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The use of standardized anthropomorphic test devices and test conditions prevent current vehicle development and safety assessments from capturing the breadth of variability inherent in real-world occupant responses. This study introduces a methodology that overcomes these limitations by enabling the assessment of occupant response while accounting for sources of human- and non-human-related variability. Although the methodology is generic in nature, this study explores the methodology in its application to human response in far-side motor vehicle crashes as an example. A total of 405 human body model simulations were conducted in a mid-sized sedan vehicle environment to iteratively train two neural networks to predict occupant head excursion and thoracic injury as a function of occupant anthropometry, impact direction and restraint configuration. The neural networks were utilized in Monte Carlo simulations to calculate the probability of head-to-intruding-door impacts and thoracic AIS 3+ as a function of the restraint configuration. This analysis indicated that the vehicle used in this study would lead to a range of 667 to 2,448 head-to-intruding-door impacts and a range of 3,041 to 3,857 cases of thoracic AIS 3+ in the real world, depending on the seatbelt load limiter. These real-world results were later successfully validated using United States field data. This far-side assessment illustrates how the methodology incorporates the human and non-human variability, generates response surfaces that characterize the effects of the variability, and ultimately permits vehicle design considerations and injury predictions appropriate for real-world field conditions. [ABSTRACT FROM AUTHOR]

Ligament sprains account for a majority of injuries to the foot and ankle complex among athletic populations. The infeasibility of measuring the in situ response and load paths of individual ligaments has precluded a complete characterization of their mechanical behavior via experiment. In the present study a fiber-based modeling approach of in situ ankle ligaments was developed and validated for determining the heterogeneous force-elongation characteristics and the consequent injury patterns. Nine major ankle ligaments were modeled as bundles of discrete elements, corresponding functionally to the structure of collagen fibers. To incorporate the progressive nature of ligamentous injury, the limit strain at the occurrence of fiber failure was described by a distribution function ranging from 12% to 18% along the width of the insertion site. The model was validated by comparing the structural kinetic and kinematic response obtained experimentally and computationally under well-controlled foot rotations. The simulation results replicated the 6 degree-of-freedom bony motion and ligamentous injuries and, by implication, the in situ deformations of the ligaments. Gross stiffness of the whole ligament derived from the fibers was comparable to existing experimental data. The present modeling approach provides a biomechanically realistic, interpretable and computationally efficient way to characterize the in situ ligament slack, sequential and heterogeneous uncrimping of collagen fascicles and failure propagation as the external load is applied. Applications of this model include functional ankle joint mechanics, injury prevention and countermeasure design for athletes. [ABSTRACT FROM AUTHOR]

Road traffic injuries account for 1.3 million deaths per year world-wide. Mitigating both fatalities and injuries requires a detailed understanding of the tolerance of the human body to external load. To identify research priorities, it is necessary to periodically compare trends in injury tolerance research to the characteristics of injuries occurring in the field. This study sought to perform a systematic review on the last twenty years of experimental injury tolerance research, and to evaluate those results relative to available epidemiologic data. Four hundred and eight experimental injury tolerance studies from 1990–2009 were identified from a reference index of over 68,000 papers. Examined variables included the body regions, ages, and genders studied; and the experimental models used. Most (20%) of the publications studied injury to the spine. There has also been a substantial volume of biomechanical research focused on upper and lower extremity injury, thoracic injury, and injury to the elderly – although these injury types still occur with regularity in the field. In contrast, information on pediatric injury and physiological injury (especially in the central nervous system) remains lacking. Given their frequency of injury in the field, future efforts should also include improving our understanding of tolerances and protection of vulnerable road users (e.g., motorcyclists, pedestrians). [ABSTRACT FROM AUTHOR]

This study quantified the mechanical interactions of 19 American football cleats with a natural grass and an infill-type artificial surface under loading conditions designed to represent play-relevant manoeuvres of elite athletes. Variation in peak forces and torques was observed across cleats when tested on natural grass (2.8–4.2 kN in translation, 120–174 Nm in rotation). A significant (p < 0.05) relationship was found between the peak force and torque on natural grass. Almost all of the cleats caused shear failure of the natural surface, which generated a divot following a test. This is a force-limiting cleat release mode. In contrast, all but one of the cleat types held fast in the artificial turf, resulting in force and torque limited by the prescribed input load from the test device (nom. 4.8 kN and 200 Nm). Only one cleat pattern, consisting of small deformable nubs, released on the artificial surface and generated force (3.9 kN) comparable to the range observed with natural grass. These findings (1) should inform the design of cleats intended for use on natural and artificial surfaces and (2) suggest a mechanical explanation for a higher lower-limb injury rate in elite athletes playing on artificial surfaces. [ABSTRACT FROM PUBLISHER]

This study quantified the mechanical interactions between an American football cleat and eight surfaces used by professional American football teams. Loading conditions were applied with a custom-built testing apparatus designed to represent play-relevant maneuvers of elite athletes. Two natural grass and six infill artificial surfaces were tested with the cleated portion of a shoe intended for use on either surface type. In translation tests with a 2. 8-kN vertical load, the grass surfaces limited the horizontal force on the cleats by tearing. This tearing was not observed with the artificial surfaces, which allowed less motion and generated greater horizontal force (3.2 kN vs. 4.5 kN,p < 0.05). Similarly, rotation tests generated less angular displacement and greater torque on the artificial surfaces (145 N m vs. 197 N m,p < 0.05). Translation/drop tests, in which the foot-form was launched into the surfaces with both horizontal and vertical velocity components generated less peak horizontal force on the natural surfaces than on the artificial surfaces (2.4 kN vs. 3.0 kN,p < 0.05). These results suggest a force-limiting mechanism inherent to natural grass surfaces. Future work should consider implications of these findings for performance and injury risk and should evaluate the findings' sensitivity to cleat pattern and playing conditions. [ABSTRACT FROM PUBLISHER]

The costal cartilage often undergoes progressive calcification with age. This study sought to investigate the effects of calcification on the structural mechanics of whole costal cartilage segments. Models were developed for five costal cartilage specimens, including representations of the cartilage, the perichondrium, calcification, and segments of the rib and sternum. The material properties of the cartilage were determined through indentation testing; the properties of the perichondrium were determined through optimisation against structural experiments. The calcified regions were then expanded or shrunk to develop five different sensitivity analysis models for each. Increasing the relative volume of calcification from 0% to 24% of the cartilage volume increased the stiffness of the costal cartilage segments by a factor of 2.3–3.8. These results suggest that calcification may have a substantial effect on the stiffness of the costal cartilage which should be considered when modelling the chest, especially if age is a factor. [ABSTRACT FROM AUTHOR]

Abstract: Powered two-wheelers (PTWs – mopeds, motorcycles, and scooters) remain the most dangerous form of travel on today''s roads. This study used hospital discharge data from eight European countries to examine the frequencies and patterns of injury among PTW users (age≥14 years), the predicted incidence of the loss of functional ability, and the mechanisms of the head injuries observed (all in light of increased helmet use). Of 977,557 injured patients discharged in 2004, 12,994 were identified as having been injured in PTW collisions. Lower extremity injuries accounted for 26% (25.6–26.7, 95% C.I.) of the total injuries, followed by upper extremity injuries (20.7%: 20.3–21.2), traumatic brain injuries (TBI) (18.5%: 18–19), and thoracic injuries (8.2%: 7.8–8.5). Approximately 80% of the lower extremity injury cases were expected to exhibit some functional disability one year following discharge (predicted Functional Capacity Index, pFCI-AIS98<100), compared to 47% of the upper extremity injury cases and 24% of the TBI cases. Although it occurred less frequently, patients that were expected to experience some functional limitation from TBI were predicted to fair worse on average (lose more functional ability) than patients expected to have functional limitations from extremity injuries. Cerebral concussion was the most common head injury observed (occurring in 56% of head injury cases), with most concussion cases (78%) exhibiting no other head injury. Among the AIS3+ head injuries that could be mapped to an injury mechanism, 48% of these were associated with a translational-impact mechanism, and 37% were associated with a rotational mechanism. The observation of high rates of expected long-term disability suggests that future efforts aim to mitigate lower and upper extremity injuries among PTW users. Likewise, the high rates of concussion and head injuries associated with a rotational mechanism provide goals for the next phase of PTW user head protection. [Copyright &y& Elsevier]

Automobile collisions are a major source of injury, death, and disability worldwide. Roadway injuries are affected by societal and cultural influences as much as any other health-related event, but have historically received relatively little attention from the medical anthropology community. The development of safety intervention strategies is affected by notions of responsibility for preventive care, including a balance between regulation, technology, and personal choice. This balance may be affected by perceptions of the risks associated with roadway use, potentially related to notions of individual control and the portrayal of collisions in the popular media and lexicon. Prevention efforts are also affected by the definition of injury as a disease-a biological phenomenon requiring research and intervention efforts from the medical and public health communities. Injury prevention priorities and strategies also differ across cultures and locales, dependent in part on economic constraints, native mobility practices, and the quality and expediency of post-trauma care. Progressing injury prevention worldwide requires multidisciplinary action, including an examination of these various cultural and societal influences. We believe that future efforts will benefit from the expertise and analysis of the medical anthropology community. [ABSTRACT FROM AUTHOR]

Abstract: Contemporary computer models of the thorax designed to predict injury in automobile collisions model the costal cartilage as a homogeneous material using properties derived from local material characterization tests. No studies have validated the accuracy of these models in predicting the structural mechanics of costal cartilage. Two heterogeneities – the perichondrium and calcified regions – may affect the behavior of costal cartilage in a manner not accounted for by current models. This study sought to investigate the predictive ability of subject-specific models of whole costal cartilage segments, with the calcified regions modeled distinctly and with the perichondrium removed (from the physical specimens as well as from the simulations). Finite element models were developed in the case of five cadaveric costal cartilage segments. The properties of the cartilage were derived from indentation testing of each specimen, where the characteristic average instantaneous elastic moduli ranged from 8.7 to 12.6MPa. Matched simulations and experiments were then performed, subjecting each specimen to cantilever-like loading with a dynamic posterior displacement of the sternal boundary (all other boundary degrees-of-freedom fixed). The models predicted the resulting peak anterior–posterior forces generated on the costal boundary with a minimum error of 1% and a maximum error of 36%. These results provide support to the previous implicit assumption that insight can be gained into the structural behavior of costal cartilage by observing the local material properties (when calcified regions are included and the perichondrium is removed). Future work includes the addition of the perichondrium, so as to model the whole costal cartilage composite structure. [Copyright &y& Elsevier]

The Test Device for Human Occupant Restraint (THOR) 50th percentile male anthropomorphic test device (ATD) aims to improve the ability to predict the risk of chest injury to restrained automobile occupants by measuring dynamic chest deflection at multiple locations. This research aimed to describe the methods for developing a thoracic injury risk function (IRF) using the multi-point chest deflection metrics from the 50th percentile male THOR Metric ATD with the SD-3 shoulder and associating to post-mortem human subjects (PMHS) outcomes that were matched on identical frontal and frontal-oblique impact sled testing conditions. Several deflection metrics were assessed as potential predictor variables for AIS 3+ injury risk, including a combined metric, called PC Score, which was generated from a principal component analysis. A parametric survival analysis (specifically, accelerated failure time (AFT) with Weibull distribution) was assessed in the development of the IRF. Model fit was assessed using various modeling diagnostics, including the area under the receiver operating characteristic curve (AUC). Models based on resultant deflection consistently exhibited improved fit compared to models based on x-axis deflection or chord deflection. Risk functions for the THOR PC Score and C max (maximum resultant deflection) were qualitatively equivalent, producing AUCs of 0.857 and 0.861, respectively. Adjusting for the potential confounding effects of age, AFT survival models with C max or PC Score as the primary deflection metric resulted in the THOR injury risk models with the best combination of biomechanical appropriateness, potential utility and model fit, and may be recommended as injury predictors. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine the long-time and transient characteristics of the moment generated by external (ER) and internal (IR) rotation of the calcaneus with respect to the tibia. Two human cadaver legs were disarticulated at the knee joint while maintaining the connective tissue between the tibia and fibula. An axial rotation of 21° was applied to the proximal tibia to generate either ER or IR while the fibula was unconstrained and the calcaneus was permitted to translate in the transverse plane. These boundary conditions were intended to allow natural motion of the fibula and for the effective applied axis of rotation to move relative to the ankle and subtalar joints based on natural articular motions among the tibia, fibula, talus, and calcaneus. A load cell at the proximal tibia measured all components of force and moment. A quasi-linear model of the moment along the tibia axis was developed to determine the transient and long-time loads generated by this ER/IR. Initially neutral, everted, inverted, dorsiflexed, and plantarflexed foot orientations were tested. For the neutral position, the transient elastic moment was 16.5 N-m for one specimen and 30.3 N-m for the other in ER with 26.3 and 32.1 N-m in IR. The long-time moments were 5.5 and 13.2 N-m (ER) and 9.0 and 9.5 N-m (IR). These loads were found to be transient over time similar to previous studies on other biological structures where the moment relaxed as time progressed after the initial ramp in rotation. [ABSTRACT FROM AUTHOR]

Computational human body models (HBMs) are important tools for predicting human biomechanical responses under automotive crash environments. In many scenarios, the prediction of the occupant response will be improved by incorporating active muscle control into the HBMs to generate biofidelic kinematics during different vehicle maneuvers. In this study, we have proposed an approach to develop an active muscle controller based on reinforcement learning (RL). The RL muscle activation control (RL-MAC) approach is a shift from using traditional closed-loop feedback controllers, which can mimic accurate active muscle behavior under a limited range of loading conditions for which the controller has been tuned. Conversely, the RL-MAC uses an iterative training approach to generate active muscle forces for desired joint motion and is analogous to how a child develops gross motor skills. In this study, the ability of a deep deterministic policy gradient (DDPG) RL controller to generate accurate human kinematics is demonstrated using a multibody model of the human arm. The arm model was trained to perform goal-directed elbow rotation by activating the responsible muscles and investigated using two recruitment schemes: as independent muscles or as antagonistic muscle groups. Simulations with the trained controller show that the arm can move to the target position in the presence or absence of externally applied loads. The RL-MAC trained under constant external loads was able to maintain the desired elbow joint angle under a simplified automotive impact scenario, implying the robustness of the motor control approach. [ABSTRACT FROM AUTHOR]

Injuries to the hollow organs of the lower digestive system carry substantial risk of complication due to infection and blood loss, and commonly require invasive abdominal surgery to diagnose and treat. The causes of, and risk factors for, lower abdomen injury in automobile collisions are poorly understood. The goal of this study was to investigate the risk factors and potential mechanisms of hollow-organ, lower abdomen injury in belted automobile occupants in frontal collisions. A field survey data analysis was performed to examine the relationship between various occupant and collision factors and the risk of moderate or greater severity injury (i.e., Abbreviated Injury Scale, AIS 2+) to the small intestine, large intestine, or mesentery among belted occupants involved in frontal collisions. Descriptive and comparative risk factor analyses were performed with data originating from that National Automotive Sampling System Crashworthiness Data System (NASS-CDS) over the years 2000–2011. Multivariable logistic regression models were developed to describe the effects of these factors on hollow-organ injury risk. Potential injury mechanisms were further investigated through in-depth examination of select cases exhibiting hollow-organ injuries from the Crash Investigation Research and Engineering Network (CIREN). The inclusion criteria yielded 25,407 individual cases from NASS-CDS, representing a weighted population of 11,373,358 exposed automobile occupants. Within this dataset, 143 cases (weighted frequency: 7962 occupants) exhibited AIS 2+ injury to hollow abdominal organs. Multivariable regression analysis indicated a statistically significant increased risk of moderate or greater severity injuries to the hollow organs of the abdomen with increased in Δ V (odds ratio (OR) 1.07, 95% confidence interval: 1.06–1.09) and age (OR: 1.03, 1.01–1.06). Albeit non-statistically significant, a positive association between BMI and injury risk was observed, especially among obese individuals (OR: 3.55, 0.82–15.2). No association was observed for gender or seated location within the vehicle. Result from this study indicate that hollow abdominal organ injury is a universal problem in frontal collisions, not confined to a specific gender or seating location. Examination of CIREN cases suggests these types of injuries are associated with direct loading of the lower abdomen by the lap belt, either through poor initial belt positioning or through a “submarining” type of kinematic where the lap belt slips off of the pelvis and loads into the abdomen. Potential countermeasures against hollow-organ abdominal injury should include measures to improve initial lap belt fit, and to retain engagement of the lap belt on the pelvis throughout the collision event. [ABSTRACT FROM AUTHOR]

Player-to-player contact inherent in many unhelmeted sports means that head impacts are a frequent occurrence. Model-Based Image- Matching (MBIM) provides a technique for the assessment of three-dimensional linear and rotational motion patterns from multiple camera views of a head impact event, but the accuracy is unknown for this application. The goal of this study is to assess the accuracy of the MBIM method relative to reflective marker-based motion analysis data for estimating six degree of freedom head displacements and velocities in a staged pedestrian impact scenario at 40 km/h. Results showed RMS error was under 20 mm for all linear head displacements and 0.01-0.04 rad for head rotations. For velocities, the MBIM method yielded RMS errors between 0.42 and 1.29 m/s for head linear velocities and 3.53-5.38 rad/s for angular velocities. This method is thus beneficial as a tool to directly measure six degree of freedom head positional data from video of sporting head impacts, but velocity data is less reliable. MBIM data, combined in future with velocity/acceleration data from wearable sensors could be used to provide input conditions and evaluate the outputs of multibody and finite element head models for brain injury assessment of sporting head impacts. [ABSTRACT FROM AUTHOR]

Vehicle safety systems have substantially decreased motor vehicle crash-related injuries and fatalities, but injuries to the lumbar spine still have been reported. Experimental and computational analyses of upright and, particularly, reclined occupants in frontal crashes have shown that the lumbar spine can be subjected to simultaneous and out-of-phase combined axial compression and flexion loading. Lumbar spine failure tolerance in combined compression-flexion has not been widely explored in the literature. Therefore, the goal of this study was to measure the failure tolerance of the lumbar spine in combined compression and flexion. Forty lumbar spine segments with three vertebrae (one unconstrained) and two intervertebral discs (both unconstrained) were pre-loaded with axial compression (2200N, 3300N, or 4500N) and then subjected to rotation-controlled dynamic flexion bending until failure. Clinically relevant middle vertebra fractures were observed in twenty-one of the specimens, including compression and burst fractures. The remaining nineteen specimens experienced failure at the potting-grip interface. Failure tolerance varied within the sample and were categorized by the appropriate data censoring, with clinically relevant middle vertebrae fractures characterized as uncensored or left-censored and potting-grip fractures characterized as right-censored. Average failure force and moment were 3290N (range: 1580N to 5042N) and 51Nm (range: 0Nm to 156 Nm) for uncensored data, 3686N (range: 3145N to 4112N) and 0Nm for left-censored data, and 3470N (range: 2138N to 5062N) and 101Nm (range: 27Nm to 182Nm) for right-censored data. These data can be used to develop and improve injury prediction tools for lumbar spine fractures and further research in future safety systems. [ABSTRACT FROM AUTHOR]