman, Rosalind, additional, Reeves, Westley H., additional, Richez, Christophe, additional, Rosetti, Florencia, additional, Rovin, Brad H., additional, Rubin, Robert L., additional, Saeli, Stephanie, additional, Saggu, G., additional, Sammaritano, Lisa R., additional, Satoh, Minoru, additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Sciascia, Savino, additional, Shaharir, Syahrul Sazliyana, additional, Sharabi, Amir, additional, Shen, Nan, additional, Shmerling, Robert H., additional, Simard, Julia F., additional, Sisirak, Vanja, additional, Slight-Webb, Samantha, additional, Stillman, Isaac Ely, additional, Sung, Sun-Sang J., additional, Thakkar, Payal, additional, Theofilopoulos, Argyrios N., additional, Thomas, Jr, Donald E., additional, Tissera, Hiromi, additional, Touma, Zahi, additional, Tsao, Betty P., additional, Ugarte-Gil, Manuel F., additional, Urowitz, Murray B., additional, Vieira, Silvio Manfredo, additional, Wainwright, Benjamin, additional, Wallace, Daniel J., additional, Wang, Hongyang, additional, Wu, Haijing, additional, Yahia, Soad Haj, additional, Yu, C. Yung, additional, Zhao, Zhenhuan, additional, and Zhuang, Haoyang, additional

Published
2021
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13. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Strand, Vibeke, primary, Jayne, David R W, additional, Horomanski, Audra, additional, Yue, Huibin, additional, Bekker, Pirow, additional, Merkel, Peter A, additional, Au Peh, Chen, additional, Chakera, Aron, additional, Cooper, Bruce, additional, Kurtkoti, Jagadeesh, additional, Langguth, Daman, additional, Levidiotis, Vicki, additional, Luxton, Grant, additional, Mount, Peter, additional, Mudge, David, additional, Noble, Euan, additional, Phoon, Richard, additional, Ranganathan, Dwarakanathan, additional, Ritchie, Angus, additional, Ryan, Jessica, additional, Suranyi, Michael, additional, Rosenkranz, Alexander, additional, Lhotta, Karl, additional, Kronbichler, Andreas, additional, Demoulin, Nathalie, additional, Bovy, Christophe, additional, Hellemans, Rachel, additional, Hougardy, Jean-Michel, additional, Sprangers, Ben, additional, Wissing, Karl Martin, additional, Pagnoux, Christian, additional, Barbour, Sean, additional, Brachemi, Soumeya, additional, Cournoyer, Serge, additional, Girard, Louis-Philippe, additional, Laurin, Louis-Philippe, additional, Liang, Patrick, additional, Philibert, David, additional, Walsh, Michael, additional, Tesar, Vladimir, additional, Becvar, Radim, additional, Horak, Pavel, additional, Rychlik, Ivan, additional, Szpirt, Wladimir, additional, Dieperink, Hans, additional, Gregersen, Jon Waarst, additional, Ivarsen, Per, additional, Krarup, Elizabeth, additional, Lyngsoe, Cecilie, additional, Rigothier, Claire, additional, Augusto, Jean-Francois, additional, Belot, Alexandre, additional, Chauveau, Dominique, additional, Cornec, Divi, additional, Jourde-Chiche, Noemie, additional, Ficheux, Maxence, additional, Karras, Alexandre, additional, Klein, Alexandre, additional, Maurier, Francois, additional, Mesbah, Rafik, additional, Moranne, Olivier, additional, Neel, Antoine, additional, Quemeneur, Thomas, additional, Saadoun, David, additional, Terrier, Benjamin, additional, Zaoui, Philippe, additional, Schaier, Matthias, additional, Benck, Urs Tobias, additional, Bergner, Raoul, additional, Busch, Martin, additional, Floege, Juergen, additional, Grundmann, Franziska, additional, Haller, Hermann, additional, Haubitz, Marion, additional, Hellmich, Bernhard, additional, Henes, Joerg Christoph, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Iking-Konert, Christof, additional, Arndt, Fabian, additional, Kubacki, T, additional, Kotter, Ina, additional, Lamprecht, Peter, additional, Lindner, Tom, additional, Halbritter, Jan, additional, Mehling, Heidrun, additional, Schönermarck, Ulf, additional, Venhoff, Nils, additional, Vielhauer, Volker, additional, Witzke, Oliver, additional, Szombati, Istvan, additional, Szucs, Gabriella, additional, Garibotto, Giacomo, additional, Alberici, Federico, additional, Brunetta, Enrico, additional, Dagna, Lorenzo, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Gabrielli, Armando, additional, Manenti, Lucio, additional, Pieruzzi, Federico, additional, Roccatello, Dario, additional, Salvarani, Carlo, additional, Harigai, Masayoshi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Fujimoto, Shoichi, additional, Hagino, Noboru, additional, Ihata, Atsushi, additional, Kaname, Shinya, additional, Kaneko, Yuko, additional, Katagiri, Akira, additional, Katayama, Masao, additional, Kirino, Yohei, additional, Kitagawa, Kiyoki, additional, Komatsuda, Atsushi, additional, Kono, Hajime, additional, Kurasawa, Takahiko, additional, Matsumura, Ryutaro, additional, Mimura, Toshihide, additional, Morinobu, Akio, additional, Murakawa, Yohko, additional, Naniwa, Taio, additional, Nanki, Toshihiro, additional, Ogawa, Noriyoshi, additional, Oshima, Hisaji, additional, Sada, Kenei, additional, Sugiyama, Eiji, additional, Takeuchi, Tohru, additional, Taki, Hirofumi, additional, Tamura, Naoto, additional, Tsukamoto, Tatsuo, additional, Yamagata, Kunihiro, additional, Yamamura, Masahiro, additional, van Daele, Paulus Leon Arthur, additional, Rutgers, Abraham, additional, Teng, Y.K. Onno, additional, Walker, Robert, additional, Chua, Ignatius, additional, Collins, Michael, additional, Rabindranath, Kannaiyan, additional, de Zoysa, Janak, additional, Svensson, My Hanna Sofia, additional, Grevbo, Bard-Waldum, additional, Kalstad, Synove, additional, Little, Mark, additional, Clarkson, Michael, additional, Molloy, Eamonn, additional, Agraz Pamplona, Irene, additional, Anton, Jordi, additional, Barrio Lucia, Vicente, additional, Ciggaran, Secundino, additional, Cinta Cid, Maria, additional, Diaz Encarnacion, Montserrat, additional, Fulladosa Oliveras, Xavier, additional, Jose Soler, Maria, additional, Marco Rusinol, Helena, additional, Praga, Manuel, additional, Quintana Porras, Luis, additional, Segarra, Alfons, additional, Bruchfeld, Annette, additional, Segelmark, Marten, additional, Soveri, Inga, additional, Thomaidi, Eleni, additional, Westman, Kerstin, additional, Neumann, Thomas, additional, Burnier, Michel, additional, Daikeler, Thomas, additional, Dudler, Jean, additional, Hauser, Thomas, additional, Seeger, Harald, additional, Vogt, Bruno, additional, Burton, James, additional, Al Jayyousi, Reem, additional, Amin, Tania, additional, Andrews, Jacqueline, additional, Baines, Laura Anne, additional, Brogan, Paul, additional, Dasgupta, Bhaskar, additional, Doulton, Timothy William Ronald, additional, Flossmann, Oliver, additional, Griffin, Sian V., additional, Harper, Janice Marian, additional, Harper, Lorraine, additional, Kidder, Dana, additional, Klocke, Rainer, additional, Lanyon, Peter Charles, additional, Luqmani, Raashid, additional, McLaren, John Stuart, additional, Makanjuola, David Osagie, additional, McCann, Liza, additional, Nandagudi, Anupama C., additional, Selvan, Shilpa, additional, O'Riordan, Edmond, additional, Patel, Mumtaz, additional, Patel, Rajan Kantilal, additional, Pusey, Charles Dickson, additional, Rajakariar, Ravindra, additional, Robson, Joanna C., additional, Robson, Michael, additional, Salama, Alan David, additional, Smyth, Lucy, additional, Sznajd, Jan, additional, Taylor, Joanne, additional, Sreih, Antonie G., additional, Belilos, Elise, additional, Bomback, Andrew S., additional, Carlin, Jeffrey, additional, Chang Chen Lin, Yih, additional, Derebail, Vimal K., additional, Dragoi, Serban, additional, Dua, Anisha, additional, Forbess, Lindsy, additional, Geetha, Duvuru, additional, Gipson, Patrick, additional, Gohh, Reginald, additional, Greenwood, Gregory Todd, additional, Hugenberg, Steven T., additional, Jimenez, Richard A.H., additional, Kaskas, Marwan Omar, additional, Kermani, Tanaz, additional, Kivitz, Alan J., additional, Koening, Curry, additional, Langford, Carol A., additional, Marder, Galina, additional, Mohamed, Amr Ahmed El-Huesseini, additional, Monach, Paul, additional, Neyra, Nilda Roxana, additional, Niemer, Gregory W., additional, Niles, John, additional, Obi, Reginald, additional, Owens, Charles, additional, Parks, Deborah L., additional, Podoll, Amber S., additional, Rovin, Brad, additional, Sam, R, additional, Shergy, William Julius, additional, Silva, Arnold Lawrence, additional, Specks, Ulrich, additional, Spiera, Robert, additional, Springer, Jason M., additional, Striebich, Christopher Charles, additional, Swarup, Areena, additional, Thakar, Surabhi, additional, Tiliakos, Athan N., additional, Tsai, Yong, additional, Waguespack, Dia R., additional, and Chester Wasko, Mary, additional

Published
2023
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14. A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

Author

Callejas, José Luis, Caminal-Montero, Luis, Corbera-Bellalta, Marc, de Miguel, Eugenio, López, J. Bernardino Díaz, García-Villanueva, María Jesús, Gómez-Vaquero, Carmen, Guijarro-Rojas, Mercedes, Hidalgo-Conde, Ana, Marí-Alfonso, Begoña, Berriochoa, Agustín Martínez, Zapico, Aleida Martínez, Martínez-Taboada, Víctor Manuel, Miranda-Filloy, José A., Monfort, Jordi, Ortego-Centeno, Norberto, Pérez-Conesa, Mercedes, Prieto-González, Sergio, Raya, Enrique, Fernández, Raquel Ríos, Sánchez-Martín, Julio, Sopeña, Bernardo, Tío, Laura, Unzurrunzaga, Ainhoa, Gough, Andrew, Isaacs, John D., Green, Michael, McHugh, Neil, Hordon, Lesley, Kamath, Sanjeet, Nisar, Mohammed, Patel, Yusuf, Yee, Cee-Seng, Stevens, Robert, Nandi, Pradip, Nandagudi, Anupama, Jarrett, Stephen, Li, Charles, Levy, Sarah, Mollan, Susan, Salih, Abdel, Wordsworth, Oliver, Sanders, Emma, Roads, Esme, Gill, Anne, Carr, Lisa, Routledge, Christine, Culfear, Karen, Nugaliyadde, Asanka, James, Lynne, Spimpolo, Jenny, Kempa, Andy, Mackenzie, Felicity, Fong, Rosanna, Peters, Genessa, Rowbotham, Bridie, Masqood, Zahira, Hollywood, Jane, Gondo, Prisca, Wood, Rose, Martin, Steve, Rashid, Lubna Haroon, Robinson, James I., Morgan, Mike, Sorensen, Louise, Taylor, John, Carette, Simon, Chung, Sharon, Cuthbertson, David, Forbess, Lindsy J., Gewurz-Singer, Ora, Hoffman, Gary S., Koening, Curry L., Maksimowicz-McKinnon, Kathleen M., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Spiera, Robert F., Sreih, Antoine, Warrington, Kenneth J., Weisman, Michael, Carmona, F. David, Vaglio, Augusto, Mackie, Sarah L., Hernández-Rodríguez, José, Monach, Paul A., Castañeda, Santos, Solans, Roser, Morado, Inmaculada C., Narváez, Javier, Ramentol-Sintas, Marc, Pease, Colin T., Dasgupta, Bhaskar, Watts, Richard, Khalidi, Nader, Langford, Carol A., Ytterberg, Steven, Boiardi, Luigi, Beretta, Lorenzo, Govoni, Marcello, Emmi, Giacomo, Bonatti, Francesco, Cimmino, Marco A., Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Sailler, Laurent, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Øyvind, Diamantopoulos, Andreas P., Voskuyl, Alexandre, Brouwer, Elisabeth, Daikeler, Thomas, Berger, Christoph T., Molloy, Eamonn S., O’Neill, Lorraine, Blockmans, Daniel, Lie, Benedicte A., Mclaren, Paul, Vyse, Timothy J., Wijmenga, Cisca, Allanore, Yannick, Koeleman, Bobby P.C., Barrett, Jennifer H., Cid, María C., Salvarani, Carlo, Merkel, Peter A., Morgan, Ann W., González-Gay, Miguel A., and Martín, Javier

Published
2017
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17. Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: an international randomised controlled trial

Author

Smith, Rona M, primary, Jones, Rachel B, additional, Specks, Ulrich, additional, Bond, Simon, additional, Nodale, Marianna, additional, Al-jayyousi, Reem, additional, Andrews, Jacqueline, additional, Bruchfeld, Annette, additional, Camilleri, Brian, additional, Carette, Simon, additional, Cheung, Chee Kay, additional, Derebail, Vimal, additional, Doulton, Tim, additional, Ferraro, Alastair, additional, Forbess, Lindsy, additional, Fujimoto, Shouichi, additional, Furuta, Shunsuke, additional, Gewurz-Singer, Ora, additional, Harper, Lorraine, additional, Ito-Ihara, Toshiko, additional, Khalidi, Nader, additional, Klocke, Rainer, additional, Koening, Curry, additional, Komagata, Yoshinori, additional, Langford, Carol, additional, Lanyon, Peter, additional, Luqmani, Raashid, additional, McAlear, Carol, additional, Moreland, Larry W, additional, Mynard, Kim, additional, Nachman, Patrick, additional, Pagnoux, Christian, additional, Peh, Chen Au, additional, Pusey, Charles, additional, Ranganathan, Dwarakanathan, additional, Rhee, Rennie L, additional, Spiera, Robert, additional, Sreih, Antoine G, additional, Tesar, Vladamir, additional, Walters, Giles, additional, Wroe, Caroline, additional, Jayne, David, additional, and Merkel, Peter A, additional

Published
2023
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18. A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Author

Martínez-Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo-Conde, Ana, Madroñero-Vuelta, Ana B., Fernández-Nebro, Antonio, Ordóñez-Cañizares, M. Carmen, Escalante, Begoña, Marí-Alfonso, Begoña, Sopeña, Bernardo, Magro, César, Raya, Enrique, Grau, Elena, Román, José A., de Miguel, Eugenio, López-Longo, F. Javier, Martínez, Lina, Gómez-Vaquero, Carmen, Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Luis, Díaz-López, J. Bernardino, Caminal-Montero, Luis, Martínez-Zapico, Aleida, Monfort, Jordi, Tío, Laura, Sánchez-Martín, Julio, Alegre-Sancho, Juan J., Sáez-Comet, Luis, Pérez-Conesa, Mercedes, Corbera-Bellalta, Marc, García-Villanueva, M. Jesús, Fernández-Contreras, M. Encarnación, Sanchez-Pernaute, Olga, Blanco, Ricardo, Ortego-Centeno, Norberto, Ríos-Fernández, Raquel, Callejas, José L., Fanlo-Mateo, Patricia, Martínez-Taboada, Víctor M., Carmona, F. David, Mackie, Sarah L., Martín, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castañeda, Santos, Cid, Maria C., Hernández-Rodríguez, José, Prieto-González, Sergio, Solans, Roser, Ramentol-Sintas, Marc, González-Escribano, M. Francisca, Ortiz-Fernández, Lourdes, Morado, Inmaculada C., Narváez, Javier, Miranda-Filloy, José A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schönau, Verena, Franke, Andre, Palm, Øyvind, Molberg, Øyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Gregersen, Peter K., Pease, Colin T., Gough, Andrew, Green, Michael, Hordon, Lesley, Jarrett, Stephen, Watts, Richard, Levy, Sarah, Patel, Yusuf, Kamath, Sanjeet, Dasgupta, Bhaskar, Worthington, Jane, Koeleman, Bobby P.C., de Bakker, Paul I.W., Barrett, Jennifer H., Salvarani, Carlo, Merkel, Peter A., González-Gay, Miguel A., Morgan, Ann W., and Martín, Javier

Published
2015
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20. Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: an international randomised controlled trial

Author

Smith, Rona M, Jones, Rachel B, Specks, Ulrich, Bond, Simon, Nodale, Marianna, Al-Jayyousi, Reem, Andrews, Jacqueline, Bruchfeld, Annette, Camilleri, Brian, Carette, Simon, Cheung, Chee Kay, Derebail, Vimal, Doulton, Tim, Ferraro, Alastair, Forbess, Lindsy, Fujimoto, Shouichi, Furuta, Shunsuke, Gewurz-Singer, Ora, Harper, Lorraine, Ito-Ihara, Toshiko, Khalidi, Nader, Klocke, Rainer, Koening, Curry, Komagata, Yoshinori, Langford, Carol, Lanyon, Peter, Luqmani, Raashid, McAlear, Carol, Moreland, Larry W, Mynard, Kim, Nachman, Patrick, Pagnoux, Christian, Peh, Chen Au, Pusey, Charles, Ranganathan, Dwarakanathan, Rhee, Rennie L, Spiera, Robert, Sreih, Antoine G, Tesar, Vladamir, Walters, Giles, Wroe, Caroline, Jayne, David, Merkel, Peter A, RITAZAREM Co-Investigators, Smith, Rona M [0000-0002-7438-5156], Nodale, Marianna [0000-0002-0333-8918], Fujimoto, Shouichi [0000-0002-0025-4030], Furuta, Shunsuke [0000-0003-2482-2685], Harper, Lorraine [0000-0003-1343-9234], Khalidi, Nader [0000-0002-8270-2617], Rhee, Rennie L [0000-0002-4907-0304], Spiera, Robert [0000-0003-2911-6800], Walters, Giles [0000-0003-4854-9353], Jayne, David [0000-0002-1712-0637], and Apollo - University of Cambridge Repository

Subjects
granulomatosis with polyangiitis, Remission Induction, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antibodies, Antineutrophil Cytoplasmic, rituximab, Treatment Outcome, Recurrence, Azathioprine, B-lymphocytes, therapeutics, Humans, systemic vasculitis, Cyclophosphamide, Immunosuppressive Agents
Abstract

Peer reviewed: True, Acknowledgements: The RITAZAREM trial is directed by the European Vasculitis Society and the Vasculitis Clinical Research Consortium (VCRC). The primary sponsor is Cambridge University Hospitals NHS Foundation Trust, and there are collaboration and data-sharing agreements with the University of Pennsylvania and the University of Miyazaki and Okayama University in Japan., Funder: Research Committee on Intractable Vasculitides, the Ministry of Health, Labour and Welfare of Japan, OBJECTIVE: Following induction of remission with rituximab in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) relapse rates are high, especially in patients with history of relapse. Relapses are associated with increased exposure to immunosuppressive medications, the accrual of damage and increased morbidity and mortality. The RITAZAREM trial compared the efficacy of repeat-dose rituximab to daily oral azathioprine for prevention of relapse in patients with relapsing AAV in whom remission was reinduced with rituximab. METHODS: RITAZAREM was an international randomised controlled, open-label, superiority trial that recruited 188 patients at the time of an AAV relapse from 29 centres in seven countries between April 2013 and November 2016. All patients received rituximab and glucocorticoids to reinduce remission. Patients achieving remission by 4 months were randomised to receive rituximab intravenously (1000 mg every 4 months, through month 20) (85 patients) or azathioprine (2 mg/kg/day, tapered after month 24) (85 patients) and followed for a minimum of 36 months. The primary outcome was time to disease relapse (either major or minor relapse). RESULTS: Rituximab was superior to azathioprine in preventing relapse: HR 0.41; 95% CI 0.27 to 0.61, p

Published
2023
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22. Contributors

Author

Abida, Rym, Aftab, Iqra, Ahearn, Joseph M., Alarcón, Graciela S., Amarnani, Abhimanyu, Askanase, Anca, Atisha-Fregoso, Yemil, Aviña-Zubieta, J. Antonio, Bacalao, Maria, Baer, Alan N., Ben-Zvi, Ayal, Bernatsky, Sasha, Bichile, Tanmayee, Blanco, Irene, Bowman, Simon, Bruce, Ian N., Brunner, Hermine I., Bukiri, Heather, Buyon, Jill P., Cabling, Marven G., Chaichian, Yashaar, Chakravarty, Eliza F., Choi, May Y., Chong, Benjamin F., Cohan, Pejman, Cohen, Hannah, Costenbader, Karen H., Crispín, José C., Crow, Mary K., Daftarian, Narsis, Dall’Era, Maria, Davidson, Anne, Diamond, Betty, Drenkard, Cristina, Dumusc, Alexandre, Dvorkina, Olga, Elkon, Keith B., Esdaile, John M., Farina, Nicola, Jimenez, Dominique Feterman, Fisher, Benjamin A., Forbess, Lindsy J., Fox, Carla M., Fox, Robert I., Frame, Elizabeth W., Friedman, Deborah, Furie, Richard, Ghetie, Daniela, Giles, Ian I., Ginzler, Ellen M., Guthridge, Joel M., Hagiwara, Audrey M., Hahn, Bevra Hannahs, Hanly, John G., Hiepe, Falk, Hile, Grace A., Hou, Guojun, Humrich, Jens Y., Imundo, Lisa, Ioannou, Yiannis, Isenberg, David A., Ishimori, Mariko L., Izmirly, Peter M., James, Judith A., Jefferies, Caroline A., Jolly, Meenakshi, Kahlenberg, J. Michelle, Kalunian, Kenneth, Kamen, Diane L., Karim, Samiha T., Karp, David R., Karpouzas, George A., Kehl, Amy, Kilian, Adam, Kim, Alfred H.J., Kirou, Kyriakos A., Kolasinski, Sharon L., Kono, Dwight H., Kono, Michihito, Cava, Antonio La, Lee, Christine H., Legge, Alexandra, Lim, Lyndell L., Lim, S. Sam, Liu, Chau-Ching, Lood, Christian, Mak, Anselm, Manocha, Sonia, Manzi, Susan, Mariette, Xavier, McMahon, Maureen A., Means, Terry K., Mejia-Vilet, Juan M., Mendel, Arielle, Moore, Erica, Moore, Richard E., Morand, Eric, Murphy, Grainne, Nataraja, Champa, Nayar, Saba, Niewold, Timothy B., Nocturne, Gaetane, Nowling, Tamara K., Oates, Jim C., Oberst, Andrew, Ogbu, Ekemini A., Olsen, Nancy J., Parker, Ben, Pasadhika, Sirichai, Perl, Andras, Petri, Michelle, Pimentel-Quiroz, Victor R., Putterman, Chaim, Rahman, Anisur, Riemekasten, Gabriela, Rosenbaum, James T., Rovin, Brad H., Sammaritano, Lisa R., Sandhu, Vaneet K., Schuler, Andrew, Sheikh, Saira Z., Shen, Nan, Shen, Yiwei, Silverman, Gregg J., Skaggs, Brian, Su, Valerie L., Sun, Enid Y., Tang, Yuanjia, Tohidi-Esfahani, Ibrahim, Topilow, James, Torralba, Karina D., Tsao, Betty P., Tsokos, George C., Ugarte-Gil, Manuel F., Vara, Emily L., Venuturupalli, Swamy, Volkmann, Elizabeth R., Wagner, Catriona A., Wainwright, Benjamin, Wallace, Daniel J., Wang, Runci, Weinberg, Stacy, Werth, Victoria P., Xiang, Chunyan, Yang, Wanling, Yazdany, Jinoos, Yiu, Gloria, Zhang, Yutong, Zickuhr, Lisa, and Zou, Yong-Rui

Published
2025
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26. Neutrophils Contribute to ER Stress in Lung Epithelial Cells in the Pristane-Induced Diffuse Alveolar Hemorrhage Mouse Model

Author

Tumurkhuu, Gantsetseg, primary, Laguna, Duygu Ercan, additional, Moore, Richard E., additional, Contreras, Jorge, additional, Santos, Gabriela De Los, additional, Akaveka, Luisa, additional, Montano, Erica N., additional, Wang, Yizhou, additional, Ishimori, Mariko, additional, Venuturupalli, Swamy, additional, Forbess, Lindsy J., additional, Stripp, Barry R., additional, Wallace, Daniel J., additional, and Jefferies, Caroline A., additional

Published
2022
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28. Neutrophils contribute to ER stress in lung epithelial cells in the pristane-induced diffuse alveolar hemorrhage mouse model

Author

Tumurkhuu, Gantsetseg, primary, Laguna, Duygu Ercan, additional, Moore, Richard E., additional, Contreras, Jorge, additional, De Los Santos, Gabriela, additional, Akaveka, Luisa, additional, Montano, Erica N., additional, Wang, Yizhou, additional, Ishimori, Mariko, additional, Venuturupalli, Swamy, additional, Forbess, Lindsy, additional, Stripp, Barry R., additional, Wallace, Daniel J., additional, and Jefferies, Caroline A., additional

Published
2021
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29. The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial

Author

Odler, Balazs, Riedl, Regina, Geetha, Duvuru, Szpirt, Wladimir M., Hawley, Carmel, Uchida, Lisa, Wallace, Zachary S., Walters, Giles, Muso, Eri, Tesar, Vladimir, Pusey, Charles D., Little, Mark A., Merkel, Peter A., Walsh, Michael, Jayne, David R.W., Kronbichler, Andreas, Paizis, Kathy, Walters, Giles, Jardine, Meg, Milton, Caroline, Ibraham, Abu, Siva, Brian, Desmond, Michael, Perkovic, Vlado, Kurtkoti, Jadadeesh, Vilayur, Eswari, Cass, Alan, Summers, Shaun, Brown, Fiona, Ryan, Jessica, Kerr, Peter, Noble, Euan, Luxton, Grant, Mudge, David W., Hawley, Carmel, Johnson, David W., Peh, Chen Au, Faull, Randall J., Ranganathan, Dwarakanathan, Jeffs, Lisa, Nicholls, Kathy, Hughes, Peter, Cooper, Bruce, Boudville, Neil, Ford, Sharon, Langham, Robyn, Reidlinger, Donna, AliciaMorrish, Badve, Sunil V., Pascoe, Elaine, Paul-Brent, Peta-Anne, Robison, Laura, Valks, Andrea, Blockmans, Daniel, Henckaerts, Liesbet, Sprangers, Ben, Suri, Rita, Brachemi, Soumeya, Clark, William, Garg, Amit, Carette, Simon, Pagnoux, Christian, Reich, Heather, Barth, David, Walsh, Michael, Khalidi, Nader, Cox, Gerry, Mazzetti, Andrea, Robins, Diane, Wald, Ron, Perl, Jeffrey, Pavenski, Katerina, Dacouris, Niki, Levin, Adeera, Copland, Michael, Fairhead, Todd, Pannu, Neesh, Qarni, Muhammad Uwais, Habib, Syed, Girard, Louis, Manns, Braden, Tesar, Vladimir, Hruskova, Zdenka, Chocova, Zdenka, Povlsen, Johan, Gregersen, Jon, Ivarsen, Per, Birn, Henrik, Krarup, Elizabeth, Pedersen, Erling B., Thomsen, Ingrid, Bech, Jesper Nørgaard, Szpirt, Wladmir, Egfjord, Martin, Mesbah, Rafik, Bataille, Pierre, Rey, Isabelle, Chantrel, François, Vanhille, Philipe, Quémeneur, Thomas, Carron, Pierre-Louis, Zaoui, Philippe, de Moreuil, Claire, Gosselin, Morgane, Delluc, Aurélien, Hanrotel-Saliou, Catherine, Le Jeune, Mathilde, Ficheux, Maxence, Aniort, Julien, Lavigne, Christian, Augusto, Jean Francois, Chauveau, Dominique, Guitard, Joëlle, Huart, Antoine, Ribes, David, Gatault, Philippe, Becmeur, Camille, Muller, Sandrine, Betz, Valérie, Klein, Alexandre, Blaison, Gilles, Seror, Raphaele, Francois, Hélène, Mariette, Xavier, Aubrun, Aurore, Coustet, Baptiste, Palazzo, Elisabeth, Ottaviani, Sébastien, Goulenok, Tiphaine, Daugas, Eric, Dieudé, Philipe, Papo, Thomas, Lebas, Céline, Lionet, Arnaud, Guillevin, Loïc, Mouthon, Luc, Puéchal, Xavier, Jourde-Chiche, Noémie, Ruivard, Marc, Karras, Alexandre, Limal, Nicolas, Kofman, Thomas, Le Quellec, Alain, Maurier, François, Gibelin, Aude, Parrot, Antoine, Bachmeyer, Claude, Gombert, Bruno, Nouvier, Mathilde, Lega, Jean-Christophe, Fain, Olivier, Andrès, Emmanuel, Cottet, Rachel, Gregorini, Gina, Jeannin, Guido, Possenti, Stefano, Buzio, Carlo, Vaglio, Augusto, Oliva, Elena, Makino, Hirofumi, Muso, Eri, Endo, Tomomi, Kakita, Hiroko, Suzuki, Hiroyuki, Handa, Takaya, Kang, Youngna, Ariyasu, Yuki, Tsukamoto, Tatsuo, Endo, Shuichiro, Miyata, Hitomi, Yamada, Hiroyuki, Ito-Ihara, Toshiko, Uchida, Shunya, Kono, Hajime, Fujigaki, Yoshihide, Kikuchi, Hirotoshi, Nanki, Toshihiro, Kato, Hideki, Okamoto, Akiko, Asako, Kurumi, Suzuki, Kazuo, Hamano, Yoshitomo, Yamagata, Kunihiro, Usui, Joichi, Fujimoto, Shouichi, Sato, Yuji, Kikuchi, Masao, Flores-Suárez, Luis Felipe, Sánchez-Guerrero, Sergio A., Collins, Michael, Schollum, John, de Zoysa, Janak, Quincy, Vicki, Sizeland, Peter, Aasarod, Knut, Solbu, Marit, Bruun, Trude Jannecke, Koldingsnes, Wenche, Wludarczyk, Anna, Nowak, Ilona, Gorka, Jacek, Sznajd, Jan, Padjas, Agnieszka, Jankowski, Milosz, Widawska, Agnieszka, Szczeklik, Wojciech, Ballarin, Jose, Bruchfeld, Annette, Efvergren, Mats, Eriksson, Per, Westman, Kerstin, Selga, Daina, Heijl, Caroline, Ohlsson, Sophie, Segelmark, Marten, Basu, Neil, Kidder, Dana, Fluck, Nicholas, Jayne, David R.W., Smith, Rona, Wilcocks, Lisa, McClure, Mark, Jones, Rachel, Trivedi, Sapna, Gopaluni, Seerapani, Brettell, Elizabeth, Crump, Paul, Feilbach, Annika, Hewitt, Catherine, Hilken, Nick, Howman, Andrew, Hughes, Terry, Ives, Natalie, Jarrett, Hugh, Mehta, Samir, Record, Rebecca, Ryan, Gemma, Sidile, Chaka, Wheatley, Keith, Sheerin, Brown, Alison, Baines, Laura Anne, Lordan, Jim, Pusey, Charles, Tanna, Anisha, McAdoo, Stephen, Levy, Jeremy, Griffith, Megan, Klebe, Bernhard, Doulton, Timothy, Warwick, Graham, Burton, James, Barratt, Jonathon, Topham, Peter, Baines, Richard, Brunskill, Nigel, Al-Jayyousi, Reem, Hamilton, Patrick, Patel, Mumtaz, Mitra, Sandip, Brown, Nina, Sharples, Edward, Luqmani, Raashid, Harper, Lorraine, Rhodes, Benjamin, Chanouzas, Dimitrios, Morgan, Matthew, Hewins, Peter, Floßmann, Oliver, Bhandary, Nitin, Foxton, Julie, Jones, Linda, King, Jenny, Smyth, Lucy, D’Souza, Richard, Haigh, Richard, Hough, Maxine, Smyth, Lucy, Haigh, Richard, Hough, Maxine, Salama, Alan, Burns, Aine, Little, Mark, Dhaun, Neeraj, Dhaygude, Ajay, Basnayake, Kolitha, Iggo, Neil, Jones, Daniel, Oliveira, David, MacPhee, Iain A.M., Dunn, Emma, Lewington, Andrew J.P., Fan, Stanley Linsun, Rajakariar, Ravindra, Yaqoob, Magdi, Short, Andrew, Geddes, Colin, Mackinnon, Bruce, Jardine, Alan G., Monach, Paul, Merkel, Peter A., Amudala, Naomi, Quillen, Karen, Weisman, Michael, Wallace, Daniel, Forbess, Lindsy, Venuturupalli, Swamy, Langford, Carol, Hajj-Ali, Rula, Koo, Anna, Hoffman, Gary, Specks, Ulrich, Keogh, Karina, Ytterberg, Steven, Winters, Jeff, Warrington, Kenneth, Cartin-Ceba, Rodrigo, Peikert, Tobias, Fervenza, Fernando, Baqir, Misbah, Nachman, Patrick, Detwiler, Randy, Mottl, Amy, Derebail, Vimal, McGregor, JulieAnne, Merkel, Peter A., Sreih, Antoine, Rhee, Rennie, McAlear, Carol, Aqui, Nicole, Moreland, Larry, Kiss, Joseph, Liang, Kimberly, Mohan, Niveditha, Balogun, Rasheed, Li, Tingting, and Brasington, Richard

Abstract

Therapeutic plasma exchange (PLEX) is an adjunctive treatment for patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and kidney involvement. Little is known about the effect of PLEX on early changes in kidney function. This post-hocanalysis of the PEXIVAS trial investigated the effects of PLEX on changes in kidney function within 12 months. PEXIVAS was a randomized controlled trial recruiting 691 patients with ANCA-associated glomerulonephritis, of whom 349 underwent PLEX and 342 received no-PLEX. The primary outcomes of this post hocstudy of PEXIVAS were change in estimated glomerular filtration rate (eGFR) from baseline and recovery of kidney function (defined as eGFR increase of 15ml/min/1.73m2or more). Baseline eGFR was 21.7 ± 20.3 and 20.6 ± 18.7 ml/min/1.73m2in the PLEX and no-PLEX groups, respectively. Mean improvements in eGFR at weeks two, four, and eight after initiation of therapy were greater for the PLEX vs. the no-PLEX groups. The greatest significant difference in recovery of kidney function in the PLEX compared to the no-PLEX groups was at week four (relative risk (RR): 1.41; 95% confidence interval:1.09-1.82). Increased eGFR or recovery of kidney function at week four were significantly associated with lower risk for end-stage kidney disease at week 52 (RR: 0.96: 0.95-0.97, and RR: 0.29: 0.16-0.52; respectively). Neither changes in eGFR nor recovery of kidney function differed by reduced- compared to standard-dose glucocorticoid group. Overall, our study indicates that PLEX improves early kidney function in patients with ANCA-associated glomerulonephritis.

Published
2025
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30. Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis

Author

Smith, Rona M, Jones, Rachel Bronwen, Specks, Ulrich, Bond, Simon, Nodale, Marianna, Aljayyousi, Reem, Andrews, Jacqueline, Bruchfeld, Annette, Camilleri, Brian, Carette, Simon, Cheung, Chee Kay, Derebail, Vimal, Doulton, Tim, Forbess, Lindsy, Fujimoto, Shouichi, Furuta, Shunsuke, Gewurz-Singer, Ora, Harper, Lorraine, Ito-Ihara, Toshiko, Khalidi, Nader, Klocke, Rainer, Koening, Curry, Komagata, Yoshinori, Langford, Carol, Lanyon, Peter, Luqmani, Raashid Ahmed, Makino, Hirofumi, McAlear, Carole, Monach, Paul, Moreland, Larry W, Mynard, Kim, Nachman, Patrick, Pagnoux, Christian, Pearce, Fiona, Peh, Chen Au, Pusey, Charles, Ranganathan, Dwarakanathan, Rhee, Rennie L, Spiera, Robert, Sreih, Antoine G, Tesar, Vladimir, Walters, Giles, Weisman, Michael H, Wroe, Caroline, Merkel, Peter, Jayne, David, RITAZAREM Co-Investigators, Arimura, Y, Clarkson, M, De Zoysa, J, Endo, T, Hamano, Y, Kono, H, Lawman, S, Muso, E, Sada, K, Smith, R, Suzuki, K, Tsukamoto, T, Uchida, S, Vaglio, A, Watts, R, Smith, Rona M [0000-0002-7438-5156], Jones, Rachel Bronwen [0000-0003-4790-283X], Nodale, Marianna [0000-0002-0333-8918], Harper, Lorraine [0000-0003-1343-9234], Rhee, Rennie L [0000-0002-4907-0304], Walters, Giles [0000-0003-4854-9353], and Apollo - University of Cambridge Repository

Subjects
Vasculitis, B cells, granulomatosis with polyangiitis, treatment, systemic vasculitis
Abstract

Funder: Research Committee on Intractable Vasculitides; The Ministry of Health, Labour and Welfare of Japan., Objectives: Evaluation of rituximab and glucocorticoids as therapy to induce remission after relapse in ANCA-associated vasculitis (AAV) in a prospective observational cohort of patients enrolled into the induction phase of the RITAZAREM trial. Methods: Patients relapsing with granulomatosis with polyangiitis or microscopic polyangiitis were prospectively enrolled and received remission-induction therapy with rituximab (4×375 mg/m2) and a higher or lower dose glucocorticoid regimen, depending on physician choice: reducing from either 1 mg/kg/day or 0.5 mg/kg/day to 10 mg/day by 4 months. Patients in this cohort achieving remission were subsequently randomised to receive one of two regimens to prevent relapse. Results: 188 patients were studied: 95/188 (51%) men, median age 59 years (range 19–89), prior disease duration 5.0 years (range 0.4–34.5). 149/188 (79%) had previously received cyclophosphamide and 67/188 (36%) rituximab. 119/188 (63%) of relapses had at least one major disease activity item, and 54/188 (29%) received the higher dose glucocorticoid regimen. 171/188 (90%) patients achieved remission by 4 months. Only six patients (3.2% of the study population) did not achieve disease control at month 4. Four patients died in the induction phase due to pneumonia (2), cerebrovascular accident (1), and active vasculitis (1). 41 severe adverse events occurred in 27 patients, including 13 severe infections. Conclusions: This large prospective cohort of patients with relapsing AAV treated with rituximab in conjunction with glucocorticoids demonstrated a high level of efficacy for the reinduction of remission in patients with AAV who have relapsed, with a similar safety profile to previous studies.

Published
2020
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31. MR Multitasking for Multi-dimensional Assessment of Cardiovascular System (MT-MACS): Development and Feasibility Study on the Thoracic Aorta

Author

Hu, Zhehao, Christodoulou, Anthony G., Wang, Nan, Shaw, Jaime L., Song, Shlee S., Maya, Marcel M., Ishimori, Mariko L., Forbess, Lindsy J., Xiao, Jiayu, Bi, Xiaoming, Han, Fei, Li, Debiao, and Fan, Zhaoyang

Subjects
Magnetic Resonance Spectroscopy, Aortic Diseases, Feasibility Studies, Humans, Reproducibility of Results, Aorta, Thoracic, Article
Abstract

PURPOSE: To develop an MR MultiTasking (MT) based Multi-dimensional Assessment of Cardiovascular System (MACS) with ECG- and navigator-free data acquisition for a comprehensive evaluation of thoracic aortic diseases. METHODS: MT-MACS adopts a low-rank tensor image model with a cardiac time dimension for phase-resolved cine imaging and a T2-prepared inversion recovery dimension for multi-contrast assessment. Twelve healthy subjects and two patients with thoracic aortic diseases were recruited for the study at 3T, and both qualitative (image quality score) and quantitative (contrast-to-noise ratio [CNR] between lumen and wall, lumen [LA] and wall area [WA], aortic strain index) analyses were performed in all healthy subjects. The overall image quality was scored based on a 4-point scale: 3-excellent, 2-good, 1-fair and 0-poor. Statistical analysis was used to test the measurement agreement between MT-MACS and their corresponding 2D references. RESULTS: MT-MACS images reconstructed from acquisitions as short as 6 minutes demonstrated good or excellent image quality for bright-blood (2.58±0.46), dark-blood (2.58±0.50) and gray-blood (2.17±0.53) contrast weightings, respectively. The CNRs for the three weightings were 49.2±12.8, 20.0±5.8 and 2.8±1.8, respectively. There were good agreements in the lumen and wall area (intraclass correlation coefficient [ICC]=0.993, P

Published
2020

35. Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis

Author

Smith, Rona M, primary, Jones, Rachel Bronwen, additional, Specks, Ulrich, additional, Bond, Simon, additional, Nodale, Marianna, additional, Aljayyousi, Reem, additional, Andrews, Jacqueline, additional, Bruchfeld, Annette, additional, Camilleri, Brian, additional, Carette, Simon, additional, Cheung, Chee Kay, additional, Derebail, Vimal, additional, Doulton, Tim, additional, Forbess, Lindsy, additional, Fujimoto, Shouichi, additional, Furuta, Shunsuke, additional, Gewurz-Singer, Ora, additional, Harper, Lorraine, additional, Ito-Ihara, Toshiko, additional, Khalidi, Nader, additional, Klocke, Rainer, additional, Koening, Curry, additional, Komagata, Yoshinori, additional, Langford, Carol, additional, Lanyon, Peter, additional, Luqmani, Raashid Ahmed, additional, Makino, Hirofumi, additional, McAlear, Carole, additional, Monach, Paul, additional, Moreland, Larry W, additional, Mynard, Kim, additional, Nachman, Patrick, additional, Pagnoux, Christian, additional, Pearce, Fiona, additional, Peh, Chen Au, additional, Pusey, Charles, additional, Ranganathan, Dwarakanathan, additional, Rhee, Rennie L, additional, Spiera, Robert, additional, Sreih, Antoine G, additional, Tesar, Vladimir, additional, Walters, Giles, additional, Weisman, Michael H, additional, Wroe, Caroline, additional, Merkel, Peter, additional, and Jayne, David, additional

Published
2020
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36. Contributors

Author

Abelson, Abby G., Abraham, Mary, Abramson, Steven B., Adachi, Jonathan D., Aggarwal, Rohit, Akira, Shizuo, Aletaha, Daniel, Ashraf Ali, Amjid, Allem, Kavitta B., Almehthel, Mohammed, Almohaya, Mohammed, Riera Alonso, Elena, Amigo, Mary-Carmen, Aringer, Martin, Arkema, Elizabeth V., Ascherman, Dana P., Atamas, Sergei P., Atkinson, Timothy J., Azeez, Maha A., Baer, Alan N., Baraliakos, Xenofon, Bardin, Thomas, Barnsley, Leslie, Barr, Andrew J., Bathon, Joan M., Belch, Jill J.F., Bellido, Teresita, Ben-Artzi, Ami, Benedetti, Fabrizio, Bennell, Kim L., Bennett, Sarah E., Berard, Roberta A., Berenbaum, Francis, Berman, Brian, Bermas, Bonnie L., Elizabeth Berry, Alice, Bertsias, George, Bhana, Suleman, Bhattacharyya, Shamik, Bilginer, Yelda, Bleasel, Jane F., Block, Joel A., Böhm, Markus, Bonelli, Michael, Boumpas, Dimitrios T., Bozec, Aline, Brasington, Richard D., Braun, Jürgen, Brouwer, Elisabeth, Brown, Jacques P., Brown, Matthew A., Brown, Matthew L., Buch, Maya H., Buckley, Christopher D., Bugbee, William D., Burmester, Gerd-Rüdiger, Burns, Jane C., Burr, David B., Buttgereit, Frank, Buxbaum, Joel N., Bykerk, Vivian P., Calabrese, Cassandra, Calabrese, Leonard H., Callen, Jeffrey P., Carr, Andrew J., Carrino, John A., Cavallo, Sabrina, Cervera, Ricard, Chang, Christopher, Chang, Joyce C., Chaon, Benjamin C., Chaudhary, Prateek, Choi, Hyon K., Choy, Ernest H.S., Christopher-Stine, Lisa, Chung, Lorinda, Ciccia, Francesco, Clauw, Daniel J., Clinch, Jacqui, Clowse, Megan E.B., Coghlan, John (Gerry), Colbert, Robert A., Conaghan, Philip G., Cooper, Cyrus, Costello, Wendy, Costenbader, Karen H., Cox, George L.D., Creamer, Paul, Cronstein, Bruce N., Cross, Raymond K., Curtis, Jeffrey R., D'Adamo, Chris, D'Agati, Vivette D., Daikh, David I., Dakin, Stephanie G., Dalbeth, Nicola, Davis, Aileen M., D'Cruz, David P., Eduardo de Barros Branco, Carlos, de Boer, Berber, De Craemer, Ann-Sophie, de Jesus, Adriana A., De Vita, Salvatore, de Wit, Maarten, Deal, Chad L., Deane, Kevin D., Dellaripa, Paul F., Dennison, Elaine, Denton, Christopher P., DiCarlo, Edward F., Distler, Oliver, Donlan, Pamela, Doyle, Tracy J., du Preez, Hannah, Dyer, George S.M., Eastell, Richard, Ehrchen, Jan, Elewaut, Dirk, Emery, Paul, Emmerling, Max R., Espinosa, Gerard, Espinoza, Luis R., Eyre, Stephen, Fanouriakis, Antonis, Farber, Joshua, Fasth, Anders, Feist, Eugen, Feldman, Candace H., Fernandez-Ruiz, Ruth, Filer, Andrew, Fiorentino, David F., Fisher, Benjamin A., Fisk, John D., Flajnik, Martin F., Forbess, Lindsy, Fox, David A., Frech, Tracy M., Frisaldi, Elisa, Gabay, Cem, Gadina, Massimo, Gandolfo, Saviana, Garelick, Daniela, Gay, Steffen, Geifman, Nophar, George, Michael D., Eric Gershwin, M., Ghadiali, Jay, Gilis, Elisabeth, Gold, Deborah T., Gold, Garry E., Goldbach-Mansky, Raphaela, Gómez-Puerta, José A., Goodman, Susan M., Gordon, Caroline, Gordon, Sharon, Gossec, Laure, Grainger, Andrew J., Grainger, Rebecca, Gravallese, Ellen M., Greenberg, Jeffrey D., Guglielmi, Luiza Guilherme, Gül, Ahmet, Gullapalli, Rao P., Guma, Monica, Gupta, Sarthak, Han, Shuhong, Hanly, John G., Hanson, Eric P., Haraoui, Boulos, Harley, John B., Haroun, Tayseer G., Hashkes, Philip J., Hasni, Sarfaraz A., Bassim Hassan, Andrew, Haupt, Lukas, Hausmann, Jonathan S., Hawker, Gillian A., Heiberg, Turid, Helfgott, Simon M., Hinman, Rana S., Hoffmann-Vold, Anna-Maria, Holroyd, Christopher R., Holt, Cathy, Horomanski, Audra, Huizinga, Thomas W.J., Humby, Frances, Elaine Husni, M., Hwang, Jonathan, Hyrich, Kimme, Inman, Robert D., Inoue, Dai, Isaac, Zacharia, Isaacs, John D., Isenberg, David, Iversen, Maura D., Jabs, Douglas A., James, Judith A., Jandali, Bochra, Kassim Javaid, M., Javier, Rose-Marie, Jefferis, Roy, Jeffries, Matlock A., Johnson, Sindhu R., Johnstone, Brian, Helena Jonsson, Anna, Joyce, Andrew A., Jung, Michelle, Kado, Ruba, Kaisho, Tsuneyasu, Kamal, Natasha, Kane, David, Kaplan, Mariana J., Karr, Timothy L., Kassimos, Dimitrios G., Kastner, Daniel L., Katz, Jeffrey N., Kawano, Mitsuhiro, Kay, Jonathan, Keating, Richard M., Kelly, Jennifer A., Kendler, David, Keyser, Randall E., Khamashta, Munther A., Khanna, Dinesh, Khokhar, Kiran, Kiefer, David, King, Lauren K., Kloppenburg, Margreet, Kolasinski, Sharon L., Kolstad, Kathleen D., Kottyan, Leah C., Byers Kraus, Virginia, Kronberger, Leo R.W., Kroopnick, Jeffrey M., Kvien, Tore K., LaBaer, Joshua, Lafyatis, Robert, Lakkis, Jay I., Landewé, Robert B.M., Langford, Carol A., Laster, Marciana L., Latourte, Augustin, Lau, Arthur N., Laurynenka, Viktoryia, Lavin, Robert A., Laxer, Ronald M., Li, Suzanne C., Liao, Katherine P., Lieberman, Scott M., Liew, Jean W., Littlejohn, Geoffrey O., Liu, Eva S., Lo, Lawrence, Lories, Rik J., Luger, Thomas A., Lundberg, Ingrid E., Luqmani, Raashid A., Machado, Pedro M., Machold, Klaus P., Ronald MacKenzie, C., Major, Tanya J., Malfait, Anne-Marie, Malley, Tamir, Manasson, Julia, March, Lyn M., Olivé Marqués, Alejandro, Márquez, Javier, Martin, Paul, Martínez-Lavín, Manuel, Matteson, Eric L., Mayes, Maureen D., McAlindon, Timothy, McCarthy, Edward F., McCarthy, Geraldine M., McDermott, Michael F., McDonnell, Patrick J., McGonagle, Dennis, Simon Meara, Alexa, Mehta, Jay J., Melville, Andrew R., Merola, Joseph F., Micheletti, Robert G., Michou, Laëtitia, Middleton, Rob, Midha, Disha, Mikdashi, Jamal A., Miller, Frederick W., Minden, Kirsten, Miner, Jonathan J., Minhas, Deeba, Helene Moe, Rikke, Möller, Ingrid, Mopuru, Renuka, Mortaji, Parisa, Mueller, Alisa A., Myasoedova, Elena, Namur, Gauthier, Naredo, Esperanza, Navarro-Compán, Victoria, Neerinckx, Barbara, Nelson, Amanda E., Nerviani, Alessandra, Nicolson, Philippa J.A., Nordal, Ellen B., Nöth, Ulrich, Ntatsaki, Eleana, Obenhuber, Tilman, Oddis, Chester V., Ogdie-Beatty, Alexis R., Omar, Ahmed, Ombrello, Michael J., Omisade, Antonina, Onel, Karen B., Ong, Voon H., Orcel, Philippe, Orozco, Gisela, Orr, Carl, O'Shea, John J., Ospelt, Caroline, Østensen, Monika, Özen, Seza, Park, Elizabeth, Parker, Matthew J.S., Pathan, Ejaz, Patrono, Carlo, Perez-Chada, Lourdes M., Pijnenburg, Luc, Pillinger, Michael H., Pineda, Carlos, Pipitone, Nicolò, Pitzalis, Costantino, Poddubnyy, Denis, Pope, Janet E., Postolova, Anna, Price, Andrew J., Pryor, Katherine P., Quartuccio, Luca, Rackwitz, Lars, Radner, Helga, Rajendran, Aardra, Ramiro, Sofia, Raychaudhuri, Soumya, Redmond, Anthony C., Reeves, Westley H., Remmers, Elaine F., Requena, Luis, Reynolds, Gary, Reynolds, John A., Ribbens, Clio, Richards, Bethan, Richardson, Bruce, Richette, Pascal, Ritchlin, Christopher T., Ritter, Susan Y., Robinson, Philip C., Robinson, William H., Rogers, Valerie J., Romain, Paul L., Rosas, Ivan O., Rosenthal, Ann K., Rubin, Elka, Rudwaleit, Martin, Rutgers, Bram A., Rygg, Marite, Saag, Kenneth G., Salmon, Jane E., Salusky, Isidro B., Salvarani, Carlo, Sandell, Linda J., Sandhu, Vaneet K., Sandovici, Maria, Sand-Svartrud, Anne-Lene, Scanzello, Carla R., Schaible, Hans-Georg, Scher, Jose U., Schett, Georg, Schiffenbauer, Adam I., Schiller, Alan L., Schlesinger, Naomi, Schreiber, Benjamin E., Schwartz, Daniella M., Shaibani, Aziz, Sharma, Leena, Shmerling, Robert H., Siaton, Bernadette C., Siegel, Richard M., Sieghart, Daniela, Silverman, Stuart L., Simard, Julia F., Simmons, Barry P., Simms, Robert W., Singer, Nora G., Sirotich, Emily, Smith, Judith A., Smith, Stacy E., Smolen, Josef S., Solomon, Daniel H., Sparks, Jeffrey A., Stack, John, Stanley, David, Steen, Virginia D., Steere, Allen C., Stegeman, Coen A., Steiner, Günter, Steinert, Andre F., Stojan, George, Strand, Vibeke, Sufka, Paul, Sullivan, James K., Szulc, Pawel, Tang, Chen, Tang, Shiyu, Taylor, Peter C., Terkeltaub, Robert, Thomas, Afton R., Thorne, Jennifer E., Topping, Louise M., Toprover, Michael, Torralba, Karina, Touma, Zahi, Tremoulet, Adriana H., Trouw, Leendert, Tuan, Rocky S., Uçkay, Ilker, Umehara, Hisanori, van der Geest, Kornelis S.M., van der Heijde, Désirée, van Gaalen, Floris A., Van Mechelen, Margot, van Vollenhoven, Ronald F., Vandevelde, Claire Y.J., Varga, John, Vassilopoulos, Dimitrios, Veale, Douglas J., Verstappen, Gwenny M., Viatte, Sebastien, Vincent, Tonia L., Vital, Edward M., von Loga, Isabell S., Wahezi, Dawn M., Wallace, Daniel J., Wallace, Zachary S., Warburton, Gary, Watad, Abdulla, Watts, Richard A., Weinblatt, Michael E., Weir, Matthew R., Weisman, Michael H., Weiss, Pamela F., Branford White, Harriet, White, Kenneth E., Wilkinson, David J., Williams, David E., Williams, Richard, Wilson, Hannah, Winthrop, Kevin L., Witt, Claudia M., Witzmann, Gerhard, Wong, John B., Woolf, Anthony D., Paul Wordsworth, B., Xu, Huji, Yazdany, Jinoos, Young, David A., Young, Stephen P., Md Yusof, Md Yuzaiful, and Zhuang, Haoyang

Published
2023
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38. 148. SHORT-FORM 36 AS A MEASURE OF HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH GIANT CELL ARTERITIS

Author

Kermani, Tanaz, primary, Sreih, Antoine, additional, Tomasson, Gunnar, additional, Cuthbertson, David, additional, Borchin, Renee, additional, Carette, Simon, additional, Forbess, Lindsy, additional, Khalidi, Nader, additional, Koening, Curry, additional, McAlear, Carol, additional, Monach, Paul, additional, Moreland, Larry, additional, Pagnoux, Christian, additional, Seo, Philip, additional, Spiera, Robert, additional, Warrington, Kenneth, additional, Ytterberg, Steven, additional, Langford, Carol, additional, and Merkel, Peter, additional

Published
2019
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39. Clinical Manifestations and Long‐Term Outcomes of Eosinophilic Granulomatosis With Polyangiitis in North America.

Author

Doubelt, Irena, Cuthbertson, David, Carette, Simon, Chung, Sharon A., Forbess, Lindsy J., Khalidi, Nader A., Koening, Curry L., Langford, Carol, McAlear, Carol A., Moreland, Larry W., Monach, Paul A., Seo, Philip, Specks, Ulrich, Spiera, Robert F., Springer, Jason M., Sreih, Antoine G., Warrington, Kenneth J., Merkel, Peter A., and Pagnoux, Christian

Subjects
CHURG-Strauss syndrome, TREATMENT effectiveness, ANTINEUTROPHIL cytoplasmic antibodies, VASCULITIS, GLUCOCORTICOIDS
Abstract

Objective: To describe clinical manifestations and outcomes in patients with eosinophilic granulomatosis with polyangiitis (EGPA) in North America. Methods: Analysis of patients aged 18 years or older who fulfilled the 1990 American College of Rheumatology Classification Criteria for EGPA enrolled in the Vasculitis Clinical Research Consortium from 2003 to 2019. Main clinical characteristics, treatments, outcomes, and accumulated damage were studied. Results: The cohort included 354 patients; 59% female; age at diagnosis of 50.0 (±14) years; 39% were antineutrophil cytoplasm antibody (ANCA) positive. Time from diagnosis to last follow‐up was 7.0 (±6.2) years; 49.4% had one or more relapse. Patients positive for ANCA more commonly had neurological and kidney involvement when compared with patients negative for ANCA, who had more cardiac and lung manifestations. At last study visit, only 35 (12.6%) patients had been off all therapy for more than 2 years during their follow‐up. The overall mortality rate was 4.0% and did not differ by ANCA status or cyclophosphamide use. Scores on the Vasculitis Damage Index (VDI) for 134 patients with two or more visits and more than 1 year of follow‐up increased from 1.7 (±1.8) at enrollment (3.7 [±5.1] years after diagnosis) to 3.35 (±2.1) at last follow‐up (7.5 [±5.8] years after diagnosis), mainly represented by chronic asthma (67.5%), peripheral neuropathy (49.6%), and chronic sinusitis (31.3%). Longer duration of glucocorticoid use and relapse were associated with higher VDI scores. Conclusion: This analysis describes the many clinical manifestations and varied outcomes of EGPA and highlights the ongoing need to attain more sustained, long‐term remission to limit the accrual of disease‐related damage. [ABSTRACT FROM AUTHOR]

Published
2021
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40. MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE

Author

Smith, Siobhán, Fernando, Thilini, Wu, Pei Wen, Seo, Jane, Ní Gabhann, Joan, Piskareva, Olga, McCarthy, Eoghan, Howard, Donough, O'Connell, Paul, Conway, Richard, Gallagher, Phil, Molloy, Eamonn, Stallings, Raymond L., Kearns, Grainne, Forbess, Lindsy, Ishimori, Mariko, Venuturupalli, Swamy, Wallace, Daniel, Weisman, Michael, and Jefferies, Caroline A.

Published
2017
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41. Sequence‐Based Screening of Patients With Idiopathic Polyarteritis Nodosa, Granulomatosis With Polyangiitis, and Microscopic Polyangiitis for Deleterious Genetic Variants in ADA2.

Author

Schnappauf, Oskar, Sampaio Moura, Natalia, Aksentijevich, Ivona, Stoffels, Monique, Ombrello, Amanda K., Hoffmann, Patrycja, Barron, Karyl, Remmers, Elaine F., Hershfield, Michael, Kelly, Susan J., Cuthbertson, David, Carette, Simon, Chung, Sharon A., Forbess, Lindsy, Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Monach, Paul A., and Moreland, Larry

Subjects
MICROSCOPIC polyangiitis, SEQUENCE analysis, GENETICS, MEDICAL screening, GRANULOMATOSIS with polyangiitis, HYDROLASES, POLYARTERITIS nodosa
Abstract

Objective: Deficiency of adenosine deaminase 2 (DADA2) is a monogenic form of vasculitis that can resemble polyarteritis nodosa (PAN). This study was undertaken to identify potential disease‐causing sequence variants in ADA2 in patients with idiopathic PAN, granulomatosis with polyangiitis (GPA), or microscopic polyangiitis (MPA). Methods: Patients with idiopathic PAN (n = 118) and patients with GPA or MPA (n = 1,107) were screened for rare nonsynonymous variants in ADA2 using DNA sequencing methods. ADA‐2 enzyme activity was assessed in selected serum samples. Results: Nine of 118 patients with PAN (7.6%) were identified as having rare nonsynonymous variants in ADA2. Four patients (3.4%) were biallelic for pathogenic or likely pathogenic variants, and 5 patients (4.2%) were monoallelic carriers for 3 variants of uncertain significance and 2 likely pathogenic variants. Serum samples from 2 patients with PAN with biallelic variants were available and showed markedly reduced ADA‐2 enzyme activity. ADA‐2 enzyme testing of 86 additional patients revealed 1 individual with strongly reduced ADA‐2 activity without detectable pathogenic variants. Patients with PAN and biallelic variants in ADA2 were younger at diagnosis than patients with 1 or no variant in ADA2, with no other clinical differences noted. None of the patients with GPA or MPA carried biallelic variants in ADA2. Conclusion: A subset of patients with idiopathic PAN meet genetic criteria for DADA2. Given that tumor necrosis factor inhibition is efficacious in DADA2 but is not conventional therapy for PAN, these findings suggest that ADA‐2 testing should strongly be considered in patients with hepatitis B virus–negative idiopathic PAN. [ABSTRACT FROM AUTHOR]

Published
2021
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42. IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation

Author

Smith, Siobhan, primary, Wu, Pei Wen, additional, Seo, Jane J., additional, Fernando, Thilini, additional, Jin, Mengyao, additional, Contreras, Jorge, additional, Montano, Erica N., additional, Gabhann, Joan Ní, additional, Cunningham, Kyle, additional, Widaa, Amro, additional, McCarthy, Eoghan M., additional, Molloy, Eamonn S., additional, Kearns, Grainne, additional, Murphy, Conor C., additional, Kong, Weiping, additional, Björkbacka, Harry, additional, Kornfeld, Hardy, additional, Forbess, Lindsy, additional, Venuturupalli, Swamy, additional, Ishimori, Mariko, additional, Wallace, Daniel, additional, Weisman, Michael H., additional, and Jefferies, Caroline A., additional

Published
2018
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43. A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Author

David Carmona, F., Mackie, Sarah L., Martin, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castaneda, Santos, Cid, Maria C., Hernandez-Rodriguez, Jose, Prieto-Gonzalez, Sergio, Solans, Roser, Ramentol-Sintas, Marc, Francisca Gonzalez-Escribano, M., Ortiz-Fernandez, Lourdes, Morado, Inmaculada C., Narvaez, Javier, Miranda-Filloy, Jose A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schoenau, Verena, Franke, Andre, Palm, Oyvind, Molberg, Oyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Koeleman, Bobby P. C., de Bakker, Paul I. W., and Spanish GCA Grp

Subjects
PRIMARY BILIARY-CIRRHOSIS, FOXP3 EXPRESSION, TYROSINE-PHOSPHATASE PTPN22, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, NF-KAPPA-B, Journal Article, ATOPIC-DERMATITIS, POLYMYALGIA-RHEUMATICA, GENOME-WIDE ASSOCIATION, EXTENDED HUMAN MHC, RISK LOCI, RHEUMATOID-ARTHRITIS
Abstract

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip array. We also imputed HLA data with a previously validated imputation method to perform a more comprehensive analysis of this genomic region. The strongest association signals were observed in the HLA region, with rs477515 representing the highest peak (p = 4.05 x 10(-40), OR = 1.73). A multivariate model including class II amino acids of HLA-DR beta 1 and HLA-DQ alpha 1 and one class I amino acid of HLA-B explained most of the HLA association with GCA, consistent with previously reported associations of classical HLA alleles like HLA-DRB1*04. An omnibus test on polymorphic amino acid positions highlighted DR beta 1 13 (p = 4.08 x 10(-43)) and HLA-DQ alpha 1 47 (p = 4.02 x 10(-46)), 56, and 76 (both p = 1.84 x 10(-45)) as relevant positions for disease susceptibility. Outside the HLA region, the most significant loci included PTPN22 (rs2476601, p = 1.73 x 10(-6), OR = 1.38), LRRC32 (rs10160518, p = 4.39 x 10(-6), OR = 1.20), and REL (rs115674477, p = 1.10 x 10(-5), OR = 1.63). Our study provides evidence of a strong contribution of HLA class I and II molecules to susceptibility to GCA. In the non-HLA region, we confirmed a key role for the functional PTPN22 rs2476601 variant and proposed other putative risk loci for GCA involved in Th1, Th17, and Treg cell function.

Published
2015

44. Contributors

Author

Abelson, Abby G., Abramson, Steven B., Adachi, Jonathan D., Adams, Michael A., Aggarwal, Rohit, Aigner, Thomas, Akira, Shizuo, Albert, Daniel A., Aletaha, Daniel, Alevizos, Ilias, Allem, Kavitta B., Almehthel, Mohammed, Almohaya, Mohamed, Alonso, Elena Riera, Amigo, Mary-Carmen, Arden, Nigel K., Aringer, Martin, Arkema, Elizabeth V., Ascherman, Dana P., Atamas, Sergei P., Atkinson, Timothy J., Azeez, Maha A., Azevedo, Pedro M., Baer, Alan N., Baeten, Dominique, Baines, Colin P., Balsa, Alejandro, Baraliakos, Xenofon, Bardin, Thomas, Barnes, Jammie K., Barnsley, Les, Barr, Andrew J., Bathon, Joan M., Bauch, Angela, Bay-Jensen, Anne-Christine, Belch, Jill J.F., Bellamy, Nicholas, Bellido, Teresita, Benjamin, Michael, Bennell, Kim L., Beresford, Michael W., Berman, Brian, Bermas, Bonnie L., Bertsias, George, Bhalla, Sonal, Bilginer, Yelda, Birnbaum, Julius, Bleasel, Jane F., Block, Joel A., Blom, Ashley W., Böhm, Markus, Bonelli, Michael, Borchert, Grace, Boros, Christina A., Boumpas, Dimitrios T., Bozec, Aline, Brasington, Richard D., Jr., Braun, Jürgen, Brouwer, Elisabeth, Brown, Jacques P., Brown, Matthew A., Bruce, Ian N., Buch, Maya H., Buckley, Christopher D., Bugbee, William D., Burmester, Gerd-Rüdiger, Burns, Jane C., Burr, David B., Buttgereit, Frank, Bykerk, Vivian P., Calabrese, Leonard H., Callen, Jeffrey P., Carr, Andrew J., Carroll, Graeme J., Cavallo, Sabrina, Cervera, Ricard, Chaudhary, Prateek, Choi, Hyon K., Choy, Ernest H., Christopher-Stine, Lisa, Chu, Alvina D., Chung, Lorinda, Ciccia, Francesco, Clauw, Daniel J., Clinch, Jacqui, Clowse, Megan E.B., Coghlan, J. Gerard, Colbert, Robert A., Conaghan, Philip G., Cooper, Cyrus, Cooper, Robert G., Costenbader, Karen H., Cox, George L.D., Creamer, Paul, Cronstein, Bruce N., Cross, Raymond, Cutolo, Maurizio, D’Adamo, Chris, D’Agati, Vivette D., Daikh, David I., Dakin, Stephanie G., Dalbeth, Nicola, Davis, Aileen M., D’Cruz, David P., Ceulaer, Karel De, Rheum, Dipl, de Jesus, Adriana A., De Vita, Salvatore, de Wit, Maarten, Deal, Chad L., Deane, Kevin D., Dellaripa, Paul F., Dennison, Elaine, Denton, Christopher P., Dieppe, Paul, Dolan, Patricia, Doyle, Tracy J., Dyer, George S.M., Emery, Paul, Espinosa, Gerard, Espinoza, Luis R., Eyre, Stephen, Fanouriakis, Antonis C., Farber, Joshua, Fasth, Anders, Feist, Eugen, Feldman, Candace H., Feldman, Debbie, Filer, Andrew, Fiorentino, David F., Fisher, Benjamin A., Fisk, John D., Flores, Raymond H., Forbess, Lindsy, Fox, David A., Freemont, Anthony J., Fricka, Kevin B., Gabay, Cem, Gadina, Massimo, Gandolfo, Saviana, Gauntlett-Gilbert, Jeremy, Gay, Steffen, Gensler, Lianne S., Gerlag, Danielle M., Gold, Garry E., Goldbach-Mansky, Raphaela, Goldingay, Sarah J., Gómez-Puerta, José A., Goodman, Susan M., Gordon, Caroline, Gordon, Sharon M., Gorodkin, Rachel, Görtz, Simon, Grainger, Andrew J., Gravallese, Ellen M., Greenberg, Jeffrey D., Grieve, Sharon, Guilherme, Luiza, Gül, Ahmet, Gupta, Sarthak, Hagan, Matilda, Hagley, Karlene, Han, Shuhong, Hanly, John G., Hanson, Eric P., Haraoui, Boulos, Hardcastle, Sarah A., Harley, John B., Haroun, Tayseer G., Hashkes, Philip J., Hassan, Andrew Bassim, Haupt, Lukas, Hawker, Gillian A., Hawkins, Philip N., Heeringa, Peter, Heiberg, Turid, Heinegård, Dick, Helfgott, Simon M., Henriksen, Kim, Hinman, Rana S., Ho, Pauline Y.P., Hochberg, Marc C., Hoffmann, Markus H., Holick, Michael F., Holroyd, Christopher R., Holt, Cathy, Huizinga, Thomas W.J., Husni, M. Elaine, Inman, Robert D., Inoue, Dai, Isaac, Zacharia, Isaacs, John D., Iversen, Maura D., Jabs, Douglas A., Jaimungal, Sarada, James, Judith A., Javaid, M. Kassim, Javidan, Pooya, Javier, Rose-Marie, Jefferis, Roy, Johnsen, Alyssa K., Jordan, Joanne M., Joyce, Andrew A., Jung, Michelle, Kado, Ruba, Kaisho, Tsuneyasu, Kallenberg, Cees G.M., Kane, David, Kaplan, Mariana J., Karsdal, Morten Asser, Kassimos, Dimitrios G., Kastner, Daniel L., Kawano, Mitsuhiro, Kay, Jonathan, Keating, Richard M., Kelly, Jennifer A., Kendler, David, Khamashta, Munther A., Khan, Irfan R., Khanna, Dinesh, Klokkerud, Mari, Kolstad, Kathleen D., Kottyan, Leah, Kraus, Virginia Byers, Kvien, Tore K., Lafyatis, Robert, Landewé, Robert B.M., Langford, Carol A., Lau, Arthur N., Lavin, Robert A., Laxer, Ronald M., Learch, Thomas J., Leatherwood, Cianna, Lewis, Jennifer S., Lewith, George, Liao, Katherine P., Lightfoot, Adam P., Littlejohn, Geoffrey O., Lorenzo, Pilar, Lories, Rik J.U., Luger, Thomas A., Lundberg, Ingrid E., Luqmani, Raashid A., Lythgoe, Hanna M., MacDougall, Kristin J., MacKenzie, C. Ronald, Manasson, Julia, Mangham, David Charles, Mao, Rong, March, Lyn M., Marqués, Alejandro Olivé, Márquez, Javier, Martín-Mola, Emilio, Martínez-Lavín, Manuel, Matteson, Eric L., Matzat, Stephen J., Mayes, Maureen D., McAlindon, Timothy, McCabe, Candy S., McCarthy, Edward F., McCarthy, Geraldine M., McDermott, Michael F., McGonagle, Dennis, McLean, Lachy, Ian Melville, Andrew Robert, Michou, Laëtitia, Middleton, Rob, Mikdashi, Jamal A., Miller, Frederick W., Miller, Paul D., Minden, Kirsten, Miner, Jonathan J., Moe, Rikke Helene, Möller, Ingrid, Monach, Paul A., Mons, Barend, Myasoedova, Elena, Nam, Jackie L., Namur, Gauthier, Naredo, Esperanza, Neerinckx, Barbara, Nelson, Amanda E., Nicolson, Philippa J.A., Nieves, César E. Fors, Nordal, Ellen B., Nöth, Ulrich, Ntatsaki, Eleana, Oddis, Chester V., Omar, Ahmed, Ombrello, Michael J., Omisade, Antonina, Ong, Voon H., Önnerfjord, Patrik, Orcel, Philippe, Orr, Carl, O'Shea, John J., Ospelt, Caroline, Özen, Seza, Parker, Matthew J.S., Patrono, Carlo, Pilkington, Clarissa A., Pillinger, Michael H., Pineda, Carlos, Pipitone, Nicolò, Poddubnyy, Denis, Pope, Janet E., Postolova, Anna, Price, Andrew, Quartuccio, Luca, Rackwitz, Lars, Radner, Helga, Raychaudhuri, Soumya, Redmond, Anthony C., Rees, Jonathan L., Reeves, Westley H., Rehaume, Linda M., Remmers, Elaine F., Requena, Luis, Reynolds, Gary, Ribbens, Clio, Richards, Bethan, Richardson, Bruce C., Richette, Pascal, Richter, Adrian, Ritchlin, Christopher T., Ritter, Susan Y., Robinson, William H., Rogers, Valerie, Rosas, Ivan O., Rosenthal, Ann K., Rowan, Andrew D., Rudwaleit, Martin, Rull, Marina, Rygg, Marite, Saag, Kenneth G., Salmon, Jane E., Salter, Donald M., Salvarani, Carlo, Sandell, Linda J., Sandigursky, Sabina, Saxne, Tore, Schaible, Hans-Georg, Scher, Jose U., Schett, Georg, Schiffenbauer, Adam I., Schiller, Alan L., Schlesinger, Naomi, Schreiber, Benjamin E., Schwartz, Daniella Muallem, Shapiro, Lauren M., Sharma, Leena, Siaton, Bernadette C., Siegel, Richard M., Sieper, Joachim, Simard, Julia Fridman, Simmons, Barry P., Simms, Robert W., Singer, Nora G., Smith, Judith A., Smith, Stacy E., Smolen, Josef S., Solomon, Daniel H., Stack, John, Stanley, David, Steen, Virginia D., Steere, Allen C., Steiner, Günter, Steinert, Andre F., Stojan, George, Strand, Vibeke, Straub, Rainer H., Streeten, Elizabeth A., Superti-Furga, Giulio, Tak, Paul P., Tang, Chen, Taylor, Peter C., Terkeltaub, Robert, Thomas, Beje, Thomas, Ranjeny, Thorne, Jennifer E., Tobias, Jonathan H., Tremoulet, Adriana H., Trouw, Leendert A., Tuan, Rocky S., Turesson, Carl, Umehara, Hisanori, Valdes, Ana M., van der Heijde, Désirée, van Vollenhoven, Ronald F., Vanderstukken, Joke, Varga, John, Vassilopoulos, Dimitrios, Veale, Douglas J., Viatte, Sebastien, Vincent, Tonia, Vital, Edward M., von Loga, Isabell S., Wallace, Daniel J., Walsh, Nicola, Warber, Sara L., Warburton, Gary, Ward, Robert J., Watts, Laura, Watts, Richard A., Wedderburn, Lucy R., Weinblatt, Michael E., Weir, Matthew R., Sr., Weisman, Michael H., Weiss, Pamela F., Wenham, Claire Y.J., West, Sterling G., White, Harriet Branford, White, Kenneth E., Wilkinson, David J., Williams, David E., Williams, Richard, Wilson, Hannah, Winthrop, Kevin L., Witt, Claudia M., Witzmann, Gerhard, Wong, John B., Woolf, Anthony D., Wordsworth, Paul B., Worthington, Jane, Wysham, Katherine D., Xu, Huji, Young, David A., Young, Stephen P., Yusof, Md Yuzaiful Md, Zhuang, Haoyang, and Zink, Angela

Published
2019
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45. A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

Author

Carmona, F. David, primary, Vaglio, Augusto, additional, Mackie, Sarah L., additional, Hernández-Rodríguez, José, additional, Monach, Paul A., additional, Castañeda, Santos, additional, Solans, Roser, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Ramentol-Sintas, Marc, additional, Pease, Colin T., additional, Dasgupta, Bhaskar, additional, Watts, Richard, additional, Khalidi, Nader, additional, Langford, Carol A., additional, Ytterberg, Steven, additional, Boiardi, Luigi, additional, Beretta, Lorenzo, additional, Govoni, Marcello, additional, Emmi, Giacomo, additional, Bonatti, Francesco, additional, Cimmino, Marco A., additional, Witte, Torsten, additional, Neumann, Thomas, additional, Holle, Julia, additional, Schönau, Verena, additional, Sailler, Laurent, additional, Papo, Thomas, additional, Haroche, Julien, additional, Mahr, Alfred, additional, Mouthon, Luc, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P., additional, Voskuyl, Alexandre, additional, Brouwer, Elisabeth, additional, Daikeler, Thomas, additional, Berger, Christoph T., additional, Molloy, Eamonn S., additional, O’Neill, Lorraine, additional, Blockmans, Daniel, additional, Lie, Benedicte A., additional, Mclaren, Paul, additional, Vyse, Timothy J., additional, Wijmenga, Cisca, additional, Allanore, Yannick, additional, Koeleman, Bobby P.C., additional, Barrett, Jennifer H., additional, Cid, María C., additional, Salvarani, Carlo, additional, Merkel, Peter A., additional, Morgan, Ann W., additional, González-Gay, Miguel A., additional, Martín, Javier, additional, Callejas, José Luis, additional, Caminal-Montero, Luis, additional, Corbera-Bellalta, Marc, additional, de Miguel, Eugenio, additional, López, J. Bernardino Díaz, additional, García-Villanueva, María Jesús, additional, Gómez-Vaquero, Carmen, additional, Guijarro-Rojas, Mercedes, additional, Hidalgo-Conde, Ana, additional, Marí-Alfonso, Begoña, additional, Berriochoa, Agustín Martínez, additional, Zapico, Aleida Martínez, additional, Martínez-Taboada, Víctor Manuel, additional, Miranda-Filloy, José A., additional, Monfort, Jordi, additional, Ortego-Centeno, Norberto, additional, Pérez-Conesa, Mercedes, additional, Prieto-González, Sergio, additional, Raya, Enrique, additional, Fernández, Raquel Ríos, additional, Sánchez-Martín, Julio, additional, Sopeña, Bernardo, additional, Tío, Laura, additional, Unzurrunzaga, Ainhoa, additional, Gough, Andrew, additional, Isaacs, John D., additional, Green, Michael, additional, McHugh, Neil, additional, Hordon, Lesley, additional, Kamath, Sanjeet, additional, Nisar, Mohammed, additional, Patel, Yusuf, additional, Yee, Cee-Seng, additional, Stevens, Robert, additional, Nandi, Pradip, additional, Nandagudi, Anupama, additional, Jarrett, Stephen, additional, Li, Charles, additional, Levy, Sarah, additional, Mollan, Susan, additional, Salih, Abdel, additional, Wordsworth, Oliver, additional, Sanders, Emma, additional, Roads, Esme, additional, Gill, Anne, additional, Carr, Lisa, additional, Routledge, Christine, additional, Culfear, Karen, additional, Nugaliyadde, Asanka, additional, James, Lynne, additional, Spimpolo, Jenny, additional, Kempa, Andy, additional, Mackenzie, Felicity, additional, Fong, Rosanna, additional, Peters, Genessa, additional, Rowbotham, Bridie, additional, Masqood, Zahira, additional, Hollywood, Jane, additional, Gondo, Prisca, additional, Wood, Rose, additional, Martin, Steve, additional, Rashid, Lubna Haroon, additional, Robinson, James I., additional, Morgan, Mike, additional, Sorensen, Louise, additional, Taylor, John, additional, Carette, Simon, additional, Chung, Sharon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Gewurz-Singer, Ora, additional, Hoffman, Gary S., additional, Koening, Curry L., additional, Maksimowicz-McKinnon, Kathleen M., additional, McAlear, Carol A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert F., additional, Sreih, Antoine, additional, Warrington, Kenneth J., additional, and Weisman, Michael, additional

Published
2017
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47. Practice Patterns of ANCA-Associated Vasculitis: Exploring Differences Among Subspecialties at a Single Academic Medical Center

Author

Forbess, Lindsy J, Griffin, Kenneth W, and Spiera, Robert F

Subjects
Adult, Male, Medication Therapy Management, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Article, Antibodies, Antineutrophil Cytoplasmic, Antibodies, Monoclonal, Murine-Derived, Sex Factors, Risk Factors, Secondary Prevention, Humans, Practice Patterns, Physicians', Cyclophosphamide, Glucocorticoids, Aged, Patient Selection, Remission Induction, Age Factors, Patient Acuity, Middle Aged, United States, Health Care Surveys, Drug Therapy, Combination, Female, Rituximab, Immunosuppressive Agents
Abstract

Clinical trial data help guide physician treatment choices for ANCA-associated vasculitis (AAV), but when data are lacking, treatment choices are largely driven by physician preference. Our aim was to examine AAV treatment preferences to determine if patient gender and age, and physician subspecialty affect treatment choices.Rheumatologists, nephrologists and pulmonologists from an academic medical centre participated in a web-based survey. Three scenarios (remission induction in severe disease; remission maintenance in severe disease; remission induction in limited disease) were presented for 4 patient profiles (28- and 68-year-old female/male). Physician treatment choices and reasons for these choices were obtained. Differences between groups were analysed using Chi-Square and Fisher's exact tests.Physicians were significantly more likely to choose rituximab for young females for remission induction in severe AAV, with toxicity being the main reason for this choice. There was a trend toward rheumatologists choosing rituximab over cyclophosphamide compared with other subspecialties for this scenario. Most physicians switched to a less toxic agent for remission maintenance, but there was little agreement as to choice of maintenance therapy among subspecialties. For remission induction in limited disease, most physicians chose rituximab, particularly for young females.Currently, there are very few data for remission maintenance therapy following rituximab in severe disease, as well as the use of rituximab in limited disease. Choices for treatment of AAV differ among subspecialties, are affected by patient gender and age, and tend to be largely driven by physician preference when data are limited or lacking.

Published
2014

48. A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Author

Genetica Groep Koeleman, Child Health, CMM Groep Kaaij, Infection & Immunity, JC onderzoeksprogramma Methodologie, Cancer, David Carmona, F., Mackie, Sarah L., Martin, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castaneda, Santos, Cid, Maria C., Hernandez-Rodriguez, Jose, Prieto-Gonzalez, Sergio, Solans, Roser, Ramentol-Sintas, Marc, Francisca Gonzalez-Escribano, M., Ortiz-Fernandez, Lourdes, Morado, Inmaculada C., Narvaez, Javier, Miranda-Filloy, Jose A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schoenau, Verena, Franke, Andre, Palm, Oyvind, Molberg, Oyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Koeleman, Bobby P. C., de Bakker, Paul I. W., Spanish GCA Grp, Genetica Groep Koeleman, Child Health, CMM Groep Kaaij, Infection & Immunity, JC onderzoeksprogramma Methodologie, Cancer, David Carmona, F., Mackie, Sarah L., Martin, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castaneda, Santos, Cid, Maria C., Hernandez-Rodriguez, Jose, Prieto-Gonzalez, Sergio, Solans, Roser, Ramentol-Sintas, Marc, Francisca Gonzalez-Escribano, M., Ortiz-Fernandez, Lourdes, Morado, Inmaculada C., Narvaez, Javier, Miranda-Filloy, Jose A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schoenau, Verena, Franke, Andre, Palm, Oyvind, Molberg, Oyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Koeleman, Bobby P. C., de Bakker, Paul I. W., and Spanish GCA Grp

Published
2015

49. A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Author

Carmona, F. David, primary, Mackie, Sarah L., additional, Martín, Jose-Ezequiel, additional, Taylor, John C., additional, Vaglio, Augusto, additional, Eyre, Stephen, additional, Bossini-Castillo, Lara, additional, Castañeda, Santos, additional, Cid, Maria C., additional, Hernández-Rodríguez, José, additional, Prieto-González, Sergio, additional, Solans, Roser, additional, Ramentol-Sintas, Marc, additional, González-Escribano, M. Francisca, additional, Ortiz-Fernández, Lourdes, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Miranda-Filloy, José A., additional, Beretta, Lorenzo, additional, Lunardi, Claudio, additional, Cimmino, Marco A., additional, Gianfreda, Davide, additional, Santilli, Daniele, additional, Ramirez, Giuseppe A., additional, Soriano, Alessandra, additional, Muratore, Francesco, additional, Pazzola, Giulia, additional, Addimanda, Olga, additional, Wijmenga, Cisca, additional, Witte, Torsten, additional, Schirmer, Jan H., additional, Moosig, Frank, additional, Schönau, Verena, additional, Franke, Andre, additional, Palm, Øyvind, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P., additional, Carette, Simon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Hoffman, Gary S., additional, Khalidi, Nader A., additional, Koening, Curry L., additional, Langford, Carol A., additional, McAlear, Carol A., additional, Moreland, Larry, additional, Monach, Paul A., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Spiera, Robert, additional, Sreih, Antoine G., additional, Warrington, Kenneth J., additional, Ytterberg, Steven R., additional, Gregersen, Peter K., additional, Pease, Colin T., additional, Gough, Andrew, additional, Green, Michael, additional, Hordon, Lesley, additional, Jarrett, Stephen, additional, Watts, Richard, additional, Levy, Sarah, additional, Patel, Yusuf, additional, Kamath, Sanjeet, additional, Dasgupta, Bhaskar, additional, Worthington, Jane, additional, Koeleman, Bobby P.C., additional, de Bakker, Paul I.W., additional, Barrett, Jennifer H., additional, Salvarani, Carlo, additional, Merkel, Peter A., additional, González-Gay, Miguel A., additional, Morgan, Ann W., additional, Martín, Javier, additional, Martínez-Berriochoa, Agustín, additional, Unzurrunzaga, Ainhoa, additional, Hidalgo-Conde, Ana, additional, Madroñero-Vuelta, Ana B., additional, Fernández-Nebro, Antonio, additional, Ordóñez-Cañizares, M. Carmen, additional, Escalante, Begoña, additional, Marí-Alfonso, Begoña, additional, Sopeña, Bernardo, additional, Magro, César, additional, Raya, Enrique, additional, Grau, Elena, additional, Román, José A., additional, de Miguel, Eugenio, additional, López-Longo, F. Javier, additional, Martínez, Lina, additional, Gómez-Vaquero, Carmen, additional, Fernández-Gutiérrez, Benjamín, additional, Rodríguez-Rodríguez, Luis, additional, Díaz-López, J. Bernardino, additional, Caminal-Montero, Luis, additional, Martínez-Zapico, Aleida, additional, Monfort, Jordi, additional, Tío, Laura, additional, Sánchez-Martín, Julio, additional, Alegre-Sancho, Juan J., additional, Sáez-Comet, Luis, additional, Pérez-Conesa, Mercedes, additional, Corbera-Bellalta, Marc, additional, García-Villanueva, M. Jesús, additional, Fernández-Contreras, M. Encarnación, additional, Sanchez-Pernaute, Olga, additional, Blanco, Ricardo, additional, Ortego-Centeno, Norberto, additional, Ríos-Fernández, Raquel, additional, Callejas, José L., additional, Fanlo-Mateo, Patricia, additional, and Martínez-Taboada, Víctor M., additional

Published
2015
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50. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Giant Cell Arteritis.

Author

Langford, Carol A., Cuthbertson, David, Ytterberg, Steven R., Khalidi, Nader, Monach, Paul A., Carette, Simon, Seo, Philip, Moreland, Larry W., Weisman, Michael, Koening, Curry L., Sreih, Antoine G., Spiera, Robert, McAlear, Carol A., Warrington, Kenneth J., Pagnoux, Christian, McKinnon, Kathleen, Forbess, Lindsy J., Hoffman, Gary S., Borchin, Renée, and Krischer, Jeffrey P.

Subjects
PREDNISONE, ABATACEPT, GIANT cell arteritis, MEDICAL cooperation, PLACEBOS, PROBABILITY theory, RESEARCH, RANDOMIZED controlled trials, TREATMENT effectiveness, BLIND experiment, THERAPEUTICS
Abstract

Objective To compare the efficacy of abatacept to that of placebo for the treatment of giant cell arteritis (GCA). Methods In this multicenter trial, patients with newly diagnosed or relapsing GCA were treated with abatacept 10 mg/kg intravenously on days 1, 15, and 29 and week 8, together with prednisone administered daily. At week 12, patients in remission underwent a double-blinded randomization to continue to receive abatacept monthly or switch to placebo. Patients in both study arms received a standardized prednisone taper, with discontinuation of prednisone at week 28. All patients remained on their randomized assignment until meeting criteria for early termination or until 12 months after enrollment of the last patient. The primary end point was duration of remission (relapse-free survival rate). Results Forty-nine eligible patients with GCA were enrolled and treated with prednisone and abatacept; of these, 41 reached the week 12 randomization and underwent a blinded randomization to receive abatacept or placebo. Prednisone was tapered using a standardized schedule, reaching a daily dosage of 20 mg at week 12 with discontinuation in all patients at week 28. The relapse-free survival rate at 12 months was 48% for those receiving abatacept and 31% for those receiving placebo ( P = 0.049). A longer median duration of remission was seen in those receiving abatacept compared to those receiving placebo (median duration 9.9 months versus 3.9 months; P = 0.023). There was no difference in the frequency or severity of adverse events, including infection, between the treatment arms. Conclusion In patients with GCA, the addition of abatacept to a treatment regimen with prednisone reduced the risk of relapse and was not associated with a higher rate of toxicity compared to prednisone alone. [ABSTRACT FROM AUTHOR]

Published
2017
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