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5. International consensus statement on microbiome testing in clinical practice

Author

Porcari, Serena, Mullish, Benjamin H, Asnicar, Francesco, Ng, Siew C, Zhao, Liping, Hansen, Richard, O'Toole, Paul W, Raes, Jeroen, Hold, Georgina, Putignani, Lorenza, Hvas, Christian Lodberg, Zeller, Georg, Koren, Omry, Tun, Hein, Valles-Colomer, Mireia, Collado, Maria Carmen, Fischer, Monika, Allegretti, Jessica, Iqbal, Tariq, Chassaing, Benoit, Keller, Josbert, Baunwall, Simon Mark, Abreu, Maria, Barbara, Giovanni, Zhang, Faming, Ponziani, Francesca Romana, Costello, Sam P, Paramsothy, Sudarshan, Kao, Dina, Kelly, Colleen, Kupcinskas, Juozas, Youngster, Ilan, Franceschi, Francesco, Khanna, Sahil, Vehreschild, Maria, Link, Alexander, De Maio, Flavio, Pasolli, Edoardo, Miguez, Aitor Blanco, Brigidi, Patrizia, Posteraro, Brunella, Scaldaferri, Franco, Stojanovic, Mirjana Rajilic, Megraud, Francis, Malfertheiner, Peter, Masucci, Luca, Arumugam, Manimozhiyan, Kaakoush, Nadeem, Segal, Eran, Bajaj, Jasmohan, Leong, Rupert, Cryan, John, Weersma, Rinse K, Knight, Robert, Guarner, Francisco, Shanahan, Fergus, Cani, Patrice D, Elinav, Eran, Sanguinetti, Maurizio, de Vos, Willem M, El-Omar, Emad, Dorè, Joel, Marchesi, Julian, Tilg, Herbert, Sokol, Harry, Segata, Nicola, Cammarota, Giovanni, Gasbarrini, Antonio, and Ianiro, Gianluca

Published
2025
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6. Diagnosis of acute aortic syndromes with ultrasound and d-dimer: the PROFUNDUS study

Author

Ardito, Arianna, Bartalucci, Alice, Calzolari, Gilberto, Giachino, Francesca, Leone, Dario, Locatelli, Stefania, Scategni, Virginia, Tizzani, Maria, Rubiolo, Francesca, Becucci, Alessandro, Bondi, Ernesta, Cavallaro, Gabriele, Caviglioli, Cosimo, Guerrini, Stefania, Haxhiraj, Eriola, Paladini, Barbara, Prota, Alessio, Ronchetti, Mattia, Guerra, Federica, Tavares de Oliveira, Múcio, Jr., Soares, Paulo Rogério, Malacarne, Margerita, Santini, Massimo, Bonzi, Mattia, Bartalucci, Paola, Coppa, Alessandro, Mueller, Christian, Nickel, Christian H., Bingisser, Roland, Fong, Chan Pei, Franceschi, Francesco, Tullo, Gianluca, Ceschi, Ludovica, Schwameis, Michael, Morello, Fulvio, Bima, Paolo, Castelli, Matteo, Capretti, Elisa, de Matos Soeiro, Alexandre, Cipriano, Alessandro, Costantino, Giorgio, Vanni, Simone, Leidel, Bernd A., Kaufmann, Beat A., Osman, Adi, Candelli, Marcello, Capsoni, Nicolò, Behringer, Wilhelm, Capuano, Marialessia, Ascione, Giovanni, Leal, Tatiana de Carvalho Andreucci Torres, Ghiadoni, Lorenzo, Pivetta, Emanuele, Grifoni, Stefano, Lupia, Enrico, and Nazerian, Peiman

Published
2024
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9. Revision of a Failed Humeral Stem with Sufficient Bone Stock

Author

Giovannetti de Sanctis, Edoardo, Palumbo, Alessio, Baldari, Angelo, D’Ossat, Gian Mauro De Angelis, Saccone, Luca, La Verde, Luca, Franceschi, Francesco, Franceschi, Francesco, editor, Athwal, George S., editor, Lädermann, Alexandre, editor, and Giovannetti de Sanctis, Edoardo, editor

Published
2023
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17. Arthroscopic Treatment of Hill-Sachs Lesions

Author

Franceschi, Francesco, de Sanctis, Edoardo Giovannetti, Perricone, Giovanni, Franceschetti, Edoardo, Milano, Giuseppe, editor, Grasso, Andrea, editor, Brzóska, Roman, editor, and Kovačič, Ladislav, editor

Published
2023
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26. Standing Bishop Saint.

Author

Franceschi, Francesco dei and Franceschi, Francesco dei

Subjects
Painting, Italian 15th century., Men., Bishops., Saints., Scepters., Books., Miters., Men, Saints, Books, Peinture italienne 15e siècle., Hommes., Évêques., Saints., Sceptres., Livres., men (male humans), scepters., books., Bishops., Books., Men., Miters., Painting, Italian., Saints., Scepters.
Published
2024

31. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Steering Committee, Landi, Francesco, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field investigators, Gastroenterology team, Porcari, Serena, Settanni, Carlo Romano, Geriatric team, Benvenuto, Francesca, Bramato, Giulia, Brandi, Vincenzo, Carfì, Angelo, Ciciarello, Francesca, Fabrizi, Sofia, Galluzzo, Vincenzo, Lo Monaco, Maria Rita, Martone, Anna Maria, Marzetti, Emanuele, Napolitano, Carmen, Pagano, Francesco Cosimo, Pais, Cristina, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Tosato, Matteo, Tritto, Marcello, Zazzara, Maria Beatrice, Calvani, Riccardo, Catalano, Lucio, Picca, Anna, Savera, Giulia, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, Giovanni, Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, Federica, Cacciatore, Stefano, Infectious disease team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, A., Di Gianbenedetto, Simona, Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine team, Stella, Leonardo, Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Gertrude, Zocco, M.A., Microbiology team, Sanguinetti, Maurizio, Cattani, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, G., Cozzupoli, G.M., Culiersi, C., Otolaryngology team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Y., Tricarico, L., Santantonio, M., Pediatric team, Buonsenso, Danilo, Valentini, P., Pata, D., Sinatti, D., De Rose, C., Pneumology team, Richeldi, Luca, Lombardi, Francesco, Calabrese, A., Leone, Paolo Maria, Calvello, Maria Rosaria, Intini, Enrica, Montemurro, Giuliano, Psychiatric team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., odica, M., Radiology team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology team, Paglionico, Annamaria, Petricca, Luca, Gigante, Luca, Natalello, G., Fedele, A.L., Lizzio, M.M., Tolusso, B., Di Mario, Clara, Alivernini, S., Vascular team, Santoliquido, Angelo, Santoro, Luca, Di Giorgio, Angela, Nesci, Antonio, and Popolla, V.

Published
2022
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32. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Fiorinni, Giulia, Saracino, Ilaria Maria, Carrasco, Manuel Pabon, Huerga, Alma Keco, Almajano, Enrique Alfaro, Martinez Dominguez, Samuel Jesus, Galan, Horacio Alonso, Velayos, Benito, Sadornil, Carmen Dueñas, Botargues Bote, Jose Maria, Gonzalez-Cordero, Pedro Luis, Areia, Miguel, Gomez Rodriguez, Blas Jose, Pellicano, Rinaldo, Nuñez, Óscar, Franceschi, Francesco, Alekseenko, Sergey, Perona, Monica, Abdulkhakov, Rustam, Dominguez-Cajal, Manuel, Notari, Pedro Almela, Camarero, Judith Gomez, Moreno, Manuel Jimenez, Algaba, Alicia, Bermejo, Fernando, Tejada, Javier Tejedor, Susanibar, Elida Oblitas, Boltin, Doron, Georgopoulos, Sotirios, OMorain, Colm, Qasim, Asghar, Beales, Ian, Bakulina, Natalia, Fadeenko, Galina, Malfertheiner, Peter, Rosania, Rosa, Ilchishina, Tatiana, Bogomolov, Pavel, Bakulin, Igor, Zaytsev, Oleg, Gravina, Antonietta Gerarda, Romano, Marco, Di Leo, Alfredo, Losurdo, Giuseppe, Grigorieva, Ludmila, Guillena, Pedro Delgado, Marusic, Marinko, Jurcic, Dragan, Dekhnich, Natalia Nikolaevna, Iyo, Eduardo, de la Peña Negro, Luisa Carmen, Baryshnikova, Natalia, Bakanova, Natalia, Simsek, Halis, Simsek, Cem, Gridnyev, Oleksiy, Fernandez-Bermejo, Miguel, Angueira, Teresa, Ruiz-Zorrilla Lopez, Rafael, Gomez, Barbara, Kovacheva-Slavova, Mila, Lahat, Adi, Alcedo, Javier, Campillo, Ana, Belousova, Liya Nikolaevna, Villarroya, Ramon Pajares, Ljubicic, Neven, Nikolic, Marko, González-Santiago, Jesús M., Santamaría, Diego Burgos, Pakhomova, Anna, Sekulic-Spasic, Izabela, Ghisa, Matteo, Farinati, Fabio, Sagdati, Sabir Irfan, Panic, Nikola, Heluwaert, Frederic, Amorena, Edurne, Moreira, Leticia, Esparrach, Gloria Fernandez, Plotnikova, Ekaterina Yuryevna, Kukla, Michal, Kamburov, Victor, Lamuela Calvo, Luis Javier, Rankovic, Ivan, Lavín, Antonio Cuadrado, Lazaro, Yolanda Arguedas, Carrera Agnieszka Dobrowolska, Victor Gonzalez, Eder, Piotr, Kononova, Alla, Nyssen, Olga P., Vaira, Dino, Pérez Aísa, Ángeles, Rodrigo, Luis, Castro-Fernandez, Manuel, Jonaitis, Laimas, Tepes, Bojan, Vologzhanina, Liudmila, Caldas, María, Lanas, Angel, Lucendo, Alfredo J., Bujanda, Luis, Ortuño, Juan, Barrio, Jesús, Huguet, Jose M., Voynovan, Irina, Lasala, Jorge Perez, Sarsenbaeva, Aiman Silkanovna, Fernandez-Salazar, Luis, Molina-Infante, Javier, Jurecic, Natasa Brglez, Gasbarrini, Antonio, Kupčinskas, Juozas, Bordin, Dmitry, Marcos-Pinto, Ricardo, Lerang, Frode, Leja, Marcis, Buzas, Gyorgy M., Niv, Yaron, Rokkas, Theodore, Phull, Perminder, Smith, Sinead, Shvets, Oleg, Venerito, Marino, Milivojevic, Vladimir, Simsek, Ilkay, Lamy, Vincent, Bytzer, Peter, Boyanova, Lyudmila, Kunovský, Lumír, Beglinger, Christoph, Doulberis, Michael, Marlicz, Wojciech, Goldis, Adrian, Tonkić, Ante, Capelle, Lisette, Puig, Ignasi, Megraud, Francis, Morain, Colm O’, and Gisbert, Javier P.

Published
2022
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34. Hospital admissions from the emergency department of adult patients affected by myopathies

Author

Monforte, Mauro, Torchia, Eleonora, Bortolani, Sara, Ravera, Beatrice, Ricci, Enzo, Silvestri, Gabriella, Servidei, Serenella, Primiano, Guido Alessandro, Mirabella, Massimiliano, Sabatelli, Mario, Mercuri, Eugenio Maria, Franceschi, Francesco, Calabresi, Paolo, Covino, Marcello, Tasca, Giorgio, Ricci, Enzo (ORCID:0000-0003-3092-3597), Silvestri, Gabriella (ORCID:0000-0002-1950-1468), Servidei, Serenella (ORCID:0000-0001-8478-2799), Primiano, Guido, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Sabatelli, Mario (ORCID:0000-0001-6635-4985), Mercuri, Eugenio (ORCID:0000-0002-9851-5365), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Covino, Marcello (ORCID:0000-0002-6709-2531), Monforte, Mauro, Torchia, Eleonora, Bortolani, Sara, Ravera, Beatrice, Ricci, Enzo, Silvestri, Gabriella, Servidei, Serenella, Primiano, Guido Alessandro, Mirabella, Massimiliano, Sabatelli, Mario, Mercuri, Eugenio Maria, Franceschi, Francesco, Calabresi, Paolo, Covino, Marcello, Tasca, Giorgio, Ricci, Enzo (ORCID:0000-0003-3092-3597), Silvestri, Gabriella (ORCID:0000-0002-1950-1468), Servidei, Serenella (ORCID:0000-0001-8478-2799), Primiano, Guido, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Sabatelli, Mario (ORCID:0000-0001-6635-4985), Mercuri, Eugenio (ORCID:0000-0002-9851-5365), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Covino, Marcello (ORCID:0000-0002-6709-2531)

Abstract

Background and purposeMyopathies are associated with classic signs and symptoms, but also with possible life-threatening complications that may require assistance in an emergency setting. This phenomenon is understudied in the literature. We aimed to assess the presentation, management, and outcomes of clinical manifestations potentially related to a muscle disorder requiring referral to the adult emergency department (ED) and hospitalization.MethodsAnonymized patient data retrieved using the International Classification of Diseases, Ninth Revision codes related to muscle disorders over 4 years were retrospectively analyzed. Medical reports were evaluated to extract demographic and clinical variables, along with outcomes. Two groups were defined based on the presence (known diagnosis [KD] group) or absence (unknown diagnosis [UD] group) of a diagnosed muscle disorder at arrival.ResultsA total of 244 patients were included, 51% of whom were affected by a known myopathy, predominantly limb-girdle muscular dystrophies and myotonic dystrophies. The main reasons for ED visits in the KD group were respiratory issues, worsening of muscle weakness, and gastrointestinal problems. Heart complications were less prevalent. In the UD group, 27 patients received a new diagnosis of a specific primary muscle disorder after the ED access, mostly an inflammatory myopathy. Death during hospitalization was recorded in 26 patients, with a higher rate in the KD group and in patients affected by mitochondrial and inflammatory myopathies. Sepsis and dyspnea were associated with increased death risk.ConclusionsRespiratory complications are the most common reason for myopathic patients accessing the ED, followed by gastrointestinal issues. Infections are severe threats and, once hospitalized, these patients have relatively high mortality.

Published
2024

35. A novel risk score predicting 30-day hospital re-admission of patients with acute stroke by machine learning model

Author

Mercurio, Giovanna, Gottardelli, Benedetta, Lenkowicz, Jacopo, Patarnello, Stefano, Bellavia, Simone, Scala, Irene, Rizzo, Pierandrea, de Belvis, Antonio Giulio, Del Signore, Anna Benedetta, Maviglia, Riccardo, Bocci, Maria Grazia, Olivi, Alessandro, Franceschi, Francesco, Urbani, Andrea, Calabresi, Paolo, Valentini, Vincenzo, Antonelli, Massimo, Frisullo, Giovanni, Olivi, Alessandro (ORCID:0000-0002-4489-7564), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Urbani, Andrea (ORCID:0000-0001-9168-3174), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Mercurio, Giovanna, Gottardelli, Benedetta, Lenkowicz, Jacopo, Patarnello, Stefano, Bellavia, Simone, Scala, Irene, Rizzo, Pierandrea, de Belvis, Antonio Giulio, Del Signore, Anna Benedetta, Maviglia, Riccardo, Bocci, Maria Grazia, Olivi, Alessandro, Franceschi, Francesco, Urbani, Andrea, Calabresi, Paolo, Valentini, Vincenzo, Antonelli, Massimo, Frisullo, Giovanni, Olivi, Alessandro (ORCID:0000-0002-4489-7564), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Urbani, Andrea (ORCID:0000-0001-9168-3174), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), and Antonelli, Massimo (ORCID:0000-0003-3007-1670)

Abstract

Background: The 30-day hospital re-admission rate is a quality measure of hospital care to monitor the efficiency of the healthcare system. The hospital re-admission of acute stroke (AS) patients is often associated with higher mortality rates, greater levels of disability and increased healthcare costs. The aim of our study was to identify predictors of unplanned 30-day hospital re-admissions after discharge of AS patients and define an early re-admission risk score (RRS).Methods: This observational, retrospective study was performed on AS patients who were discharged between 2014 and 2019. Early re-admission predictors were identified by machine learning models. The performances of these models were assessed by receiver operating characteristic curve analysis.Results: Of 7599 patients with AS, 3699 patients met the inclusion criteria, and 304 patients (8.22%) were re-admitted within 30 days from discharge. After identifying the predictors of early re-admission by logistic regression analysis, RRS was obtained and consisted of seven variables: hemoglobin level, atrial fibrillation, brain hemorrhage, discharge home, chronic obstructive pulmonary disease, one and more than one hospitalization in the previous year. The cohort of patients was then stratified into three risk categories: low (RRS = 0-1), medium (RRS = 2-3) and high (RRS >3) with re-admission rates of 5%, 8% and 14%, respectively.Conclusions: The identification of risk factors for early re-admission after AS and the elaboration of a score to stratify at discharge time the risk of re-admission can provide a tool for clinicians to plan a personalized follow-up and contain healthcare costs.

Published
2024

36. Ursodeoxycholic acid does not affect the clinical outcome of SARS-CoV-2 infection: A retrospective study of propensity score-matched cohorts

Author

Marrone, Giuseppe, Covino, Marcello, Merra, Giuseppe, Piccioni, Andrea, Amodeo, Annamaria, Novelli, Angela, Murri, Rita, Pompili, Maurizio, Gasbarrini, Antonio, Franceschi, Francesco, Covino, Marcello (ORCID:0000-0002-6709-2531), Murri, Rita (ORCID:0000-0003-4263-7854), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Marrone, Giuseppe, Covino, Marcello, Merra, Giuseppe, Piccioni, Andrea, Amodeo, Annamaria, Novelli, Angela, Murri, Rita, Pompili, Maurizio, Gasbarrini, Antonio, Franceschi, Francesco, Covino, Marcello (ORCID:0000-0002-6709-2531), Murri, Rita (ORCID:0000-0003-4263-7854), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Franceschi, Francesco (ORCID:0000-0001-6266-445X)

Abstract

Background: Ursodeoxycholic acid (UDCA) has been recently proposed as a modulator of angiotensin-converting enzyme 2 (ACE2) receptor expression, with potential effects on COVID-19.Aim and Study Design: We retrospectively evaluated the clinical course and outcome of subjects taking UDCA admitted to the hospital for COVID-19 compared with matched infected subjects. Differences regarding the severity and outcome of the disease between treated and non-treated subjects were assessed. The Kaplan-Meier survival analysis and log-rank test were used to evaluate the effect of UDCA on all-cause intra-hospital mortality.Results: Among 6444 subjects with confirmed COVID-19 admitted to the emergency department (ED) from 1 March 2020 to 31 December 2022, 109 subjects were taking UDCA. After matching 629 subjects were included in the study: 521 in the no UDCA group and 108 in the UDCA group. In our matched cohort, 144 subjects (22.9%) died, 118 (22.6%) in the no-UDCA group and 26 (24.1%) in the UDCA group. The Kaplan-Meier analysis showed no significant difference in survival between groups. In univariate regression analysis, the presence of pneumonia, National Early Warning Score (NEWS) score, and Charlson Comorbidity Index (CCI) were significant independent predictors of death. At multivariate Cox regression analysis, age, NEWS, pneumonia and CCI index were confirmed significant independent predictors of death. UDCA treatment was not a predictor of survival both in univariate and multivariate regressions.Conclusions: UDCA treatment does not appear to have significant effects on the outcome of COVID-19. Specially designed prospective studies are needed to evaluate efficacy in preventing infection and severe disease.

Published
2024

37. Head CT Scans in the Emergency Department during the COVID-19 Pandemic: Use or Overuse?

Author

Covino, Marcello, Piccioni, Andrea, Merra, Giuseppe, Giordano, Carolina, Russo, Rosellina, Infante, Amato, Ausili Cefaro, Luca, Natale, Luigi, Franceschi, Francesco, Gaudino, Simona, Covino, Marcello (ORCID:0000-0002-6709-2531), Natale, Luigi (ORCID:0000-0002-7949-5119), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Gaudino, Simona (ORCID:0000-0003-1681-4343), Covino, Marcello, Piccioni, Andrea, Merra, Giuseppe, Giordano, Carolina, Russo, Rosellina, Infante, Amato, Ausili Cefaro, Luca, Natale, Luigi, Franceschi, Francesco, Gaudino, Simona, Covino, Marcello (ORCID:0000-0002-6709-2531), Natale, Luigi (ORCID:0000-0002-7949-5119), Franceschi, Francesco (ORCID:0000-0001-6266-445X), and Gaudino, Simona (ORCID:0000-0003-1681-4343)

Abstract

Background: The COVID-19 pandemic seemed to mainly involve the respiratory system, but it was realized that it could affect any organ, including the CNS. The pandemic has followed a wave-like trend, with its peaks being due to the COVID-19 different variants and the introduction of the vaccine, which led to an apparent reduction in hospitalizations but also brought about perplexities related to its adverse effects. The aim of this study was to analyze the changes in the use of head CT/contrast CT and their impacts on the onset of cerebrovascular disease in our emergency department during the COVID-19 period and the vaccine rollout. Methods: Patients >= 18 years old admitted to our emergency department from January 2018 to September 2021 were enrolled. The patients were divided into three groups. The COVID-19 period included patients who visited our emergency department from 1 March 2020 to 31 January 2021; the vaccine period was considered to range from 1 February 2021 to 30 September 2021. The patients who visited the emergency department from 1 January 2018 to 31 January 2020 were considered the controls. Results: We found an increase in head CT/contrast CT requests during the COVID-19 period and increase in head contrast CT during the vaccine period, without an increase in the incidence of cerebrovascular disease. Conclusions: The uncertainty regarding the possible thrombotic events associated with COVID-19 and its vaccine increased the relative use of head CT/contrast CT by about 20% compared to the control period

Published
2024

38. Foot and Ankle Trauma: Epidemiology Before, During, and Post COVID-19 Pandemic in a Level I Trauma Center: A 5-Year Experience and Data Analysis.

Author

Mascio, Antonio, Greco, Tommaso, Comisi, Chiara, Cinelli, Virginia, De Gasperis, Nicola, Candelli, Marcello, Franceschi, Francesco, Covino, Marcello, Maccauro, Giulio, and Perisano, Carlo

Subjects
COVID-19 pandemic, ANKLE injuries, TRAUMA centers, FOOT injuries, COVID-19
Abstract

Background: Foot and ankle injuries are one of the leading orthopedic causes of emergency department (ED) admissions. The purpose of this study was to analyze, through 5 years of data collection, differences in number and type of admissions, as well as the severity of foot and ankle trauma to the ED in the pre-pandemic period, during the COVID-19 emergency, and in the post-pandemic period. This study aims to assess epidemiological and clinical data. Methods: Five years of data were collected on admissions to the ED at the Fondazione Policlinico Universitario A. Gemelli using an electronic database. The system allowed the use of a numeric code assessed at triage ranging from 1 to 5, where 1 indicated a patient with compromised vital functions, and it continued in decreasing criticality. Data were extensively analyzed and extrapolated to obtain epidemiological and clinical evaluation. Results: Data from 3787 patients, including 1945 males with a mean age of 41.4 years, were collected. Data were evaluated in the three different periods. In the pre-pandemic period, 2228 ED admissions were recorded, including 1138 males with a mean age of 37.4 years and a mean of 2.79 admissions per day. Codes 3 and 4 reported in the ED triage were 4.8% and 90.1%, respectively; the average surgical treatment was 5.6%. During the COVID period, the total number of admissions was 981, with 501 males with an average age of 43.8 years and a mean of 1.30 admissions per day. Codes 3 and 4 were 22.5% and 72.7%, respectively; the average surgical treatment was 10.4%. In the post-COVID period, 578 admissions were, including 306 males with a mean age of 43.2 years, and a daily access rate of 1.58 patients. Codes 3 and 4 reported in the ED triage were 25.4% and 70.8%, respectively; the average surgical treatment was 8.6%. Conclusions: During the pandemic period due to COVID-19 a substantial decrease in total admissions per day in the ED was noted, but an increase in more complex codes occurred, as evidenced by the percentage increase in surgical admissions compared to total admissions during the pandemic; the mean age of users gradually increased. Total hospitalization data remained stable in the post-pandemic period, likely due to the global impact of the pandemic. COVID-19 radically and concretely changed people's living habits and priorities for accessing the ED. [ABSTRACT FROM AUTHOR]

Published
2024
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39. The Efficacy of a Combination of Milk Thistle, Artichoke, and Green Tea in the Treatment of Biliary Sludge: An Interventional Prospective Open Study.

Author

Saviano, Angela, Sicilia, Ida, Migneco, Alessio, Petruzziello, Carmine, Brigida, Mattia, Candelli, Marcello, Franceschi, Francesco, and Ojetti, Veronica

Abstract

Background: In Western countries, 10–20% of adults have gallstones, of which about 1–3% of patients are symptomatic for biliary colic. The treatment with ursodeoxycholic acid is debated. Silymarin is emerging nowadays as a natural substance with choleretic and beneficial properties, useful in the case of gallbladder sludge. Aim: The aim of our study was to evaluate the efficacy of supplementation with a mix of natural compounds (milk thistle 150 mg, artichoke 150 mg, and green tea 150 mg) in patients affected by biliary sludge in reducing biliary colic and biliary sludge and improving lipid profiles after 3 months of treatment compared to a control group. Patients and Methods: This was an interventional open study on 65 consecutive adult patients (23 M/42 F; mean age 61.0 ± 18.7 years) affected by biliary sludge without indication for surgery, admitted to the Internal Medicine Department of San Carlo di Nancy Hospital Rome. Forty patients were treated with milk thistle 150 mg, artichoke 150 mg, and green tea 150 mg, 2 capsules/day for three months, and followed up for abdominal ultrasound, the frequency of occurrence of biliary colic, and blood tests. Twenty-five control group patients were followed up for abdominal ultrasound, the frequency of occurrence of biliary colic, and blood tests after 3 months. Results: In Group A, we observed a disappearance of biliary sludge in 32.4% (12/37) of patients compared to 8.7% in the control group (p < 0.05). In 32.4% of treated patients, we report a reduction in biliary sludge. There were no side effects during treatment. In both groups, we registered a significant reduction in transaminases and gamma-glutamyl transferase (γ-GT) (p < 0.05). No significant modification of the lipid profile was observed. Conclusions: The treatment with a mix of natural compounds (milk thistle, artichoke, and green tea) in patients affected by symptomatic biliary colic resulted in efficacy and safety in reducing biliary sludge, biliary colic, and transaminases levels after three months of treatment. The limitations of this study include a small number of patients and the absence of long-term follow up after the end of treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Outcomes of Patients with Heart Failure Hospitalized for COVID-19—A Study in a Tertiary Italian Center.

Author

Cianci, Rossella, Caldarelli, Mario, Rio, Pierluigi, Pignataro, Giulia, Sacco Fernandez, Marta, Ocarino, Francesca, Della Polla, Davide Antonio, Franceschi, Francesco, Gasbarrini, Antonio, Gambassi, Giovanni, and Candelli, Marcello

Subjects
COVID-19, COMORBIDITY, CHRONIC obstructive pulmonary disease, PROPENSITY score matching, OLDER people, CHRONIC kidney failure
Abstract

Background: Coronavirus Disease 2019 (COVID-19), triggered by SARS-CoV-2, has represented a global pandemic associated with an elevated rate of mortality, mainly among older individuals. The extensive pulmonary involvement by the viral infection might have precipitated pre-existing chronic conditions in this vulnerable population, including heart failure (HF). Materials and Methods: The aim of this retrospective, observational study was to assess the impact of COVID-19 in patients with a prior diagnosis of HF referred to the Emergency Department of the Agostino Gemelli University Hospital between March 2020 and January 2023. A total of 886 HF patients (444 men and 442 women, mean age of 80 ± 10 years) were identified. Patients were matched in a 1:1 ratio by gender, age, number of comorbidities (excluding HF), and vaccination status, using a propensity score matching (PSM) procedure. We compared the outcomes of 189 patients with a concomitant diagnosis of HF with those of 189 matched controls without HF. Results: Among patients with HF, there was a significantly higher prevalence of valvular disease (p = 0.004), atrial fibrillation (p = 0.003), use of anticoagulants (p = 0.001), chronic obstructive pulmonary diseases (p = 0.03), and chronic kidney disease (p = 0.001). In contrast, hypertension was more prevalent among controls than HF patients (p = 0.04). In addition, controls exhibited higher lymphocytes counts and a higher PaO2/FiO2 ratio compared to HF patients. During hospitalization, patients with HF were more frequently treated with high-flow nasal cannulas (p = 0.01), required more frequent admission to an intensive care unit (ICU) (p = 0.04), and showed a significantly higher mortality rate (p 0.0001) than controls. Conclusions: HF is an independent risk factor for ICU admission and death in COVID-19 patients. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Subacromial Decompression in Patients With Shoulder Impingement With an Intact Rotator Cuff: An Expert Consensus Statement Using the Modified Delphi Technique Comparing North American to European Shoulder Surgeons

Author

Alentorn-Geli, Eduard, Bak, Klaus, Beitzel, Knut, Bøe, Berte, Calvo, Emilio, Di Giacomo, Giovanni, Favard, Luc, Franceschi, Francesco, Funk, Lennard, Glanzmann, Michael, Imhoff, Andreas, Lädermann, Alexandre, Levy, Ofer, Ludvigsen, Tom, Milano, Giuseppe, Moroder, Philipp, Rosso, Claudio, Siebenlist, Sebastian, Abrams, Jeffrey, Arciero, Robert, Athwal, George, Burks, Robert, Gillespie, Robert, Kibler, Ben, Levine, William, Mazzocca, Augustus, Millett, Peter, Ryu, Richard, Safran, Marc, Sanchez-Sotelo, Joaquin, Savoie, Felix “Buddy”, Sethi, Paul, Shea, Kevin, Verma, Nikhil, Warner, Jon J.P., Weber, Stephen, Wolf, Brian, Hohmann, Erik, Glatt, Vaida, and Tetsworth, Kevin

Published
2022
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43. A real-time integrated framework to support clinical decision making for covid-19 patients

Author

Murri, Rita, Masciocchi, Carlotta, Lenkowicz, Jacopo, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Landolfi, Raffaele, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, and Valentini, Vincenzo

Published
2022
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48. Diagnosis of acute aortic syndromes with ultrasound and d-dimer: the PROFUNDUS study

Author

Morello, Fulvio, primary, Bima, Paolo, additional, Castelli, Matteo, additional, Capretti, Elisa, additional, de Matos Soeiro, Alexandre, additional, Cipriano, Alessandro, additional, Costantino, Giorgio, additional, Vanni, Simone, additional, Leidel, Bernd A., additional, Kaufmann, Beat A., additional, Osman, Adi, additional, Candelli, Marcello, additional, Capsoni, Nicolò, additional, Behringer, Wilhelm, additional, Capuano, Marialessia, additional, Ascione, Giovanni, additional, Leal, Tatiana de Carvalho Andreucci Torres, additional, Ghiadoni, Lorenzo, additional, Pivetta, Emanuele, additional, Grifoni, Stefano, additional, Lupia, Enrico, additional, Nazerian, Peiman, additional, Ardito, Arianna, additional, Bartalucci, Alice, additional, Calzolari, Gilberto, additional, Giachino, Francesca, additional, Leone, Dario, additional, Locatelli, Stefania, additional, Scategni, Virginia, additional, Tizzani, Maria, additional, Rubiolo, Francesca, additional, Becucci, Alessandro, additional, Bondi, Ernesta, additional, Cavallaro, Gabriele, additional, Caviglioli, Cosimo, additional, Guerrini, Stefania, additional, Haxhiraj, Eriola, additional, Paladini, Barbara, additional, Prota, Alessio, additional, Ronchetti, Mattia, additional, Guerra, Federica, additional, Tavares de Oliveira, Múcio, additional, Soares, Paulo Rogério, additional, Malacarne, Margerita, additional, Santini, Massimo, additional, Bonzi, Mattia, additional, Bartalucci, Paola, additional, Coppa, Alessandro, additional, Mueller, Christian, additional, Fong, Chan Pei, additional, Franceschi, Francesco, additional, Tullo, Gianluca, additional, Ceschi, Ludovica, additional, and Schwameis, Michael, additional

Published
2024
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