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4. Posterior capsular opacification and YAG laser capsulotomy in uveitis patients following cataract surgery

Author

Levy-Clarke, Grace A., Newcomb, Craig W., Ying, Gui-Shuang, Groth, Sylvia L., Kothari, Srishti, Payal, Abhishek, Begum, Hosne, Liesegang, Teresa L., Foster, C. Stephen, Jabs, Douglas A., Nussenblatt, Robert, Rosenbaum, James T., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Dreger, Kurt A., Buchanich, Jeanine M., Kempen, John H., and Gangaputra, Sapna

Published
2024
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6. Use of Immunosuppression and the Risk of Subsequent Overall or Cancer Mortality

Author

Kempen, John H., Newcomb, Craig W., Washington, Terri L., Foster, C. Stephen, Sobrin, Lucia, Thorne, Jennifer E., Jabs, Douglas A., Suhler, Eric B., Rosenbaum, James T., Sen, H. Nida, Levy-Clarke, Grace A., Nussenblatt, Robert B., Bhatt, Nirali P., Lowder, Careen Y., Goldstein, Debra A., Leiderman, Yannek I., Acharya, Nisha R., Holland, Gary N., Read, Russell W., Dunn, James P., Dreger, Kurt A., Artornsombudh, Pichaporn, Begum, Hosne A., Fitzgerald, Tonetta D., Kothari, Srishti, Payal, Abhishek R., Daniel, Ebenezer, Gangaputra, Sapna S., Kaçmaz, R. Oktay, Liesegang, Teresa L., Pujari, Siddharth S., Khachatryan, Naira, Maghsoudlou, Armin, Suga, Hilkiah K., Pak, Clara M., Helzlsouer, Kathy J., and Buchanich, Jeanine M.

Published
2023
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7. Incidence of and Risk Factors for Cataract in Anterior Uveitis

Author

Papaliodis, George N., Rosner, Bernard A., Dreger, Kurt A., Fitzgerald, Tonetta D., Artornsombudh, Pichaporn, Kothari, Srishti, Gangaputra, Sapna S., Levy-Clarke, Grace A., Nussenblatt, Robert B., Rosenbaum, James T., Sen, H. Nida, Suhler, Eric B., Thorne, Jennifer E., Bhatt, Nirali P., Foster, C. Stephen, Jabs, Douglas A., Pak, Clara M., Ying, Gui-shuang, and Kempen, John H.

Published
2023
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9. Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy A Multicenter Randomized Vehicle-Controlled Pivotal Trial

Author

Pflugfelder, Stephen C, Massaro-Giordano, Mina, Perez, Victor L, Hamrah, Pedram, Deng, Sophie X, Espandar, Ladan, Foster, C Stephen, Affeldt, John, Seedor, John A, Afshari, Natalie A, Chao, Wendy, Allegretti, Marcello, Mantelli, Flavio, and Dana, Reza

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Trials and Supportive Activities, Physical Injury - Accidents and Adverse Effects, Eye Disease and Disorders of Vision, Neurosciences, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Eye, Administration, Ophthalmic, Adult, Aged, Aged, 80 and over, Cornea, Corneal Ulcer, Double-Blind Method, Epithelium, Corneal, Female, Fluorophotometry, Follow-Up Studies, Humans, Male, Middle Aged, Nerve Growth Factor, Ophthalmic Solutions, Recombinant Proteins, Treatment Outcome, Trigeminal Nerve Diseases, Visual Acuity, Wound Healing, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PURPOSE:To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic keratopathy. DESIGN:Multicenter, randomized, double-masked, vehicle-controlled trial. PARTICIPANTS:Patients with neurotrophic persistent epithelial defect with or without stromal thinning. METHODS:The NGF0214 trial, conducted among 11 sites in the United States, randomized 48 patients 1:1 to cenegermin 20 μg/ml or vehicle eye drops, 6 drops daily for 8 weeks of masked treatment. Follow-up was 24 weeks. Safety was assessed in all patients who received study drug. Efficacy was assessed by intention to treat. MAIN OUTCOME MEASURES:The primary end point was healing of the neurotrophic lesion (persistent epithelial defect or corneal ulcer) after 8 weeks of masked treatment. Masked central readers measured neurotrophic lesions in randomized clinical pictures, then assessed healing status conventionally (

Published
2020

10. Allergy and Immune-Mediated Tissue Injury

Author

Mousa, Hazem M., Saban, Daniel R., Foster, Charles Stephen, Cordero-Coma, Miguel, Streilein, J. Wayne, Perez, Victor, Section editor, Foster, C. Stephen, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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12. Anterior Uveitis

Author

Venkateswaran, Nandini, Soifer, Matias, Perez, Victor L., Perez, Victor, Section editor, Foster, C. Stephen, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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13. Immunology: An Overview

Author

Maleki, Arash, Drenen, Kayla, Foster, Charles Stephen, Perez, Victor L., Section editor, Foster, C. Stephen, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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14. The Cells of the Immune System

Author

Maldonado Cerda, Anapatricia, Garcia, Cristina M., Foster, Charles Stephen, Perez, Victor L., Section editor, Foster, C. Stephen, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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15. T Lymphocyte Responses

Author

St. Leger, Anthony J., Previte, Dana M., Dana, M. Reza, Perez, Victor, Section editor, Foster, C. Stephen, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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16. Regulation of Immune Responses

Author

Maleki, Arash, Manhapra, Ambika, Mousa, Hazem M., Foster, Charles Stephen, Perez, Victor L., Section editor, Foster, C. Stephen, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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21. Crohn’s Disease-Associated Uveitis

Author

Kubaisi, Buraa, Kopplin, Laura, Agarwal, Aniruddha, Rosenbaum, James T., Foster, C. Stephen, Nguyen, Quan Dong, Gupta, Vishali, editor, Nguyen, Quan Dong, editor, LeHoang, Phuc, editor, and Agarwal, Aniruddha, editor

Published
2020
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25. Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

Author

Holbrook, Janet T, Sugar, Elizabeth A, Burke, Alyce E, Vitale, Albert T, Thorne, Jennifer E, Davis, Janet L, Jabs, Douglas A, Jaffe, Glenn J, Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora M, Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha, Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A, Scott, Adrienne Williams, See, Robert F, Shuler, Robert K, Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F, Srivastava, Sunil, Dunn, James P, Begum, Hosne, Boring, Jeff, Brotherson, Kristen L, Burkholder, Bryn, Butler, Nicholas J, Cain, Dennis, Cook, Mary A, Emmert, David, Graul, Janis R, Herring, Mark, Laing, Ashley, Leung, Theresa G, Mahon, Michael C, Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L, Reed, Terry, Arnold, Ellen, Barnabie, Patricia M, Belair, Marie-Lynn, Bolton, Stephen G, Brodine, Joseph B, Brown, Diane M, Brune, Lisa M, Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A, Livingston, Alison G, Morton, Yavette, Nolan, Kisten, Peters, George B, Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C Stephen, Anesi, Stephen D, Bruner, Linda, Ceron, Olga, Hinkle, David M, Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q, Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S, Sprague, Janet, and Yilmaz, Taygan

Subjects
Clinical Trials and Supportive Activities, Brain Disorders, Eye Disease and Disorders of Vision, Bioengineering, Clinical Research, Prevention, Neurosciences, Eye, Adolescent, Adult, Aged, Aged, 80 and over, Drug Implants, Equipment Failure, Female, Fluocinolone Acetonide, Follow-Up Studies, Foreign-Body Migration, Glucocorticoids, Humans, Intravitreal Injections, Male, Middle Aged, Postoperative Complications, Reoperation, Risk Factors, Time Factors, Uveitis, Visual Acuity, Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial.DesignRandomized clinical trial with extended follow-up.MethodsReview of data collected on the first implant in the eye(s) of participants. Dissociation was defined as the drug pellet no longer being affixed to the strut and categorized as spontaneous or surgically related.ResultsA total of 250 eyes (146 patients) had at least 1 implant placed. Median follow-up time after implant placement was 6 years (range 0.5-9.2 years). Thirty-four dissociations were reported in 30 participants. There were 22 spontaneous events in 22 participants; 6-year cumulative risk of a spontaneous dissociation was 4.8% (95% confidence interval [CI]: 2.4%-9.1%). The earliest event occurred 4.8 years after placement. Nine of 22 eyes with data had a decline in visual acuity ≥5 letters temporally related to the dissociation. Thirty-nine implant removal surgeries were performed, 33 with replacement. Twelve dissociations were noted during implant removal surgeries in 10 participants (26%, 95% CI 15%-48%); 5 of these eyes had a decline in visual acuity ≥5 letters after surgery. The time from implant placement to removal surgery was longer for the surgeries at which dissociated implants were identified than for those without one (5.7 vs 3.7 years, P < .001). Overall, visual acuity declined 15 or more letters from pre-implant values in 22% of affected eyes; declines were frequently associated with complications of uveitis or its treatment.ConclusionThere is an increasing risk of dissociation of Retisert implants during follow-up; the risk is greater with removal/exchange surgeries, but the risk of both spontaneous and surgically related events increases with longevity of the implants. In 22% of affected eyes visual acuity declined by 15 letters. In the context of eyes with moderate to severe uveitis for years, this rate is not unexpected.

Published
2016

29. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Kempen, John H, Van Natta, Mark L, Altaweel, Michael M, Dunn, James P, Jabs, Douglas A, Lightman, Susan L, Thorne, Jennifer E, Holbrook, Janet T, Jaffe, Glenn J, Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora M, Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha, Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A, Scott, Adrienne Williams, See, Robert F, Shuler, Robert K, Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F, Srivastava, Sunil, Begum, Hosne, Boring, Jeff, Brotherson, Kristen L, Burkholder, Bryn, Butler, Nicholas J, Cain, Dennis, Cook, Mary A, Emmert, David, Graul, Janis R, Herring, Mark, Laing, Ashley, Leung, Theresa G, Mahon, Michael C, Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L, Reed, Terry, Arnold, Ellen, Barnabie, Patricia M, Belair, Marie-Lynn, Bolton, Stephen G, Brodine, Joseph B, Brown, Diane M, Brune, Lisa M, Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A, Livingston, Alison G, Morton, Yavette, Nolan, Kisten, Peters, George B, Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C Stephen, Anesi, Stephen D, Bruner, Linda, Ceron, Olga, Hinkle, David M, Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q, Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S, and Sprague, Janet

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Eye Disease and Disorders of Vision, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Eye, Aged, Drug Implants, Female, Follow-Up Studies, Glucocorticoids, Humans, Male, Middle Aged, Panuveitis, Time Factors, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity, Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

PurposeTo identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes.DesignCohort study using randomized controlled trial data.MethodsMulticenter Uveitis Steroid Treatment (MUST) Trial masked BCVA measurements at baseline and at 2 years follow-up used gold-standard methods. Twenty-three clinical centers documented characteristics per protocol, which were evaluated as potential predictive factors for baseline BCVA and 2-year change in BCVA.ResultsBaseline factors significantly associated with reduced BCVA included age ≥50 vs 10 vs grade 0; cataract; macular thickening; and exudative retinal detachment. Over 2 years, eyes better than 20/50 and 20/50 or worse at baseline improved, on average, by 1 letter (P = .52) and 10 letters (P < .001), respectively. Both treatment groups and all sites of uveitis improved similarly. Factors associated with improved BCVA included resolution of active AC cells, resolution of macular thickening, and cataract surgery in an initially cataractous eye. Factors associated with worsening BCVA included longer duration of uveitis (6-10 or >10 vs

Published
2015

33. List of Contributors

Author

Aleman, Tomas S., primary, Arepalli, Sruthi, additional, Belfort, Rubens, additional, Blodi, Frederick R., additional, Bodaghi, Bahram, additional, Chan, Weilin, additional, Chang, Peter Yuwei, additional, Chorfi, Sarah, additional, Conrady, Christopher, additional, Eliott, Dean, additional, Foster, C. Stephen, additional, Trief, Danielle, additional, Hassan, Muhammad, additional, Kaliki, Swathi, additional, Kaplan, Henry J., additional, Karadzic, Jelena, additional, Kerley, Madison E., additional, Levison, Ashleigh L., additional, Lindeke-Myers, Aaron, additional, Magrath, George, additional, Maguire, Albert M., additional, Minkus, Caroline L., additional, Modjtahedi, Bobeck S., additional, Mohay, Judith, additional, Moussa, Kareem, additional, Munk, Marion Ronit, additional, Nguyen, Quan Dong, additional, Onghanseng, Neil, additional, Papaliodis, George N., additional, Pepple, Kathryn, additional, Radosavljevic, Aleksandra, additional, Ramasubramanian, Aparna, additional, Rathinam, Sivakumar R., additional, Sadiq, Mohammad Ali, additional, Sandhu, Harpal S., additional, Shantha, Jessica G., additional, Shields, Ryan A., additional, Sobrin, Lucia, additional, Stanescu, Dinu, additional, Strässle, Kim Anne, additional, Suhler, Eric, additional, Thanos, Aristomenis, additional, Touhami, Sara, additional, Toutee, Adelaide, additional, Uchiyama, Eduardo, additional, Gelder, Russell Neil Van, additional, Ventura, Camila V., additional, Ventura, Liana O., additional, Vitale, Albert, additional, Yeh, Steven, additional, and Zierhut, Manfred, additional

Published
2021
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36. Scleroderma

Author

Foster, C. Stephen, primary, Papaliodis, George N., additional, Drenen, Kayla, additional, and Walsh, Marisa, additional

Published
2021
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47. Crohn’s Disease-Associated Uveitis

Author

Kubaisi, Buraa, primary, Kopplin, Laura, additional, Agarwal, Aniruddha, additional, Rosenbaum, James T., additional, Foster, C. Stephen, additional, and Nguyen, Quan Dong, additional

Published
2019
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49. Late recurrence in birdshot chorioretinopathy

Author

Maleki, Arash, primary, Look-Why, Sydney, additional, Manhapra, Ambika, additional, Asgari, Soheila, additional, Philip, Andrew M., additional, Chang, Peter Y., additional, Anesi, Stephen D., additional, and Foster, C. Stephen, additional

Published
2023
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