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1. Additional file 3: S3. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Abstract

Pharmacokinetic analysis details. (DOCX 689 kb)

Published
2017
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2. A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Adoke, Yeka, Tiono, Alfred B., Duong, Tran T., Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Tinto, Halidou, Bassat Orellana, Quique, Issifou, Saadou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart E., Biguenet, Sophie, Kibuuka, Afizi, Tshefu, Antoinette, Smith, Melnick, Foster, Chanelle, Leipoldt, Illse, Kremsner, Peter G., Phuc, Bui Q., Ouedraogo, Alphonse, Ramharter, Michael, and OZ-Piperaquine Study Group

Subjects
Male, Artefenomel, lcsh:Medicine, modelling and simulation, Pharmacokinetics, Phase II B, Tratamiento médico, 0302 clinical medicine, 030212 general & internal medicine, Malaria, Falciparum, Young adult, Child, Children, Enfermedades infecciosas en niños, education.field_of_study, biology, General Medicine, Middle Aged, OZ439, Artemisinins, 3. Good health, Piperaquine, Treatment Outcome, Tolerability, Child, Preschool, Quinolines, Drug Therapy, Combination, Female, Uncomplicated Plasmodium falciparum malaria, Research Article, Adult, medicine.medical_specialty, Adolescent, Plasmodium falciparum, 030231 tropical medicine, Population, Malària, Paludismo, Antimalarials, Young Adult, 03 medical and health sciences, Asian People, Double-Blind Method, Internal medicine, parasitic diseases, medicine, Humans, Single dose combination treatment, education, Antipalúdicos--Ensayos clínicos, Dose-Response Relationship, Drug, business.industry, lcsh:R, Infant, medicine.disease, biology.organism_classification, Surgery, Malaria, Africa, Dose–response, business
Abstract

Background The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination of artefenomel and piperaquine phosphate (PQP) has the potential to achieve satisfactory cure rates as a single dose therapy. The primary objective of the study was to determine whether a single dose of artefenomel (800 mg) plus PQP in ascending doses is an efficacious treatment for uncomplicated Plasmodium falciparum malaria in the 'target' population of children ≤ 5 years of age in Africa as well as Asian patients of all ages. Methods Patients in six African countries and in Vietnam were randomised to treatment with follow-up for 42–63 days. Efficacy, tolerability, safety and pharmacokinetics were assessed. Additional key objectives were to characterise the exposure–response relationship for polymerase chain reaction (PCR)-adjusted adequate clinical and parasitological response at day 28 post-dose (ACPR28) and to further investigate Kelch13 mutations. Patients in Africa (n = 355) and Vietnam (n = 82) were included, with 85% of the total population being children 95% PCR-adjusted ACPR at day 28. Achieving very high efficacy following single dose treatment is challenging, since > 95% of the population must have sufficient concentrations to achieve cure across a range of parasite sensitivities and baseline parasitaemia levels. While challenging, the development of tools suitable for deployment as single encounter curative treatments for adults and children in Africa and to support elimination strategies remains a key development goal. Trial registration ClinicalTrials.gov, NCT02083380. Registered on 7 March 2014. Electronic supplementary material The online version of this article (doi:10.1186/s12916-017-0940-3) contains supplementary material, which is available to authorized users.

Published
2017

3. Additional file 2: S2. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Abstract

Statistical analysis plan. (PDF 1515 kb)

Published
2017
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4. Additional file 4: S4. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Abstract

Exposureâ response analysis details. (DOCX 269 kb)

Published
2017
Full Text
View/download PDF

5. Additional file 4: S4. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Subjects
3. Good health
Abstract

Exposureâ response analysis details. (DOCX 269 kb)

6. Additional file 3: S3. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Subjects
3. Good health
Abstract

Pharmacokinetic analysis details. (DOCX 689 kb)

7. Additional file 2: S2. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Subjects
3. Good health
Abstract

Statistical analysis plan. (PDF 1515 kb)

8. Additional file 1: S1. of A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Author

Macintyre, Fiona, Yeka Adoke, Tiono, Alfred, Duong, Tran, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Halidou Tinto, Bassat, Quique, Saadou Issifou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart, Biguenet, Sophie, Afizi Kibuuka, Tshefu, Antoinette, Melnick Smith, Foster, Chanelle, Illse Leipoldt, Kremsner, Peter, Bui Phuc, Ouedraogo, Alphonse, and Ramharter, Michael

Subjects
3. Good health
Abstract

Study Protocol. (PDF 1822 kb)

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