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17 results on '"Fréret, Manuel"'

2. Icos gene disruption in non‐obese diabetic mice elicits myositis associated with anti‐troponin T3 autoantibodies

Author

Bourdenet, Gwladys, primary, Pileyre, Baptiste, additional, Drouot, Laurent, additional, Martinet, Jérémie, additional, Bécourt, Chantal, additional, Carrette, Marion, additional, Riou, Gaétan, additional, Bergua, Cécile, additional, Jaworski, Thara, additional, Chan, Philippe, additional, Jean, Laetitia, additional, Fréret, Manuel, additional, Cosette, Pascal, additional, Boitard, Christian, additional, Abad, Catalina, additional, and Boyer, Olivier, additional

Published
2023
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3. IgG N-glycosylation from Patients with Pemphigus Treated with Rituximab

Author

Font, Guillaume, primary, Walet-Balieu, Marie-Laure, additional, Petit, Marie, additional, Burel, Carole, additional, Maho-Vaillant, Maud, additional, Hébert, Vivien, additional, Chan, Philippe, additional, Fréret, Manuel, additional, Boyer, Olivier, additional, Joly, Pascal, additional, Calbo, Sébastien, additional, Bardor, Muriel, additional, and Golinski, Marie-Laure, additional

Published
2022
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6. Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies

Author

Brevet, Pauline, primary, Lattard, Claire, additional, Guillou, Clément, additional, Rottenberg, Pascal, additional, Fardellone, Patrice, additional, Le-Loët, Xavier, additional, Lequerré, Thierry, additional, Cosette, Pascal, additional, Boyer, Olivier, additional, Fréret, Manuel, additional, and Vittecoq, Olivier, additional

Published
2021
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8. The IgG2 isotype of anti-transcription intermediary factor 1-gamma autoantibodies is a biomarker of mortality and cancer in adult dermatomyositis

Author

Aussy, Audrey, Fréret, Manuel, Gallay, Laure, Drouot, Laurent, Jouen, Fabienne, Allenbach, Yves, Benveniste, Olivier, Cordel, Nadège, Boyer, Olivier, Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2019

10. Additional file 1: Table S1. of Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors

Author

Marie-Laure Golinski, Vandhuick, Thibault, Derambure, Céline, Fréret, Manuel, Lecuyer, Matthieu, Guillou, Clément, Hiron, Martine, Boyer, Olivier, Loët, Xavier Le, Vittecoq, Olivier, and Lequerré, Thierry

Subjects
musculoskeletal diseases, skin and connective tissue diseases, humanities
Abstract

Clinical and biological characteristics of rheumatoid arthritis (RA) patients treated with adalimumab, etanercept or abatacept. (DOC 61 kb)

Published
2015
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12. The IgG2 Isotype of Anti–Transcription Intermediary Factor 1γ Autoantibodies Is a Biomarker of Cancer and Mortality in Adult Dermatomyositis.

Author

Aussy, Audrey, Fréret, Manuel, Gallay, Laure, Bessis, Didier, Vincent, Thierry, Jullien, Denis, Drouot, Laurent, Jouen, Fabienne, Joly, Pascal, Marie, Isabelle, Meyer, Alain, Sibilia, Jean, Bader‐Meunier, Brigitte, Hachulla, Eric, Hamidou, Mohammed, Huë, Sophie, Charuel, Jean‐Luc, Fabien, Nicole, Viailly, Pierre‐Julien, and Allenbach, Yves

Subjects
*TUMOR diagnosis, *TUMOR risk factors, *AGE distribution, *AUTOANTIBODIES, *BIOMARKERS, *CREATINE kinase, *DERMATOMYOSITIS, *IMMUNOASSAY, *IMMUNOGLOBULINS, *MEDICAL cooperation, *MULTIVARIATE analysis, *RESEARCH, *RISK assessment, *SEX distribution, *STATISTICS, *TRANSCRIPTION factors, *SYMPTOMS, *PREDICTIVE tests, *PROPORTIONAL hazards models, *DISEASE complications, MORTALITY risk factors
Abstract

Objective: Anti–transcription intermediary factor 1γ (anti‐TIF1γ) antibodies are the main predictors of cancer in dermatomyositis (DM). Yet, a substantial proportion of anti‐TIF1γ–positive DM patients do not develop cancer. This study was undertaken to identify biomarkers to better evaluate the risk of cancer and mortality in DM. Methods: This multicenter study was conducted in adult anti‐TIF1γ–positive DM patients from August 2013 to August 2017. Anti‐TIF1γ autoantibody levels and IgG subclasses were identified using a newly developed quantitative immunoassay. Age, sex, DM signs and activity, malignancy, and creatine kinase (CK) level were recorded. Risk factors were determined by univariate and multivariate analysis according to a Cox proportional hazards regression model. Results: Among the 51 adult patients enrolled (mean ± SD age 61 ± 17 years; ratio of men to women 0.65), 40 (78%) had cancer and 21 (41%) died, with a mean ± SD survival time of 10 ± 6 months. Detection of anti‐TIF1γ IgG2 was significantly associated with mortality (P = 0.0011) and occurrence of cancer during follow‐up (P < 0.0001), with a 100% positive predictive value for cancer when the mean fluorescence intensity of anti‐TIF1γ IgG2 was >385. None of the patients developed cancer after 24 months of follow‐up. Univariate survival analyses showed that mortality was also associated with age >60 years (P = 0.0003), active DM (P = 0.0042), cancer (P = 0.0031), male sex (P = 0.011), and CK level >1,084 units/liter (P = 0.005). Multivariate analysis revealed that age >60 years (P = 0.015) and the presence of anti‐TIF1γ IgG2 (P = 0.048) were independently associated with mortality. Conclusion: Our findings indicate that anti‐TIF1γ IgG2 is a potential new biomarker of cancer that should be helpful in identifying the risk of mortality in anti‐TIF1γ–positive DM patients. [ABSTRACT FROM AUTHOR]

Published
2019
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13. Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function

Author

Guillou, Clément, primary, Fréret, Manuel, additional, Fondard, Emeline, additional, Derambure, Céline, additional, Avenel, Gilles, additional, Golinski, Marie-Laure, additional, Verdet, Mathieu, additional, Boyer, Olivier, additional, Caillot, Frédérique, additional, Musette, Philippe, additional, Lequerré, Thierry, additional, and Vittecoq, Olivier, additional

Published
2016
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14. Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors

Author

Golinski, Marie-Laure, primary, Vandhuick, Thibault, additional, Derambure, Céline, additional, Fréret, Manuel, additional, Lecuyer, Matthieu, additional, Guillou, Clément, additional, Hiron, Martine, additional, Boyer, Olivier, additional, Le Loët, Xavier, additional, Vittecoq, Olivier, additional, and Lequerré, Thierry, additional

Published
2015
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15. Prophylactic Injection of Recombinant Alpha-Enolase Reduces Arthritis Severity in the Collagen-Induced Arthritis Mice Model

Author

Guillou, Clément, primary, Derambure, Céline, additional, Fréret, Manuel, additional, Verdet, Mathieu, additional, Avenel, Gilles, additional, Golinski, Marie-Laure, additional, Sabourin, Jean-Christophe, additional, Loarer, François Le, additional, Adriouch, Sahil, additional, Boyer, Olivier, additional, Lequerré, Thierry, additional, and Vittecoq, Olivier, additional

Published
2015
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