324 results on '"Forouhar, Farhad"'
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2. MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis
3. The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma
4. Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
5. Small-molecule allosteric inhibitors of GPX4
6. OPDA signaling channels resource (e−) allocation from the photosynthetic electron transfer chain to plastid cysteine biosynthesis in defense activation.
7. Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19
8. Characterization of a patient-derived variant of GPX4 for precision therapy
9. Oligomeric interactions maintain active‐site structure in a noncooperative enzyme family
10. Sensory Domains That Control Cyclic di-GMP-Modulating Proteins: A Critical Frontier in Bacterial Signal Transduction
11. Structures of Human Phosphofructokinase-1 and Atomic Basis of Cancer-Associated Mutations
12. Author Correction: Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
13. Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
14. Systematic enhancement of protein crystallization efficiency by bulk lysine‐to‐arginine (KR) substitution
15. Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
16. Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator
17. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia
18. Structural and Biochemical Studies Identify Tobacco SABP2 as a Methyl Salicylate Esterase and Implicate It in Plant Innate Immunity
19. Computational protein engineering for systematic enhancement of crystallization propensity
20. The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma
21. Kinases Controlling Stability of the Oncogenic MYCN Protein.
22. Data from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
23. Supplementary Table from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
24. Supplementary Figure from Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
25. Unanticipated coordination of tris buffer to the Radical SAM cluster of the RimO methylthiotransferase
26. Computational structure prediction methods enable the systematic identification of oncogenic mutations
27. Enzymatic Basis for N-Glycan Sialylation: STRUCTURE OF RAT α2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATION
28. Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations
29. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
30. The methylthiolation reaction mediated by the Radical-SAM enzymes
31. Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification
32. Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
33. Structural Conservation of the Myoviridae Phage Tail Sheath Protein Fold
34. Novel C-terminal Motif within Sec7 Domain of Guanine Nucleotide Exchange Factors Regulates ADP-ribosylation Factor (ARF) Binding and Activation
35. Molecular Insights into Substrate Recognition and Catalysis by Tryptophan 2,3-Dioxygenase
36. S-Adenosylmethionine-dependent radical-based modification of biological macromolecules
37. Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA
38. Post-translational Modification of Ribosomal Proteins: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF RimO FROM THERMOTOGA MARITIMA, A RADICAL S-ADENOSYLMETHIONINE METHYLTHIOTRANSFERASE
39. Characterization of a patient-derived variant of GPX4 for precision therapy
40. A community resource of experimental data for NMR / X-ray crystal structure pairs
41. Use of a Synthetic Salicylic Acid Analog to Investigate the Roles of Methyl Salicylate and Its Esterases in Plant Disease Resistance
42. Two poplar methyl salicylate esterases display comparable biochemical properties but divergent expression patterns
43. Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening
44. Molecular Insights into the Biosynthesis of the F420 Coenzyme
45. Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila
46. NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway
47. The structural basis of cyclic diguanylate signal transduction by PilZ domains
48. Functional insights from structural genomics
49. Crystal Structures of Two Bacterial 3-Hydroxy-3-methylglutaryl-CoA Lyases Suggest a Common Catalytic Mechanism among a Family of TIM Barrel Metalloenzymes Cleaving Carbon-Carbon Bonds
50. Crystal Structure of Human 3-Hydroxy-3-methylglutaryl-CoA Lyase: INSIGHTS INTO CATALYSIS AND THE MOLECULAR BASIS FOR HYDROXYMETHYLGLUTARIC ACIDURIA
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