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147 results on '"Francesconi K"'

4. AS3MT, Locus 10q24 and arsenic metabolism biomarkers in American Indians: The Strong Heart Family Study

Author

Balakrishnan, P, primary, Vaidya, D, additional, Franceschini, N, additional, Voruganti, V, additional, Gribble, M, additional, Haack, K, additional, Laston, S, additional, Umans, J, additional, Francesconi, K, additional, Goessler, W, additional, North, K, additional, Lee, E, additional, Yracheta, J, additional, Best, L, additional, MacCluer, J, additional, Kent, J, additional, Cole, S, additional, and Navas-Acien, A, additional

Published
2016
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15. La rieducazione propriocettiva

Author

Francesconi, K. and Gandini, Giovanni

Subjects
propriocezione, Settore M-EDF/01 - METODI E DIDATTICHE DELLE ATTIVITÀ MOTORIE, Riabilitazione, Riabilitazione, propriocezione
Published
2018

18. In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5tx00122f Click here for additional data file

Author

Meyer, S., Raber, G., Ebert, F., Leffers, L., Müller, S. M., Taleshi, M. S., Francesconi, K. A., and Schwerdtle, T.

Subjects
inorganic chemicals, Chemistry, integumentary system
Abstract

Arsenic-containing fatty acids are bioavailable and toxic to human liver cells in culture., Arsenic-containing fatty acids are a group of fat-soluble arsenic species (arsenolipids) which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group of arsenolipids, exert toxicity in similar concentrations comparable to arsenite although the toxic modes of action differ. Hence, a risk assessment of arsenolipids is urgently needed. In this study the cellular toxicity of a saturated (AsFA 362) and an unsaturated (AsFA 388) arsenic-containing fatty acid and three of their proposed metabolites (DMAV, DMAPr and thio-DMAPr) were investigated in human liver cells (HepG2). Even though both arsenic-containing fatty acids were less toxic as compared to arsenic-containing hydrocarbons and arsenite, significant effects were observable at μM concentrations. DMAV causes effects in a similar concentration range and it could be seen that it is metabolised to its highly toxic thio analogue thio-DMAV in HepG2 cells. Nevertheless, DMAPr and thio-DMAPr did not exert any cytotoxicity. In summary, our data indicate that risks to human health related to the presence of arsenic-containing fatty acids in marine food cannot be excluded. This stresses the need for a full in vitro and in vivo toxicological characterisation of these arsenolipids.

Published
2015

19. La rieducazione propriocettiva

Author

Pietro Pasquetti, Giuseppe Falcone, Gandini, Giovanni, Francesconi, K, GIOVANNI GANDINI, Pietro Pasquetti, Giuseppe Falcone, Gandini, Giovanni, Francesconi, K, and GIOVANNI GANDINI

Abstract

Il capitolo illustra i principali strumenti terapeutici dei riabilitatori e le attuali tecniche di rieducazione motoria e di fisioterapia, nell’ottica di una sinergia terapeutica tra di esse e di un approccio olistico alla riabilitazione.

Published
2018

23. Early-life exposure to selenium and metals and neuropsychological development at 2 years

Author

Francesconi K, Eggesbø M, Lenters, Iszatt N, and Hein Stigum

Subjects
Gerontology, Global and Planetary Change, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Neuropsychology, chemistry.chemical_element, Pollution, Early life, chemistry, Medicine, business, Selenium
Published
2019

27. Cadmium body burden and increased blood pressure in middle-aged American Indians: the Strong Heart Study

Author

Franceschini, N, primary, Fry, R C, additional, Balakrishnan, P, additional, Navas-Acien, A, additional, Oliver-Williams, C, additional, Howard, A G, additional, Cole, S A, additional, Haack, K, additional, Lange, E M, additional, Howard, B V, additional, Best, L G, additional, Francesconi, K A, additional, Goessler, W, additional, Umans, J G, additional, and Tellez-Plaza, M, additional

Published
2016
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29. Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

Author

Finke, H., Ebert, F., Kopp, J. F., Kleuser, B., Schwerdtle, T., Müller, S. M., Schumacher, F., Francesconi, K. A., and Raber, G.

Subjects
GENE expression, PHYSIOLOGICAL effects of arsenic, DNA methylation, METABOLISM, MASS spectrometry -- Medical applications, GENETICS
Abstract

Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsHCs (AsHC 332 and AsHC 360) on the expression of 44 genes covering DNA repair, stress response, cell death, autophagy, and epigenetics via RT-qPCR in human liver (HepG2) cells. Both AsHCs affected the gene expression, but to different extents. After treatment with AsHC 360, flap structure-specific endonuclease 1 (FEN1) as well as xeroderma pigmentosum group A complementing protein (XPA) and (cytosine-5)-methyltransferase 3A (DNMT3A) showed time- and concentration-dependent alterations in gene expression, thereby indicating an impact on genomic stability. In the subsequent analysis of epigenetic markers, within 72 h, neither AsHC 332 nor AsHC 360 showed an impact on the global DNA methylation level, whereas incubation with AsHC 360 increased the global DNA hydroxymethylation level. Analysis of cell extracts and cell media by HPLC-mass spectrometry revealed that both AsHCs were considerably biotransformed. The identified metabolites include not only the respective thioxo-analogs of the two AsHCs, but also several arsenic-containing fatty acids and fatty alcohols, contributing to our knowledge of biotransformation mechanisms of arsenolipids. [ABSTRACT FROM AUTHOR]

Published
2018
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36. Arsenic concentrations correlate with salinity for fish taken from the North Sea and Baltic waters

Author

Larsen, Erik Huusfeldt, Francesconi, K. A., Larsen, Erik Huusfeldt, and Francesconi, K. A.

Abstract

Total arsenic concentrations were determined in three teleost species (herring Clupea harengus; cod Gadus morhua, and flounder Platichthys flesus) taken. from four locations in the Baltic and North Sea with salinities ranging from 8 to 32 psu. Individual arsenic concentrations ranged from 0.04 to 10.9 mg/kg wet mass, and there was a positive linear relationship between arsenic concentration and salinity for all three species (r(2) 0.44 to 0.72, all P <0.001). Although it is well known that marine fish contain much higher concentrations of arsenic than do freshwater fish, the data reported here are the first showing a relationship between the total arsenic concentration in fish and salinity.

Published
2003

48. In vitrotoxicological characterisation of arsenic-containing fatty acids and three of their metabolitesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5tx00122f

Author

Meyer, S., Raber, G., Ebert, F., Leffers, L., Müller, S. M., Taleshi, M. S., Francesconi, K. A., and Schwerdtle, T.

Abstract

Arsenic-containing fatty acids are a group of fat-soluble arsenic species (arsenolipids) which are present in marine fish and other seafood. Recently, it has been shown that arsenic-containing hydrocarbons, another group of arsenolipids, exert toxicity in similar concentrations comparable to arsenite although the toxic modes of action differ. Hence, a risk assessment of arsenolipids is urgently needed. In this study the cellular toxicity of a saturated (AsFA 362) and an unsaturated (AsFA 388) arsenic-containing fatty acid and three of their proposed metabolites (DMAV, DMAPr and thio-DMAPr) were investigated in human liver cells (HepG2). Even though both arsenic-containing fatty acids were less toxic as compared to arsenic-containing hydrocarbons and arsenite, significant effects were observable at μM concentrations. DMAVcauses effects in a similar concentration range and it could be seen that it is metabolised to its highly toxic thio analogue thio-DMAVin HepG2 cells. Nevertheless, DMAPr and thio-DMAPr did not exert any cytotoxicity. In summary, our data indicate that risks to human health related to the presence of arsenic-containing fatty acids in marine food cannot be excluded. This stresses the need for a full in vitroand in vivotoxicological characterisation of these arsenolipids.

Published
2015
Full Text
View/download PDF

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