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8,942 results on '"Fornaro, A"'

1. Nanostructuring of AlCu alloy NPs obtained by FLASiS{\dag}

Author

Santillán, Jesica M. J., Arboleda, David Muñetón, Fornaro, Osvaldo, Lester, Marcelo, Schinca, Daniel C., and Scaffardi, Lucía B.

Subjects
Physics - Optics, Condensed Matter - Materials Science
Abstract

In the nanometric scale, alloy nanomaterials behave as new materials since they are able to display structures and properties which are different from those of the pure metal nanostructures or bulk alloys. In this work, the compositional characteristics of AlCu alloy nanoparticles obtained by {\dag}Femtosecond Laser Ablation Synthesis in Solution (FLASiS) on solid targets with different percentages of Al and Cu were studied. Morphology, structure, composition and plasmonic behaviour of the nanoparticles were analysed by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-ray Spectroscopy (EDS) and Optical Extinction Spectroscopy (OES). From the obtained results, underlying formation mechanism and a configuration model of a host alumina matrix with copper inclusions is proposed. Analysis of the plasmonic resonance spectral region in the extinction spectra of the synthesized colloids using this model show that the nanoparticles have a Cu filling factors of about 0.02 which agrees with those determined independently from TEM images. The amount of Al and Cu components in the nanoparticle depends on their relative percentages in the initial solid target. Here we describe the possible kinetic formation mechanism of these nanostructures., Comment: 37 pages, 12 figures

Published
2024

2. The EUSO-SPB2 Fluorescence Telescope for the Detection of Ultra-High Energy Cosmic Rays

Author

Adams Jr., James H., Allard, Denis, Alldredge, Phillip, Anchordoqui, Luis, Anzalone, Anna, Battisti, Matteo, Belov, Alexander A., Bertaina, Mario, Bertone, Peter F., Blin-Bondil, Sylvie, Burton, Julia, Cafagna, Francesco S., Casolino, Marco, Černý, Karel, Christ, Mark J., Colalillo, Roberta, Crawford, Hank J., Creusot, Alexandre, Cummings, Austin, Diesing, Rebecca, Di Nola, Alessandro, Ebisuzaki, Toshikazu, Eser, Johannes, Ferrarese, Silvia, Filippatos, George, Finch, William W., Flaminio, Flavia, Fornaro, Claudio, Fuehne, Duncan, Fuglesang, Christer, Garg, Diksha, Golzio, Alessio, Guarino, Fausto, Guépin, Claire, Heibges, Tobias, Judd, Eleanor G., Klimov, Pavel A., Krizmanic, John F., Kungel, Viktoria, Kupari, Luke, Kuznetsov, Evgeny, Manfrin, Massimiliano, Marszal, Wlodzimierz, Matthews, John N., Mese, Marco, Meyer, Stephan S., Mignone, Marco, Miyamoto, Hiroko, Murashov, Alexey S., Nachtman, Jane M., Olinto, Angela V., Onel, Yasar, Osteria, Giuseppe, Panico, Beatrice, Parizot, Ètienne, Paul, Tom, Pech, Miroslav, Perfetto, Francesco, Piotrowski, Lech W., Plebaniak, Zbigniew, Posligua, Jonatan, Prévôt, Guillaume, Przybylak, Marika, Reardon, Patrick, Reno, Mary Hall, Ricci, Marco, Sarazin, Fred, Schovánek, P., Scotti, Valentina, Shinozaki, Kenji, Soriano, Jorge F., Stillwell, Ben K., Szabelski, Jacek, Takizawa, Yoshiyuki, Trofimov, Daniil, Unel, Fredrik, Valore, Laura, Venters, Tonia M., Watts Jr., John, Wiencke, Lawrence, Wistrand, Hannah, and Young, Roy

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Extreme Universe Space Observatory on a Super Pressure Balloon 2 (EUSO-SPB2) flew on May 13$^{\text{th}}$ and 14$^{\text{th}}$ of 2023. Consisting of two novel optical telescopes, the payload utilized next-generation instrumentation for the observations of extensive air showers from near space. One instrument, the fluorescence telescope (FT) searched for Ultra-High Energy Cosmic Rays (UHECRs) by recording the atmosphere below the balloon in the near-UV with a 1~$\mu$s time resolution using 108 multi-anode photomultiplier tubes with a total of 6,912 channels. Validated by pre-flight measurements during a field campaign, the energy threshold was estimated around 2~EeV with an expected event rate of approximately 1 event per 10 hours of observation. Based on the limited time afloat, the expected number of UHECR observations throughout the flight is between 0 and 2. Consistent with this expectation, no UHECR candidate events have been found. The majority of events appear to be detector artifacts that were not rejected properly due to a shortened commissioning phase. Despite the earlier-than-expected termination of the flight, data were recorded which provide insights into the detectors stability in the near-space environment as well as the diffuse ultraviolet emissivity of the atmosphere, both of which are impactful to future experiments.

Published
2024
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3. EUSO-SPB1 Mission and Science

Author

Collaboration, JEM-EUSO, Abdellaoui, G., Abe, S., Adams. Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Desiato, J., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Gorodetzky, P., Gregg, R., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Mastafa, M., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sánchez, J. L., Balanzar, J. C. Sanchez, Santangelo, A., Sanz-Andrés, A., Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts. Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33~km). After 12~days and 4~hours aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of approximately 3 EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search., Comment: 18 pages, 19 figures

Published
2024
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4. JEM-EUSO Collaboration contributions to the 38th International Cosmic Ray Conference

Author

Abe, S., Adams Jr., J. H., Allard, D., Alldredge, P., Aloisio, R., Anchordoqui, L., Anzalone, A., Arnone, E., Bagheri, M., Baret, B., Barghini, D., Battisti, M., Bellotti, R., Belov, A. A., Bertaina, M., Bertone, P. F., Bianciotto, M., Bisconti, F., Blaksley, C., Blin-Bondil, S., Bolmgren, K., Briz, S., Burton, J., Cafagna, F., Cambiè, G., Campana, D., Capel, F., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Černý, K., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., Diesing, R., Dinaucourt, P., Di Nola, A., Ebisuzaki, T., Eser, J., Fenu, F., Ferrarese, S., Filippatos, G., Finch, W. W., Flaminio, F., Fornaro, C., Fuehne, D., Fuglesang, C., Fukushima, M., Gadamsetty, S., Gardiol, D., Garipov, G. K., Gazda, E., Golzio, A., Guarino, F., Guépin, C., Haungs, A., Heibges, T., Isgrò, F., Judd, E. G., Kajino, F., Kaneko, I., Kim, S. -W., Klimov, P. A., Krizmanic, J. F., Kungel, V., Kuznetsov, E., Martínez, F. López, Mandát, D., Manfrin, M., Marcelli, A., Marcelli, L., Marszał, W., Matthews, J. N., Mese, M., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Nagataki, S., Nachtman, J. M., Naumov, D., Neronov, A., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Panico, B., Parizot, E., Park, I. H., Paul, T., Pech, M., Perfetto, F., Picozza, P., Piotrowski, L. W., Plebaniak, Z., Posligua, J., Potts, M., Prevete, R., Prévôt, G., Przybylak, M., Reali, E., Reardon, P., Reno, M. H., Ricci, M., Matamala, O. F. Romero, Romoli, G., Sagawa, H., Sakaki, N., Saprykin, O. A., Sarazin, F., Sato, M., Schovánek, P., Scotti, V., Selmane, S., Sharakin, S. A., Shinozaki, K., Stepanoff, S., Soriano, J. F., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Thomas, S. B., Tkachev, L. G., Tomida, T., Toscano, S., Traïche, M., Trofimov, D., Tsuno, K., Vallania, P., Valore, L., Venters, T. M., Vigorito, C., Vrábel, M., Wada, S., Watts Jr., J., Wiencke, L., Winn, D., Wistrand, H., Yashin, I. V., Young, R., and Zotov, M. Yu.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

This is a collection of papers presented by the JEM-EUSO Collaboration at the 38th International Cosmic Ray Conference (Nagoya, Japan, July 26-August 3, 2023)

Published
2023

5. Developments and results in the context of the JEM-EUSO program obtained with the ESAF Simulation and Analysis Framework

Author

Abe, S., Adams Jr., J. H., Allard, D., Alldredge, P., Anchordoqui, L., Anzalone, A., Arnone, E., Baret, B., Barghini, D., Battisti, M., Bayer, J., Bellotti, R., Belov, A. A., Bertaina, M., Bertone, P. F., Bianciotto, M., Biermann, P. L., Bisconti, F., Blaksley, C., Blin-Bondil, S., Bobik, P., Bolmgren, K., Briz, S., Burton, J., Cafagna, F., Cambié, G., Campana, D., Capel, F., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Černý, K., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Diesing, R., Dinaucourt, P., Di Nola, A., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Ferrarese, S., Filippatos, G., Finch, W. W., Flaminio, F., Fornaro, C., Fuehne, D., Fuglesang, C., Fukushima, M., Gardiol, D., Garipov, G. K., Golzio, A., Gorodetzky, P., Guarino, F., Guépin, C., Guzmán, A., Haungs, A., Heibges, T., Hernández-Carretero, J., Isgrò, F., Judd, E. G., Kajino, F., Kaneko, I., Kawasaki, Y., Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Kungel, V., Kuznetsov, E., Martínez, F. López, Mackovjak, S., Mandát, D., Manfrin, M., Marcelli, A., Marcelli, L., Marszał, W., Matthews, J. N., Menshikov, A., Mernik, T., Mese, M., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A Morales de los, Nagataki, S., Nachtman, J. M., Naumov, D., Neronov, A., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Pagliaro, A., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Perfetto, F., Picozza, P., Piotrowski, L. W., Plebaniak, Z., Posligua, J., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Putis, M., Reali, E., Reardon, P., Reno, M. H., Ricci, M., Frías, M. Rodríguez, Romoli, G., Cano, G. Sáez, Sagawa, H., Sakaki, N., Santangelo, A., Saprykin, O. A., Sarazin, F., Sato, M., Schieler, H., Schovánek, P., Scotti, V., Selmane, S., Sharakin, S. A., Shinozaki, K., Soriano, J. F., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Tenzer, C., Thomas, S. B., Tkachev, L. G., Tomida, T., Toscano, S., Traïche, M., Trofimov, D., Tsuno, K., Vallania, P., Valore, L., Venters, T. M., Vigorito, C., von Ballmoos, P., Vrabel, M., Wada, S., Watts Jr., J., Weindl, A., Wiencke, L., Wilms, J., Winn, D., Wistrand, H., Yashin, I. V., Young, R., and Zotov, M. Yu.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

JEM--EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAFin the framework of the JEM--EUSO program and explain the physical assumptions used. We present here the implementation of the JEM--EUSO, POEMMA, K--EUSO, TUS, Mini--EUSO, EUSO--SPB1 and EUSO--TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.

Published
2023
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7. Durvalumab Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Biliary Tract Cancer: a Real-World Retrospective, Multicenter Study

Author

Rimini, Margherita, Masi, Gianluca, Lonardi, Sara, Nichetti, Federico, Pressiani, Tiziana, Lavacchi, Daniele, Jessica, Lucchetti, Giordano, Guido, Scartozzi, Mario, Tamburini, Emiliano, Pastorino, Alessandro, Rapposelli, Ilario Giovanni, Daniele, Bruno, Martinelli, Erika, Garajova, Ingrid, Aprile, Giuseppe, Schirripa, Marta, Formica, Vincenzo, Salani, Francesca, Winchler, Costanza, Bergamo, Francesca, Balsano, Rita, Gusmaroli, Eleonora, Lorenzo, Angotti, Landriscina, Matteo, Pretta, Andrea, Toma, Ilaria, Pirrone, Chiara, Diana, Anna, Leone, Francesco, Brunetti, Oronzo, Brandi, Giovanni, Garattini, Silvio Ken, Satolli, Maria Antonietta, Rossari, Federico, Fornaro, Lorenzo, Niger, Monica, Zanuso, Valentina, De Rosa, Antonio, Ratti, Francesca, Aldrighetti, Luca, De Braud, Filippo, Foti, Silvia, Rizzato, Mario Domenico, Vivaldi, Caterina, Stefano, Cascinu, Rimassa, Lorenza, Antonuzzo, Lorenzo, and Casadei-Gardini, Andrea

Published
2024
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9. The Data Processor of the SPB2 Fluorescence Telescope: in flight performance

Author

Scotti, Valentina, Anastasio, Antonio, Boiano, Alfonso, Cafagna, Francesco, Fornaro, Claudio, Masone, Vincenzo, Mese, Marco, Osteria, Giuseppe, Perfetto, Francesco, Tortone, Gennaro, and Vanzanella, Antonio

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

EUSO-SPB2 (Extreme Universe Space Observatory on a Super Pressure Balloon II) is a precursor mission for a future space observatory for multi-messenger astrophysics, planned to be launched in Spring 2023 with a flight duration target of 100 days. The Fluorescence Telescope (FT) hosted on board is designed to detect Ultra High Energy Cosmic Rays via the UV fluorescence emission of the Extensive Air Showers in the atmosphere. The Data Processor (DP) of the FT is the component of the electronics system that performs data management and instrument control for the telescope. The DP controls front-end electronics, tags events with arrival time and payload position through a GPS system, provides signals for time synchronization of the event and measures the live and dead time of the telescope. Furthermore, it manages mass memory for data storage, performs housekeeping monitoring, and controls the power-on and power-off sequences. Finally, the data processor combines the data from the PDMs and onboard differential GPS and prioritizes data for download. The long duration of the flight poses strict requirements on electronics and data handling. The operations at high altitude in an unpressurized environment represent a technological challenge for heat dissipation. This contribution will provide an overview of the innovative elements developed and the results of the integration and field test campaigns. We will also present some preliminary analysis of the performance during the flight.

Published
2023
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10. Differentiability in infinite dimension and the Malliavin calculus

Author

Bignamini, Davide A., Ferrari, Simone, Fornaro, Simona, and Zanella, Margherita

Subjects
Mathematics - Functional Analysis, Mathematics - Probability, 28C20, 46G05
Abstract

In this paper we study two notions of differentiability introduced by P. Cannarsa and G. Da Prato (see [28]) and L. Gross (see [56]) in both the framework of infinite dimensional analysis and the framework of Malliavin calculus.

Published
2023

13. Investigating the stability of aromatic carboxylic acids in hydrated magnesium sulfate under UV irradiation to assist detection of organics on Mars

Author

Alberini, Andrew, Fornaro, Teresa, García-Florentino, Cristina, Biczysko, Malgorzata, Poblacion, Iratxe, Aramendia, Julene, Madariaga, Juan Manuel, Poggiali, Giovanni, Vicente-Retortillo, Álvaro, Benison, Kathleen C., Siljeström, Sandra, Biancalani, Sole, Lorenz, Christian, Cloutis, Edward A., Applin, Dan M., Gómez, Felipe, Steele, Andrew, Wiens, Roger C., Hand, Kevin P., and Brucato, John R.

Published
2024
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15. Correction to: A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY tract cancers (BTC) at high risk for recurrence: PURITY study

Author

Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Rafaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, and Mazzaferro, Vincenzo

Published
2024
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16. A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study

Author

Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Raffaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, and Mazzaferro, Vincenzo

Published
2024
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17. Different Genomic Clusters Impact on Responses in Advanced Biliary Tract Cancer Treated with Cisplatin Plus Gemcitabine Plus Durvalumab

Author

Rimini, Margherita, Loi, Eleonora, Rizzato, Mario Domenico, Pressiani, Tiziana, Vivaldi, Caterina, Gusmaroli, Eleonora, Antonuzzo, Lorenzo, Martinelli, Erika, Garajova, Ingrid, Giordano, Guido, Lucchetti, Jessica, Schirripa, Marta, Cornara, Noemi, Rossari, Federico, Vitiello, Francesco, Amadeo, Elisabeth, Persano, Mara, Piva, Vittoria Matilde, Balsano, Rita, Salani, Francesca, Pircher, Chiara, Cascinu, Stefano, Niger, Monica, Fornaro, Lorenzo, Rimassa, Lorenza, Lonardi, Sara, Scartozzi, Mario, Zavattari, Patrizia, and Casadei-Gardini, Andrea

Published
2024
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19. Investigating the stability of aromatic carboxylic acids in hydrated magnesium sulfate under UV irradiation to assist detection of organics on Mars

Author

Andrew Alberini, Teresa Fornaro, Cristina García-Florentino, Malgorzata Biczysko, Iratxe Poblacion, Julene Aramendia, Juan Manuel Madariaga, Giovanni Poggiali, Álvaro Vicente-Retortillo, Kathleen C. Benison, Sandra Siljeström, Sole Biancalani, Christian Lorenz, Edward A. Cloutis, Dan M. Applin, Felipe Gómez, Andrew Steele, Roger C. Wiens, Kevin P. Hand, and John R. Brucato

Subjects
Aromatic organic compounds, FTIR spectroscopy, UV irradiation, Signs of biological activity, Mars 2020 Perseverance mission, Medicine, Science
Abstract

Abstract The Scanning Habitable Environments with Raman and Luminescence for Organics and Chemicals (SHERLOC) instrument onboard the Mars 2020 Perseverance rover detected so far some of the most intense fluorescence signals in association with sulfates analyzing abraded patches of rocks at Jezero crater, Mars. To assess the plausibility of an organic origin of these signals, it is key to understand if organics can survive exposure to ambient Martian UV after exposure by the Perseverance abrasion tool and prior to analysis by SHERLOC. In this work, we investigated the stability of organo-sulfate assemblages under Martian-like UV irradiation and we observed that the spectroscopic features of phthalic and mellitic acid embedded into hydrated magnesium sulfate do not change for UV exposures corresponding to at least 48 Martian sols and, thus, should still be detectable in fluorescence when the SHERLOC analysis takes place, thanks to the photoprotective properties of magnesium sulfate. In addition, different photoproduct bands diagnostic of the parent carboxylic acid molecules could be observed. The photoprotective behavior of hydrated magnesium sulfate corroborates the hypothesis that sulfates might have played a key role in the preservation of organics on Mars, and that the fluorescence signals detected by SHERLOC in association with sulfates could potentially arise from organic compounds.

Published
2024
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20. Parents’ Participation in Care during Neonatal Intensive Care Unit Stay in COVID-19 Era: An Observational Study

Author

Emanuele Buccione, Davide Scarponcini Fornaro, Damiana Pieragostino, Luca Natale, Adelaide D’Errico, Valentina Chiavaroli, Laura Rasero, Stefano Bambi, Carlo Della Pelle, and Susanna Di Valerio

Subjects
neonatal intensive care unit, parenthood, newborn, preterm, nurse, Nursing, RT1-120
Abstract

Background: Parents play a crucial role in the care of infants during their stay in the neonatal intensive care unit (NICU). Recent studies have reported a decrease in parental participation due to the coronavirus disease (COVID-19) pandemic, which has led to restricted access policies in hospitals. The aim of this study was to describe the barriers to good parental participation during their stay in the neonatal intensive care unit in the COVID-19 era. Methods: This was a quantitative, observational study. Results: A total of 270 parents participated in this study. Mothers’ participation in care was higher than that of fathers (p = 0.017). Parents who lived at the birth of their first child reported a better level of participation in care compared to those who lived at the birth of their second-born (p = 0.005). Parents of extremely preterm neonates reported a lower interaction with their infants than parents of term newborns (p < 0.001). Conclusions: Some disadvantaged categories reported lower scores for cultural and linguistic minorities, parents of multiple children, and fathers. The COVID-19 pandemic has made several family-centred care activities impossible, with a higher impact on those who benefited most of these facilities. This study was prospectively approved by the IRB-CRRM of the University “G. d’Annunzio” Chieti-Pescara on 23 January 2024 (approval number CRRM: 2023_12_07_01).

Published
2024
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21. Radiation-induced alteration of apatite on the surface of Mars: first in situ observations with SuperCam Raman onboard Perseverance

Author

E. Clavé, O. Beyssac, S. Bernard, C. Royer, G. Lopez-Reyes, S. Schröder, K. Rammelkamp, O. Forni, A. Fau, A. Cousin, J. A. Manrique, A. Ollila, J. M. Madariaga, J. Aramendia, S. K. Sharma, T. Fornaro, S. Maurice, R. C. Wiens, and the SuperCam Science team

Subjects
Medicine, Science
Abstract

Abstract Planetary exploration relies considerably on mineral characterization to advance our understanding of the solar system, the planets and their evolution. Thus, we must understand past and present processes that can alter materials exposed on the surface, affecting space mission data. Here, we analyze the first dataset monitoring the evolution of a known mineral target in situ on the Martian surface, brought there as a SuperCam calibration target onboard the Perseverance rover. We used Raman spectroscopy to monitor the crystalline state of a synthetic apatite sample over the first 950 Martian days (sols) of the Mars2020 mission. We note significant variations in the Raman spectra acquired on this target, specifically a decrease in the relative contribution of the Raman signal to the total signal. These observations are consistent with the results of a UV-irradiation test performed in the laboratory under conditions mimicking ambient Martian conditions. We conclude that the observed evolution reflects an alteration of the material, specifically the creation of electronic defects, due to its exposure to the Martian environment and, in particular, UV irradiation. This ongoing process of alteration of the Martian surface needs to be taken into account for mineralogical space mission data analysis.

Published
2024
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22. Science Priorities for the Extraction of the Solid MSR Samples from their Sample Tubes

Author

Dauphas, N., Russell, S. S., Beaty, D., Thiessen, F., Barnes, J., Bonal, L., Bridges, J., Bristow, T., Eiler, J., Ferriere, L., Fornaro, T., Gattacceca, J., Hoffman, B., Javaux, E. J., Kleine, T., McSween, H. Y., Prasad, M., Rampe, L., Schmidt, M., Schoene, B., Siebach, K. L., Stern, J., and Tosca, N.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Physics - Geophysics
Abstract

Preservation of the chemical and structural integrity of samples that will be brought back from Mars is paramount to achieving the scientific objectives of MSR. Given our knowledge of the nature of the samples retrieved at Jezero by Perseverance, at least two options need to be tested for opening the sample tubes: (1) One or two radial cuts at the end of the tube to slide the sample out. (2) Two radial cuts at the ends of the tube and two longitudinal cuts to lift the upper half of the tube and access the sample. Strategy 1 will likely minimize contamination but incurs the risk of affecting the physical integrity of weakly consolidated samples. Strategy 2 will be optimal for preserving the physical integrity of the samples but increases the risk of contamination and mishandling of the sample as more manipulations and additional equipment will be needed. A flexible approach to opening the sample tubes is therefore required, and several options need to be available, depending on the nature of the rock samples returned. Both opening strategies 1 and 2 may need to be available when the samples are returned to handle different sample types (e.g., loosely bound sediments vs. indurated magmatic rocks). This question should be revisited after engineering tests are performed on analogue samples. The MSR sample tubes will have to be opened under stringent BSL4 conditions and this aspect needs to be integrated into the planning., Comment: 8 pages, 3 figures, 1 table, report NASA-ESA Mars Rock Team Report

Published
2023

23. Moonraker -- Enceladus Multiple Flyby Mission

Author

Mousis, O., Bouquet, A., Langevin, Y., André, N., Boithias, H., Durry, G., Faye, F., Hartogh, P., Helbert, J., Iess, L., Kempf, S., Masters, A., Postberg, F., Renard, J. -B., Vernazza, P., Vorburger, A., Wurz, P., Atkinson, D. H., Barabash, S., Berthomier, M., Brucato, J., Cable, M., Carter, J., Cazaux, S., Coustenis, A., Danger, G., Dehant, V., Fornaro, T., Garnier, P., Gautier, T., Groussin, O., Hadid, L. Z., Ize, J. -C., Kolmasova, I., Lebreton, J. -P., Maistre, S. Le, Lellouch, E., Lunine, J. I., Mandt, K. E., Martins, Z., Mimoun, D., Nenon, Q., Caro, G. M. Munõz, Rannou, P., Rauer, H., Schmitt-Kopplin, P., Schneeberger, A., Simons, M., Stephan, K., Van Hoolst, T., Vaverka, J., Wieser, M., and Wörner, L.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Enceladus, an icy moon of Saturn, possesses an internal water ocean and jets expelling ocean material into space. Cassini investigations indicated that the subsurface ocean could be a habitable environment having a complex interaction with the rocky core. Further investigation of the composition of the plume formed by the jets is necessary to fully understand the ocean, its potential habitability, and what it tells us about Enceladus' origin. Moonraker has been proposed as an ESA M-class mission designed to orbit Saturn and perform multiple flybys of Enceladus, focusing on traversals of the plume. The proposed Moonraker mission consists of an ESA-provided platform, with strong heritage from JUICE and Mars Sample Return, and carrying a suite of instruments dedicated to plume and surface analysis. The nominal Moonraker mission has a duration of 13.5 years. It includes a 23-flyby segment with 189 days allocated for the science phase, and can be expanded with additional segments if resources allow. The mission concept consists in investigating: i) the habitability conditions of present-day Enceladus and its internal ocean, ii) the mechanisms at play for the communication between the internal ocean and the surface of the South Polar Terrain, and iii) the formation conditions of the moon. Moonraker, thanks to state-of-the-art instruments representing a significant improvement over Cassini's payload, would quantify the abundance of key species in the plume, isotopic ratios, and physical parameters of the plume and the surface. Such a mission would pave the way for a possible future landed mission., Comment: Accepted for publication in The Planetary Science Journal

Published
2022

24. Prediction of medical admissions after psychiatric inpatient hospitalization in bipolar disorder: a retrospective cohort study

Author

Alessandro Miola, Michele De Prisco, Marialaura Lussignoli, Nicola Meda, Elisa Dughiero, Riccardo Costa, Nicolas A. Nunez, Michele Fornaro, Marin Veldic, Mark A. Frye, Eduard Vieta, Marco Solmi, Joaquim Radua, and Fabio Sambataro

Subjects
bipolar disorder, comorbidity, premature mortality, general medicine admission, machine learning, clinical decision-making, Psychiatry, RC435-571
Abstract

ObjectiveBipolar Disorder (BD) is a severe mental illness associated with high rates of general medical comorbidity, reduced life expectancy, and premature mortality. Although BD has been associated with high medical hospitalization, the factors that contribute to this risk remain largely unexplored. We used baseline medical and psychiatric records to develop a supervised machine learning model to predict general medical admissions after discharge from psychiatric hospitalization.MethodsIn this retrospective three-year cohort study of 71 patients diagnosed with BD (mean age=52.19 years, females=56.33%), lasso regression models combining medical and psychiatric records, as well as those using them separately, were fitted and their predictive power was estimated using a leave-one-out cross-validation procedure.ResultsThe proportion of medical admissions in patients with BD was higher compared with age- and sex-matched hospitalizations in the same region (25.4% vs. 8.48%). The lasso model fairly accurately predicted the outcome (area under the curve [AUC]=69.5%, 95%C.I.=55–84.1; sensitivity=61.1%, specificity=75.5%, balanced accuracy=68.3%). Notably, pre-existing cardiovascular, neurological, or osteomuscular diseases collectively accounted for more than 90% of the influence on the model. The accuracy of the model based on medical records was slightly inferior (AUC=68.7%, 95%C.I. = 54.6-82.9), while that of the model based on psychiatric records only was below chance (AUC=61.8%, 95%C.I.=46.2–77.4).ConclusionOur findings support the need to monitor medical comorbidities during clinical decision-making to tailor and implement effective preventive measures in people with BD. Further research with larger sample sizes and prospective cohorts is warranted to replicate these findings and validate the predictive model.

Published
2024
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25. Astrobiological Potential of Rocks Acquired by the Perseverance Rover at a Sedimentary Fan Front in Jezero Crater, Mars

Author

T. Bosak, D. L. Shuster, E. L. Scheller, S. Siljeström, M. J. Zawaski, L. Mandon, J. I. Simon, B. P. Weiss, K. M. Stack, E. N. Mansbach, A. H. Treiman, K. C. Benison, A. J. Brown, A. D. Czaja, K. A. Farley, E. M. Hausrath, K. Hickman‐Lewis, C. D. K. Herd, J. R. Johnson, L. E. Mayhew, M. E. Minitti, K. H. Williford, B. V. Wogsland, M.‐P. Zorzano, A. C. Allwood, H. E. F. Amundsen, J. F. Bell III, K. Benzerara, S. Bernard, O. Beyssac, D. K. Buckner, M. Cable, F. Calef III, G. Caravaca, D. C. Catling, E. Clavé, E. Cloutis, B. A. Cohen, A. Cousin, E. Dehouck, A. G. Fairén, D. T. Flannery, T. Fornaro, O. Forni, T. Fouchet, E. Gibbons, F. Gomez Gomez, S. Gupta, K. P. Hand, J. A. Hurowitz, H. Kalucha, D. A. K. Pedersen, G. Lopes‐Reyes, J. N. Maki, S. Maurice, J. I. Nuñez, N. Randazzo, J. W. Rice Jr., C. Royer, M. A. Sephton, S. Sharma, A. Steele, C. D. Tate, K. Uckert, A. Udry, R. C. Wiens, and A. Williams

Subjects
Mars, sedimentary geochemistry, planetary geochemistry, origin of life, hydrothermal systems and weathering on other planets, hydrology and fluvial processes, Geology, QE1-996.5, Geophysics. Cosmic physics, QC801-809
Abstract

Abstract The Perseverance rover has collected seven oriented samples of sedimentary rocks, all likely older than the oldest signs of widespread life on Earth, at the exposed base of the western fan in Jezero crater, Mars. The samples include a sulfate‐ and clay‐bearing mudstone and sandstone, a fluvial sandstone from a stratigraphically low position at the fan front, and a carbonate‐bearing sandstone deposited above the sulfate‐bearing strata. All samples contain aqueously precipitated materials and most or all were aqueously deposited. Although the rover instruments have not confidently detected organic matter in the rocks from the fan front, the much more sensitive terrestrial instruments will still be able to search for remnants of prebiotic chemistries and past life, and study Mars's past habitability in the samples returned to Earth. The hydrated, sulfate‐bearing mudstone has the highest potential to preserve organic matter and biosignatures, whereas the carbonate‐bearing sandstones can be used to constrain when and for how long Jezero crater contained liquid water. Returned sample science analyses of sulfate, carbonate, clay, phosphate and igneous minerals as well as trace metals and volatiles that are present in the samples acquired at the fan front would provide transformative insights into past habitable environments on Mars, the evolution of its magnetic field, atmosphere and climate and the past and present cycling of atmospheric and crustal water, sulfur and carbon.

Published
2024
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33. A Comparison Between Different Hybrid Electric Propulsion System Configurations by Means of Vibrational Analysis and Fuel Consumption

Author

Niola, Vincenzo, Fornaro, Enrico, Spirto, Mario, Malfi, Pierangelo, Melluso, Francesco, Ceccarelli, Marco, Series Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Quaglia, Giuseppe, editor, Boschetti, Giovanni, editor, and Carbone, Giuseppe, editor

Published
2024
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34. Torque and Angular Velocity Estimation of an Electric Machine Through Neural Networks Based Approach

Author

Fornaro, Enrico, Melluso, Francesco, Nicolella, Armando, Spirto, Mario, Ceccarelli, Marco, Series Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Quaglia, Giuseppe, editor, Boschetti, Giovanni, editor, and Carbone, Giuseppe, editor

Published
2024
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35. Bridging the AI Knowledge Gap with Open Online Education in Europe

Author

Assante, Dario, Fornaro, Claudio, Laura, Luigi, Pirrone, Daniele, Gokdemir, Ali, Jecheva, Veselina, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Auer, Michael E., editor, Langmann, Reinhard, editor, May, Dominik, editor, and Roos, Kim, editor

Published
2024
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40. Concordance of microsatellite instability and mismatch repair status in paired biopsies and surgical specimens of resectable gastroesophageal adenocarcinoma: time for a call to action

Author

Fornaro, Lorenzo, Lonardi, Sara, Catanese, Silvia, Nappo, Floriana, Pietrantonio, Filippo, Pellino, Antonio, Angerilli, Valentina, Signorini, Francesca, Salani, Francesca, Murgioni, Sabina, Neculaescu, Ioana Ancuta, Bruno, Rossella, Vivaldi, Caterina, Ricagno, Gianmarco, Masi, Gianluca, Bergamo, Francesca, Ugolini, Clara, and Fassan, Matteo

Published
2023
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41. A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study

Author

Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi, Raffaella Longarini, Giuseppina Arcangeli, Salvatore Corallo, Laura Delliponti, Stefano Tamberi, Elena Fea, Giovanni Brandi, Ilario Giovanni Rapposelli, Massimiliano Salati, Paolo Baili, Rosalba Miceli, Silva Ljevar, Ilaria Cavallo, Elisa Sottotetti, Antonia Martinetti, Michele Droz Dit Busset, Carlo Sposito, Maria Di Bartolomeo, Filippo Pietrantonio, Filippo de Braud, and Vincenzo Mazzaferro

Subjects
Biliary tract cancers, Cholangiocarcinoma, Neoadjuvant chemotherapy, Cisplatin gemcitabine nabpaclitaxel, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1–3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures that have a remarkable risk of postoperative morbidity and mortality, the 5-year survival rate after radical surgery (R0) is 20–40% and recurrence rates are up to ~ 75%(4–6). Up to ~ 40% of patients relapse within 12 months after resection, and half of these patient will recur systemically(4–6). There is no standard of care for neoadjuvant chemotherapy (NAC) in resectable BTC, but retrospective reports suggest its potential benefit (7, 8). Methods PURITY is a no-profit, multicentre, randomized phase II/III trial aimed at evaluating the efficacy of the combination of gemcitabine, cisplatin and nabpaclitaxel (GAP) as neoadjuvant treatment in patients with resectable BTC at high risk for recurrence. Primary objective of this study is to evaluate the efficacy of neoadjuvant GAP followed by surgery as compared to upfront surgery, in terms of 12-month progression-free survival for the phase II part and of progression free survival (PFS) for the phase III study. Key Secondary objectives are event free survival (EFS), relapse-free survival, (RFS), overall survival (OS), R0/R1/R2 resection rate, quality of life (QoL), overall response rate (ORR), resectability. Safety analyses will include toxicity rate and perioperative morbidity and mortality rate. Exploratory studies including Next-Generation Sequencing (NGS) in archival tumor tissues and longitudinal ctDNA analysis are planned to identify potential biomarkers of primary resistance and prognosis. Discussion Considering the poor prognosis of resected BTC experiencing early tumor recurrence and the negative prognostic impact of R1/R2 resections, PURITY study is based on the rationale that NAC may improve R0 resection rates and ultimately patients’ outcomes. Furthermore, NAC should allow early eradication of microscopic distant metastases, undetectable by imaging but already present at the time of diagnosis and avoid mortality and morbidity associated with resection for patients with rapid progression or worsening general condition during neoadjuvant therapy. The randomized PURITY study will evaluate whether patients affected by BTC at high risk from recurrence benefit from a neoadjuvant therapy with GAP regimen as compared to immediate surgery. Trial registration PURITY is registered at ClinicalTrials.gov (NCT06037980) and EuCT(2023–503295-25–00).

Published
2024
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46. SAR interferometry

Author

Fornaro, Gianfranco, primary, Schirinzi, Gilda, additional, Pauciullo, Antonio, additional, Pascazio, Vito, additional, and Reale, Diego, additional

Published
2024
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49. 2D SAR focusing

Author

Fornaro, Gianfranco, primary, Schirinzi, Gilda, additional, Pauciullo, Antonio, additional, Pascazio, Vito, additional, and Reale, Diego, additional

Published
2024
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50. SAR tomography

Author

Fornaro, Gianfranco, primary, Schirinzi, Gilda, additional, Pauciullo, Antonio, additional, Pascazio, Vito, additional, and Reale, Diego, additional

Published
2024
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