810 results on '"Fox, Patricia"'
Search Results
2. HTO and selenate diffusion through compacted Na-, Na–Ca-, and Ca-montmorillonite
- Author
-
Fox, Patricia M, Tournassat, Christophe, Steefel, Carl, and Nico, Peter S
- Subjects
Hydrology ,Earth Sciences ,Selenium diffusion ,Radioactive waste ,Interlayer cation ,Engineered barriers ,Anion exclusion ,Geochemistry ,Environmental Science and Management ,Geochemistry & Geophysics - Abstract
Radionuclide transport in smectite clay barrier systems used for nuclear waste disposal is controlled by diffusion, with adsorption significantly retarding transport rates. While a relatively minor component of spent nuclear fuel, 79Se is a major driver of the safety case for spent fuel disposal due to its long half-life (3.3 × 105 yr) and its low adsorption to clay (KD < 10 L/kg), thus a thorough understanding of Se diffusion through clay is critical for understanding the long-term safety of spent fuel disposal systems. Through-diffusion experiments with tritiated water (HTO, conservative tracer) and Se(VI) were conducted with a well-characterized, purified montmorillonite source clay (SWy-2) under a constant ionic strength (0.1 M) and three different electrolyte compositions: Na+, Ca2+, and a Na + -Ca2+ mixture at pH 6.5 in order to probe the effects of electrolyte composition and interlayer cation composition on clay microstructure, Se(VI) aqueous speciation, and ultimately diffusion. The results were modeled using a reactive transport modeling approach to determine values of porosity (ε), De (effective diffusion coefficient), and KD (distribution coefficient for adsorption). HTO diffusive flux was higher in Ca-montmorillonite (De = 1.68 × 10−10 m2 s−1) compared to Na-montmorillonite (De = 7.83 × 10−11 m2 s−1). This increase in flux is likely due to a greater degree of clay layer stacking in the presence of Ca2+ compared to Na+, which leads to larger inter-particle pores. Overall, the Se(VI) flux was much lower than the HTO flux due to anion exclusion, with Se(VI) flux following the order Ca (De = 1.03 × 10−11 m2 s−1) > Na–Ca (De = 2.12 × 10−12 m2 s−1) > Na (De = 1.28 × 10−12 m2 s−1). These differences in Se(VI) flux are due to a combination of factors, including (1) larger accessible porosity in Ca-montmorillonite due to clay layer stacking and smaller electrostatic effects compared to Na-montmorillonite, (2) larger accessible porosity for neutral-charge CaSeO4 species which makes up 32% of aqueous Se(VI) in the pure Ca system, and (3) possibly higher Se(VI) adsorption for Ca-montmorillonite. Through a combination of experimental and modeling work, this study highlights the compounding effects that electrolyte and counterion compositions can have on radionuclide transport through clay. Diffusion models that neglect these effects are not transferable from laboratory experimental conditions to in situ repository conditions.
- Published
- 2024
3. Specialist cancer hospital-based smoking cessation service provision in Ireland.
- Author
-
Lyons, Ailsa, Bhardwaj, Nancy, Masalkhi, Mouayad, Fox, Patricia, McCann, Amanda, Syed, Shiraz, Niranjan, Vikram, Kelleher, Cecily, Kavanagh, Paul, Fitzpatrick, Patricia, and Frazer, Kelly
- Subjects
Cessation ,Health services ,Prevention ,Smoking topography ,Adult ,Humans ,Smoking Cessation ,Ireland ,Cross-Sectional Studies ,Cancer Care Facilities ,Tertiary Care Centers ,Neoplasms - Abstract
BACKGROUND: While much progress has been made in reducing tobacco use in many countries, both active and passive smoking remain challenges. The benefits of smoking cessation are universally recognized, and the hospital setting is an ideal setting where smokers can access smoking cessation services as hospital admission can be a cue to action. Consistent delivery of good quality smoking cessation care across health services is an important focus for reducing the harm of tobacco use, especially among continued smokers. AIMS: Our objective was to document the smoking cessation medication and support services provided by specialist adult cancer hospitals across Ireland, a country with a stated tobacco endgame goal. METHODS: A cross-sectional survey based on recent national clinical guidelines was used to determine smoking cessation care delivery across eight specialist adult cancer tertiary referral university hospitals and one specialist radiotherapy center. Survey responses were collected using Qualtrics, a secure online survey software tool. The data was grouped, anonymized, and analyzed in Microsoft Excel. RESULTS: All responding hospitals demonstrated either some level of smoking cessation information or a service available to patients. However, there is substantial variation in the type and level of smoking cessation information offered, making access to smoking cessation services inconsistent and inequitable. CONCLUSION: The recently launched National Clinical Guideline for smoking cessation provides the template for all hospitals to ensure health services are in a position to contribute to Irelands tobacco endgame goal.
- Published
- 2024
4. Molecular Nature of Mineral-Organic Associations within Redox-Active Mountainous Floodplain Sediments
- Author
-
Anderson, Cam G, Goebel, Genevieve M, Tfaily, Malak M, Fox, Patricia M, Nico, Peter S, Fendorf, Scott, and Keiluweit, Marco
- Subjects
Earth Sciences ,Geochemistry ,Chemical Sciences ,Geology ,Soil organic carbon ,Floodplains ,Redox gradients ,Mineral-organic associations ,Climate change ,Chemical sciences ,Earth sciences ,Physical sciences - Abstract
Floodplains are critical terrestrial-aquatic interfaces that act as hotspots of organic carbon (OC) cycling, regulating ecosystem carbon storage as well as export to riverine systems. Within floodplain sediments, regular flooding and textural gradients interact to create dynamic redox conditions. While anaerobic protection of OC upon burial is a well-recognized carbon storage mechanism in redox-active floodplain sediments, the impact of protective mineral-organic associations is relatively unknown. Here we determined the quantitative importance and chemical composition of mineral-organic associations along well-defined redox gradients emerging from textural variations and depth within meander sediments of the subalpine East River watershed (Gothic, CO). We characterized mineral-organic associations using a combination of sequential extractions, physical fractionation, and high-resolution mass spectrometry. Across the meander, we found that mineral-associated OC constitutes a significant fraction of total OC, and that extractable iron (Fe) and aluminum (Al) phases as well as high-density isolates were strongly correlated with total OC content, suggesting that mineral-organic associations are quantitatively important for floodplain sediment OC protection. Our mass spectrometry results showed OC associated with increasingly ordered Fe and Al phases are relatively enriched in low-molecular weight, oxidized, aromatic compounds. Surprisingly, however, total OC content showed weak or no correlation with indicators of anaerobic protection, such as relatively bioavailable OC pools (water-extractable and particulate OC) or the molecular weight and oxidation state of OC. Overall, this work highlights that protection of OC bound to reactive mineral phases─in addition to anaerobic protection─can play a quantitatively important role in controlling soil carbon storage in redox-active floodplain sediments.
- Published
- 2023
5. Resolving experimental biases in the interpretation of diffusion experiments with a user-friendly numerical reactive transport approach
- Author
-
Tournassat, Christophe, Steefel, Carl I, Fox, Patricia M, and Tinnacher, Ruth M
- Subjects
Hydrology ,Earth Sciences ,Bioengineering - Abstract
The reactive transport code CrunchClay was used to derive effective diffusion coefficients (De), clay porosities (ε), and adsorption distribution coefficients (KD) from through-diffusion data while considering accurately the influence of unavoidable experimental biases on the estimation of these diffusion parameters. These effects include the presence of filters holding the solid sample in place, the variations in concentration gradients across the diffusion cell due to sampling events, the impact of tubing/dead volumes on the estimation of diffusive fluxes and sample porosity, and the effects of O-ring-filter setups on the delivery of solutions to the clay packing. Doing so, the direct modeling of the measurements of (radio)tracer concentrations in reservoirs is more accurate than that of data converted directly into diffusive fluxes. While the above-mentioned effects have already been described individually in the literature, a consistent modeling approach addressing all these issues at the same time has never been described nor made easily available to the community. A graphical user interface, CrunchEase, was created, which supports the user by automating the creation of input files, the running of simulations, and the extraction and comparison of data and simulation results. While a classical model considering an effective diffusion coefficient, a porosity and a solid/solution distribution coefficient (De-ε-KD) may be implemented in any reactive transport code, the development of CrunchEase makes it easy to apply by experimentalists without a background in reactive transport modeling. CrunchEase makes it also possible to transition more easily from a De-ε-KD modeling approach to a state-of-the-art process-based understanding modeling approach using the full capabilities of CrunchClay, which include surface complexation modeling and a multi-porosity description of the clay packing with charged diffuse layers.
- Published
- 2023
6. Response of testate amoeba assemblages to peatland drain blocking
- Author
-
Evans, Callum R. C., Mullan, Donal J., Roe, Helen M., Fox, Patricia M., Gray, Simon, and Swindles, Graeme T.
- Published
- 2024
- Full Text
- View/download PDF
7. Barriers and Facilitators in Pain Management in Long-Term Care Institutions: A Qualitative Study
- Author
-
Fox, Patricia, Solomon, Patricia, Raina, Parminder, and Jadad, Alejandro R
- Published
- 2004
8. River thorium concentrations can record bedrock fracture processes including some triggered by distant seismic events
- Author
-
Gilbert, Benjamin, Carrero, Sergio, Dong, Wenming, Joe-Wong, Claresta, Arora, Bhavna, Fox, Patricia, Nico, Peter, and Williams, Kenneth H
- Subjects
Earth Sciences ,Geochemistry ,Geology ,Geophysics - Abstract
Fractures are integral to the hydrology and geochemistry of watersheds, but our understanding of fracture dynamics is very limited because of the challenge of monitoring the subsurface. Here we provide evidence that long-term, high-frequency measurements of the river concentration of the ultra-trace element thorium (Th) can provide a signature of bedrock fracture processes spanning neighboring watersheds in Colorado. River Th concentrations show abrupt (subdaily) excursions and biexponential decay with approximately 1-day and 1-week time constants, concentration patterns that are distinct from all other solutes except beryllium and arsenic. The patterns are uncorrelated with daily precipitation records or seasonal trends in atmospheric deposition. Groundwater Th analyses are consistent with bedrock release and dilution upon mixing with river water. Most Th excursions have no seismic signatures that are detectable 50 km from the site, suggesting the Th concentrations can reveal aseismic fracture or fault events. We find, however, a weak statistical correlation between Th and seismic motion caused by distant earthquakes, possibly the first chemical signature of dynamic earthquake triggering, a phenomenon previously identified only through geophysical methods.
- Published
- 2023
9. Systematic Review of Smoking Cessation Interventions for Smokers Diagnosed with Cancer.
- Author
-
Frazer, Kate, Bhardwaj, Nancy, Fox, Patricia, Stokes, Diarmuid, Niranjan, Vikram, Quinn, Seamus, Kelleher, Cecily, and Fitzpatrick, Patricia
- Subjects
cancer ,co-design ,smoking cessation ,systematic review ,tobacco control ,Adult ,Humans ,Smoking Cessation ,Smokers ,Inventions ,Head and Neck Neoplasms ,Delivery of Health Care - Abstract
The detrimental impact of smoking on health and wellbeing are irrefutable. Additionally, smoking is associated with the development of cancer, a reduction treatment outcomes and poorer health outcomes. Nevertheless, a significant number of people continue to smoke following a cancer diagnosis. Little is understood of the smoking cessation services provided to smokers with cancer or their engagement with them. This systematic review aimed to identify existing smoking cessation interventions for this cohort diagnosed with breast, head and neck, lung and cervical cancers (linked to risk). Systematic searches of Pubmed, Embase, Psych Info and CINAHL from 1 January 2015 to 15 December 2020 were conducted. Included studies examined the characteristics of smoking cessation interventions and impact on referrals and quit attempts. The impact on healthcare professionals was included if reported. Included studies were restricted to adults with a cancer diagnosis and published in English. No restriction was placed on study designs, and narrative data synthesis was conducted due to heterogeneity. A review protocol was registered on PROSPERO CRD 42020214204, and reporting adheres to PRISMA reporting guidelines. Data were screened, extracted in duplicate and an assessment of the quality of evidence undertaken using Mixed Methods Assessment Tool. 23 studies met the inclusion criteria, representing USA, Canada, England, Lebanon, Australia and including randomized controlled trials (9), observational studies (10), quality improvement (3), and one qualitative study. Hospital and cancer clinics [including a dental clinic] were the settings for all studies. 43% (10/23) of studies reported interventions for smokers diagnosed with head and neck cancer, 13% (3/23) for smokers diagnosed with lung cancer, one study provides evidence for breast cancer, and the remaining nine studies (39%) report on multiple cancers including the ones specified in this review. Methodological quality was variable. There were limited data to identify one optimal intervention for this cohort. Key elements included the timing and frequency of quit conversations, use of electronic records, pharmacotherapy including extended use of varenicline, increased counselling sessions and a service embedded in oncology departments. More studies are required to ensure tailored smoking cessation pathways are co-developed for smokers with a diagnosis of cancer to support this population.
- Published
- 2022
10. HTO and selenate diffusion through compacted Na-, Na–Ca-, and Ca-montmorillonite
- Author
-
Fox, Patricia M., Tournassat, Christophe, Steefel, Carl, and Nico, Peter S.
- Published
- 2024
- Full Text
- View/download PDF
11. Sulfur Biogeochemical Cycling and Redox Dynamics in a Shale‐Dominated Mountainous Watershed
- Author
-
Fox, Patricia M, Carrero, Sergio, Anderson, Cam, Dewey, Christian, Keiluweit, Marco, Conrad, Mark, Naughton, Hannah R, Fendorf, Scott, Carroll, Rosemary, Dafflon, Baptiste, Malenda‐Lawrence, Helen, Dwivedi, Dipankar, Gilbert, Benjamin, Christensen, John N, Boye, Kristin, Beutler, Curtis, Brown, Wendy, Newman, Alexander, Versteeg, Roelof, Williams, Kenneth H, and Nico, Peter S
- Subjects
Earth Sciences ,Geochemistry ,Geology ,Geophysics - Abstract
Sulfur (S) is an essential macronutrient and important component of the earth’s crust, and its cycling has critical impacts on trace metal mobility, water quality, and human health. Pyrite weathering is the primary pathway by which sulfur enters surface waters. However, biogeochemical cycling of sulfur in soils and the river corridor mediates sulfate exports. In this study, we identified the major forms of sulfur across multiple compartments and scales in a pristine mountainous watershed, including shale bedrock weathering profiles, hillslope soils, and alluvial floodplain sediments, in order to provide insight into biogeochemical sulfur cycling in a hydrologically variable alpine system. X-ray absorption near-edge spectroscopy (XANES) analysis of shale weathering profiles showed clear evidence of pyrite oxidation to sulfate, with large accumulations of intermediate S(0) (20%–53%). Micro-scale XANES showed evidence of reprecipitation of pyrite at fracture surfaces within the permanently saturated zone. Organic sulfur dominated S speciation in shallow hillslope soil and floodplain sediment, with little evidence of reduced inorganic S. However, mackinawite formation, representing active sulfate reduction, was observed in saturated oxbow sediments and saturated weathered shale underlying floodplain sediments. Further evidence of sulfate reduction from aqueous sulfur isotopic analysis was observed in shallow groundwater transects across an Fe-reducing meander, whereas increases in pore water sulfate concentrations implied sulfur oxidation at other locations. The data present an integrated picture of sulfur cycling in a shale-dominated watershed, where riverine sulfate exports are mediated by biological cycling, particularly in redox-stratified and temporally dynamic hyporheic zone sediments.
- Published
- 2022
12. Smoking Cessation Support: A Marathon, Not a Sprint; The Perspectives of Cancer Patients Who Smoke
- Author
-
Fox, Patricia, Bhardwaj, Nancy, Lyons, Ailsa, Niranjan, Vikram, Frazer, Kate, Syed, Shiraz, McCann, Amanda, Brennan, Sinead, Brennan, Donal, Kelly, Catherine, Keane, Michael, and Fitzpatrick, Patricia
- Published
- 2024
- Full Text
- View/download PDF
13. Social determinants of health influencing the adherence to post-endoscopic mucosal resection surveillance
- Author
-
Vashi, Bijal, Norwood, Dalton A., Sullivan, Rebecca, Hegazy, Yassmin, Sánchez-Luna, Sergio A., Ajayi-Fox, Patricia, Ahmed, Ali M., Baig, Kondal R. Kyanam Kabir, Peter, Shajan, and Mulki, Ramzi
- Published
- 2024
- Full Text
- View/download PDF
14. Beaver dams overshadow climate extremes in controlling riparian hydrology and water quality
- Author
-
Dewey, Christian, Fox, Patricia M, Bouskill, Nicholas J, Dwivedi, Dipankar, Nico, Peter, and Fendorf, Scott
- Subjects
Hydrology ,Biological Sciences ,Ecology ,Earth Sciences ,Climate Action ,Animals ,Water Quality ,Ecosystem ,Rodentia ,Rivers ,Climate Change - Abstract
Hydrologic extremes dominate chemical exports from riparian zones and dictate water quality in major river systems. Yet, changes in land use and ecosystem services alongside growing climate variability are altering hydrologic extremes and their coupled impacts on riverine water quality. In the western U.S., warming temperatures and intensified aridification are increasingly paired with the expanding range of the American beaver-and their dams, which transform hydrologic and biogeochemical cycles in riparian systems. Here, we show that beaver dams overshadow climatic hydrologic extremes in their effects on water residence time and oxygen and nitrogen fluxes in the riparian subsurface. In a mountainous watershed in Colorado, U.S.A., we find that the increase in riparian hydraulic gradients imposed by a beaver dam is 10.7-13.3 times greater than seasonal hydrologic extremes. The massive hydraulic gradient increases hyporheic nitrate removal by 44.2% relative to seasonal extremes alone. A drier, hotter climate in the western U.S. will further expand the range of beavers and magnify their impacts on watershed hydrology and biogeochemistry, illustrating that ecosystem feedbacks to climate change will alter water quality in river systems.
- Published
- 2022
15. Has the National Fall in Smoking Rates in Ireland Been Replicated in Cancer Patients? A 5-Year Report
- Author
-
Fitzpatrick, Patricia, Bhardwaj, Nancy, Lyons, Ailsa, Doherty, Kirsten, Frazer, Kate, McCann, Amanda, Niranjan, Vikram, Syed, Shiraz, and Fox, Patricia
- Subjects
Biomedical and Clinical Sciences ,Health Services and Systems ,Nursing ,Health Sciences ,Oncology and Carcinogenesis ,Tobacco ,Prevention ,Clinical Research ,Tobacco Smoke and Health ,Cancer ,Breast Cancer ,Respiratory ,Good Health and Well Being ,Head and Neck Neoplasms ,Humans ,Ireland ,Smoking ,Smoking Cessation ,Tobacco Smoking ,smoking ,prevalence ,cancer ,patients ,Toxicology - Abstract
Smoking among cancer patients leads to poorer outcomes, yet many patients continue smoking. As part of a feasibility study of smoking cessation for cancer patients in Ireland, smoking rates were reviewed. Hospital Inpatient Enquiry (HIPE) data on the smoking status of discharges with a cancer diagnosis (overall, breast, lung, cervical and head and neck cancer) were used (2014-2018). During 2014-2017, current smoking increased for overall (10.5-11.7%) and lung cancer (24.7-27.2%), then decreased to 11.4% and 24.1%, respectively, in 2018. Current smoking increased for cervical during 2014-2018 (11-19.8%) and initially (2014-2016) for head and neck (3-12.7%) cancer, decreasing to 7.6% in 2018; breast cancer was stable at 6 ± 0.6%. These rates are lower than the Irish (23-20%) and European (29% (average)) general population. During 2014-2017, past smoking increased among overall (15.2-21%) and specific cancers, which was lower than the Irish general population (23-28%). Current smoking was highest among 50-59-year-olds (14-16%), which contrasts with the Irish general population (24-35 years at 32-28%). HIPE data are subject to potential duplicate episodes of care and under-documentation of smoking. However, trend analysis is useful, as these limitations should be stable. Rates remain high; therefore, robust documentation and smoking cessation referrals for cancer patients are important.
- Published
- 2022
16. Production of hydrogen peroxide in an intra-meander hyporheic zone at East River, Colorado
- Author
-
Yuan, Xiu, Liu, Tongxu, Fox, Patricia, Bhattacharyya, Amrita, Dwivedi, Dipankar, Williams, Kenneth H, Davis, James A, Waite, T David, and Nico, Peter S
- Subjects
Hydrology ,Earth Sciences - Abstract
The traditionally held assumption that photo-dependent processes are the predominant source of H2O2 in natural waters has been recently questioned by an increrasing body of evidence showing the ubiquitiousness of H2O2 in dark water bodies and in groundwater. In this study, we conducted field measurement of H2O2 in an intra-meander hyporheic zone and in surface water at East River, CO. On-site detection using a sensitive chemiluminescence method suggests H2O2 concentrations in groundwater ranging from 6 nM (at the most reduced region) to ~ 80 nM (in a locally oxygen-rich area) along the intra-meander transect with a maxima of 186 nM detected in the surface water in an early afternoon, lagging the maximum solar irradiance by ∼ 1.5 h. Our results suggest that the dark profile of H2O2 in the hyporheic zone is closely correlated to local redox gradients, indicating that interactions between various redox sensitive elements could play an essential role. Due to its transient nature, the widespread presence of H2O2 in the hyporheic zone indicates the existence of a sustained balance between H2O2 production and consumption, which potentially involves a relatively rapid succession of various biogeochemically important processes (such as organic matter turnover, metal cycling and contaminant mobilization). More importantly, this study confirmed the occurrence of reactive oxygen species at a subsurface redox transition zone and further support our understanding of redox boundaries on reactive oxygen species generation and as key locations of biogeochemical activity.
- Published
- 2022
17. Engineered Barrier System Research Activities at LBNL: FY20 Progress Report
- Author
-
Zheng, LianGe, Lammers, Laura, Fox, Patricia, Chang, chun, Xu, hao, Borglin, sharon, Whittaker, michael, Chou, chunwei, Tournassat, Christophe, Subramanian, Nithya, Wu, Yuxin, Nico, Peter, Gilbert, Benjamin, and Kneafsey, tim
- Published
- 2021
18. Modeling the Impact of Riparian Hollows on River Corridor Nitrogen Exports
- Author
-
Rogers, D Brian, Newcomer, Michelle E, Raberg, Jonathan H, Dwivedi, Dipankar, Steefel, Carl, Bouskill, Nicholas, Nico, Peter, Faybishenko, Boris, Fox, Patricia, Conrad, Mark, Bill, Markus, Brodie, Eoin, Arora, Bhavna, Dafflon, Baptiste, Williams, Kenneth H, and Hubbard, Susan S
- Abstract
Recent studies in snowmelt-dominated catchments have documented changes in nitrogen (N) retention over time, such as declines in watershed exports of N, though there is a limited understanding of the controlling processes driving these trends. Working in the mountainous headwater East River Colorado watershed, we explored the effects of riparian hollows as N-cycling hotspots and as important small-scale controls on observed watershed trends. Using a modeling-based approach informed by remote sensing and in situ observations, we simulated the N-retention capacity of riparian hollows with seasonal and yearly hydrobiogeochemical perturbations imposed as drivers. We then implemented a scaling approach to quantify the relative contribution of riparian hollows to the total river corridor N budget. We found that riparian hollows primarily serve as N sinks, with N-transformation rates significantly limited by periods of enhanced groundwater upwelling and promoted at the onset of rainfall events. Given these observed hydrologic controls, we expect that the nitrate (NO3-) sink capacity of riparian hollows will increase in magnitude with future climatic perturbations, specifically the shift to more frequent rainfall events and fewer snowmelt events, as projected for many mountainous headwater catchments. Our current estimates suggest that while riparian hollows provision ~5–20% of NO3- to the river network, they functionally act as inhibitors to upland NO3- reaching the stream. Our work linking transient hydrological conditions to numerical biogeochemical simulations is an important step in assessing N-retaining features relative to the watershed N budget and better understanding the role of small-scale features within watersheds.
- Published
- 2021
19. Microbial Phosphorus Mobilization Strategies Across a Natural Nutrient Limitation Gradient and Evidence for Linkage With Iron Solubilization Traits.
- Author
-
Wang, Shi, Walker, Robert, Schicklberger, Marcus, Nico, Peter S, Fox, Patricia M, Karaoz, Ulas, Chakraborty, Romy, and Brodie, Eoin L
- Subjects
iron complexed organic phosphorus ,microbial traits ,phosphorus limitation ,phosphorus mobilization ,siderophores ,Environmental Science and Management ,Soil Sciences ,Microbiology - Abstract
Microorganisms have evolved several mechanisms to mobilize and mineralize occluded and insoluble phosphorus (P), thereby promoting plant growth in terrestrial ecosystems. However, the linkages between microbial P-solubilization traits and the preponderance of insoluble P in natural ecosystems are not well known. We tested the P solubilization traits of hundreds of culturable bacteria representative of the rhizosphere from a natural gradient where P concentration and bioavailability decline as soil becomes progressively more weathered. Aluminum, iron phosphate and organic P (phytate) were expected to dominate in more weathered soils. A defined cultivation medium with these chemical forms of P was used for isolation. A combination of soil chemical, spectroscopic analyses and 16S rRNA gene sequencing were used to understand the in situ ability for solubilization of these predominant forms of P. Locations with more occluded and organic P harbored the greatest abundance of P-mobilizing microorganisms, especially Burkholderiaceae (Caballeronia and Paraburkholderia spp.). Nearly all bacteria utilized aluminum phosphate, however fewer could subsist on iron phosphate (FePO4) or phytate. Microorganisms isolated from phytic acid were also most effective at solubilizing FePO4, suggesting that phytate solubilization may be linked to the ability to solubilize Fe. Significantly, we observed Fe to be co-located with P in organic patches in soil. Siderophore addition in lab experiments reinstated phytase mediated P-solubilization from Fe-phytate complexes. Taken together, these results indicate that metal-organic-P complex formation may limit enzymatic P solubilization from phytate in soil. Additionally, the linked traits of phytase and siderophore production were mostly restricted to specific clades within the Burkholderiaceae. We propose that Fe complexation of organic P (e.g., phytate) represents a major constraint on P turnover and availability in acidic soils, as only a limited subset of bacteria appear to possess the traits required to access this persistent pool of soil P.
- Published
- 2021
20. Correction to: Specialist cancer hospital‑based smoking cessation service provision in Ireland
- Author
-
Lyons, Ailsa, Bhardwaj, Nancy, Masalkhi, Mouayad, Fox, Patricia, Frazer, Kate, McCann, Amanda, Syed, Shiraz, Niranjan, Vikram, Kelleher, Cecily C., Kavanagh, Paul, and Fitzpatrick, Patricia
- Published
- 2023
- Full Text
- View/download PDF
21. Engineered Barrier System Research Activities at LBNL: FY20 Progress Report
- Author
-
Zheng, LianGe, Lammers, Laura, Fox, Patricia, Chang, chun, Xu, hao, Borglin, sharon, Whittaker, michael, Chou, chunwei, Tournassat, Christophe, Subramanian, Nithya, Wu, Yuxin, Nico, Peter, Gilbert, Benjamin, and Kneafsey, tim
- Published
- 2020
22. Shale as a Source of Organic Carbon in Floodplain Sediments of a Mountainous Watershed
- Author
-
Fox, Patricia M, Bill, Markus, Heckman, Katherine, Conrad, Mark, Anderson, Carolyn, Keiluweit, Marco, and Nico, Peter S
- Subjects
Earth Sciences ,Geochemistry ,Geology ,shale ,kerogen ,carbon cycle ,organic carbon ,radiocarbon ,sediments ,Geophysics - Abstract
Shales contain high levels of organic carbon (OC) and represent a large fraction of the Earth's reduced carbon stocks. While recent evidence suggests that shale-derived OC may be actively cycled in riverine systems, this process is poorly understood and not currently considered in global C models. Through the use of sediment density fractionations, extractions, radiocarbon measurements, and chemical characterization, we provide information on the abundance, chemistry, and mobility of shale-derived OC in floodplain sediments of a shale-rich mountainous watershed. The heavy fraction of the sediment, representing mineral-associated OC, is the largest (84 ± 6% of TOC) and oldest (Δ14C values −224 to −853‰) OC pool. Evidence of shale-derived OC is observed in all sediment C pools (i.e., occluded light fraction, water-soluble, and pyrophosphate-extractable) except the free light fraction, which is entirely modern. Relatively consistent chemistry was observed across samples for extracted and density-separated OC, despite wide ranges of Δ14C values. Carbon spectroscopy revealed that floodplain sediments had a higher degree of functionalized aromatic groups and lower carbonate content compared to shale collected nearby, consistent with chemical alteration and mixing with other C sources in the floodplain. We estimate that approximately 23–34% of sediment OC is derived from shale, with implications for other shale-derived elements (e.g., N). This study demonstrates the important contribution of shale-OC, particularly in environments with low litter inputs. The large impact of radiocarbon-dead shale-OC, which has a thermally altered chemical structure distinct from plant litter, on Δ14C values and reactivity of sediment-OC must be considered.
- Published
- 2020
23. Effects of bentonite heating on U(VI) adsorption
- Author
-
Fox, Patricia M, Tinnacher, Ruth M, Cheshire, Michael C, Caporuscio, Florie, Carrero, Sergio, and Nico, Peter S
- Subjects
Earth Sciences ,Geology ,Uranium ,Adsorption ,Bentonite ,Nuclear waste disposal ,Radioactive waste ,FEBEX ,Engineered barriers ,EGD-Geothermal Energy ,EGD-Spent Fuel and Nuclear Waste ,EGD-Floating Offshore Wind ,Geochemistry ,Environmental Science and Management ,Geochemistry & Geophysics - Abstract
Engineered barrier systems designed to isolate high-level radioactive waste utilize bentonite, a montmorillonite-rich material, to restrict contaminant transport due to its low hydraulic conductivity and high adsorption capacity. High temperatures (100–200 °C) near waste canisters resulting from radioactive decay may alter the clay's ability to adsorb contaminants. In this study, we examine U(VI) adsorption onto two different bentonite samples subjected to (1) 18 years of in situ heating during an underground experiment and (2) short-term (7-week), high temperature (300 °C) heating in the laboratory. Results show that U(VI) adsorption was lower for field-heated bentonite located closest to the heater, which experienced temperatures of approximately 95 °C, compared to a control sample, which experienced temperatures of approximately 20 °C, over a range of aqueous chemical conditions. On average, Kd values for U(VI) adsorption were 31% lower for 95 °C heated samples. By contrast, U(VI) adsorption onto intermediate-heated bentonite (50 °C) was indistinguishable from the adsorption onto the cold-zone (20 °C) sample. U(VI) adsorption onto lab-heated bentonite was also lower than onto control bentonite over the pH range 4.5–8.0, with an average decrease in Kd values of 50% after heating. Lower U(VI) adsorption to field-heated bentonite persisted after bentonite was purified to isolate the clay fraction. This allows us to rule out changes in pore-water chemistry or accessory mineral composition as causes of the lower adsorption. No evidence of montmorillonite illitization was observed in the heated samples. While some of the lower U(VI) adsorption in the lab-heated bentonite can be explained by changes in aqueous U(VI) speciation, we propose that lower U(VI) adsorption to field-heated bentonite may be primarily due to changes in the montmorillonite edge structure. The observed changes in U(VI) adsorption to bentonite after heating have implications for U(VI) diffusive transport through engineered barriers and must be considered when designing radioactive waste disposal repositories.
- Published
- 2019
24. ANOTHER ANGLE : THE FUTURE ISN’T WHAT IT USED TO BE
- Author
-
FOX, PATRICIA
- Published
- 2021
25. ANOTHER ANGLE : EQUITY FOR ET GRADS
- Author
-
FOX, PATRICIA
- Published
- 2021
26. Conditioning with busulfan plus melphalan versus melphalan alone before autologous haemopoietic cell transplantation for multiple myeloma: an open-label, randomised, phase 3 trial.
- Author
-
Bashir, Qaiser, Thall, Peter, Milton, Denái, Fox, Patricia, Kawedia, Jitesh, Kebriaei, Partow, Shah, Nina, Patel, Krina, Andersson, Borje, Nieto, Yago, Valdez, Ben, Parmar, Simrit, Rondon, Gabriela, Delgado, Ruby, Hosing, Chitra, Popat, Uday, Oran, Betul, Ciurea, Stefan, Lin, Pei, Weber, Donna, Thomas, Sheeba, Lee, Hans, Manasanch, Elisabet, Orlowski, Robert, Williams, Loretta, Champlin, Richard, and Qazilbash, Muzaffar
- Subjects
Adult ,Aged ,Antineoplastic Combined Chemotherapy Protocols ,Busulfan ,Female ,Hematopoietic Stem Cell Transplantation ,Humans ,Kaplan-Meier Estimate ,Male ,Melphalan ,Middle Aged ,Multiple Myeloma ,Neoplasm Grading ,Transplantation Conditioning ,Transplantation ,Autologous ,Treatment Outcome - Abstract
BACKGROUND: Retrospective studies suggest that conditioning therapy with busulfan plus melphalan could result in longer progression-free survival compared with melphalan alone in patients with multiple myeloma undergoing autologous haemopoietic cell transplantation (auto-HCT). We aimed to test this hypothesis in a randomised trial. METHODS: The primary objective of the study was to compare progression-free survival with conditioning of busulfan plus melphalan with melphalan alone in patients with multiple myeloma. Patients with newly diagnosed multiple myeloma who were eligible for cell transplantation, aged 70 years or younger, with at least stable disease, were randomly assigned (1:1) to treatment. Patients received either busulfan plus melphalan, with a test dose of busulfan 32 mg/m2 followed by pharmacokinetically adjusted doses on days -7, -6, -5, and -4 to achieve a target daily area under the curve (AUC) of 5000 mmol-minute and melphalan 70 mg/m2 per day on days -2 and -1 (total melphalan dose 140 mg/m2), or a melphalan dose of 200 mg/m2 on day -2. Randomisation was performed via a Clinical Trial Conduct Website at the University of Texas MD Anderson Cancer Center. The accrual is complete and final results are presented here. The study is registered with ClinicalTrials.gov, number NCT01413178. FINDINGS: Between Oct 12, 2011, and March 22, 2017, 205 patients were assessed for eligibility and randomly assigned to treatment. The primary analysis of progression-free survival was measured in 202 patients who received treatment: 104 patients in the busulfan plus melphalan group and 98 patients in the melphalan alone group. 90 days after auto-HCT, 102 (98%) of 104 patients given busulfan plus melphalan and 95 (97%) of 98 patients given melphalan alone achieved partial response or better. The median follow-up in the busulfan plus melphalan group was 22·6 months (IQR 15·2-47·1) and 20·2 months (IQR 8·8-46·6) in the melphalan alone group. Median progression-free survival was 64·7 months (32·9-64·7) with busulfan plus melphalan versus 43·5 months (19·9-not estimated) with melphalan alone (hazard ratio 0·53 [95% CI 0·30-0·91]; p=0·022). There were no treatment-related deaths by day 100 in either group. Grade 2-3 mucositis was observed in 77 (74%) of 104 patients in the busulfan plus melphalan group versus 14 (14%) of 98 patients in the melphalan alone group. INTERPRETATION: These findings, if confirmed in other ongoing studies, suggest that busulfan plus melphalan could replace melphalan alone as the conditioning regimen for auto-HCT in patients with newly diagnosed myeloma. FUNDING: This study was funded in part by the National Institutes of Health (NIH) through MD Andersons Cancer Center Support Grant (CA016672).
- Published
- 2019
27. Geochemical Exports to River From the Intrameander Hyporheic Zone Under Transient Hydrologic Conditions: East River Mountainous Watershed, Colorado
- Author
-
Dwivedi, Dipankar, Steefel, Carl I, Arora, Bhavna, Newcomer, Michelle, Moulton, J David, Dafflon, Baptiste, Faybishenko, Boris, Fox, Patricia, Nico, Peter, Spycher, Nicolas, Carroll, Rosemary, and Williams, Kenneth H
- Subjects
Hydrology ,Earth Sciences ,Physical Geography and Environmental Geoscience ,Civil Engineering ,Environmental Engineering ,Civil engineering ,Environmental engineering - Abstract
To understand how redox processes influence carbon, nitrogen, and iron cycling within the intrameander hyporheic zone, we developed a biotic and abiotic reaction network and incorporated it into the reactive transport simulator PFLOTRAN. Two-dimensional reactive flow and transport simulations were performed (1) to evaluate how transient hydrological conditions control the lateral redox zonation within an intrameander region of the East River in Colorado and (2) to quantify the impact of a single meander on subsurface exports of carbon and other geochemical species to the river. The meander's overall contribution to the river was quantified by integrating geochemical outfluxes along the outside of the meander bend. The model was able to capture the field-observed trends of dissolved oxygen, nitrate, iron, pH, and total inorganic carbon along a 2-D transect. Consistent with field observations, simulated dissolved oxygen and nitrate decreased along the intrameander flow paths while iron (Fe2+) concentration increased. The simulation results further demonstrated that the reductive potential of the lateral redox zonation was controlled by groundwater velocities resulting from river stage fluctuations, with low-water conditions promoting reducing conditions. The sensitivity analysis results showed that permeability had a more significant impact on biogeochemical zonation compared to the reaction pathways under transient hydrologic conditions. The simulation results further indicated that the meander acted as a sink for organic and inorganic carbon as well as iron during the extended baseflow and high-water conditions; however, these geochemical species were released into the river during the falling limb of the hydrograph.
- Published
- 2018
28. Mine waste rock as a soil amendment for enhanced weathering, ecosystem services, and bioenergy production.
- Author
-
Russell, Mackenzie D., Heckman, Katherine A., Pan, Lei, Ye, Xinyu, Zalesny Jr, Ronald S., Kane, Evan S., Suhrhoff, Tim Jesper, and Fox, Patricia
- Subjects
MINE waste ,SOIL amendments ,ECOSYSTEM services ,SOIL solutions ,ENVIRONMENTAL soil science ,CALCIUM - Abstract
Enhanced weathering of terrestrial rock material is a promising method for the removal of anthropogenic CO
2 emissions from the atmosphere. Herein, we demonstrate that an ameliorated mining waste product can be effectively weathered in the soil environment when used as a soil amendment in conjunction with the cultivation of fast-growing willows (Salix matsudana Koidz. χ S. alba L. "Austree") in a pot study environment. Utilizing this locally sourced amendment minimizes emissions associated with grinding and transportation of enhanced weathering materials. Results showed that the willows were able to tolerate the relatively high metal concentrations of this amendment and sequester inorganic carbon (C) through the production of bicarbonate in soil solution. During the period of peak plant growth (10 weeks after planting), alkalinity measurements of soil solution from pots with willows and the addition of 25% by mass mine waste product indicated an additional 10 mg of inorganic C sequestration per liter of leached soil solution compared to unamended soils with willows. This represents 4.5 times the inorganic C sequestration rate of unamended soils. The addition of ameliorated mining waste also increased the pH of the soil solution by up to two units (pH of 6 in control vs. pH of 8 with the addition of 25% by mass mineral amendment). In addition to inorganic C sequestration, weathering of the ameliorated mining waste product may also provide base cations (such as calcium and magnesium) which could improve soil fertility. These results are encouraging for future investigation of ameliorated mine waste rock to sequester carbon and enhance the production of willows grown for ecosystem services and phytotechnologies. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
29. Effects of Mineral Impurities and Heat on Uranium(VI) Sorption onto Bentonite (Final Report)
- Author
-
Tinnacher, Ruth, primary, Bhattacharyya, Amrita, additional, Huang, Patrick, additional, Massey, Michael, additional, Tournassat, Christophe, additional, Fox, Patricia, additional, Nico, Peter, additional, Whittaker, Michael, additional, Caporuscio, Florie, additional, Rock, Marlena, additional, Sauer, Kristen, additional, and Holmboe, Michael, additional
- Published
- 2023
- Full Text
- View/download PDF
30. Learning from data to predict future symptoms of oncology patients.
- Author
-
Papachristou, Nikolaos, Puschmann, Daniel, Barnaghi, Payam, Cooper, Bruce, Hu, Xiao, Maguire, Roma, Apostolidis, Kathi, Conley, Yvette P, Hammer, Marilyn, Katsaragakis, Stylianos, Kober, Kord M, Levine, Jon D, McCann, Lisa, Patiraki, Elisabeth, Furlong, Eileen P, Fox, Patricia A, Paul, Steven M, Ream, Emma, Wright, Fay, and Miaskowski, Christine
- Subjects
Humans ,Neoplasms ,Depression ,Anxiety ,Models ,Psychological ,Female ,Male ,Support Vector Machine ,Neural Networks ,Computer ,Models ,Psychological ,Neural Networks ,Computer ,General Science & Technology - Abstract
Effective symptom management is a critical component of cancer treatment. Computational tools that predict the course and severity of these symptoms have the potential to assist oncology clinicians to personalize the patient's treatment regimen more efficiently and provide more aggressive and timely interventions. Three common and inter-related symptoms in cancer patients are depression, anxiety, and sleep disturbance. In this paper, we elaborate on the efficiency of Support Vector Regression (SVR) and Non-linear Canonical Correlation Analysis by Neural Networks (n-CCA) to predict the severity of the aforementioned symptoms between two different time points during a cycle of chemotherapy (CTX). Our results demonstrate that these two methods produced equivalent results for all three symptoms. These types of predictive models can be used to identify high risk patients, educate patients about their symptom experience, and improve the timing of pre-emptive and personalized symptom management interventions.
- Published
- 2018
31. Characterization of natural organic matter in low-carbon sediments: Extraction and analytical approaches
- Author
-
Fox, Patricia M, Nico, Peter S, Tfaily, Malak M, Heckman, Katherine, and Davis, James A
- Subjects
Analytical Chemistry ,Chemical Sciences ,Natural organic matter ,Soil ,Sediment ,Chemical extraction ,Chemical characterization ,FTIR ,ESI-FTICR-MS ,Earth Sciences ,Environmental Sciences ,Geochemistry & Geophysics ,Chemical sciences ,Earth sciences ,Environmental sciences - Abstract
Organic carbon (OC) concentrations in subsurface sediments are typically 10 to 200 times lower than in surface soils, posing a distinct challenge for characterization. In this study, a range of chemical extractions were evaluated for extraction of natural organic matter (NOM) from two low-carbon (< 0.2%) alluvial sediments. The OC extraction efficiency followed the order pyrophosphate (PP) > NaOH > HCl, hydroxylamine hydrochloride > dithionite, water. A NOM extraction and purification scheme was developed using sequential extraction with water (MQ) and sodium pyrophosphate at pH 10 (PP), combined with purification by dialysis and solid phase extraction in order to isolate different fractions of sediment-associated NOM. Characterization of these pools of NOM for metal content and by Fourier transform infrared spectroscopy (FITR) showed that the water soluble fraction (MQ-SPE) had a higher fraction of aliphatic and carboxylic groups, while the PP-extractable NOM (PP-SPE and PP > 1kD) had higher fractions of C[dbnd]C groups and higher residual metals. This trend from aliphatic to more aromatic is also supported by the specific UV absorbance at 254 nm (SUVA254) (3.5 vs 5.4 for MQ-SPE and PP-SPE, respectively) and electrospray ionization Fourier transform ion cyclotron resonance spectrometry (ESI-FTICR-MS) data which showed a greater abundance of peaks in the low O/C and high H/C region (0–0.4 O/C, 0.8–2.0 H/C) for the MQ-SPE fraction of NOM. Radiocarbon measurements yielded standard radiocarbon ages of 1020, 3095, and 9360 years BP for PP-SPE, PP > 1kD, and residual (non-extractable) OC fractions, indicating an increase in NOM stability correlated with greater metal complexation, apparent molecular weight, and aromaticity.
- Published
- 2017
32. ANOTHER ANGLE : A VOTE OF CONFIDENCE
- Author
-
FOX, PATRICIA
- Published
- 2020
33. ANOTHER ANGLE : ET TAKES THE HILL
- Author
-
FOX, PATRICIA
- Published
- 2019
34. Gastrointestinal Hemorrhage With Gastritis and Pancolitis as the Sole Presentation for Granulomatosis With Polyangiitis Flare
- Author
-
Khan, Sarah, Alkhayyat, Motasem, Albakri, Almaza, Setrakian, Sebouh, Falloon, Katherine, Abou Saleh, Mohannad, and Ajayi-Fox, Patricia
- Published
- 2022
- Full Text
- View/download PDF
35. The eSMART study protocol: a randomised controlled trial to evaluate electronic symptom management using the advanced symptom management system (ASyMS) remote technology for patients with cancer.
- Author
-
Maguire, Roma, Fox, Patricia A, McCann, Lisa, Miaskowski, Christine, Kotronoulas, Grigorios, Miller, Morven, Furlong, Eileen, Ream, Emma, Armes, Jo, Patiraki, Elisabeth, Gaiger, Alexander, Berg, Geir V, Flowerday, Adrian, Donnan, Peter, McCrone, Paul, Apostolidis, Kathi, Harris, Jenny, Katsaragakis, Stylianos, Buick, Alison R, and Kearney, Nora
- Subjects
Humans ,Breast Neoplasms ,Colorectal Neoplasms ,Hematologic Neoplasms ,Antineoplastic Agents ,Drug Monitoring ,Self Care ,Severity of Illness Index ,Telemedicine ,Research Design ,International Cooperation ,Quality of Life ,Adolescent ,Adult ,Aged ,Middle Aged ,Cost-Benefit Analysis ,Europe ,Female ,Male ,Young Adult ,Surveys and Questionnaires ,Patient Reported Outcome Measures ,Cell Phone ,cancer ,chemotherapy ,information technology ,randomised controlled trial ,symptom management ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences - Abstract
IntroductionWhile some evidence exists that real-time remote symptom monitoring devices can decrease morbidity and prevent unplanned admissions in oncology patients, overall, these studies have significant methodological weaknesses. The electronic Symptom Management using the Advanced Symptom Management System (ASyMS) Remote Technology (eSMART) study is designed to specifically address these weaknesses with an appropriately powered, repeated-measures, parallel-group stratified randomised controlled trial of oncology patients.Methods and analysisA total of 1108 patients scheduled to commence first-line chemotherapy (CTX) for breast, colorectal or haematological cancer will be recruited from multiple sites across five European countries.Patients will be randomised (1:1) to the ASyMS intervention (intervention group) or to standard care currently available at each site (control group). Patients in the control and intervention groups will complete a demographic and clinical questionnaire, as well as a set of valid and reliable electronic patient-reported outcome measures at enrolment, after each of their CTX cycles (up to a maximum of six cycles) and at 3, 6, 9 and 12 months after completion of their sixth cycle of CTX. Outcomes that will be assessed include symptom burden (primary outcome), quality of life, supportive care needs, anxiety, self-care self-efficacy, work limitations and cost effectiveness and, from a health professional perspective, changes in clinical practice (secondary outcomes).Ethics and disseminationEthical approval will be obtained prior to the implementation of all major study amendments. Applications will be submitted to all of the ethics committees that granted initial approval.eSMART received approval from the relevant ethics committees at all of the clinical sites across the five participating countries. In collaboration with the European Cancer Patient Coalition (ECPC), the trial results will be disseminated through publications in scientific journals, presentations at international conferences, and postings on the eSMART website and other relevant clinician and consumer websites; establishment of an eSMART website (www.esmartproject.eu) with publicly accessible general information; creation of an eSMART Twitter Handle, and production of a toolkit for implementing/utilising the ASyMS technology in a variety of clinical practices and other transferable health care contexts.Trial registration numberNCT02356081.
- Published
- 2017
36. Effects of magnetic field strength and b value on the sensitivity and specificity of quantitative breast diffusion-weighted MRI
- Author
-
Eghtedari, Mohammad, Ma, Jingfei, Fox, Patricia, Guvenc, Inanc, Yang, Wei T, and Dogan, Basak E
- Subjects
Engineering ,Atomic ,Molecular and Optical Physics ,Physical Sciences ,Biomedical Engineering ,Breast Cancer ,Health Services ,Clinical Research ,Biomedical Imaging ,Cancer ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Breast MRI ,diffusion-weighted imaging ,b value ,magnetic field strength ,benign and malignant lesions ,Condensed Matter Physics ,Optical Physics ,Other Physical Sciences ,Biomedical engineering ,Atomic ,molecular and optical physics - Abstract
BackgroundTo evaluate the effect of b value or the magnetic field strength (B0) on the sensitivity and specificity of quantitative breast diffusion-weighted imaging (DWI).MethodsA total of 126 patients underwent clinical breast MRI that included pre-contrast DWI imaging using b values of both 1,000 and 1,500 s/mm2 at either 1.5 T (n=86) or 3.0 T (n=40). Quantitative apparent diffusion coefficients (ADC) were measured and compared for 18 benign, 33 malignant lesions, and 126 normal breast tissues. Optimal ADCmean threshold for differentiating benign and malignant lesions was estimated and the effect of b values and B0 were examined using a generalized estimating equations (GEE) model.ResultsThe optimal ADCmean threshold was 1.235×10-3 mm2/s for b value of 1,000 and 0.934×10-3 mm2/s for b value of 1,500. Using these thresholds, the sensitivities and specificities were 96% and 89% (b value =1,000, B0 =1.5 T), 89% and 98% (b value =1,000, B0 =3.0 T), 88% and 96% (b value =1,500, B0 =1.5 T), and 67% and 100% (b value =1,500, B0 =3.0 T). No significant difference was found between different B0 (P=0.26) or b values (P=0.28).ConclusionsBetter sensitivity is achieved with DWI of b value =1,000 than with b value =1,500. However, b value and B0 do not significantly impact diagnostic performance of DWI when using appropriate thresholds.
- Published
- 2016
37. ANOTHER ANGLE : ENGINEERING TECHNOLOGY’S BENEFITS
- Author
-
FOX, PATRICIA
- Published
- 2018
38. Autologous Hematopoietic Stem Cell Transplantation in Dialysis-Dependent Myeloma Patients.
- Author
-
El Fakih, Riad, Fox, Patricia, Popat, Uday, Nieto, Yago, Shah, Nina, Parmar, Simrit, Oran, Betul, Ciurea, Stefan, Kebriaei, Partow, Hosing, Chitra, Ahmed, Sairah, Shah, Jatin, Orlowski, Robert, Champlin, Richard, Qazilbash, Muzaffar, and Bashir, Qaiser
- Subjects
Autologous stem cell transplant ,Melphalan ,Mortality ,Multiple myeloma ,Renal failure ,Adult ,Aged ,Disease-Free Survival ,Female ,Hematopoietic Stem Cell Transplantation ,Humans ,Incidence ,Male ,Middle Aged ,Multiple Myeloma ,Retrospective Studies ,Transplantation Conditioning ,Transplantation ,Autologous - Abstract
BACKGROUND: We retrospectively analyzed our transplant database from July 2000 to June 2012 to identify myeloma patients who received autologous stem cell transplantation while dialysis-dependent. PATIENTS: 2091 patients underwent autologous high-dose therapy during this period. Twenty-four patients were dialysis-dependent. RESULTS: The 100-day and the 6, and 12-month treatment-related mortality was 0%. Overall response rate was 92%. The median progression-free survival and overall survival were 1.9 years and 3.8 years, respectively. A multivariate analysis was not performed because of the small sample size. Only 3 patients became dialysis-independent after transplantation. Cardiac, gastrointestinal, genitourinary, infectious, neurologic, and pulmonary all grade toxicities were all higher in the melphalan 200 group versus < 200 group, however, none of them were statistically significant. CONCLUSION: Because of a lack of clear survival benefit with higher-dose melphalan and potential higher toxicity in this group, it is reasonable to use lower-dose melphalan in dialysis-dependent myeloma patients.
- Published
- 2015
39. Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis
- Author
-
Poon, Michelle L, Fox, Patricia S, Samuels, Barry I, O’Brien, Susan, Jabbour, Elias, Hsu, Yvonne, Gulbis, Alison, Korbling, Martin, Champlin, Richard, Abruzzo, Lynne V, Bassett, Roland L, and Khouri, Issa F
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Stem Cell Research ,Cancer ,Stem Cell Research - Nonembryonic - Human ,Clinical Research ,Lymphoma ,Rare Diseases ,Hematology ,Transplantation ,Adult ,Aged ,Chromosome Deletion ,Chromosomes ,Human ,Pair 17 ,Female ,Follow-Up Studies ,Graft vs Host Disease ,Humans ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Referral and Consultation ,Retrospective Studies ,Stem Cell Transplantation ,Survival Analysis ,Survival Rate ,Time Factors ,Transplantation ,Homologous ,Treatment Outcome ,17p− ,CLL ,allogeneic transplant ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology - Abstract
Allogeneic stem cell transplant (alloSCT) can overcome the adverse prognosis of chronic lymphocytic leukemia with 17p deletion (17p- CLL). However, its applicability remains unclear. Since 2007, our leukemia service has referred patients with 17p- CLL for alloSCT at presentation. In this study, the outcomes of these patients were reviewed retrospectively to determine whether they underwent alloSCT and why patients did not undergo alloSCT. Fifty-two patients with 17p- CLL who were referred to the transplant service from 2007 to 2010 were identified. Of these patients, 32 (62%) did not undergo alloSCT, mainly because of treatment- or disease-related complications (n = 15). The 2-year post-referral overall survival rates of the alloSCT and non-SCT groups were 64% and 25%, respectively (p = 0.001). These findings suggest that while alloSCT is an effective therapy in patients with 17p- CLL, pre-SCT complications may preclude a significant proportion of patients from undergoing the procedure.
- Published
- 2015
40. Bicarbonate impact on U(VI) bioreduction in a shallow alluvial aquifer
- Author
-
Long, Philip E, Williams, Kenneth H, Davis, James A, Fox, Patricia M, Wilkins, Michael J, Yabusaki, Steven B, Fang, Yilin, Waichler, Scott R, Berman, Elena SF, Gupta, Manish, Chandler, Darrell P, Murray, Chris, Peacock, Aaron D, Giloteaux, Ludovic, Handley, Kim M, Lovley, Derek R, and Banfield, Jillian F
- Subjects
Earth Sciences ,Geology ,Geochemistry ,Physical Geography and Environmental Geoscience ,Geochemistry & Geophysics - Abstract
Field-scale biostimulation and desorption tracer experiments conducted in a uranium (U) contaminated, shallow alluvial aquifer have provided insight into the coupling of microbiology, biogeochemistry, and hydrogeology that control U mobility in the subsurface. Initial experiments successfully tested the concept that Fe-reducing bacteria such as Geobacter sp. could enzymatically reduce soluble U(VI) to insoluble U(IV) during in situ electron donor amendment (Anderson et al., 2003; Williams et al., 2011). In parallel, in situ desorption tracer tests using bicarbonate amendment demonstrated rate-limited U(VI) desorption (Fox et al., 2012). These results and prior laboratory studies underscored the importance of enzymatic U(VI)-reduction and suggested the ability to combine desorption and bioreduction of U(VI). Here we report the results of a new field experiment in which bicarbonate-promoted uranium desorption and acetate amendment were combined and compared to an acetate amendment-only experiment in the same experimental plot. Results confirm that bicarbonate amendment to alluvial aquifer sediments desorbs U(VI) and increases the abundance of Ca-uranyl-carbonato complexes. At the same time, the rate of acetate-promoted enzymatic U(VI) reduction was greater in the presence of added bicarbonate in spite of the increased dominance of Ca-uranyl-carbonato aqueous complexes. A model-simulated peak rate of U(VI) reduction was ~3.8 times higher during acetate-bicarbonate treatment than under acetate-only conditions. Lack of consistent differences in microbial community structure between acetate-bicarbonate and acetate-only treatments suggest that a significantly higher rate of U(VI) reduction in the bicarbonate-impacted sediment may be due to a higher intrinsic rate of microbial reduction induced by elevated concentrations of the bicarbonate oxyanion. The findings indicate that bicarbonate amendment may be useful in improving the engineered bioremediation of uranium in aquifers.
- Published
- 2015
41. Chemotherapy Dose Intensity and Overall Survival Among Patients With Advanced Breast or Ovarian Cancer
- Author
-
Denduluri, Neelima, Lyman, Gary H., Wang, Yunfei, Morrow, Phuong Khanh, Barron, Richard, Patt, Debra, Bhowmik, Debajyoti, Li, Xiaoyan, Bhor, Menaka, Fox, Patricia, Dhanda, Rahul, Saravanan, Shanmugapriya, Jiao, Xiaolong, Garcia, Jacob, and Crawford, Jeffrey
- Published
- 2018
- Full Text
- View/download PDF
42. Specialist cancer hospital-based smoking cessation service provision in Ireland
- Author
-
Lyons, Ailsa, primary, Bhardwaj, Nancy, additional, Masalkhi, Mouayad, additional, Fox, Patricia, additional, Frazer, Kate, additional, McCann, Amanda, additional, Syed, Shiraz, additional, Niranjan, Vikram, additional, Kelleher, Cecily C., additional, Kavanagh, Paul, additional, and Fitzpatrick, Patricia, additional
- Published
- 2023
- Full Text
- View/download PDF
43. Power and leadership of women within the catholic church in Australia
- Author
-
Fox, Patricia
- Published
- 2018
44. Engineered Barrier System Research Activities at LBNL: FY20 Progress Report
- Author
-
Zheng, LianGe, Lammers, Laura, Fox, Patricia, Chang, chun, Xu, hao, Borglin, sharon, Whittaker, michael, Chou, chunwei, Tournassat, Christophe, Subramanian, Nithya, Wu, Yuxin, Nico, Peter, Gilbert, Benjamin, and Kneafsey, tim
- Published
- 2023
45. The assessment and management of chemotherapy-related toxicities in patients with breast cancer, colorectal cancer, and Hodgkin’s and non-Hodgkin’s lymphomas: A scoping review
- Author
-
Fox, Patricia, Darley, Andrew, Furlong, Eileen, Miaskowski, Christine, Patiraki, Elisabeth, Armes, Jo, Ream, Emma, Papadopoulou, Constantina, McCann, Lisa, Kearney, Nora, and Maguire, Roma
- Published
- 2017
- Full Text
- View/download PDF
46. Long-Term Outcomes after Treatment with Clofarabine ± Fludarabine with Once-Daily Intravenous Busulfan as Pretransplant Conditioning Therapy for Advanced Myeloid Leukemia and Myelodysplastic Syndrome
- Author
-
Alatrash, Gheath, Thall, Peter F., Valdez, Benigno C., Fox, Patricia S., Ning, Jing, Garber, Haven R., Janbey, Selma, Worth, Laura L., Popat, Uday, Hosing, Chitra, Alousi, Amin M., Kebriaei, Partow, Shpall, Elizabeth J., Jones, Roy B., de Lima, Marcos, Rondon, Gabriela, Chen, Julianne, Champlin, Richard E., and Andersson, Borje S.
- Published
- 2016
- Full Text
- View/download PDF
47. Strategic Interorganization Management: An Approach for Evaluating the Impact of New Technologies on Distribution Channel Structures and Relationships
- Author
-
El-Ansary, Adel I., Fox, Patricia B., Academy of Marketing Science, and Malhotra, Naresh K., editor
- Published
- 2015
- Full Text
- View/download PDF
48. Table S1 from Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations
- Author
-
Bucheit, Amanda D., primary, Chen, Guo, primary, Siroy, Alan, primary, Tetzlaff, Michael, primary, Broaddus, Russell, primary, Milton, Denai, primary, Fox, Patricia, primary, Bassett, Roland, primary, Hwu, Patrick, primary, Gershenwald, Jeffrey E., primary, Lazar, Alexander J., primary, and Davies, Michael A., primary
- Published
- 2023
- Full Text
- View/download PDF
49. Supplementary Table 3 - 4 from Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
- Author
-
Radvanyi, Laszlo G., primary, Bernatchez, Chantale, primary, Zhang, Minying, primary, Fox, Patricia S., primary, Miller, Priscilla, primary, Chacon, Jessica, primary, Wu, Richard, primary, Lizee, Gregory, primary, Mahoney, Sandy, primary, Alvarado, Gladys, primary, Glass, Michelle, primary, Johnson, Valen E., primary, McMannis, John D., primary, Shpall, Elizabeth, primary, Prieto, Victor, primary, Papadopoulos, Nicholas, primary, Kim, Kevin, primary, Homsi, Jade, primary, Bedikian, Agop, primary, Hwu, Wen-Jen, primary, Patel, Sapna, primary, Ross, Merrick I., primary, Lee, Jeffrey E., primary, Gershenwald, Jeffrey E., primary, Lucci, Anthony, primary, Royal, Richard, primary, Cormier, Janice N., primary, Davies, Michael A., primary, Mansaray, Rahmatu, primary, Fulbright, Orenthial J., primary, Toth, Christopher, primary, Ramachandran, Renjith, primary, Wardell, Seth, primary, Gonzalez, Audrey, primary, and Hwu, Patrick, primary
- Published
- 2023
- Full Text
- View/download PDF
50. Data from Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations
- Author
-
Bucheit, Amanda D., primary, Chen, Guo, primary, Siroy, Alan, primary, Tetzlaff, Michael, primary, Broaddus, Russell, primary, Milton, Denai, primary, Fox, Patricia, primary, Bassett, Roland, primary, Hwu, Patrick, primary, Gershenwald, Jeffrey E., primary, Lazar, Alexander J., primary, and Davies, Michael A., primary
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.