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2. Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy

Author

Bruno, F., primary, Castelli, G., additional, Li, B., additional, Reale, S., additional, Carra, E., additional, Vitale, F., additional, Scibetta, S., additional, Calzolari, M., additional, Varani, S., additional, Ortalli, M., additional, Franceschini, E., additional, Gennari, W., additional, Rugna, G., additional, and Späth, G. F., additional

Published
2024
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6. Genomic and epidemiological evidence for the emergence of a putativeL. donovani/L. infantumhybrid with unusual epidemiology in Northern Italy

Author

Bruno, F., primary, Castelli, G., additional, Li, B., additional, Reale, S., additional, Carra, E., additional, Vitale, F., additional, Scibetta, S., additional, Calzolari, M., additional, Varani, S., additional, Ortalli, M., additional, Franceschini, E., additional, Gennari, W., additional, Rugna, G., additional, and Späth, G.F., additional

Published
2023
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8. Quantitative near-infrared spectroscopy on patients with peripheral vascular disease

Author

Franceschini, MA, Fantini, S, Palumbo, R, Pasqualini, L, Vaudo, G, Franceschini, E, Gratton, E, Palumbo, B, Innocente, S, and Mannarino, E

Subjects
peripheral vascular disease, near-infrared spectroscopy, hemoglobin saturation, skeletal muscle
Abstract

We have used near-infrared spectroscopy to measure the hemoglobin saturation at rest and during exercise on patients affected by peripheral vascular disease (PVD). The instrument used in our study is a frequency-domain tissue oximeter which employs intensity modulated (110 MHz) laser diodes. We examined 9 subjects, 3 of which were controls and 6 were patients affected by stage II PVD. The optical probe was located on the calf muscle of the subjects. The measurement protocol consisted of: (1) baseline (∼5 min); (2) stationary bicycle exercise (∼5 min); (3) recovery (∼15 min). The change in hemoglobin saturation during exercise (ΔY) and the recovery time after exercise (trec) were significantly greater in the PVD patients (ΔY = -21±3%, trec= 5.9±3.8 min) than in the control subjects (ΔY = 2±3%, trec = 0.6±0.1 min).

Published
1997

12. Breast Ductal Computer Phantom

Author

Franceschini, E., Mensah, S., Amy, D., Lefebvre, J.-P., André, Michael P., editor, Akiyama, Iwaki, editor, Andre, Michael, editor, Arnold, Walter, editor, Bamber, Jeff, editor, Burov, Valentin, editor, Chubachi, Noriyoshi, editor, Erikson, Kenneth, editor, Ermert, Helmut, editor, Fink, Mathias, editor, Gan, Woon S., editor, Granz, Bernd, editor, Greenleaf, James, editor, Hu, Jiankai, editor, Jones, Joie P., editor, Khuri-Yakub, Pierre, editor, Laugier, Pascal, editor, Lee, Hua, editor, Lees, Sidney, editor, Levin, Vadim M., editor, Maev, Roman, editor, Masotti, Leonardo, editor, Nowicki, Andrzej, editor, O’Brien, William, editor, Prasad, Manika, editor, Rafter, Patrick, editor, Rouseff, Daniel, editor, Thijssen, Johan, editor, Tittmann, Bernard, editor, Tortoli, Piero, editor, Van der Steen, Anton, editor, Waag, Robert, editor, and Wells, Peter, editor

Published
2007
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13. Hypokalemia in Patients with COVID-19

Author

Alfano, G., Ferrari, A., Fontana, F., Perrone, R., Mori, G., Ascione, E., Magistroni, R., Venturi, G., Pederzoli, S., Margiotta, G., Romeo, M., Piccinini, F., Franceschi, G., Volpi, S., Faltoni, M., Ciusa, G., Bacca, E., Tutone, M., Raimondi, A., Menozzi, M., Franceschini, E., Cuomo, G., Orlando, G., Santoro, A., Di Gaetano, M., Puzzolante, C., Carli, F., Bedini, A., Milic, J., Meschiari, M., Mussini, C., Cappelli, G., Guaraldi, G., Borghi, V., Burastero, G., Corradi, L., Dolci, G., Fantini, R., Iadisernia, V., Larne, D., Pellegrino, F., Rogati, C., Tonelli, R., Yaacoub, D., Alfan, S., Marco, B., Pulizzi, R., Leonelli, M., Facchini, F., Damiano, F., Girardis, M., Andreotti, A., Biagioni, E., Bondi, F., Busani, S., Chierego, G., Scotti, M., Cossarizza, L. S. A., Bellinazzi, C., Borella, R., De Biasi, S., De Gaetano, A., Fidanza, L., Gibellini, L., Iannone, A., Tartaro, D. L., Mattioli, M., Nasi, M., Paolini, A., and Pinti, M.

Subjects
Male, Pediatrics, Physiology, medicine.medical_treatment, 030232 urology & nephrology, Urine, 030204 cardiovascular system & hematology, Electrolytes, 0302 clinical medicine, Risk Factors, 80 and over, Prevalence, Medicine, Magnesium, Hospital Mortality, Diuretics, COVID, Aged, 80 and over, Urinary potassium loss, Middle Aged, Hypokalemia, Nephrology, Cohort, Original Article, Female, SOFA score, medicine.symptom, Coronavirus, Potassium, Aged, COVID-19, Humans, Retrospective Studies, SARS-CoV-2, Electrolyte Disorder, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Anorexia, 03 medical and health sciences, Physiology (medical), Internal medicine, Hyperventilation, In patient, business.industry, Retrospective cohort study, Odds ratio, Diuretic, business
Abstract

Patients with COVID-19 may experience multiple conditions (e.g., fever, hyperventilation, anorexia, gastroenteritis, acid-base disorder) that may cause electrolyte imbalances. Hypokalemia is a concerning electrolyte disorder that may increase the susceptibility to various kinds of arrhythmia. This study aimed to estimate prevalence, risk factors and outcome of hypokalemia in a cohort of non-critically ill patients. A retrospective analysis was conducted on 290 hospitalized patients with confirmed COVID-19 infection at the tertiary teaching hospital of Modena, Italy.Hypokalemia (Hypokalemia is a frequent disorder in COVID-19 patients and urinary potassium loss may be the main cause of hypokalemia. The disorder was mild in the majority of the patients and was unrelated to poor outcomes. Nevertheless, hypokalemic patients required potassium supplements to dampen the risk of arrhythmias.

Published
2021
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14. First and second wave among hospitalized COVID-19 patients with severe pneumonia: a comparison of 28-day mortality over 1-year pandemic in a tertiary university hospital in Italy

Author

Meschiari, M, Cozzi-Lepri, A, Tonelli, R, Bacca, E, Menozzi, M, Franceschini, E, Cuomo, G, Bedini, A, Volpi, S, Milic, J, Brugioni, L, Romagnoli, E, Pietrangelo, A, Corradini, E, Coloretti, I, Biagioni, E, Busani, S, Girardis, M, Cossarizza, A, Clini, E, Guaraldi, G, and Mussini, C.

Subjects
Thoracic medicine, Epidemiology Infectitious diseases, COVID-19, Respiratory infections, COVID-19, Epidemiology Infectitious diseases, Respiratory infections, Thoracic medicine
Published
2022

16. Development of a Risk Prediction Model for Carbapenem-resistant Enterobacteriaceae Infection after Liver Transplantation: A Multinational Cohort Study

Author

Giannella, M., Freire, M., Rinaldi, M., Abdala, E., Rubin, A., Mularoni, A., Gruttadauria, S., Grossi, P., Shbaklo, N., Tandoi, F., Ferrarese, A., Burra, P., Fernandes, R., Aranha Camargo, L. F., Asensio, A., Alagna, L., Bandera, A., Simkins, J., Abbo, L., Halpern, M., Santana Girao, E., Valerio, M., Munoz, P., Fernandez Yunquera, A., Statlender, L., Yahav, D., Franceschini, E., Graziano, E., Morelli, M. C., Cescon, M., Viale, P., Lewis, R., Bartoletti, M., Pascale, R., Campoli, C., Coladonato, S., Cristini, F., Tumietto, F., Siniscalchi, A., Laici, C., Ambretti, S., Romagnoli, R., De Rosa, F. G., Muscatello, A., Mangioni, D., Gori, A., Antonelli, B., Dondossola, D., Rossi, G., Invernizzi, F., Peghin, M., Cillo, U., Mussini, C., Benedetto, F. D., Terrabuio, D. R. B., Bittante, C. D., Toniolo, A. D. R., Balbi, E., Garcia, J. H. P., Morras, I., Ramos, A., Cruz, A. F., Salcedo, M., Giannella M., Freire M., Rinaldi M., Abdala E., Rubin A., Mularoni A., Gruttadauria S., Grossi P., Shbaklo N., Tandoi F., Ferrarese A., Burra P., Fernandes R., Aranha Camargo L.F., Asensio A., Alagna L., Bandera A., Simkins J., Abbo L., Halpern M., Santana Girao E., Valerio M., Munoz P., Fernandez Yunquera A., Statlender L., Yahav D., Franceschini E., Graziano E., Morelli M.C., Cescon M., Viale P., Lewis R., Bartoletti M., Pascale R., Campoli C., Coladonato S., Cristini F., Tumietto F., Siniscalchi A., Laici C., Ambretti S., Romagnoli R., De Rosa F.G., Muscatello A., Mangioni D., Gori A., Antonelli B., Dondossola D., Rossi G., Invernizzi F., Peghin M., Cillo U., Mussini C., Benedetto F.D., Terrabuio D.R.B., Bittante C.D., Toniolo A.D.R., Balbi E., Garcia J.H.P., Morras I., Ramos A., Cruz A.F., and Salcedo M.

Subjects
Microbiology (medical), Adult, medicine.medical_specialty, medicine.medical_treatment, Carbapenem-resistant enterobacteriaceae, Liver transplantation, CRE carriage, CRE infection, SOT, liver transplantation, Anti-Bacterial Agents, Carbapenems, Cohort Studies, Humans, Risk Factors, Carbapenem-Resistant Enterobacteriaceae, Enterobacteriaceae Infections, Liver Transplantation, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Anti-Bacterial Agent, Medicine, 030212 general & internal medicine, Carbapenem, Univariate analysis, business.industry, Risk Factor, Area under the curve, Nomogram, Enterobacteriaceae Infection, Transplantation, Infectious Diseases, 030211 gastroenterology & hepatology, Cohort Studie, business, Human, Cohort study
Abstract

BackgroundPatients colonized with carbapenem-resistant Enterobacteriaceae (CRE) are at higher risk of developing CRE infection after liver transplantation (LT), with associated high morbidity and mortality. Prediction model for CRE infection after LT among carriers could be useful to target preventive strategies.MethodsMultinational multicenter cohort study of consecutive adult patients underwent LT and colonized with CRE before or after LT, from January 2010 to December 2017. Risk factors for CRE infection were analyzed by univariate analysis and by Fine-Gray subdistribution hazard model, with death as competing event. A nomogram to predict 30- and 60-day CRE infection risk was created.ResultsA total of 840 LT recipients found to be colonized with CRE before (n = 203) or after (n = 637) LT were enrolled. CRE infection was diagnosed in 250 (29.7%) patients within 19 (interquartile range [IQR], 9–42) days after LT. Pre- and post-LT colonization, multisite post-LT colonization, prolonged mechanical ventilation, acute renal injury, and surgical reintervention were retained in the prediction model. Median 30- and 60-day predicted risk was 15% (IQR, 11–24) and 21% (IQR, 15–33), respectively. Discrimination and prediction accuracy for CRE infection was acceptable on derivation (area under the curve [AUC], 74.6; Brier index, 16.3) and bootstrapped validation dataset (AUC, 73.9; Brier index, 16.6). Decision-curve analysis suggested net benefit of model-directed intervention over default strategies (treat all, treat none) when CRE infection probability exceeded 10%. The risk prediction model is freely available as mobile application at https://idbologna.shinyapps.io/CREPostOLTPredictionModel/.ConclusionsOur clinical prediction tool could enable better targeting interventions for CRE infection after transplant.

Published
2021

17. Statins in patients with advanced hcc treated with atezolizumab/bevacizumab: a propensity score-matched cohort analysis from arte an Italian prospective multicentric dataset.

Author

Dalbeni, A., Cattazzo, F., Auriemma, A., Tovoli, F., Iavarone, M., Marra, F., Cabibbo, G., Vivaldi, C., Palloni, A., Soldà, C., Vicardi, M., Natola, L.A., Franceschini, E., Bruccoleri, M., Campani, C., Celsa, C., Masi, G., Brandi, G., Lonardi, S., and Ponziani, F. Romana

Abstract

Statins have been suggested to exert anticancer properties by modulating angiogenesis, fibrosis, inflammation, and the tumor microenvironment, generating interest in their clinical use for chronic liver diseases (CLD) and hepatocellular carcinoma (HCC) chemoprevention. However, the effects of statin therapy in patients treated with immune checkpoint inhibitors for CLD-associated HCC remain unknown. This study primarily aimed to assess the potential effect of statins on overall survival (OS) mand progression-free survival (PFS) in patients with advanced HCC treated with atezolizumab and bevacizumab (A+B). The ARTE dataset, a retro-prospectively maintained database, includes 305 consecutive patients with unresectable HCC treated with A+B, enrolled from 12 tertiary care centers in Italy. From the original cohort, a 1:1 propensity score matching was performed to balance potential confounding factors between 63 patients on statin therapy and those who were not. The primary outcomes were OS and PFS, while secondary outcomes included all-cause mortality, liver-related death, treatment interruption, and incidence of liver decompensation events. Among the matched population of 126 patients, 75% had liver cirrhosis, with metabolic disfunction-associated steatotic liver disease (MASLD) being the most common etiology. Ninety-seven patients (32%) had diabetes. No significant differences were found between statin users and non-users for OS, PFS, or liver-related death. Additionally, the log-rank test revealed no significant difference between the groups in terms of treatment interruption due to liver decompensation events (p=0.28). Statin use did not show any impact on OS, PFS, or reduction in mortality or treatment interruption due to liver-related decompensation events in patients with advanced HCC treated with A+B. [ABSTRACT FROM AUTHOR]

Published
2025
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18. Predictors of esophago-gastric varices and variceal bleeding in patients receiving atezolizumab/bevacizumab for unresectable hepatocellular carcinoma.

Author

Ascari, S., Chen, R., Iavarone, M., Stefanini, B., Marra, F., Cabibbo, G., Vivaldi, C., Palloni, A., Soldà, C., Ponziani, F.R., Valenzi, E., Ravaioli, F., Franceschini, E., Tosetti, G., Campani, C., Celsa, C., Masi, G., Brandi, G., Lonardi, S., and Stella, L.

Abstract

Atezolizumab/bevacizumab (atezo/bev) is a standard treatment for unresectable hepatocellular carcinoma (HCC). Bevacizumab may increase the risk of bleeding, causing concerns of variceal bleeding in patients with cirrhosis. Assess the predictors of esofago-gastric varices, high-risk varices (according to the Baveno criteria), and variceal bleeding in a population receiving atezo/bev for HCC. Analysis of prospectively collected data from 15 Italian centers included in the ARTE database (March 2022-June2024). Logistic regressions were run for predictors of varices amongst patients who had received an upper-gastrointestinal endoscopy (UGE) <6 months before starting treatment. Competing-risk analyses were performed to assess the predictors of variceal bleeding. Among 317 patients treated with atezo/bev included in the ARTE database, 256 had a recently performed UGE and were considered for this study. The main characteristcs of the study population were: median age 70 years, 83% male, 58% viral etiology, 88% Child-Pugh A, 52% ALBIgrade 1, 34.3% neoplastic portal vein thrombosis (nPVT), 59.9% Barcelona Clinic Liver Cancer-C stage. At treatment start, 27.3% of patients were receiving non-selective beta-blockers, and 5.8% had received a prior elastica band ligation. The prevalence of any-type and high-risk varices was 32.0 and 8.6%, respectively. Independent predictors of varices were: platelet count < 150.000/mmc (OR 3.69, 95%CI 2.06-6.61), ALBI grade >1 (OR 1.95, 95%CI 1.09-3.48), and nPVT (OR 1.78, 95%CI 1.01-3.18). High risk varices were independently associated platelet count < 150.000/mmc (OR 5.81, 95%CI 1.91-17.67) and ALBI grade >1 (OR 2.44, 95% CI 1.02-5.77). Nine patients had variceal bleeding during the follow-up (G3: n=6; G4: n=2; G5: n=1), accounting for a 3.5% 12-month cumulative incidence. Amongst patients with varices, high-risk varices were the only factor associated with bleeding (sHR 4.06, 95% CI 1.14-14.46) at the competing risk analysis. In these patients the 12-month risk was 12.7%. The risk of variceal bleeding was low, but non negligible in the subgroup of patients with high-risk varices at baseline. UGE should be performed in all patients before starting treatment: patients with platelet count < 150.000/mmc, ALBI grade > 1 or neoplastic portal vein thrombosis are at increased risk of varices. [ABSTRACT FROM AUTHOR]

Published
2025
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20. Risk factors for nosocomial rectal colonization with carbapenem-resistant Acinetobacter baumannii in hospital: a matched case-control study

Author

Meschiari, M., Kaleci, S., Orlando, G., Selmi, S., Santoro, A., Bacca, E., Menozzi, M., Franceschini, E., Puzzolante, C., Bedini, A., Sarti, M., Venturelli, C., Vecchi, E., and Mussini, C.

Subjects
Acinetobacter baumannii, Adult, Male, Adolescent, Endemic hospital, lcsh:Infectious and parasitic diseases, Tertiary Care Centers, Young Adult, Risk Factors, Drug Resistance, Multiple, Bacterial, Humans, lcsh:RC109-216, Hospital Mortality, Rectal colonization, Aged, Retrospective Studies, Aged, 80 and over, Cross Infection, Surveillance, Carbapenem-resistant Acinetobacter baumannii, Risk factors, Research, Rectum, Middle Aged, Carbapenems, Italy, Case-Control Studies, Multivariate Analysis, Female, Acinetobacter Infections
Abstract

Background During the last decade carbapenem-resistant Acinetobacter baumannii (CRAB) became hyper-endemic in hospitals due to difficult to control spreading. Our aim is to identify risk factors for nosocomial rectal CRAB colonization in an endemic hospital. Methods A retrospective matched case–control study (ratio 1:2) with a prospective inclusion of cases and concurrent selection of controls was conducted from January 2017 to December 2018 in a tertiary-care hospital. Universal active surveillance for CRAB was implemented. Univariate and multivariate logistic regression was carried out using a stepwise selection method to compare prognostic factors between cases and controls. A sub-analysis was carried out according to the type of department. Results Forty-five cases with nosocomial rectal CRAB colonization and 90 controls were included. One hundred and two (75%) patients were hospitalized in medical departments. At multivariable analysis significant risk factors associated with CRAB colonization were: use of permanent devices (OR 10.15, 95% CI 2.27–45.39; P = 0.002), mechanical ventilation (OR 40.01, 95% CI 4.05–395.1; P = 0.002), urinary catheters (OR 4.9, 95% CI 1.52–16.19; P = 0.008), McCabe score (OR 5.45, 95% CI 1.87–15.89; P = 0.002), length of stay (OR 1.03, 95% CI 1.01–1.05; P = 0.002), carbapenem use (OR 5.39, 95% CI 1.14–25.44; P = 0.033). The sub-analysis showed that patients admitted to different departments had different risk factors. In geriatric department a fatal disease and a longer hospital stay represented significant risk factors both in univariate and multivariate analysis, while in internal medicine department the use of permanent devices, current antibiotic therapy and antibiotic polytherapy represented significant risk factors for CRAB at the univariate analysis, also confirmed in multivariate analysis. Conclusions Our data suggest that active surveillance for rectal CRAB colonization should be addressed to patients with an unfavourable prognosis, longer hospitalizations and carriers of multiple devices. To counter CRAB spreading in endemic settings, clinicians must limit the use of carbapenems, and reinforce interventions aimed at proper use of devices.

Published
2021

21. Prospective Study on Incidence, Risk Factors and Outcome of Recurrent Clostridioides difficile Infections

Author

Granata, G, Petrosillo, N, Adamoli, L, Bartoletti, M, Bartoloni, A, Basile, G, Bassetti, M, Bonfanti, P, Borromeo, R, Ceccarelli, G, De Luca, A, Di Bella, S, Fossati, S, Franceschini, E, Gentile, I, Giacobbe, D, Giacometti, E, Ingrassia, F, Lagi, F, Lobreglio, G, Lombardi, A, Lupo, L, Luzzati, R, Maraolo, A, Mikulska, M, Mondelli, M, Mularoni, A, Mussini, C, Oliva, A, Pandolfo, A, Rogati, C, Trapani, F, Venditti, M, Viale, P, Caraffa, E, Cataldo, M, Granata, Guido, Petrosillo, Nicola, Adamoli, Lucia, Bartoletti, Michele, Bartoloni, Alessandro, Basile, Gregorio, Bassetti, Matteo, Bonfanti, Paolo, Borromeo, Raffaella, Ceccarelli, Giancarlo, De Luca, Anna, Di Bella, Stefano, Fossati, Sara, Franceschini, Erica, Gentile, Ivan, Giacobbe, Daniele, Giacometti, Enrica, Ingrassia, Fabrizio, Lagi, Filippo, Lobreglio, Giambattista, Lombardi, Andrea, Lupo, Laura, Luzzati, Roberto, Maraolo, Alberto, Mikulska, Malgorzata, Mondelli, Mario, Mularoni, Alessandra, Mussini, Cristina, Oliva, Alessandra, Pandolfo, Alessandro, Rogati, Carlotta, Trapani, Filippo, Venditti, Mario, Viale, Pierluigi, Caraffa, Emanuela, Cataldo, Maria, Granata, G, Petrosillo, N, Adamoli, L, Bartoletti, M, Bartoloni, A, Basile, G, Bassetti, M, Bonfanti, P, Borromeo, R, Ceccarelli, G, De Luca, A, Di Bella, S, Fossati, S, Franceschini, E, Gentile, I, Giacobbe, D, Giacometti, E, Ingrassia, F, Lagi, F, Lobreglio, G, Lombardi, A, Lupo, L, Luzzati, R, Maraolo, A, Mikulska, M, Mondelli, M, Mularoni, A, Mussini, C, Oliva, A, Pandolfo, A, Rogati, C, Trapani, F, Venditti, M, Viale, P, Caraffa, E, Cataldo, M, Granata, Guido, Petrosillo, Nicola, Adamoli, Lucia, Bartoletti, Michele, Bartoloni, Alessandro, Basile, Gregorio, Bassetti, Matteo, Bonfanti, Paolo, Borromeo, Raffaella, Ceccarelli, Giancarlo, De Luca, Anna, Di Bella, Stefano, Fossati, Sara, Franceschini, Erica, Gentile, Ivan, Giacobbe, Daniele, Giacometti, Enrica, Ingrassia, Fabrizio, Lagi, Filippo, Lobreglio, Giambattista, Lombardi, Andrea, Lupo, Laura, Luzzati, Roberto, Maraolo, Alberto, Mikulska, Malgorzata, Mondelli, Mario, Mularoni, Alessandra, Mussini, Cristina, Oliva, Alessandra, Pandolfo, Alessandro, Rogati, Carlotta, Trapani, Filippo, Venditti, Mario, Viale, Pierluigi, Caraffa, Emanuela, and Cataldo, Maria

Abstract

Background: Limited and wide-ranging data are available on the recurrent Clostridioides difficile infection (rCDI) incidence rate. Methods: We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case-control study was performed to identify risk factors associated with 30-day onset rCDI. Results: Three hundred nine patients with a first CDI were included in the study; 32% of the CDI episodes (99/309) were severe/complicated; complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up; rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR: 1.7; 95% CI: 1.1-2.7, p = 0.03). Conclusion: Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.

Published
2021

22. Recurrence of Clostridioides difficile infection: A multicenter study on incidence and risk factors

Author

Cataldo, M.A., primary, Granata, G., additional, Caraffa, E., additional, Adamoli, L., additional, Borromeo, R., additional, Fossati, S., additional, Franceschini, E., additional, Giacobbe, D.R., additional, Giacometti, E., additional, Lagi, F., additional, Lombardi, A., additional, Oliva, A., additional, Pandolfo, A., additional, Trapani, F., additional, and Petrosillo, N., additional

Published
2020
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23. Epidemiology and Outcomes of Bloodstream Infections in HIV-Patients during a 13-Year Period

Author

Franceschini, E., primary, Santoro, Antonella, additional, Menozzi, Marianna, additional, Bacca, Erica, additional, Venturelli, Claudia, additional, Zona, Stefano, additional, Bedini, Andrea, additional, Digaetano, Margherita, additional, Puzzolante, Cinzia, additional, Meschiari, Marianna, additional, Cuomo, Gianluca, additional, Orlando, Gabriella, additional, Sarti, Mario, additional, Guaraldi, Giovanni, additional, Cozzi-Lepri, Alessandro, additional, and Mussini, Cristina, additional

Published
2020
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24. Epidemiology and Risk Factors Associated With Mortality in Consecutive Patients With Bacterial Bloodstream Infection: Impact of MDR and XDR Bacteria

Author

Santoro, A., Franceschini, E., Meschiari, M., Menozzi, M., Zona, S., Venturelli, C., Digaetano, M., Rogati, C., Guaraldi, G., Paul, M., Gyssens, I.C.J., Mussini, C., Santoro, A., Franceschini, E., Meschiari, M., Menozzi, M., Zona, S., Venturelli, C., Digaetano, M., Rogati, C., Guaraldi, G., Paul, M., Gyssens, I.C.J., and Mussini, C.

Abstract

Contains fulltext : 229596.pdf (publisher's version ) (Open Access), BACKGROUND: Mortality related to bloodstream infections (BSIs) is high. The epidemiology of BSIs is changing due to the increase in multidrug resistance, and it is unclear whether the presence of multidrug-resistant (MDR) organisms, per se, is an independent risk factor for mortality. Our objectives were, first, to describe the epidemiology and outcome of BSIs and, second, to determine the risk factors associated with mortality among patients with BSI. METHODS: This research used a single-center retrospective observational study design. Patients were identified through microbiological reports. Data on medical history, clinical condition, bacteria, antimicrobial therapy, and mortality were collected. The primary outcome was crude mortality at 30 days. The relationships between mortality and demographic, clinical, and microbiological variables were analyzed by multivariate analysis. RESULTS: A total of 1049 inpatients were included. MDR bacteria were isolated in 27.83% of patients, where 2.14% corresponded to an extremely drug-resistant (XDR) isolate. The crude mortality rates at days 7, 30, and 90 were 12.11%, 25.17%, and 36.13%, respectively. Pitt score >2, lung and abdomen as site of infection, and XDR Pseudomonas aeruginosa were independent risk factors for 7-, 30-, and 90-day mortality. Charlson score >4, carbapenem-resistant Klebsiella pneumoniae, and XDR Acinetobacter baumannii were independent risk factors for 30- and 90-day mortality. Infection by XDR gram-negative bacteria, Charlson score >4, and immunosuppression were independent risk factors for mortality in patients who were stable at the time of BSI. CONCLUSIONS: BSI is an event with an extreme impact on mortality. Patients with severe clinical condition are at higher risk of death. The presence of XDR gram-negative bacteria in blood is strongly and independently associated with patient death.

Published
2020

25. PS1274 EPIDEMIOLOGY AND MANAGEMENT OF LATENT TUBERCULOSIS INFECTION IN ADULT PATIENTS WITH ACUTE LEUKEMIA OR APLASTIC ANEMIA: A RETROSPECTIVE MONOCENTER STUDY

Author

Bettelli, F., primary, Giusti, D., additional, Morselli, M., additional, Paolini, A., additional, Colaci, E., additional, Nasillo, V., additional, Messerotti, A., additional, pioli, V., additional, Arletti, L., additional, Gilioli, A., additional, Celli, M., additional, Donatelli, F., additional, Iotti, S., additional, Catellani, H., additional, Galassi, L., additional, Colasante, C., additional, Vallerini, D., additional, Barozzi, P., additional, Lagreca, I., additional, Maffei, R., additional, Riva, G., additional, Franceschini, E., additional, Codeluppi, M., additional, Mussini, C., additional, Marasca, R., additional, Narni, F., additional, Potenza, L., additional, Luppi, M., additional, and Forghieri, F., additional

Published
2019
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26. Non-linear Ultrasonic Computed Tomography (USCT) for soft and hard tissue imaging

Author

Lasaygues, P., Rouyer, J., Mensah, S., Franceschini, E., Rabau, G., Regine Guillermin, Samuel Bernard, Monteiller, V., Dimitri Komatitsch, Ondes et Imagerie (O&I), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Laboratoire de Mathématiques Informatique et Applications (LMIA), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), Technologies et systèmes d'information pour les agrosystèmes (UR TSCF), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Géosciences Environnement Toulouse (GET), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques Informatique et Applications [UHA] (LMIA), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)

Subjects
Iterative Ap- proximation, Bones, Inverse Born Approximation, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Ultrasonic Computed Tomography, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Breast, Full Waveform Imaging, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience; Ultrasonic Computed Tomography (USCT) is an imaging technique that has proven effective for soft-tissue characterization. The classical tomography procedures are adapted to broadband data acquired in scattering configurations under Born approximation for homogeneous media and far-field conditions, while the heterogeneous objects are probed by spherical waves in near-field conditions. An elliptical Fourier transform theory is then derived to solve the near-field inverse problem in case of harmonic ellipsoidal waves. More recently, the use of USCT has been envisaged for bone imaging. In this field, the large variations of impedance distribution (high impedance contrast) require that the modelling of wave propagation be integrated into the reconstruction scheme. In that case, iterative inversion schemes are proposed. These various reconstruction procedures are validated against experiments and numerical simulations .

Published
2017

27. P096 Children with “borderline” TTG values in a screening for Coeliac disease on school population: follow-up after two years

Author

Anton, F., primary, Balanzoni, L., additional, Cinquetti, M., additional, Trevisan, M.T., additional, Scattolo, N., additional, Gatti, S., additional, Lionetti, E., additional, Annibali, R., additional, Palpacelli, A., additional, Franceschini, E., additional, Galeazzi, T., additional, Verma, A., additional, Monachesi, C., additional, and Catassi, C., additional

Published
2018
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31. Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

Author

Ridker, P. M., Revkin, J., Amarenco, P., Brunell, R., Civeira, F., Flather, M., Glynn, R. J., Gregoire, J., Jukema, J. W., Karpov, Y., Kastelein, J. J. P., Koenig, W., Lorenzatti, A., Manga, P., Masiukiewicz, U., Miller, M., Mosterd, A., Murin, J., Nicolau, J. C., Nissen, S., Ponikowski, P., Santos, R. D., Schwartz, P. F., Soran, H., White, H., Wright, R. S., Vrablik, M., Yunis, C., Shear, C. L., Tardif, Conde D, J. -C., Colquhoun, D, Missault, L, Grégoire, J, Gao, R, Urina, M, Solar, M, Jensen, Hk, Grobbee, D, Savolainen, M, Schiele, Fn, Montalescot, G, Edes, I, Blake, G, Lotan, C, Maggioni, A, Savonitto, S, Lee, Cw, Leiva Pons JL, Dan, Ga, Cortada, Jb, Mellbin, L, Kahan, T, Noble, S, Hwang, Jj, Sritara, P, Tökgozoğlu, L, Tarasenko, L, Borer, Js, Black, H, Carmena, R, Furie, Kl, Mcmurray, J, Neaton, J, Zannad, F, O’Neill, B, Welty, F, Mcnamara, R, Chun, H, Abbott, Jd, Jacoby, D, Mcpherson, C, Jadbabaie, F, Pinto, D, Mccullough, L, Silverman, Ie, Sansing, Lh, Dearborn-Tomazos, J, Foody, J, Schindler, J, Piazza, G, Chakrabarti, A, Pride, Y, Gelfand, E, Baultrukonis, D, Chaudhuri, S, Frederich, R, Johnson, M, Mridha, K, Powell, C, Wang, E, Wei, C, Anderson, P, Buonanno, M, Epsley, C, Evans, B, Frolova, M, Goetsch, M, Hessinger, D, Ikehara, E, Ivanac, K, Kizko, J, Le, K, McNally-Dufort, C, Morocco, T, Nadkarni, S, Nissen, T, Nye, R, Pak, R, Pence, D, Redifer, P, Schwartz, W, 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A, Kayikcioglu, M, Sahin, T, Ozcan, T, Durakoglugil, E, Asamoah-Owusu, N, Reed, R, Bakhai, A, Dixon, L, Sharma, R, Avornyo, Aa, Jones, Af, Lip, G, Clark, R, Banerjee, M, Wakeling, J, Arden, C, Blagden, Md, Walukiewica, P, Marshall, A, Maxwell, Tg, Gunstone, Ae, Kadr, Hh, Patle, R, Arif, I, Jhund, Ps, Mckaig, G, Douglas, F, Mierzejewski, L, Turner, W, Sathyapalan, T, Ivan, P, Manoj, A, Rice, S, Collier, Dj, Nair, Dr, Thom, S, Fiore, G, De Belder, M, Price, D, Sobolewska, J, Martin, S, Takhar, A, Moriarty, A, Kondagunta, V, Myhill, T, Gibson, Jm, Cecil, Jt, Halcox, J, Annamalai, N, Gorog, Da, Mccormack, T, Pegge, N, Field, A, Adams, F, Klein, Jj, Busch, Rs, Bretton, Em, Jaffrani, N, Salacata, A, Assadourian, A, Gogia, Hs, Dyke, Ck, Rubenfire, M, Essandoh, Lk, Welker, Ja, Ledesma, G, Lupovitch, S, Delgado, Jp, Hendrix, El, Quyyumi, Aa, Riesenberg, Ra, Robertson, Dg, Weinstein, Dl, Weiss, R, Casaubon, L, Gammon, Rs, Brar, Hs, Bittar, Gd, Guarnieri, Tt, Ince CS Jr, Jrquraishi, Am, Saeed, S, Albert, M, Sotolongo, Rp, Bernard, Jv, Karlsbergg, Rp, Lepor, Ne, Kirby, We, Mclean, B, Miller, Ap, Ovalle, F, Townsend, Jc, Beckett, Pl, Eaves, Wb, West, Sh, Kosinski, Ej, Zarich, Sw, Mahal, Ss, Maw, K, Maynard, Km, Chen, Jc, Gelormini, J, Gottlieb, Dw, Gabra, Nw, Narayan, P, Sparks, J, Field, Jc, Willits, Vl, O’Steen, Mb, Pasquini, Ja, Sensebrenner, Jw, Yarows, Sa, Hiotis, L, Jagielo, Tj, Levinson, Dj, Diller, Pm, Kereiakes, Dj, Turner, Ta, Vincent, S, Camp, Ad, Denker, Ps, Manning, Mb, Rocco, Mb, Stamps, Hb, Strader, Jr, Uusinarkaus, Kt, Kennett, Jd, Leichter, Sb, Mcneil, Dl, Schumacher, Dr, Chang, Ar, Ellison, Hs, Updegrove, Jd, Hamroff, Gs, Kay, Js, Marar, Ie, Flores, E, Saini, S, Abdullah, S, Berk, Mr, Fordan, S, Joshi, Ph, Mccullough, Pa, Reynolds, Rd, Rosenstock, J, Sachson, Ra, Shammas, N, Fishbein, Gj, Randall, Wj, Henderson, Da, Nash, Ml, Barker, Ba, Cohen, Ss, Seidman, B, Odekirk, Ll, Grillo, Rs, Martinez, Lm, Multani, P, Alwine, Lk, Mcgarvey, Jf, Mollerus, Me, Miller, Ab, Kotek, Lw, Changlani, M, Zavaro, Sh, Munoz, F, Mehta, Pm, Helm, Rj, Farhat, Nz, Farsad, R, Raoof, Tj, Shultz, Jh, Geohas, Jg, Allaw, Ma, Dela Llana, A, Gutmann, Je, Inzerello, At, Alappat, P, George, Ar, Haddad, Tm, Lillestol, Mj, Grodman, R, Peniston, Jh, Wadud, K, Garcia, B, Hamilton, Me, Lerman, S, Perloff, De, Graff, A, Saxena, S, Alvarado, Op, Malik, A, Reddy, Rd, Kinzfogl, G, Cornett, Gm, Norwood, Pc, Gilbert, Jm, Willis, Jg, Mcgrew, F, Sharma, S, Castro, Ma, Cucher, Fh, Altafullah, Im, Khurana, S, Knutson, Tj, Kinnaman, Sj, Stuckey, T, Pudi, Kk, Mayfield, Rk, Funk, Gs, Nixon, Wa, Dor, I, Boyett, Be, Srivastava, S, Elosegui, Am, Isserman, Sm, Cheek, Hb, Promisloff, Sd, Tami, Lf, Zeig, S, fitz-Patrick, D, Dave, Kn, Ahmad, A, Arain, S, Ballantyne, Cm, Doshi, A, El Hafi SE, Feldman, J, Fragoso, Vg, Gilford, T, Hoffman, As, Pouzar, Je, Vivekananthan, K, Ansari, Sh, Strzinek, Ra, Crater, Ta, Robinson, Jg, Fulmer, Jj, Patel, Am, Pereira, Es, Stich, Ma, Sultan, S, Geskin, G, Ruoff, Ge, Gillespie, E, Bybee, Ka, Moriarty, Pm, Savin, V, Agaiby, Jm, Melucci, Mb, Jantzi, Cm, Davidson, E, Smith, Wb, Treasure, Cb, Wakefield, Ph, Deck, K, Edris, Ma, Gilmore, Rm, Seep, Mk, Andersen, Jl, Detweiler, Ro, Rosenfeld, Jc, Strobl, Dj, Steinhoff, Jp, Adams, A, Estevez, R, Molin, Cj, Kim, Cy, Dy, J, Fox, Ke, Farris, Nr, Wayne, Jd, Whitney, Rt, Randhawa, Pm, Mego, Dm, Macdolnald, L, Caputo, Rp, Rigolosi, R, Vannatta, B, Pacheco, Tr, El-Shahawy, M, Gonzalez, Ej, Guice, Mj, Cherlin, Rs, Bays, He, Shoukfeh, M, Morris, Fh, Loy, J, Vora, Sk, Staab, Pk, Frisoli, A, Kimmel, Ma, Cohen, Aj, Green, Cb, Whitlock, L, Butuk, Dj, Mccartney, Mj, Ables, Lr, Acosta, R, Alvarez, Jg, Barrera, Cm, Benitez, O, Berenguer, Ra, Breton, Cf, Chiong, R, Delgado, Mi, Dufreny, A, Fialkow, Ja, Franczek, S, Frias, Jj, Iglesias, C, Landron-Garcia, L, Llerena, Sn, Martinez, Rf, Miranda, Aa, Morytko, Ja, Rodriguez, Ij, Sotolongo, R, Suarez-Sarmiento, A, Terrelonge, Ae, Vaca, Ce, Venereo, Jm, Verdeza, C, Zeno, Ml, Chilka, S, Felten, Wr, Hartman, An, Shayani, Ss, Duprez, D, Knickelbine, T, Chambers, Jd, Cone, Cl, Broughton, R, Napoli, Mc, Seaton, Bl, Smith, Sk, Reedy, Ma, Kesani, Mk, Nicol, Pr, Stringam, So, Talano, Jv, Barnum, O, Desai, V, Montero, M, Jacks, Rk, Kostis, Jb, Owen, Jg, Makam, Sk, Grosman, I, Underberg, Ja, Masri, Be, Peters, Ss, Serje, J, Lenhard, Mj, Glover, R, Paraboschi, Cf, Lim, Eh, Connery, L, Kipgen, W, Bravo, P, Digiovanna, Mj, Tayoum, H, Gabriel, Jd, Ariani, Mk, Robinson, Mf, Clemens, Pc, Corder, Cn, Schifferdecker, B, Tahirkheli, Nk, Hurling, Rt, Rendell, Ms, Shivaswamy, V, Madu, Ij, Dahl, Cf, Ayesu, K, Kim, C, Barettella, Mb, Jamidar, Ha, Bloom, Sa, Vora, Kn, Ong, St, Aggarwala, G, Sack, G, Blaze, K, Krichmar, P, Murcia, A, Teltser, M, Villaman-Bencosme, Y, Fahdi, Ie, Williams, Dg, Lain, El, Garcia, Hl, Karim, Sn, Francyk, Dm, Gordon, Mb, Palchick, Ba, Mckenzie, Me, Gimness, Mp, Greiff, J, Ruiz-R, L, Vazquez-Tanus, Jb, Schlager, D, Connelly, T, Soroka, E, Hastings, Wl, O’Dea, Dj, Purdy, Da, Jackson, B, Arcanese, Ml, Strain, Je, Schmedtje JF Jr, Jrdavis, Mg, A, A, Prasada, S, Scott, Dl, Vukotic, G, Akhtar, N, Larsen, Dc, Rhudy, Jm, Zebrack, Js, Bailey, Sr, Grant, Dc, Mora, A, Perez, Ja, Reyes, Rg, Sutton, Jc, Brandon, Dm, First, Bp, Risser, Ja, Claudio, J, Figueroa-Cruz, Wl, Sosa-Padilla, Ma, Tan, Ae, Traboulssi, Ma, Morcos, Nc, Glaser, La, Bredlau, Ce, El Shahawy, M, Ramos, Mj, Kandath, Dd, Kaluski, E, Akright, L, Rictor, Kw, Pluto, Tm, Hermany, Pr, Bellingar, B, Clark, Gb, Herrod, Jn, Goisse, M, Hook, M, Barrington, P, Lentz, Jd, Singal, Dk, Gleason, Gp, Lipetz, Rs, Schuchard, Tn, Bonner, Jh, Forgosh, Lb, Lefebvre, Gc, Pierpoint, Be, Radin, Dm, Stoller, Sr, Segall, N, Shah, Sa, Ramstad, Ds, Nisnisan, Jm, Trippett, Jm, Benjamin, Sa, Labissiere, Jc, Nashed, An, Maaieh, M, Aslam, Aa, Mandviwala, M, Budoff, Mj, French, Wj, Vlach, Jj, Destefano, P, Bayron, Cj, Fraser, Nj, Sandberg, Jh, Fagan, Tc, Peart, Bc, Suryanarayana, Pg, Gupta, Dk, Lee, Mw, Bertolet, Bd, Hartley, Pa, Kelberman, M, Behmanesh, B, Buynak, Rj, Chochinov, Rh, Steinberg, Aa, Chandna, H, Bjasker, Kr, Perlman, Rl, Ball, Em, Pock, J, Singh, S, Baldari, D, Kaster, S, Lovell, Jp, Horowitz, Bs, Gorman, Ta, Pham, Dn, Landzberg, Js, Mootoo, Ki, Moon, E, Krawczyk, J, Alfieri, Ad, Janik, Mj, Herrington, Dm, Koilpillai, Rn, Waxler, Ar, Hoffman, Da, Sahul, Zh, Gumbiner, B, Cropp, A, Fujita, K, Garzone, P, Imai, K, Levisetti, M, Plowchalk, D, Sasson, S, Skaggs, J, Sweeney, K, Vincent, J., Curto, M, Ridker, P., Revkin, J., Amarenco, P., Brunell, R., Curto, M., Civeira, F., Flather, M., Glynn, R., Gregoire, J., Jukema, J., Karpov, Y., Kastelein, J., Koenig, W., Lorenzatti, A., Manga, P., Masiukiewicz, U., Miller, M., Mosterd, A., Murin, J., Nicolau, J., Nissen, S., Ponikowski, P., Santos, R., Schwartz, P., Soran, H., White, H., Wright, R., Vrablik, M., Yunis, C., Shear, C., Tardif, J., SPIRE Cardiovascular Outcome Investigators, Averna, M., Brigham and Women's Hospital [Boston], Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), Interne Geneeskunde, Ridker, P. M., Glynn, R. J., Jukema, J. W., Kastelein, J. J. P., Nicolau, J. C., Santos, R. D., Schwartz, P. F., Wright, R. S., Shear, C. L., Tardif, J. -C., SPIRE Cardiovascular Outcome Investigator, Perrone, Filardi, P, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes

Subjects
Male, STATIN THERAPY, Anticholesteremic Agents/adverse effects, Antibodie, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Injections, Subcutaneous/adverse effects, 030204 cardiovascular system & hematology, Bococizumab, law.invention, PCSK9, 0302 clinical medicine, Randomized controlled trial, law, Risk Factors, GENETIC-VARIANTS, Cardiovascular Disease, Monoclonal, Anticholesteremic Agent, 030212 general & internal medicine, Myocardial infarction, Treatment Failure, Humanized, Proprotein Convertase 9/antagonists & inhibitors, Medicine(all), Antibodies, Antibodies, Monoclonal, Humanized, Anticholesteremic Agents, Cardiovascular Diseases, Cholesterol, LDL, Double-Blind Method, Female, Follow-Up Studies, Humans, Hypercholesterolemia, Injections, Subcutaneous, Lipids, Middle Aged, Proprotein Convertase 9, Medicine (all), PCSK9 Inhibitors, antibodies monoclonal humanized, anticholesteremic agents, cardiovascular diseases, cholesterol, LDL, double-blind method, female, follow-up studies, humans, hypercholesterolemia, injections, subcutaneous, lipids, male, middle aged, proprotein convertase 9, risk factors, treatment failure, medicine (all), Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], General Medicine, Lipid, 3. Good health, LDL/blood, Multicenter Study, Cholesterol, TRIALS, Cholesterol, LDL/blood, Antibodies, Monoclonal, Humanized/adverse effects, Randomized Controlled Trial, subcutaneous, lipids (amino acids, peptides, and proteins), Cardiovascular Diseases/prevention & control, REDUCING LIPIDS, Human, medicine.medical_specialty, animal structures, Hypercholesterolemia/drug therapy, Placebo, Injections, Subcutaneou, LDL, Injections, Follow-Up Studie, EVENTS, 03 medical and health sciences, Internal medicine, medicine, Journal Article, Comparative Study, METAANALYSIS, Alirocumab, business.industry, Unstable angina, Lipids/blood, Risk Factor, fungi, Antibodies/blood, ta3121, medicine.disease, Surgery, Evolocumab, REDUCTION, Humanized/adverse effects, Subcutaneous/adverse effects, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Item does not contain fulltext BACKGROUND: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS: In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS: At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P/=70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P=0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of >/=100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P=0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P=0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P

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2017
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32. MISCELLANEA

Author

Franceschini, E.

Published
1952

35. Re-exploring the iceberg of celiac disease in children: Results of a multicenter Italian screening project, based on a rapid HLA DQ typing test

Author

Gatti, S., primary, Galeazzi, T., additional, Verma, A.K., additional, Franceschini, E., additional, Annibali, R., additional, Del Baldo, G., additional, Palpacelli, A., additional, Marchesini, A., additional, Monachesi, C., additional, Balanzoni, L., additional, Colombari, A., additional, Scattolo, N., additional, Trevisan, M., additional, Cinquetti, M., additional, Lionetti, E., additional, and Catassi, C., additional

Published
2017
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36. Re-exploring the iceberg of celiac disease in children: Preliminary results of a multicenter Italian screening project based on a rapid HLA DQ typing test

Author

Gatti, S., primary, Galeazzi, T., additional, Verma, A., additional, Franceschini, E., additional, Palpacelli, A., additional, Del Baldo, G., additional, Annibali, R., additional, Monachesi, C., additional, Balanzoni, L., additional, Colombari, A.M., additional, Trevisan, M.T., additional, Scattolo, N., additional, Cinquetti, M., additional, Lionetti, E., additional, and Catassi, C., additional

Published
2016
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37. Genetic predisposition to celiac disease and oral health: Is there an association? Preliminary results of a large Italian screening in children

Author

Annibali, R., primary, Verma, A., additional, Palpacelli, A., additional, Del Baldo, G., additional, Franceschini, E., additional, Monachesi, C., additional, Mascitti, M., additional, Santarelli, A., additional, Galeazzi, T., additional, Lionetti, E., additional, Gatti, S., additional, and Catassi, C., additional

Published
2016
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38. Distorted configuration of the epidural catheter in situ. A pilot study

Author

SAMOLSKY DEKEL, BOAZ GEDALIAHU, CAROSI, FRANCESCA, RINALDELLI, GIAMPAOLO, DI NINO, GIANFRANCO, Bonazzi F., Calli M., Campi S., Dal Checco E., Franceschini E., Mosca L., Samolsky Dekel B.G., Bonazzi F., Calli M., Campi S., Carosi F., Dal Checco E., Franceschini E., Mosca L., Rinaldelli G., and Di Nino G.

Subjects
DISTORTED CONFIGURATION, EPIDURAL CATHETER
Published
2005

39. Telecommunications Using a Front-End Minicomputer.

Author

Feinroth, Y., Franceschini, E., Goldstein, M., and Bell, G.

Subjects
*MIDRANGE computers, *LARGE scale systems
Abstract

Examines the use of a front-end minicomputer to provide varied remote terminal access to a large scale computer. Problems of embedding telecommunications input/output within an operating system; Decentralization of intelligence acquired by front-end processing; Emphasis on the main processor-minicomputer link.

Published
1973
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40. An expectation maximization framework for an improved tissue characterization using ultrasounds

Author

Alessandrini, M., Maggio, S., Porée, J., de Marchi, L., Speciale, N., Franceschini, E., Bernard, O., Basset, O., Imagerie Ultrasonore, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département Intelligence Ambiante et Systèmes Interactifs (DIASI), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Dipartimento di Elettronica, Informatica e Sistemistica, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA))

Subjects
Imagerie Ultrasonore, reseau_international, Italie, Images et Modèles, categₛt2i, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

41. Clinical and Microbiological Characteristics of Visceral Leishmaniasis Outbreak in a Northern Italian Nonendemic Area: A Retrospective Observational Study

Author

Franceschini, E., primary, Puzzolante, C., additional, Menozzi, M., additional, Rossi, L., additional, Bedini, A., additional, Orlando, G., additional, Gennari, W., additional, Meacci, M., additional, Rugna, G., additional, Carra, E., additional, Codeluppi, M., additional, and Mussini, C., additional

Published
2016
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45. Chirurgia dei vasi extracranici

Author

Spartera, C, Ventura, Marco, Petrassi, Carla, Perilli, L, Rivellini, C, Cucciolillo, L, Masturzo, M, Franceschini, E, Setacci, C, Setacci, F, and Benevento, D.

Published
2005

46. Amputazione dell'arto inferiore

Author

Petrassi, Carla, Ventura, Marco, Cuccciolillo, L, D'Adamo, R, Mastromarino, A, and Franceschini, E.

Published
2005

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