4 results on '"Francica, J. R."'
Search Results
2. Geologic mapping of the Ladakh Himalaya by computer processing of Landsat data
- Author
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Francica, J. R, Birnie, R. W, and Johnson, G. D
- Subjects
Earth Resources And Remote Sensing - Abstract
Computer processed Landsat digital data and field studies have been integrated to make a geologic map of the Indus Suture in the Ladakh Himalaya. This coordinated approach has been successful at locating and identifying the areal extent of the major rock bodies in a 2500 square kilometer area, much of which is inaccessable for conventional field geologic studies.
- Published
- 1980
3. Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria.
- Author
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Wu, R. L., Idris, A. H., Berkowitz, N. M., Happe, M., Gaudinski, M. R., Buettner, C., Strom, L., Awan, S. F., Holman, L. S. A., Mendoza, F., Gordon, J., Hu, Z., Chagas, A. Campos, Wang, L. T., Da Silva Pereiral, L., Francica, J. R., Kisalu, N. K., Flynn, BJ., Shi, W., and Kong, W.-P.
- Subjects
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MALARIA prevention , *DRUG therapy for malaria , *PROTOZOA , *CLINICAL trials , *PARASITEMIA , *MONOCLONAL antibodies - Abstract
Background: New approaches for the prevention and elimination of malaria, a leading cause of illness and death among infants and young children globally, are needed.Methods: We conducted a phase 1 clinical trial to assess the safety and pharmacokinetics of L9LS, a next-generation antimalarial monoclonal antibody, and its protective efficacy against controlled human malaria infection in healthy adults who had never had malaria or received a vaccine for malaria. The participants received L9LS either intravenously or subcutaneously at a dose of 1 mg, 5 mg, or 20 mg per kilogram of body weight. Within 2 to 6 weeks after the administration of L9LS, both the participants who received L9LS and the control participants underwent controlled human malaria infection in which they were exposed to mosquitoes carrying Plasmodium falciparum (3D7 strain).Results: No safety concerns were identified. L9LS had an estimated half-life of 56 days, and it had dose linearity, with the highest mean (±SD) maximum serum concentration (Cmax) of 914.2±146.5 μg per milliliter observed in participants who had received 20 mg per kilogram intravenously and the lowest mean Cmax of 41.5±4.7 μg per milliliter observed in those who had received 1 mg per kilogram intravenously; the mean Cmax was 164.8±31.1 in the participants who had received 5 mg per kilogram intravenously and 68.9±22.3 in those who had received 5 mg per kilogram subcutaneously. A total of 17 L9LS recipients and 6 control participants underwent controlled human malaria infection. Of the 17 participants who received a single dose of L9LS, 15 (88%) were protected after controlled human malaria infection. Parasitemia did not develop in any of the participants who received 5 or 20 mg per kilogram of intravenous L9LS. Parasitemia developed in 1 of 5 participants who received 1 mg per kilogram intravenously, 1 of 5 participants who received 5 mg per kilogram subcutaneously, and all 6 control participants through 21 days after the controlled human malaria infection. Protection conferred by L9LS was seen at serum concentrations as low as 9.2 μg per milliliter.Conclusions: In this small trial, L9LS administered intravenously or subcutaneously protected recipients against malaria after controlled infection, without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; VRC 614 ClinicalTrials.gov number, NCT05019729.). [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
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4. Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.
- Author
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Corbett, K. S., Flynn, B., Foulds, K. E., Francica, J. R., Boyoglu-Barnum, S., Werner, A. P., Flach, B., O'Connell, S., Bock, K. W., Minai, M., Nagata, B. M., Andersen, H., Martinez, D. R., Noe, A. T., Douek, N., Donaldson, M. M., Nji, N. N., Alvarado, G. S., Edwards, D. K., and Flebbe, D. R.
- Abstract
Background: Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate in nonhuman primates.Methods: Nonhuman primates received 10 or 100 μg of mRNA-1273, a vaccine encoding the prefusion-stabilized spike protein of SARS-CoV-2, or no vaccine. Antibody and T-cell responses were assessed before upper- and lower-airway challenge with SARS-CoV-2. Active viral replication and viral genomes in bronchoalveolar-lavage (BAL) fluid and nasal swab specimens were assessed by polymerase chain reaction, and histopathological analysis and viral quantification were performed on lung-tissue specimens.Results: The mRNA-1273 vaccine candidate induced antibody levels exceeding those in human convalescent-phase serum, with live-virus reciprocal 50% inhibitory dilution (ID50) geometric mean titers of 501 in the 10-μg dose group and 3481 in the 100-μg dose group. Vaccination induced type 1 helper T-cell (Th1)-biased CD4 T-cell responses and low or undetectable Th2 or CD8 T-cell responses. Viral replication was not detectable in BAL fluid by day 2 after challenge in seven of eight animals in both vaccinated groups. No viral replication was detectable in the nose of any of the eight animals in the 100-μg dose group by day 2 after challenge, and limited inflammation or detectable viral genome or antigen was noted in lungs of animals in either vaccine group.Conclusions: Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung. (Funded by the National Institutes of Health and others.). [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
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