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13 results on '"Foster, Kayla L."'

7. Clinical Assessment of Late Health Outcomes in Survivors of Wilms Tumor

Author

Foster, Kayla L., primary, Salehabadi, Sedigheh Mirzaei, additional, Green, Daniel M., additional, Xing, Mengqi, additional, Ness, Kirsten K., additional, Krull, Kevin R., additional, Brinkman, Tara M., additional, Ehrhardt, Matthew J., additional, Chemaitilly, Wassim, additional, Dixon, Stephanie B., additional, Bhakta, Nickhill, additional, Brennan, Rachel C., additional, Krasin, Matthew J., additional, Davidoff, Andrew M., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Mulrooney, Daniel A., additional

Published
2022
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8. Late health outcomes in survivors of Wilms tumor: A report from the St. Jude Lifetime (SJLIFE) cohort study.

Author

Foster, Kayla L., primary, Green, Daniel M., additional, Mirzaei Salehabadi, Sedigheh, additional, Xing, Mengqi, additional, Ness, Kirsten K., additional, Krull, Kevin R., additional, Brinkman, Tara M., additional, Ehrhardt, Matthew J., additional, Chemaitilly, Wassim, additional, Dixon, Stephanie B, additional, Bhakta, Nickhill, additional, Brennan, Rachel Christine, additional, Krasin, Matthew J., additional, Davidoff, Andrew M., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Mulrooney, Daniel A., additional

Published
2021
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10. Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort

Author

Richard, Melissa A., primary, Brown, Austin L., additional, Belmont, John W., additional, Scheurer, Michael E., additional, Arroyo, Vidal M., additional, Foster, Kayla L., additional, Kern, Kathleen D., additional, Hudson, Melissa M., additional, Leisenring, Wendy M., additional, Okcu, M. Fatih, additional, Sapkota, Yadav, additional, Yasui, Yutaka, additional, Morton, Lindsay M., additional, Chanock, Stephen J., additional, Robison, Leslie L., additional, Armstrong, Gregory T., additional, Bhatia, Smita, additional, Oeffinger, Kevin C., additional, Lupo, Philip J., additional, and Kamdar, Kala Y., additional

Published
2020
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12. Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.

Author

Richard, Melissa A., Brown, Austin L., Belmont, John W., Scheurer, Michael E., Arroyo, Vidal M., Foster, Kayla L., Kern, Kathleen D., Hudson, Melissa M., Leisenring, Wendy M., Okcu, M. Fatih, Sapkota, Yadav, Yasui, Yutaka, Morton, Lindsay M., Chanock, Stephen J., Robison, Leslie L., Armstrong, Gregory T., Bhatia, Smita, Oeffinger, Kevin C., Lupo, Philip J., and Kamdar, Kala Y.

Subjects
LYMPHOBLASTIC leukemia, BODY mass index, CHILDHOOD cancer, ACUTE leukemia, CANCER survivors, GENETIC correlations
Abstract

Background: Treatment characteristics such as cranial radiation therapy (CRT) do not fully explain adiposity risk in childhood acute lymphoblastic leukemia (ALL) survivors. This study was aimed at characterizing genetic variation related to adult body mass index (BMI) among survivors of childhood ALL. Methods: Genetic associations of BMI among 1458 adult survivors of childhood ALL (median time from diagnosis, 20 years) were analyzed by multiple approaches. A 2‐stage genome‐wide association study in the Childhood Cancer Survivor Study (CCSS) and the St. Jude Lifetime Cohort Study (SJLIFE) was performed. BMI was a highly polygenic trait in the general population. Within the known loci, the BMI percent variance explained was estimated, and additive interactions (chi‐square test) with CRT in the CCSS were evaluated. The role of DNA methylation in CRT interaction was further evaluated in a subsample of ALL survivors. Results: In a meta‐analysis of the CCSS and SJLIFE, 2 novel loci associated with adult BMI among survivors of childhood ALL (LINC00856 rs575792008 and EMR1 rs62123082; PMeta < 5E–8) were identified. It was estimated that the more than 700 known loci explained 6.2% of the variation in adult BMI in childhood ALL survivors. Within the known loci, significant main effects for 23 loci and statistical interactions with CRT at 9 loci (P < 7.0E–5) were further identified. At 2 CRT‐interacting loci, DNA methylation patterns may have differed by age. Conclusions: Adult survivors of childhood ALL have genetic heritability for BMI similar to that observed in the general population. This study provides evidence that treatment with CRT can modify the effect of genetic variants on adult BMI in childhood ALL survivors. Adult survivors of childhood acute lymphoblastic leukemia, particularly those treated with cranial radiation, are at increased risk for obesity. This study provides evidence that the body mass index in adult survivors of childhood acute lymphoblastic leukemia is a genetically heritable trait similar to that in the general population and that the effect of genetic loci from the general population may be modified by treatment with cranial radiation. [ABSTRACT FROM AUTHOR]

Published
2021
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13. DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility following cisplatin and radiation therapy for pediatric embryonal tumors

Author

Brown, Austin L, primary, Foster, Kayla L, additional, Lupo, Philip J, additional, Peckham-Gregory, Erin C, additional, Murray, Jeffrey C, additional, Okcu, M Fatih, additional, Lau, Ching C, additional, Rednam, Surya P, additional, Chintagumpala, Murali, additional, and Scheurer, Michael E, additional

Published
2017
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