7 results on '"Frances E. Oldfield"'
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2. Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties
- Author
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Eithne Costello, John P. Neoptolemos, William Greenhalf, Christopher Halloran, John F. Timms, Phoebe A. Phillips, Quentin Nunes, Rebecca Dawson, Mehdi Jalali, Milton Ashworth, Triantafillos Liloglou, Pedro A. Perez-Mancera, Zipeng Lu, Timothy Andrews, Fiona Campbell, Frances E. Oldfield, Sarah Brumskill, Brian Lane, Anthony Evans, and Lawrence N. Barrera
- Abstract
Top upstream regulators significantly enriched in PDAC vs PAT and PAT vs CP, as determined using IPA.
- Published
- 2023
- Full Text
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3. Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties
- Author
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Eithne Costello, John P. Neoptolemos, William Greenhalf, Christopher Halloran, John F. Timms, Phoebe A. Phillips, Quentin Nunes, Rebecca Dawson, Mehdi Jalali, Milton Ashworth, Triantafillos Liloglou, Pedro A. Perez-Mancera, Zipeng Lu, Timothy Andrews, Fiona Campbell, Frances E. Oldfield, Sarah Brumskill, Brian Lane, Anthony Evans, and Lawrence N. Barrera
- Abstract
Patient characteristics of UoL serum sample cohorts.
- Published
- 2023
- Full Text
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4. Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties
- Author
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Eithne Costello, John P. Neoptolemos, William Greenhalf, Christopher Halloran, John F. Timms, Phoebe A. Phillips, Quentin Nunes, Rebecca Dawson, Mehdi Jalali, Milton Ashworth, Triantafillos Liloglou, Pedro A. Perez-Mancera, Zipeng Lu, Timothy Andrews, Fiona Campbell, Frances E. Oldfield, Sarah Brumskill, Brian Lane, Anthony Evans, and Lawrence N. Barrera
- Abstract
Patient characteristics of samples included on TMAs histologically stained for TNC.
- Published
- 2023
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5. Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties
- Author
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Eithne Costello, John P. Neoptolemos, William Greenhalf, Christopher Halloran, John F. Timms, Phoebe A. Phillips, Quentin Nunes, Rebecca Dawson, Mehdi Jalali, Milton Ashworth, Triantafillos Liloglou, Pedro A. Perez-Mancera, Zipeng Lu, Timothy Andrews, Fiona Campbell, Frances E. Oldfield, Sarah Brumskill, Brian Lane, Anthony Evans, and Lawrence N. Barrera
- Abstract
Although fibrotic stroma forms an integral component of pancreatic diseases, whether fibroblasts programmed by different types of pancreatic diseases are phenotypically distinct remains unknown. Here, we show that fibroblasts isolated from patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), periampullary tumors, and adjacent normal (NA) tissue (N = 34) have distinct mRNA and miRNA profiles. Compared with NA fibroblasts, PDAC-associated fibroblasts were generally less sensitive to an antifibrotic stimulus (NPPB) and more responsive to positive regulators of activation such as TGFβ1 and WNT. Of the disease-associated fibroblasts examined, PDAC- and CP-derived fibroblasts shared greatest similarity, yet PDAC-associated fibroblasts expressed higher levels of tenascin C (TNC), a finding attributable to miR-137, a novel regulator of TNC. TNC protein and transcript levels were higher in PDAC tissue versus CP tissue and were associated with greater levels of stromal activation, and conditioned media from TNC-depleted PDAC-associated fibroblasts modestly increased both PDAC cell proliferation and PDAC cell migration, indicating that stromal TNC may have inhibitory effects on PDAC cells. Finally, circulating TNC levels were higher in patients with PDAC compared with CP. Our characterization of pancreatic fibroblast programming as disease-specific has consequences for therapeutic targeting and for the manner in which fibroblasts are used in research.Significance:Primary fibroblasts derived from various types of pancreatic diseases possess and retain distinct molecular and functional characteristics in culture, providing a series of cellular models for treatment development and disease-specific research.
- Published
- 2023
- Full Text
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6. Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties
- Author
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Eithne Costello, John P. Neoptolemos, William Greenhalf, Christopher Halloran, John F. Timms, Phoebe A. Phillips, Quentin Nunes, Rebecca Dawson, Mehdi Jalali, Milton Ashworth, Triantafillos Liloglou, Pedro A. Perez-Mancera, Zipeng Lu, Timothy Andrews, Fiona Campbell, Frances E. Oldfield, Sarah Brumskill, Brian Lane, Anthony Evans, and Lawrence N. Barrera
- Abstract
Supplementary Material and Methods
- Published
- 2023
- Full Text
- View/download PDF
7. Contributors
- Author
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Ghassan K. Abou-Alfa, Jad Abou Khalil, Pietro Addeo, N. Volkan Adsay, Anil Kumar Agarwal, Farzad Alemi, Peter J. Allen, Ahmed Al-Mukhtar, Thomas A. Aloia, Jesper B. Andersen, Christopher D. Anderson, Vittoria Arslan-Carlon, Horacio J. Asbun, Béatrice Aussilhou, Joseph Awad, Daniel Azoulay, Philippe Bachellier, Talia B. Baker, Zubin M. Bamboat, Jeffrey Stewart Barkun, Claudio Bassi, Olca Basturk, Rachel E. Beard, Pierre Bedossa, Jacques Belghiti, Omar Bellorin-Marin, Marc G.H. Besselink, Anton J. Bilchik, Leslie H. Blumgart, Franz Edward Boas, Lynn A. Brody, Karen T. Brown, Jordi Bruix, David A. Bruno, Elizabeth M. Brunt, Justin M. Burns, Giovanni Butturini, Juan Carlos Caicedo, Mark P. Callery, Abdul Saied Calvino, Danielle H. Carpenter, C. Ross Carter, François Cauchy, Chung Yip Chan, See Ching Chan, William C. Chapman, Daniel Cherqui, Clifford S. Cho, Jin Wook Chung, Jesse Clanton, Bryan Marshall Clary, Sean Patrick Cleary, Kelly M. Collins, John Barry Conneely, Louise C. Connell, Carlos U. Corvera, Guido Costa, Anne M. Covey, Jeffrey S. Crippin, Kristopher P. Croome, Hany Dabbous, Michael I. D'Angelica, Michael D. Darcy, Jeremy L. Davis, Jeroen de Jonge, Ronald P. DeMatteo, Danielle K. DePeralta, Niraj M. Desai, Eduardo de Santibañes, Martin de Santibañes, Euan J. Dickson, Christopher John DiMaio, Richard Kinh Gian Do, Safi Dokmak, Marcello Donati, M.B. Majella Doyle, Vikas Dudeja, Mark Dunphy, Truman M. Earl, Tomoki Ebata, Imane El Dika, Yousef El-Gohary, Itaru Endo, C. Kristian Enestvedt, N. Joseph Espat, Cecilia G. Ethun, Sheung Tat Fan, Paul T. Fanta, Olivier Farges, Cristina R. Ferrone, Ryan C. Fields, Mary Fischer, Sarah B. Fisher, Devin C. Flaherty, Yuman Fong, Scott L. Friedman, Ahmed Gabr, John R. Galloway, David A. Geller, Hans Gerdes, Scott R. Gerst, George K. Gittes, Jaime Glorioso, Jill S. Gluskin, Brian K.P. Goh, Stevan A. Gonzalez, Karyn A. Goodman, Gregory J. Gores, Eduardo H. Gotuzzo, Dirk J. Gouma, Paul D. Greig, James F. Griffin, Christopher M. Halloran, Neil A. Halpern, Chet W. Hammill, Paul D. Hansen, James J. Harding, Ewen M. Harrison, Werner Hartwig, Kiyoshi Hasegawa, Jaclyn F. Hechtman, Julie K. Heimbach, William S. Helton, Alan W. Hemming, J. Michael Henderson, Asher Hirshberg, James R. Howe, Christopher B. Hughes, Christine Iacobuzio-Donahue, William R. Jarnagin, Roger L. Jenkins, Zeljka Jutric, Christoph Kahlert, Joseph Ralph Kallini, Ivan Kangrga, Paul J. Karanicolas, Seth S. Katz, Steven C. Katz, Kaitlyn J. Kelly, Nancy E. Kemeny, Eugene P. Kennedy, Korosh Khalili, Adeel S. Khan, Saboor Khan, Heung Bae Kim, T. Peter Kingham, Allan D. Kirk, David S. Klimstra, Michael Kluger, Stuart J. Knechtle, Jonathan B. Koea, Norihiro Kokudo, Dionysios Koliogiannis, David A. Kooby, Kevin Korenblat, Simone Krebs, Michael J. LaQuaglia, Michael P. LaQuaglia, Nicholas F. LaRusso, Alexis Laurent, Konstantinos N. Lazaridis, Julie N. Leal, Eliza J. Lee, Major Kenneth Lee, Ser Yee Lee, Riccardo Lencioni, Alexandre Liccioni, Michael E. Lidsky, Chung-Wei Lin, David C. Linehan, Roberto Carlos Lopez-Solis, Jeffrey A. Lowell, David C. Madoff, Jason Maggi, Shishir K. Maithel, Ali W. Majeed, Peter Malfertheiner, Giuseppe Malleo, Shennen A. Mao, Giovanni Marchegiani, Luis A. Marcos, James F. Markmann, J. Wallis Marsh, Robert C.G. Martin, Ryusei Matsuyama, Matthias S. Matter, Francisco Juan Mattera, Jessica E. Maxwell, Oscar M. Mazza, Ian D. McGilvray, Colin J. McKay, Doireann M. McWeeney, Jose Melendez, Robin B. Mendelsohn, George Miller, Klaus E. Mönkemüller, Ryutaro Mori, Vitor Moutinho, Masato Nagino, David M. Nagorney, Satish Nagula, Attila Nakeeb, Geir I. Nedredal, John P. Neoptolemos, James Neuberger, Scott L. Nyberg, Rachel O'Connor, John G. O'Grady, Frances E. Oldfield, Karl J. Oldhafer, Kim M. Olthoff, Susan L. Orloff, Alessandro Paniccia, Valérie Paradis, Rowan W. Parks, Gérard Pascal, Stephen M. Pastores, Timothy M. Pawlik, Venu G. Pillarisetty, James Francis Pingpank, C. Wright Pinson, Henry Anthony Pitt, James J. Pomposelli, Fabio Procopio, Michael J. Pucci, Motaz Qadan, Kheman Rajkomar, Srinevas K. Reddy, Maria E. Reig, Joseph Arturo Reza, John Paul Roberts, Piera Marie Cote Robson, Flavio G. Rocha, Garrett Richard Roll, Sean M. Ronnekleiv-Kelly, Alexander S. Rosemurgy, Charles B. Rosen, Pierre F. Saldinger, Riad Salem, Suhail Bakr Salem, Roberto Salvia, Charbel Sandroussi, Dominic E. Sanford, Olivier Scatton, Mark Andrew Schattner, William Palmer Schecter, Hans Francis Schoellhammer, Richard D. Schulick, Lawrence H. Schwartz, Kevin N. Shah, Ross W. Shepherd, Hiroshi Shimada, Masafumi Shimoda, Junichi Shindoh, Hosein Shokouh-Amiri, Jason K. Sicklick, Robert H. Siegelbaum, Gagandeep Singh, Rory L. Smoot, Stephen B. Solomon, Olivier Soubrane, Nicholas Spinelli, John A. Stauffer, Lygia Stewart, Matthew S. Strand, James H. Tabibian, Guido Torzilli, James F. Trotter, Simon Turcotte, Yumirle P. Turmelle, Demetrios J. Tzimas, Thomas Van Gulik, Andrea Vannucci, Jean-Nicolas Vauthey, Diana Vetter, Valérie Vilgrain, Alejandra Maria Villamil, Louis P. Voigt, Charles M. Vollmer, Jack R. Wands, Julia Wattacheril, Sharon Marie Weber, Matthew J. Weiss, Jürgen Weitz, Jens Werner, Megan Winner, John Wong, Dennis Yang, Hooman Yarmohammadi, Charles J. Yeo, Theresa Pluth Yeo, Chang Jin Yoon, Adam Yopp, D. Owen Young, Kai Zhao, Gazi B. Zibari, and George Zogopoulos
- Published
- 2017
- Full Text
- View/download PDF
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