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2 results on '"Franck’s"'

1. Fungal endophthalmitis associated with compounded products.

Author

Mikosz, Christina A, Smith, Rachel M, Kim, Moon, Tyson, Clara, Lee, Ellen H, Adams, Eleanor, Straif-Bourgeois, Susanne, Sowadsky, Rick, Arroyo, Shannon, Grant-Greene, Yoran, Duran, Julie, Vasquez, Yvonne, Robinson, Byron F, Harris, Julie R, Lockhart, Shawn R, Török, Thomas J, Mascola, Laurene, Park, Benjamin J, and Fungal Endophthalmitis Outbreak Response Team

Abstract

Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck's Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Fungal Endophthalmitis Associated with Compounded Products

Author

Julie Duran, Moon Kim, Shawn R. Lockhart, Susanne Straif-Bourgeois, Thomas J. Török, Rick Sowadsky, Rachel M. Smith, Yoran Grant-Greene, Christina A. Mikosz, Ellen H. Lee, Shannon Arroyo, Yvonne Vasquez, Laurene Mascola, Clara Tyson, Eleanor Adams, Julie R. Harris, Byron F. Robinson, and Benjamin J. Park

Subjects
Male, Triamcinolone acetonide, Epidemiology, lcsh:Medicine, Blindness, Triamcinolone Acetonide, Endophthalmitis, Fusarium, Bipolaris hawaiiensis, Rosaniline Dyes, Drug Recalls, Aged, 80 and over, biology, mold, Fungal endophthalmitis, Middle Aged, Fusarium incarnatum-equiseti, compounding, Infectious Diseases, endophthalmitis, fungal, Female, medicine.drug, Microbiology (medical), medicine.medical_specialty, endophthalmitis, disease outbreaks, Vial, Retina, eye infections, fungal, lcsh:Infectious and parasitic diseases, Franck’s, medicine, Humans, lcsh:RC109-216, eye infections, Aged, business.industry, Research, lcsh:R, Outbreak, Eye infection, medicine.disease, biology.organism_classification, Dermatology, United States, Surgery, Vitreous Body, disease outbreaks, Saccharomycetales, fungi, Ophthalmic Solutions, business
Abstract

Fungal endophthalmitis is a rare but serious infection. In March 2012, several cases of probable and laboratory-confirmed fungal endophthalmitis occurring after invasive ocular procedures were reported nationwide. We identified 47 cases in 9 states: 21 patients had been exposed to the intraocular dye Brilliant Blue G (BBG) during retinal surgery, and the other 26 had received an intravitreal injection containing triamcinolone acetonide. Both drugs were produced by Franck’s Compounding Lab (Ocala, FL, USA). Fusarium incarnatum-equiseti species complex mold was identified in specimens from BBG-exposed case-patients and an unopened BBG vial. Bipolaris hawaiiensis mold was identified in specimens from triamcinolone-exposed case-patients. Exposure to either product was the only factor associated with case status. Of 40 case-patients for whom data were available, 39 (98%) lost vision. These concurrent outbreaks, associated with 1 compounding pharmacy, resulted in a product recall. Ensuring safety and integrity of compounded medications is critical for preventing further outbreaks associated with compounded products. Download MP3 Length: 1:42

Published
2014

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