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2. Perspectives on COVID-19 Vaccination and Vaccine Passports in a Diverse Urban Adolescent Population: A Youth Participatory Mixed Methods Study

Author

McKinnon, Britt, Abalovi, Krystelle, Fortin, Geneviève, Parvez, Maryam, Dalal, Sanya, Bouabid, Rania, Jasmin, Djunah, Zéphrin, Michaelson, Gupta, Nandini, Hasan, Abir Tausif, Andog-naba Sebastien, Azael, Taheem, Binal, Dubé, Ève, Tuong Nguyen, Cat, Quach, Caroline, Vandermorris, Ashley, and Zinszer, Kate

Published
2023
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3. Work Well-Being During COVID-19: A Survey of Canadian Early Childhood Education and Care Managers

Author

Bigras, Nathalie, Fortin, Geneviève, Lemay, Lise, Robert-Mazaye, Christelle, Charron, Annie, Duval, Stéphanie, Renck Jalongo, Mary, Series Editor, Crawford, Patricia A., Series Editor, Siu, Kin Wai Michael, Series Editor, Andrews, Paul, Editorial Board Member, Boyer, Wanda, Editorial Board Member, Caldarella, Paul, Editorial Board Member, Conrad Barnyak, Natalie K., Editorial Board Member, Goodwin, A. Lin, Editorial Board Member, Kirnan, Jean, Editorial Board Member, Loizou, Eleni, Editorial Board Member, Narey, Marilyn J., Editorial Board Member, Pattnaik, Jyotsna, Editorial Board Member, Szente, Judit, Editorial Board Member, Tesar, Marek, Editorial Board Member, Wasik, Barbara, Editorial Board Member, and Wasserman, Leslie Haley, Editorial Board Member

Published
2022
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9. CD47Low Status on CD4 Effectors Is Necessary for the Contraction/Resolution of the Immune Response in Humans and Mice

Author

Van, Vu Quang, primary, Baba, Nobuyasu, additional, Rubio, Manuel, additional, Wakahara, Keiko, additional, Panzini, Benoit, additional, Richard, Carole, additional, Soucy, Genevieve, additional, Franchimont, Denis, additional, Fortin, Genevieve, additional, Torres, Ana Carolina Martinez, additional, Cabon, Lauriane, additional, Susin, Santos, additional, and Sarfati, Marika, additional

Published
2012
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10. CD47low status on CD4 effectors is necessary for the contraction of the immune response in humans and mice (69.13)

Author

Van, Vu Quang, primary, Baba, Nobuyasu, additional, Rubio, Manuel, additional, Wakahara, Keiko, additional, Panzini, Benoit, additional, Richard, Carole, additional, Susin, Genevieve, additional, Franchimont, Denis, additional, Fortin, Genevieve, additional, Martinez Torres, Ana Carolina, additional, Cabon, Lauriane, additional, Susin, Santos, additional, and Sarfati, Marika, additional

Published
2012
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16. CD47Low Status on CD4 Effectors Is Necessary for the Contraction/Resolution of the Immune Response in Humans and Mice.

Author

Van, Vu Quang, Baba, Nobuyasu, Rubio, Manuel, Wakahara, Keiko, Panzini, Benoit, Richard, Carole, Soucy, Genevieve, Franchimont, Denis, Fortin, Genevieve, Tortes, Ana Carolina Martinez, Cabon, Lauriane, Susin, Santos, Sarfati, Marika, and Hoshino, Yoshihiko

Subjects
T cells, CELL death, IMMUNE response, THROMBOSPONDIN-1, PHAGOCYTOSIS, EPITOPES, CROHN'S disease
Abstract

How do effector CD4 T cells escape cell death during the contraction of the immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in cell death and phagocytosis of malignant cells. Here, we reported a reduction in SIRP-α- Fc binding to effector memory T cells (TEM) and in vitro TCR- activated human CD4 T cells that was linked to TSP-1/CD47-induced cell death. The reduced SIRP-α-Fc binding (CD47low status) was not detected when CD4 T cells were stained with two anti-CD47 mAbs, which recognize distinct epitopes. In contrast, increased SIRP-α-Fc binding (CD47high status) marked central memory T cells (TCM) as well as activated CD4 T cells exposed to IL-2, and correlated with resistance to TSP-1/CD47-mediated killing. Auto-aggressive CD4 effectors, which accumulated in lymph nodes and at mucosal sites of patients with Crohn's disease, displayed a CD47high status despite a high level of TSP-1 release in colonic tissues. In mice, CD47 (CD47low status) was required on antigen (Ag)-specific CD4+/+ effectors for the contraction of the IR in vivo, as significantly lower numbers of Ag-specific CD47+/+CD4 T cells were recovered when compared to Ag-specific CD47-/- CD4T cells. In conclusion, we demonstrate that a transient change in the status of CD47, i.e. from CD47high> to CD47low, on CD4 effectors regulates the decision-making process that leads to CD47-mediated cell death and contraction of the IR while maintenance of a CD47high status on tissue-destructive CD4 effectors prevents the resolution of the inflammatory response. [ABSTRACT FROM AUTHOR]

Published
2012
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17. CD47 in the Immune Response: Role of Thrombospondin and SIRP- Reverse Signaling

Author

Sarfati, Marika, Fortin, Genevieve, Raymond, Marianne, and Susin, Santos

Abstract

The past decades have been marked by spectacular progress towards understanding how dendritic cells (DCs) interact with T cells to elicit protective immune responses to fight infectious diseases and cancer. DCs that are lying at the interface between innate and adaptive immunity, are educated in peripheral tissues prior to their journey to the secondary lymphoid organs (SLO) whereby they dictate different classes of T cell responses. Uncontrolled or unwanted inflammatory responses are the price to pay to eliminate pathogens. However, if not self-limited, they may induce collateral damages that result in chronic inflammation often associated with autoimmune disorders. CD47 and its two ligands, i.e. thrombospondin 1 (TSP-1) and SIRP-, were identified as a previously unappreciated inhibitory axis of DC and T cell functions. TSP-1 is predominantly a negative regulator of DC and T cell function while basal SIRP- ligation on APC by CD47 enforces tolerance. Yet, CD47/SIRP- interaction positively controls DC and innate cell transendothelial migration. Due to the promiscuity of the protein interactions for CD47 and its ligands, it is quite interesting to note that deletion of the CD47 gene in mice largely agrees with the in vitro data with human cells. In fact, the well-conserved tissue distribution of CD47 and SIRP- across species may facilitate the transition from bench to bedside. We thus propose CD47/TSP- 1/SIRP- axis as an important sensor to maintain homeostasis and regulate innate and adaptive immune responses.

Published
2008

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