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Your search keyword '"Foruraghi, Ladan"' showing total 13 results
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13 results on '"Foruraghi, Ladan"'

1. A unified metric of human immune health

Author

Sparks, Rachel, Rachmaninoff, Nicholas, Lau, William W., Hirsch, Dylan C., Bansal, Neha, Martins, Andrew J., Chen, Jinguo, Liu, Candace C., Cheung, Foo, Failla, Laura E., Biancotto, Angelique, Fantoni, Giovanna, Sellers, Brian A., Chawla, Daniel G., Howe, Katherine N., Mostaghimi, Darius, Farmer, Rohit, Kotliarov, Yuri, Calvo, Katherine R., Palmer, Cindy, Daub, Janine, Foruraghi, Ladan, Kreuzburg, Samantha, Treat, Jennifer D., Urban, Amanda K., Jones, Anne, Romeo, Tina, Deuitch, Natalie T., Moura, Natalia Sampaio, Weinstein, Barbara, Moir, Susan, Ferrucci, Luigi, Barron, Karyl S., Aksentijevich, Ivona, Kleinstein, Steven H., Townsley, Danielle M., Young, Neal S., Frischmeyer-Guerrerio, Pamela A., Uzel, Gulbu, Pinto-Patarroyo, Gineth Paola, Cudrici, Cornelia D., Hoffmann, Patrycja, Stone, Deborah L., Ombrello, Amanda K., Freeman, Alexandra F., Zerbe, Christa S., Kastner, Daniel L., Holland, Steven M., and Tsang, John S.

Published
2024
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4. X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability

Author

Marciano, Beatriz E., Zerbe, Christa S., Falcone, Liana E., Ding, Li, DeRavin, Suk See, Daub, Janine, Kreuzburg, Samantha, Yockey, Lynne, Hunsberger, Sally, Foruraghi, Ladan, Barnhart, Lisa A., Matharu, Kabir, Anderson, Victoria, Darnell, Dirk N., Frein, Cathleen, Fink, Danielle L., Lau, Karen P., Priel, Debra Long A., Gallin, John I., Malech, Harry L., Uzel, Gulbu, Freeman, Alexandra F., Kuhns, Douglas B., Rosenzweig, Sergio D., and Holland, Steven M.

Published
2018
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5. Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects

Author

Hsu, Amy P., primary, Donkó, Agnes, additional, Arrington, Megan E., additional, Swamydas, Muthulekha, additional, Fink, Danielle, additional, Das, Arundhoti, additional, Escobedo, Omar, additional, Bonagura, Vincent, additional, Szabolcs, Paul, additional, Steinberg, Harry N., additional, Bergerson, Jenna, additional, Skoskiewicz, Amanda, additional, Makhija, Melanie, additional, Davis, Joie, additional, Foruraghi, Ladan, additional, Palmer, Cindy, additional, Fuleihan, Ramsay L., additional, Church, Joseph A., additional, Bhandoola, Avinash, additional, Lionakis, Michail S., additional, Campbell, Sharon, additional, Leto, Thomas L., additional, Kuhns, Douglas B., additional, and Holland, Steven M., additional

Published
2019
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7. Persistent nodal histoplasmosis in NF-κB essential modulator (NEMO) deficiency: Report of a case and review of infection in primary immunodeficiencies

Author

Lovell, Jana P., Foruraghi, Ladan, Freeman, Alexandra F., Uzel, Gulbu, Zerbe, Christa S., Su, Helen, Hsu, Amy P., and Holland, Steven M.

Subjects
Article
Abstract

In the absence of acquired or secondary immunosuppression, mutations causing failure to properly activate the IL-12/IFN-γ pathway, NF-κB, or STAT3 should be excluded in patients presenting with severe histoplasmosis.

Published
2016

9. NK Cell KIR Ligand Mismatches Influence Engraftment Following Combined Haploidentical and Umbilical Cord Blood (UCB) Transplantation In Patients With Severe Aplastic Anemia (SAA)

Author

Kotecha, Ritesh, primary, Tian, Xin, additional, Wilder, Jennifer, additional, Gormley, Nicole, additional, Khuu, Hahn, additional, Stroncek, David, additional, Leitman, Susan F., additional, Kurlander, Roger, additional, Cho, Elena, additional, Cook, Lisa, additional, Ramos, Catalina, additional, Foruraghi, Ladan, additional, Bolan, Charles D., additional, and Childs, Richard W., additional

Published
2013
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10. Taking the USPSTF to task

Author

Lineweaver, Lisa, Foruraghi, Ladan, and Fogel, Paul

Subjects
Health
Abstract

This letter is in response to the article, 'To Screen, And When To Screen' [Clinician Reviews. 2009;19(12):cover, 9]. Despite new emerging technologies, the same test of radiation mammography has been [...]

Published
2010

12. IL7 Administration in Humans Results in Preferential Expansion of Naive and Memory CD4+ & CD8+ T Cells with a Relative Decrease in Regulatory T-Cells (T-Regs).

Author

Sportes, Claude, primary, Krumlauf, Michael, primary, Babb, Rebecca, primary, Foruraghi, Ladan, primary, Daub, Janine, primary, Avila, Daniele, primary, Chow, Catherine, primary, Zhang, Hua, primary, Chua, Kevin, primary, Fry, Terry, primary, Memon, Sarfraz, primary, Hakim, Frances, primary, Fleisher, Thomas, primary, Brown, Margaret, primary, Engel, Julie, primary, Buffet, Renaud, primary, Morre, Michel, primary, Gress, Ronald, primary, and Mackall, Crystal, primary

Published
2006
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13. Multiomics integration of 22 immune-mediated monogenic diseases reveals an emergent axis of human immune health.

Author

Sparks R, Rachmaninoff N, Hirsch DC, Bansal N, Lau WW, Martins AJ, Chen J, Liu CC, Cheung F, Failla LE, Biancotto A, Fantoni G, Sellers BA, Chawla DG, Howe KN, Mostaghimi D, Farmer R, Kotliarov Y, Calvo KR, Palmer C, Daub J, Foruraghi L, Kreuzburg S, Treat J, Urban AK, Jones A, Romeo T, Deuitch NT, Moura NS, Weinstein B, Moir S, Ferrucci L, Barron KS, Aksentijevich I, Kleinstein SH, Townsley DM, Young NS, Frischmeyer-Guerrerio PA, Uzel G, Pinto-Patarroyo GP, Cudrici CD, Hoffmann P, Stone DL, Ombrello AK, Freeman AF, Zerbe CS, Kastner DL, Holland SM, and Tsang JS

Abstract

Monogenic diseases are often studied in isolation due to their rarity. Here we utilize multiomics to assess 22 monogenic immune-mediated conditions with age- and sex-matched healthy controls. Despite clearly detectable disease-specific and "pan-disease" signatures, individuals possess stable personal immune states over time. Temporally stable differences among subjects tend to dominate over differences attributable to disease conditions or medication use. Unsupervised principal variation analysis of personal immune states and machine learning classification distinguishing between healthy controls and patients converge to a metric of immune health (IHM). The IHM discriminates healthy from multiple polygenic autoimmune and inflammatory disease states in independent cohorts, marks healthy aging, and is a pre-vaccination predictor of antibody responses to influenza vaccination in the elderly. We identified easy-to-measure circulating protein biomarker surrogates of the IHM that capture immune health variations beyond age. Our work provides a conceptual framework and biomarkers for defining and measuring human immune health., Competing Interests: Declaration of Interests The authors declare no competing interests.

Published
2023
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