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5 results on '"Fraietta, J."'

2. FOURTH GENERATION HUCART19‐IL18 PRODUCES DURABLE RESPONSES IN LYMPHOMA PATIENTS PREVIOUSLY RELAPSED/REFRACTORY TO ANTI‐CD19 CAR T‐CELL THERAPY

Author

Svoboda, J., primary, Landsburg, D. L., additional, Chong, E. A., additional, Barta, S. K., additional, Nasta, S. D., additional, Ruella, M., additional, Hexner, E. O., additional, Marshall, A., additional, Leskowitz, R., additional, Four, M., additional, Shea, J., additional, Cervini, A., additional, Davis, M. M., additional, Please, G., additional, Hasenmayer, D., additional, Amortegui, J. R., additional, Hwang, W., additional, Frey, N., additional, Siegel, D. L., additional, Fraietta, J., additional, Levine, B., additional, Porter, D. L., additional, Schuster, S. J., additional, and June, C. H., additional

Published
2023
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3. BENDAMUSTINE LYMPHODEPLETION TRIGGERS REDUCED INFLAMMATORY CYTOKINES AND DECREASED TOXICITIES AFTER BOTH 4‐1BB‐ AND CD28‐COSTIMULATED CART19 FOR NON‐HODGKIN LYMPHOMA.

Author

Ghilardi, G., Paruzzo, L., Svoboda, J., Chong, E. A., Cohen, I. J., Nasta, S. D., Landsburg, D. J., Gerson, J. N., Carter, J. S., Barta, S. K., Yelton, R., Pajarillo, R., Ballard, H. J., Weber, E., Napier, E. B., Chong, E. R., Fraietta, J. A., Garfall, A. L., Porter, D. L., and Schuster, S. J.

Subjects
NON-Hodgkin's lymphoma, CYTOKINES
Abstract

We previously demonstrated that Bendamustine (Benda) LD is as effective as standard fludarabine and cyclophosphamide (Flu/Cy) LD before the 4-1BB-costimulated tisagenlecleucel, but has reduced cytokine-release syndrome (CRS), neurotoxicity (ICANS), and hematological toxicities. B Introduction: b Lymphodepletion (LD) is a key component of anti-CD19 chimeric antigen receptor T cell (CART19) immunotherapy, establishing the proper environment and cytokine milieu before CART infusion. BENDAMUSTINE LYMPHODEPLETION TRIGGERS REDUCED INFLAMMATORY CYTOKINES AND DECREASED TOXICITIES AFTER BOTH 4-1BB- AND CD28-COSTIMULATED CART19 FOR NON-HODGKIN LYMPHOMA. [Extracted from the article]

Published
2023
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5. Peripheral Blood T-Cell Fitness Is Diminished in Patients With Pancreatic Carcinoma but Can Be Improved With Homeostatic Cytokines.

Author

Xu J, Sai H, Li Y, Jordan AC, McGettigan SE, Chen JH, Bedoya F, Fraietta JA, Gladney WL, Melenhorst JJ, and Beatty GL

Subjects
CD4-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes metabolism, Cell Proliferation physiology, Cytokines, Female, Gene Expression genetics, Homeostasis, Humans, Immunotherapy methods, Interleukin-15 analysis, Interleukin-7 analysis, Male, Pancreatic Neoplasms immunology, T-Lymphocytes physiology, Transcriptome genetics, Pancreatic Neoplasms, Carcinoma, Pancreatic Ductal immunology, Carcinoma, Pancreatic Ductal physiopathology, T-Lymphocytes immunology
Published
2019
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