195 results on '"Fraga, Carlos A.M."'
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2. N-Acylhydrazones as drugs
3. Filtering promiscuous compounds in early drug discovery: is it a good idea?
4. Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor
5. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity
6. Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579
7. Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound
8. LASSBio-1422: a new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition
9. Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents
10. Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC–MS/MS: Application for a pharmacokinetic study
11. Structure-based design and biological profile of ( E)- N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β
12. Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties
13. LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model
14. Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D 2- like and 5-HT 1A receptors
15. Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A 2 synthesis inhibition
16. Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives
17. Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors
18. Synthesis, pharmacological evaluation and docking studies of new sulindac analogues
19. Novel 6-methanesulfonamide-3,4-methylenedioxyphenyl- N-acylhydrazones: Orally effective anti-inflammatory drug candidates
20. Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2- a]pyridine symbiotic prototypes
21. New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
22. CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (−)-spectaline
23. NSAIDs revisited: Putative molecular basis of their interactions with peroxisome proliferator-activated gamma receptor (PPARγ)
24. Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives
25. Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl- N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors
26. Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates
27. New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia
28. Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties
29. Development of new CoMFA and CoMSIA 3D-QSAR models for anti-inflammatory phthalimide-containing TNFα modulators
30. Design, synthesis, and pharmacological evaluation of new neuroactive pyrazolo[3,4- b]pyrrolo[3,4- d]pyridine derivatives with in vivo hypnotic and analgesic profile
31. Chiral Gas Chromatographic Separation of 2-0xabicyclo[3.3.0]octane Derivatives and Their Synthetic Precursors
32. Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition
33. The Use of Conformational Restriction in Medicinal Chemistry
34. Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives
35. Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors
36. A proposed molecular basis for the selective resveratrol inhibition of the PGHS-1 peroxidase activity
37. New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids
38. Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues
39. Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581
40. Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats
41. New class of potent antinociceptive and antiplatelet 10 H-phenothiazine-1-acylhydrazone derivatives
42. Studies on diastereoselective reduction of cyclic β-ketoesters with boron hydrides. Part 4: The reductive profile of functionalized cyclohexanone derivatives
43. Chiral separation of γ-butyrolactone derivatives by gas chromatography on 2,3-di- O-methyl-6- O- tert.-butyldimethylsilyl-β-cyclodextrin
44. Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands
45. Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives
46. Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor
47. NF-κB-IKKβ Pathway as a Target for Drug Development: Realities, Challenges and Perspectives
48. Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole
49. In vivo effect of LASSBio-785, a lipid-lowering and anti-inflammatory agent, on cardiac Ca2 +-ATPases from hypercholesterolemic rats
50. Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates
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